Osteoarthritis, knee

This study compares two types of partial knee replacements for people with arthritis on the inner side of the knee. One implant has a fixed bearing (the plastic piece stays still), while the other has a mobile bearing (the plastic piece can move slightly). Researchers will track …

This study compares a new plastic (PEEK) knee implant to a standard metal one in 200 people with severe knee osteoarthritis who need total knee replacement. The goal is to see if the plastic implant works just as well as metal in terms of pain relief, movement, and safety. Partic…

This study is a registry that will follow 300 people who receive the Freedom Total Knee System, a new artificial knee implant. The goal is to see how well the device holds up over time and how safe it is. Participants are adults with severe knee arthritis who have not gotten reli…

This Phase 3 trial tests whether a gel made from donated umbilical cord stem cells (CARTISTEM) can reduce pain and improve knee function better than a simple surgical cleanup (debridement) in people with knee cartilage damage and osteoarthritis. About 300 adults aged 18-75 with m…

This study tests whether a 6-week gait retraining program using real-time feedback can improve walking patterns and reduce early signs of knee osteoarthritis in people who have had ACL reconstruction. Seventy participants will be randomly assigned to receive either real-time biof…

This phase II trial tests whether an implant made from a patient's own nasal cartilage can treat patellofemoral osteoarthritis (knee arthritis) better than standard platelet-rich plasma injections. 75 adults aged 18–65 with moderate knee arthritis will be randomly assigned to rec…

This study tests whether Mobithron Advance, a daily oral supplement made from undenatured type II collagen, can slow or reverse cartilage loss in people with knee osteoarthritis. Over 12 months, 84 participants will take either the supplement or a placebo. Researchers will use MR…

This study compares two types of knee implants (medial congruent vs. posterior stabilized) in people having total knee replacement for arthritis. All surgeries will be done with the ROSA robotic system. Researchers will track 200 participants for up to 5 years to see which implan…

This study tests whether a new surgical irrigation solution called XPERIENCE can lower the risk of joint infection after hip or knee replacement better than the standard dilute Betadine wash. About 7,600 adults having primary hip or knee replacement will be randomly assigned to r…

This study compares two approaches for people with knee osteoarthritis who are already scheduled for knee replacement surgery. One group will have the surgery as planned, while the other will receive a comprehensive medical care plan including medications, injections, and lifesty…

This study is testing a new knee implant (Univation XF Pro) in 150 people with knee arthritis. The goal is to see how well the implant works and how safe it is over several years. Participants will have their knee function, pain, and quality of life tracked using questionnaires a…

This study tests a new way to repair damaged knee cartilage. Doctors take stem cells from the patient's bone marrow, grow them into cartilage in the lab, and then implant it into the knee. The trial includes 30 adults aged 18 to 65 with cartilage injuries or early knee osteoarthr…

This study compares two types of knee surgery for people with bow-legged knees and a torn meniscus. One surgery uses a newer bone-cut method, while the other uses a standard bone-cut method. About 20 participants will be randomly assigned to one of the two surgeries. Researchers …

This study looks at whether adding a bone marrow injection to standard knee surgery can improve pain and function for people with cartilage or meniscus injuries. Fifty adults aged 18 to 64 will be randomly assigned to get either the bone marrow injection or a placebo saltwater in…

This study tests a single injection of StromaForte, made from donor bone marrow cells, against a standard hyaluronic acid injection for knee osteoarthritis. About 140 adults with knee arthritis will receive one treatment and be followed for 12 months. The main goal is to see if S…

This Phase 2 trial tests whether a single injection of stem cells from umbilical cords can help people with knee osteoarthritis. 100 adults aged 40-70 will receive either a low or high dose of stem cells or a placebo. The study measures changes in pain, stiffness, and function ov…

This study tests whether a surgical robot (ROSA Knee) can help surgeons adjust their knee replacement plan during the operation based on the condition of the patient's soft tissues. About 80 adults with knee arthritis or rheumatoid arthritis will take part and be followed for 2 y…

This study compares two ways to perform a knee realignment surgery (high tibial osteotomy) in 50 adults with knee arthritis and bow-legged deformity. One group gets the standard surgery using X-ray guidance; the other uses a custom 3D-printed guide to make the bone cut. Researche…

This phase II trial tests whether a graft made from a patient's own nasal cartilage can treat patellofemoral osteoarthritis (knee arthritis). 150 adults with knee pain will receive either the nasal cartilage implant or standard care (a minor procedure or partial knee replacement)…

This study compares two methods of aligning a new knee joint during total knee replacement surgery: kinematic alignment and mechanical alignment. Researchers want to see which method gives better function and movement one year after surgery. The trial will involve 100 adults with…

This study tests a 12-week digital exercise program for people who had ACL knee surgery. The program uses sensors to help correct how the knee moves during walking, with the goal of reducing joint inflammation and preventing osteoarthritis. Researchers will enroll 60 adults aged …

This study tests whether a single injection of cells from your own bone marrow or belly fat can better ease knee osteoarthritis pain and stiffness. 204 adults aged 40-75 with knee OA will be randomly assigned to one of the two treatments. The goal is to see which cell source work…

This study compares two types of robotic-arm assisted knee replacement surgery in 120 people with knee osteoarthritis. One group gets cementless implants, the other gets cemented implants. The main goal is to see which approach helps patients 'forget' they have an artificial knee…

This study compares two types of knee replacement surgery for people with advanced knee arthritis: a standard total knee replacement and a robotic-assisted partial knee replacement. The goal is to see which one leads to better knee function and is more cost-effective. About 159 a…

This study follows 150 people with knee osteoarthritis and leg misalignment who had a knee osteotomy—a surgery that realigns the bones to take pressure off the damaged part of the knee. Researchers want to see how well the knee works years later and whether this surgery can help …

This Phase 3 trial tests whether injections of amniotic suspension allograft (ASA) can reduce pain and improve function in people with knee osteoarthritis. 160 participants will receive either ASA, hyaluronic acid, or a saline placebo. Researchers will track pain, knee function, …

This study is testing the Persona knee implant in 760 people who need total knee replacement due to arthritis or other knee conditions. The goal is to see if the implant is safe and improves knee function and quality of life. Participants will be followed for several years after …

This study is testing a new type of knee implant that doesn't require bone cement, in 130 people needing total knee replacement. The goal is to see if the implant improves knee function, reduces pain, and helps patients feel more natural after surgery. Researchers will track outc…

This study tests a new device called the LIFT Implant for people with kneecap arthritis. The implant lifts the kneecap tendon to reduce pressure on worn-out cartilage. Researchers will compare it to a standard surgery that moves a piece of shinbone. 245 adults aged 22 to 65 with …

This study compares two types of hip replacement materials in 100 adults aged 18 to 65 who need a total hip replacement. One group gets a ceramic-on-polyethylene implant where the polyethylene is infused with vitamin E to reduce wear. The other group gets a standard ceramic-on-ce…

This study tests whether stem cells from umbilical cords can help people with knee osteoarthritis. Sixty participants will receive either a low or high dose of these cells injected into the knee joint. The goal is to see if the treatment is safe and can reduce pain and improve kn…

This study tests whether injecting a patient's own fat tissue along with hyaluronic acid into one knee works better than fat alone in the other knee. One hundred adults with painful knee osteoarthritis will receive both treatments, and researchers will compare pain, stiffness, an…

This study compares two knee surgeries for people with knee osteoarthritis, a meniscus problem, and a misaligned leg. Half the participants will get a standard realignment surgery, and the other half will get that plus a donor meniscus transplant. The goal is to see if the combin…

This study tests whether a lab-grown sheet of human cartilage cells (CLS2901C) can improve knee function and reduce pain in people with knee osteoarthritis. About 96 adults aged 20–79 who need knee realignment surgery will receive either the cell sheet plus surgery or surgery alo…

This study tests whether a concentrated bone marrow injection (cBMA) given during repeat ACL surgery can reduce knee pain and signs of arthritis. About 40 adults aged 18-55 who need a second ACL repair will receive either cBMA plus surgery or surgery alone. Researchers will track…

This study is testing a new computer navigation system (OrthoPilot with pheno4u software) to help surgeons perform knee replacements more accurately. About 120 people who need a total knee replacement will take part. The goal is to see if the new software improves how well the im…

This early-stage study tests a new gene therapy called BBM-A101 for people with moderate knee osteoarthritis. The main goal is to check if it is safe and tolerable. About 81 adults with knee pain and joint changes will receive the treatment and be monitored for side effects and a…

This study is testing a new knee replacement system called Persona Revision for people who need a second knee replacement surgery. The goal is to see if it improves knee function, reduces pain, and is safe. About 380 adults will be followed for two years after surgery.

This study is testing whether a treatment made from a patient's own bone marrow cells (StroMed) combined with platelet-rich plasma can safely reduce pain and inflammation from knee osteoarthritis. The trial plans to enroll 4,000 people with moderate to severe knee arthritis. Rese…

This early study tests a single injection of cells made from donor gum tissue into the knee joint of 15 people with knee osteoarthritis. The main goal is to see if it is safe, but researchers will also check for pain relief and better knee function. The cells have shown anti-infl…

This study tests a new treatment called OA-SYS, made from cells taken from fat tissue, for people with moderate to severe knee osteoarthritis. The main goal is to see if it is safe and tolerable. 400 adults aged 35-75 with knee arthritis will receive the treatment and be monitore…

This study tests whether exosomes—tiny particles from stem cells—can help people with knee osteoarthritis. Twenty adults with mild to moderate knee arthritis will receive two injections of these exosomes into the knee joint. Researchers will measure changes in pain and knee funct…

This early-stage study tests a new imaging agent called 18F-4FN for PET scans to safely detect inflammation in the body. It involves 55 adults with cancer who are on immunotherapy or have suspected inflammation. The goal is to see if this agent can highlight areas of inflammation…

This study is testing whether a smartphone app can detect early knee osteoarthritis by measuring how the knee moves during simple activities like walking. Researchers will compare the app's results to standard motion-capture equipment and patient symptoms. If it works, this could…

This Mayo Clinic study tests a new 3D MRI sequence called oZTEo, enhanced with deep learning, to detect bone erosions in the hands of people with inflammatory arthritis. The goal is to see if this advanced scan finds erosions better than standard MRI or X-rays. The study will enr…

This study tests whether injecting ozone gas into the knee joint, combined with exercise, can reduce pain and improve function in people aged 40-75 with moderate knee osteoarthritis. Participants receive three weekly ozone injections at different concentrations (10, 15, or 20 µg/…

This study tests a modular, powered leg brace (exoskeleton) designed to assist knee movement and reduce pain in people with knee osteoarthritis. The brace provides a small amount of torque to help the joint, potentially lowering muscle effort and painful loads on the knee. Resear…

This study tests whether a team of pharmacists and physiotherapists can help people with early knee osteoarthritis manage their condition. Participants will get one-on-one pharmacist care, including medication review and education, plus individual or group physiotherapy sessions.…

This study compares two minimally invasive procedures—cryoneurolysis (freezing nerves) and radiofrequency (using electric pulses)—to relieve knee pain in adults with osteoarthritis who haven't responded to standard treatments like painkillers or physical therapy. Sixty participan…

This Stanford study tests whether people with knee osteoarthritis can learn to change how they activate their calf muscles while walking, using a vibrating feedback device. The goal is to reduce the force on the knee joint. Thirty-one participants will train on a treadmill or ove…

This study tests whether taking vitamin C around the time of knee replacement surgery can reduce long-term pain. About 400 adults having knee replacement will be randomly assigned to receive vitamin C or a placebo for 8 weeks. The main goal is to see if a larger study is possible…

This study tests whether injecting Botox or hyaluronic acid into the knee joint can reduce pain in people with knee osteoarthritis. Fifty adults aged 50 and older with moderate to severe knee arthritis will receive three weekly injections of one of the two treatments. The main go…

This study compares two exercise programs for people with knee osteoarthritis: supervised cycling on a stationary bike and a land-based therapeutic exercise program with strengthening and balance training. The goal is to see which approach better reduces pain sensitivity during a…

This Phase 3 study tests a once-weekly injection called eloralintide in 900 adults with osteoarthritis of the knee who are also overweight or obese. The goal is to see if it reduces knee pain and helps with weight loss compared to a placebo. Participants will be in the study for …

