Brain scans reveal why some knee pain feels different
NCT ID NCT07668674
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study uses brain MRI to compare brain activity in women over 40 with knee osteoarthritis who have two different types of pain: joint-related pain and nerve-related pain. Researchers will look at a brain region called the anterior insula to see if activity differs between the two groups. The goal is to better understand pain types, which could lead to more tailored treatments in the future. Participants will complete questionnaires, have a blood test, and undergo a non-invasive brain scan.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
What this could lead to
If successful, this study could help doctors better understand why some people with knee osteoarthritis feel nerve-related pain, potentially leading to more personalized pain treatments.
What could go wrong
This is a small, early pilot study with only 60 participants, so results may not apply to everyone. It is designed to observe and learn, not to test a new treatment.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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APHP - Pitié-Salpêtrière
Paris, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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APHP - Saint-Antoine
Paris, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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CHU Clermont-Ferrand
Clermont-Ferrand, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact