University Hospital, Clermont-ferrand

This study looks at whether a blood test can detect brain bleeding in older adults who fall repeatedly. Researchers will measure two proteins (GFAP and UCH-L1) in blood samples from 770 hospitalized patients aged 75 and older. The goal is to see if this test can safely replace so…

This study tests whether a gentle brain stimulation technique called tDCS, combined with standard rehabilitation, can prevent the development of chronic pain after a stroke. Researchers will enroll 60 stroke survivors who are at high risk for pain and give half of them real stimu…

This study will test four different medical devices (HMG, PHN, PHR, and TUR) in 160 adults with sore throat caused by viral pharyngitis or tonsillitis. The goal is to see how safe and effective they are in real-life conditions. Participants will track their symptoms and any side …

This study will follow 150 people with colds or sinus infections to see how well four medical devices work in real life. The goal is to confirm they are safe and help ease symptoms like runny nose, stuffiness, and sore throat. Participants will use the products for up to 14 days …

This study tests whether a mechanical cough-assist device (in-exsufflator) works better than manual chest physiotherapy for clearing mucus from the lungs of hospitalized patients aged 60 and older. About 120 participants with bronchial congestion will be enrolled. The goal is to …

This study looks at how often the airways close in critically ill adults who need a breathing machine (ventilator) in the ICU. About 500 patients from 39 ICUs will have their airway opening pressure measured to see if current ventilator settings may be causing lung damage. The go…

This study looks at whether a type of immune cell, called regulatory T cells (Tregs), works less effectively in women with chronic migraine. Researchers will compare blood samples from 24 women with chronic migraine and healthy women to measure how well these cells control inflam…

This study will use PET-MRI brain scans to compare the reward system in 44 Parkinson's patients, half with and half without a sleep behavior disorder called RBD. The goal is to understand why some patients develop impulse control problems, like gambling or compulsive eating, as a…

This study looks at whether it is possible and safe for patients in the intensive care unit (ICU) to have visits from their own pet dogs. The researchers will try this with 21 adult patients who own a dog and are expected to stay in the ICU for at least two days. The goal is to s…

This study looks at whether older adults (70+) with low muscle mass have a higher risk of bleeding while taking common blood thinners. Researchers will compare muscle mass, sarcopenia, and nutrition between 110 patients who had a bleeding event and those who did not. The goal is …

This study looks at 958 adults with severe stroke who need a procedure to remove a blood clot from their brain. Researchers want to find out if being fully asleep (general anesthesia) or lightly sedated (procedural sedation) leads to better recovery and less disability three mont…

This study looks at how long-term use of artificial sweeteners changes brain activity and connections in healthy adults aged 18-30. Researchers will compare brain scans of people who consume a lot of sweeteners with those who consume little or none. They will also ask some low-co…

This study looks at how one session of cycling exercise changes levels of two proteins (FGF21 and follistatin) in the blood of people with liver cancer. Researchers want to understand these changes to help design better exercise programs for patients. The study will involve 12 ad…

This study aims to understand the causes of pain in people with fibrous dysplasia of bone or McCune-Albright syndrome, rare conditions that can cause bone pain, deformities, and fractures. Researchers will compare 20 patients with 20 healthy volunteers using pain tests to see if …

This study aims to understand the obstacles families face in changing eating habits that lead to severe early childhood caries (cavities). Researchers will interview parents of 30 children under 6 who need dental treatment under general anesthesia. The goal is to identify barrier…

This study looks at 130 adults with heart failure who were part of a telemonitoring program but later left it because they no longer met eligibility rules. Researchers will track them for one year to see if they have serious heart events or need emergency care. The goal is to und…

This study looks at whether an MRI without a distension drink (which can cause vomiting or diarrhea) can still accurately measure inflammation in the small bowel for people with Crohn's disease. About 60 adults with Crohn's will get two MRIs in one week—one with the drink and one…

This study looks at whether patients who get a breathing tube in an emergency are more likely to develop pneumonia than those who get one in a planned setting. Researchers will review medical records of 600 adults intubated in 2024. The goal is to understand how urgency affects i…

This study tests a program called ADD'Pro that helps people with substance use disorders find jobs. About 100 adults will be randomly assigned to either the ADD'Pro program or standard employment services. The goal is to see if the program leads to more people working at least on…

This study follows 50 adults who have had head and neck cancer and now use a maxillofacial prosthesis (a custom-made artificial part for the face or mouth). Researchers will measure how well they chew, swallow, and speak, and how their quality of life changes over time. The goal …

This study looks at why a common gut bacterium, Enterococcus faecalis, sometimes travels to the heart and causes a serious infection called infective endocarditis. Researchers will study 90 adults with this bloodstream infection to see if changes in gut bacteria allow the germ to…