This study tests a single injection called SL1002 to see if it safely reduces knee pain in people with osteoarthritis. About 150 adults aged 40 and older with mild to moderate knee arthritis will receive either the study drug or a placebo. The main goal is to measure pain relief …

This Phase 2 trial is testing four experimental drugs (taken orally or by IV) against placebo in 10,000 people with chronic pain from knee osteoarthritis, diabetic nerve damage, or low-back pain. The goal is to see if any of these drugs can safely reduce pain. The study uses a fl…

This study is testing whether giving one dose of methadone just before total knee replacement surgery can help control pain afterward and reduce the amount of other painkillers needed. About 192 adults aged 21-75 having a knee replacement will be randomly assigned to receive meth…

This study tests whether daily cannabis extracts (CBD or THC) can reduce pain interference in people with hip or knee osteoarthritis. One hundred adults aged 40-80 will take either CBD, THC, or a placebo capsule daily for 8 weeks and track their symptoms remotely. The goal is to …

This study tests whether an enhanced recovery after surgery (ERAS) protocol helps people recover faster after total knee replacement. About 120 patients aged 50-70 will either get standard care or the ERAS plan, which includes pre-surgery exercise, shorter fasting, and early walk…

This study tests an experimental drug called Allocetra, given as a shot into the knee joint, for people aged 64+ with moderate-to-severe knee osteoarthritis. The goal is to see if it reduces pain and improves function better than a placebo. About 270 participants will be followed…

This trial tests whether a short, temporary nerve stimulation can reduce pain in people with moderate to severe knee osteoarthritis. About 100 adults aged 30 to 70 who have not found relief from oral pain medications or physical therapy will receive a brief electrical pulse to sp…

This study compares two types of balance and strength exercises added to standard physical therapy for knee osteoarthritis. Sixty adults aged 40-70 with mild to moderate knee arthritis will be randomly assigned to one of two exercise programs. The goal is to see which approach be…

This study tests a powered boot-like device (exoskeleton) to see if it can help people with knee osteoarthritis walk more easily. Nine adults with knee pain who have trouble walking will try the device in a lab. The goal is to see if the device is comfortable and can reduce strai…

This study tests two ways to guide a treatment called cooled radiofrequency ablation for knee osteoarthritis pain. The treatment uses heat to calm nerves around the knee. Researchers want to see if using ultrasound is better than the standard X-ray method for targeting the right …

This trial compares two injection treatments for knee osteoarthritis: a combination of platelet-rich plasma (PRP) and hyaluronic acid versus hyaluronic acid alone. Researchers want to see if the combined approach provides better pain relief and function after one year. The study …

This study looks at whether a special exercise method called blood flow restriction (BFR) can help reduce pain and improve muscle function in people with severe knee osteoarthritis who are waiting for knee replacement surgery. Participants will try six different exercise setups t…

This study tests whether injections of platelet-rich plasma (PRP) work better than hyaluronic acid (HA) for people with advanced knee osteoarthritis (grades III or IV). 150 participants will receive three injections of either PRP or HA and be followed for a year. The goal is to s…

This study tests whether doing leg exercises with a blood pressure cuff on the thigh can temporarily reduce pain in people with severe knee osteoarthritis who are waiting for knee replacement surgery. Forty-five participants will do two different exercise sessions (with either fi…

This study is tracking 1,200 adults with knee osteoarthritis who have not found relief from standard treatments. They will undergo a procedure called genicular artery embolization, which blocks certain blood vessels to reduce inflammation and pain. Researchers will follow partici…

This study tests whether giving patients a personalized prediction tool and extra support for mental health and physical function can improve satisfaction one year after knee replacement surgery. About 300 adults at higher risk of dissatisfaction will be randomly assigned to eith…

This study tests whether low-dose radiotherapy can reduce pain in people with knee osteoarthritis. 128 participants will receive either real radiation or a sham treatment three times a week for two weeks. Researchers will track pain scores and painkiller use for six months to see…

This study is testing whether cannabidiol (CBD) tablets can reduce pain and improve daily function in people with knee osteoarthritis. Researchers will compare pain levels between those taking CBD and those not taking it, alongside standard physical therapy. The study aims to enr…

This study looks at whether adding a technique called blood flow restriction (BFR) exercise to standard physical therapy can help people recover more quickly after total knee replacement. BFR uses a cuff to lightly restrict blood flow during low-weight exercises, which may help b…

