University Hospital, Clermont-ferrand

This pilot study tests whether fecal microbiota transplantation (FMT) can improve moderate to severe hidradenitis suppurativa (HS), a painful skin condition. Researchers will give 24 adults a single FMT and track changes in their skin lesions over 12 weeks. The goal is to see if …

This study investigates whether a supervised, adapted physical activity program can improve how the body burns fat during walking in women with overweight or obesity, both with and without polycystic ovary syndrome (PCOS). Researchers will compare changes in fat oxidation and oth…

This study compares four different sequences of biologic drugs (infliximab, filgotinib, ustekinumab, and vedolizumab) in 240 adults with moderate to severe ulcerative colitis. The goal is to see which order of treatments works best to achieve and maintain remission without steroi…

This study looks at whether a blood test can detect brain bleeding in older adults (75+) who fall repeatedly. Instead of always using a CT scan, which can be hard to get quickly, researchers will measure two proteins in the blood. The goal is to see if this test is accurate enoug…

This study tests whether a gentle electrical brain stimulation technique called tDCS, given alongside standard rehab, can prevent the development of chronic neuropathic pain after a stroke. Sixty adults who recently had a stroke will receive either real or sham tDCS for 10 sessio…

This study tests whether using a virtual reality headset (HypnoVR) during interventional radiology procedures can lower patients' anxiety and pain. Seventy adults will be randomly assigned to either use the VR headset or receive standard care. Researchers will measure anxiety wit…

This study looks at whether anti-IL-6 drugs, used for inflammatory conditions like rheumatoid arthritis, can also reduce migraine frequency and intensity. Researchers will compare 320 people taking anti-IL-6 drugs to those on anti-TNF drugs. Participants will report how their mig…

This study will test four medical devices (HMG, PHN, PHR, TUR) in 160 adults with sore throat from acute pharyngitis or viral tonsillitis. The goal is to see if they are safe and help reduce symptoms like pain when swallowing. Participants will use the device for up to 7 days and…

This study looks at two ways to help older adults in the hospital clear mucus from their lungs. One method uses a machine that gently blows air in and then sucks it out to mimic a strong cough. The other is a hands-on technique done by a physical therapist. The goal is to see whi…

This study looks at whether it's practical and safe for ICU patients to have short visits from their own pet dogs. Researchers will test this with 21 adult patients in three ICUs in France. The dog can stay for up to 15 minutes, and staff will check for any problems. The goal is …

This study surveys 1,000 adults with Restless Legs Syndrome (RLS) to find out how often pain is part of their symptoms and how it affects their daily lives. Participants fill out an online questionnaire about their medical history, sleep, pain, and quality of life. The goal is to…

This study will measure how well people with gum disease can chew. One hundred adults with periodontitis will chew a special gum for 20 cycles to test their chewing performance. Researchers will also check the severity of their gum disease to see if there is a link. This is an ob…

This study uses brain MRI to compare brain activity in women over 40 with knee osteoarthritis who have two different types of pain: joint-related pain and nerve-related pain. Researchers will look at a brain region called the anterior insula to see if activity differs between the…

This study looks at whether a type of immune cell called regulatory T cells works properly in people with chronic migraine. Researchers will compare blood samples from 24 women with chronic migraine to healthy controls. The goal is to understand if problems with these cells contr…

This study will follow 400 people who had a heart attack and have moderately reduced heart function (ejection fraction 35-50%). Participants will get a small implantable heart monitor to track their heart rhythm for up to 5 years. The goal is to identify markers that could predic…

This study looks at whether treating gum disease (periodontitis) can improve how well people chew and their overall oral quality of life. Researchers will ask 44 adults with gum disease to fill out questionnaires, do a chewing test with colored gum, and provide saliva samples. Th…

This study has two parts. First, it will adapt a questionnaire called the Iowa Infant Feeding Attitude Scale for use in France, testing its accuracy with new mothers and co-parents. Second, it will survey pregnant women and their partners to understand their cultural beliefs abou…

This study tests a program called ADD'Pro that combines addiction treatment with personalized job counseling to help people with substance use disorders return to work. About 100 adults will be randomly assigned to either the ADD'Pro program or standard employment services. Resea…

This study looks at how often the airways close in critically ill adults who need a breathing machine (ventilator) in the ICU. About 500 patients across 39 ICUs will have a simple bedside test to check for airway closure. The goal is to learn more about this common but under-reco…

This study aims to understand why people with fibrous dysplasia of bone or McCune-Albright syndrome experience chronic pain. Researchers will compare pain responses in 40 adults (20 patients and 20 healthy volunteers) using heat and cold tests. The goal is to see if the nervous s…

This study follows 50 adults who have had head and neck cancer and now use custom dental prostheses. Researchers will measure how well they chew food and how their quality of life changes over time. The goal is to understand the real-world benefits of these prostheses for cancer …

This study looks at whether an MRI without a bowel-distending drink (like PEG or mannitol) can still accurately measure inflammation in the small bowel of people with Crohn's disease. Many patients find these drinks hard to tolerate, causing vomiting or diarrhea. If skipping the …

This study looks at whether patients who get a breathing tube in an emergency are more likely to develop pneumonia than those who get one in a planned setting. Researchers will review medical records of 600 adults intubated in 2024. The goal is to understand the risk and improve …

This study uses interviews with parents of young children who have severe early childhood cavities treated under general anesthesia. The goal is to understand the real-life obstacles that make it hard for families to change sugary eating habits and prevent cavities from returning…

This study looks at why a common gut bacterium, Enterococcus faecalis, sometimes travels to the heart and causes a serious infection called infective endocarditis. Researchers will analyze the gut bacteria of 90 adults with this bloodstream infection to see if an imbalance in the…

This study will look at how a single 30-minute bike ride changes levels of certain liver proteins (FGF21 and follistatin) in 12 people with liver cancer. Researchers want to understand how exercise affects the body in these patients, which could lead to better exercise recommenda…

This study looks at 130 adults with heart failure who were part of a telemonitoring program but later left it because they no longer met eligibility rules. Researchers will track their health for one year, checking for hospital visits, heart-related deaths, and changes in heart s…

This study will use PET-MRI brain scans to compare the reward system in 44 Parkinson's patients, some of whom have a sleep disorder called RBD. The goal is to understand why some patients develop impulse control problems, like gambling or compulsive behaviors, as a side effect of…

This study looks at 958 people having a severe stroke to find out if general anesthesia (being fully asleep) or procedural sedation (being drowsy but breathing on your own) leads to better recovery after a procedure to remove a blood clot from the brain. Participants will be rand…

This study looks at how long-term use of non-nutritive artificial sweeteners (like those in diet drinks) affects brain connectivity. Researchers will use resting-state MRI scans to compare brain activity in 100 healthy young adults who consume either low or high amounts of these …

This study looks at whether older adults (70+) with low muscle mass are more likely to have serious bleeding while taking common blood thinners (apixaban or rivaroxaban). Researchers will compare muscle mass in 110 patients who had a bleeding event with those who did not. The goa…