This study tests a once-daily pill called orforglipron in 800 adults with obesity or overweight who also have painful knee osteoarthritis. The goal is to see if the drug reduces knee pain and improves physical function over about 74 weeks. Participants will be randomly assigned t…

This study tests whether a compressive cryotherapy device (Game Ready®) can reduce the need for opioid painkillers after total knee replacement surgery. About 74 adults aged 60-80 will be randomly assigned to use either the device or traditional ice packs four times daily for a w…

This study tests whether a new nerve block (quadri-block) helps people recover better after total knee replacement compared to the usual method (adductor canal block plus surgical infiltration). One hundred adults with knee arthritis scheduled for knee replacement will be randoml…

This study tests whether a special cooling cuff works better than traditional ice packs for reducing swelling and pain after total knee replacement. About 102 adults having their first knee replacement will be split into two groups: one gets the cuff, the other gets ice packs. Th…

This Phase 3 trial tests whether a once-weekly injection called NNC0487-0111 can help people with overweight or obesity and knee osteoarthritis lose weight and feel less pain. About 400 adults will receive either the drug or a placebo for several weeks. Researchers will measure c…

This study tests whether special shoe insoles can reduce pain in people with knee osteoarthritis who also have foot pain. About 31 participants will wear either lateral wedge insoles or insoles with added arch support for at least 5 hours a day over 3 months. Researchers will mea…

This study tests a device called the MISHA Knee System, a small implant placed under the skin near the knee to absorb shock and reduce pain from medial knee osteoarthritis. Researchers will compare it to non-surgical treatments like physical therapy and medication in 100 adults w…

This Phase 3 study tests a once-weekly injection called NNC0487-0111 in 400 adults who are overweight or obese and have knee osteoarthritis. The goal is to see if it helps with weight loss and reduces knee pain compared to a placebo. Participants receive either the active drug or…

This study tests whether a pharmacist-led program can help patients reduce their opioid use by about half in the weeks before knee or hip replacement surgery. 45 adults on stable, moderate-dose opioids will work with a pharmacist to create a taper plan and get weekly check-ins. T…

This study compares two steroid injections for knee osteoarthritis in people with type 2 diabetes. It aims to see which one controls pain better while causing fewer blood sugar spikes. About 120 adults with diabetes and knee arthritis will receive either a long-acting or short-ac…

This study tests a procedure called Genicular Artery Embolization for people with mild-to-moderate knee osteoarthritis. Doctors inject tiny particles into arteries that supply the knee lining to reduce blood flow and hopefully ease pain. Fifteen participants will be followed for …

This study tests whether adding a mild electrical current (interferential current) to a standard exercise program can further reduce pain and improve function in people with knee osteoarthritis. 138 adults aged 40-75 with knee pain will be split into three groups: exercise only, …

This study tests whether an app called Genus, which provides videos, exercises, and quizzes, can help people with knee osteoarthritis learn more about their condition and feel more confident in treatment decisions. About 204 adults over 50 who are waiting for a specialist appoint…

This study tests whether sleeping near a special device that claims to emit 'biophotons' can reduce chronic severe arthritis pain. About 102 adults with long-term arthritis pain will use either the active device or a placebo (inactive) device for 12 weeks. Researchers will measur…

This study compares two approaches to recovery after total knee replacement: a fast track plan designed to speed up recovery versus standard care. Researchers will measure how well patients can move and care for themselves after surgery, as well as how long they stay in the hospi…

This study looks at whether adding a special education program about chronic pain to standard exercise therapy can improve daily function and reduce pain in people with knee osteoarthritis. About 92 adults with knee OA will be randomly assigned to either exercise alone or exercis…

This study tests whether combining two nerve blocks (iPACK and adductor canal block) with a numbing drug called ropivacaine can reduce pain and inflammation after total hip replacement. Sixty older adults (65-100 years) having hip surgery will be randomly assigned to receive eith…

This study tests whether a gel containing pregabalin, applied through the skin using ultrasound (phonophoresis), combined with calf muscle stretching, can reduce nerve pain and improve walking in people with grade III knee osteoarthritis. The trial includes 35 adults aged 40-70 w…

This study looks at whether people who have knee replacement surgery can use remote monitoring and video calls instead of scheduled in-person follow-ups. About 140 patients will be split into two groups: one with standard hospital visits at 2 and 12 months, and another that answe…

This study follows 270 adults having knee replacement surgery to see if the steroid dexamethasone (given as a pill or through a vein) helps with early recovery. Researchers will measure pain, mobility, nausea, and need for extra painkillers. The study does not assign treatments—p…

This study tests whether an AI-assisted web app that personalizes home exercises can reduce pain and improve knee function in people with knee osteoarthritis, compared to a standard paper exercise program. About 84 adults with knee pain will be randomly assigned to either the AI …

This study tests two different ways to numb the back of the knee after total knee replacement surgery. Both methods are combined with a standard front-of-thigh block. The goal is to see which approach leads to better overall recovery, less pain, and less need for strong painkille…

This study looks at whether doing breathing exercises before orthopedic surgery (like knee, hip, or fracture repair) can help your lungs work better after the operation. It involves 36 adults who have used tobacco and are at risk for breathing problems after surgery. Participants…

This study tests whether taking nefopam, a non-opioid painkiller, by mouth before and after knee replacement surgery can reduce pain and the need for morphine. About 50 adults having knee replacement will be randomly assigned to receive either nefopam or a placebo. The goal is to…

This study tests whether extracorporeal shock wave therapy can reduce pain and improve function in people with knee arthritis. 72 adults with persistent knee pain will receive either shock wave therapy or a daily exercise program. Researchers will measure pain levels and joint fu…

This study tests whether using a whole-body vibration plate at home for 12 weeks can reduce knee pain and inflammation in adults aged 40-75 with osteoarthritis. Participants stand on the device for up to 20 minutes per session. Researchers will measure pain sensitivity, artery st…

This study tests whether progressive resistance exercises or aerobic exercises better improve knee cartilage and physical function in people aged 35-55 with degenerative meniscus tears. 45 participants will be split into three groups: resistance training, aerobic training, or sta…

This study compares two knee braces for people with knee arthritis affecting the inner part of the knee. Researchers will measure changes in pain and walking ability over 8 weeks. Participants must be 40-85 years old, have moderate pain, and be willing to wear the brace at least …

This study tests a single injection of Hydrogel OA 2% in 20 adults with knee osteoarthritis. The goal is to see if the gel is safe and tolerable over 13 weeks to 12 months. Participants must be 35–75 years old with a BMI between 20 and 35.

This study looks at how to best offer group physical therapy to veterans with knee osteoarthritis. About 20 VA clinics will take part to see if this approach helps more patients start and stick with therapy. The goal is to make it easier for veterans to manage knee pain and stay …

This study compares two methods of pain control during knee replacement surgery. One uses numbing medicine injected into the knee area only. The other adds nerve blocks to that injection. The goal is to see which approach provides better pain relief and reduces the need for stron…

This study tests whether adding special balance platform exercises to standard physical therapy can improve pain, balance, and daily function in people with knee osteoarthritis. About 36 adults aged 45-65 with moderate knee arthritis will be randomly assigned to either standard t…

This study tests whether an injected drug called pentosan polysulfate sodium can reduce knee pain and improve function in people with knee osteoarthritis. About 466 adults with moderate to severe knee arthritis who haven't found relief from other treatments will receive either th…

This study tests three home-based programs for people with long-term muscle or joint pain (like back pain or arthritis) who also sleep poorly. Participants will be randomly assigned to 12 months of exercise, cognitive behavioural therapy for insomnia (CBT-I), or both. The goal is…

This study tests whether a 10-week telehealth program that combines gentle exercise with mindfulness can help people with knee osteoarthritis feel less pain and move better. Researchers will compare the mindful exercise group to an exercise-only group. All sessions happen remotel…

This study tests whether helping people with insomnia sleep better before knee or hip replacement surgery can reduce pain and improve recovery afterward. One hundred adults scheduled for surgery will receive either cognitive behavioral therapy for insomnia or sleep education for …

This pilot study compares custom-made, 3D-printed knee implants (YourKnee) to standard off-the-shelf implants in 20 people with knee osteoarthritis. The custom implants are designed based on each patient's unique knee shape and are placed using patient-specific cutting guides. Th…

This study will follow 10,000 adults with common joint or tendon problems—like knee arthritis, tennis elbow, or plantar fasciitis—who choose to receive a platelet-rich plasma (PRP) injection. PRP is made from a patient's own blood, spun to concentrate healing factors. Participant…

This study looks at which extra features added to an online exercise program help people who have had a knee replacement become more active. About 336 adults who had knee surgery at least a year ago and currently do little exercise will take part. Researchers will track changes i…

This study is testing whether giving a steroid injection to the knee that is not being operated on can help reduce pain and improve function for people undergoing total knee replacement. The study will involve 60 adults with knee osteoarthritis who are scheduled for a single knee…

This study compares two types of nerve blocks to control pain after total knee replacement. 78 adults will receive one of two combinations of ultrasound-guided injections near the knee. The goal is to see which approach reduces pain and the need for opioid painkillers in the firs…

This Phase 3 trial tests whether a single injection of particles from donated placental tissue (PTP-001) can reduce pain and improve function in people with knee osteoarthritis. About 260 adults aged 40–80 with mild-to-moderate knee OA will receive either the placental injection …

This study tests two different nerve block combinations to control pain after total knee replacement. 120 adults will receive either a popliteal plexus block or a distal IPACK block, both combined with a femoral triangle block. The goal is to see which approach reduces opioid use…

This study compares a new hydrogel injection (Arthrosamid) to a standard steroid shot for treating knee osteoarthritis. About 200 adults with knee pain and moderate to severe arthritis will receive one of the two injections. The goal is to see if the hydrogel reduces pain, stiffn…

This study tests whether filling the bone gap with a synthetic putty (AttraX Putty) during knee realignment surgery can reduce pain in the first week after surgery. About 40 adults with knee osteoarthritis will be randomly assigned to get the putty or standard surgery without a g…

This study looks at whether a structured physical therapy program can improve how people walk and distribute weight on their feet after total knee replacement surgery. Researchers will measure walking speed, step length, and foot pressure in 30 female participants before and afte…

This study tests whether 99Tc-MDP (Yunke), a drug already used for rheumatoid arthritis, can reduce pain and stiffness in people with knee osteoarthritis. It compares the drug to celecoxib, a common painkiller. The trial will enroll 40 participants and measure changes in pain, jo…

This study is testing whether giving extra doses of tranexamic acid (TXA) after hip or knee replacement surgery can reduce bleeding, pain, and help people move around sooner. TXA is a drug already used during surgery to prevent blood loss. The trial will compare the standard sing…

This study tests whether high-intensity laser therapy (HILT) plus exercise works better than standard physical therapy plus exercise for knee osteoarthritis. One hundred adults aged 40 to 75 with knee arthritis will be split into two groups to compare pain relief, joint function,…

This study tests whether a painless, needle-free treatment called transcutaneous pulsed radiofrequency acupuncture can reduce pain and stiffness in people with knee osteoarthritis. About 90 adults aged 45 to 85 with long-term knee pain will receive the treatment along with standa…

This study tests whether injecting dextrose (a sugar solution) into specific spots seen on MRI works better than injecting it into the knee joint for osteoarthritis. Sixty adults aged 45-80 with moderate knee OA will receive either MRI-guided extra-articular or ultrasound-guided …

This study is testing whether using a special sensor device during knee replacement surgery leads to better results for patients. The device helps the surgeon make precise bone cuts. Researchers will follow 40 people for up to 2 years after surgery, measuring pain, function, and …

This study compares two alignment techniques—kinematic and functional—used during robotic-assisted total knee replacement. 240 people with knee osteoarthritis will be randomly assigned to receive one of two types of implant inserts. Researchers will track how well patients forget…

This study tests whether a magnesium supplement called Magnesium-L-Threonate (MgT) can improve sleep quality and reduce pain in people recovering from total knee or hip replacement. Researchers will enroll 64 adults having surgery at the University of Miami Hospital. Participants…

This study tests a new nerve block called BiFeS against the standard iPACK block for pain after knee replacement surgery. 88 adults having a knee replacement will be randomly assigned to receive one of the two blocks. The goal is to see which provides better pain relief and helps…

This study will follow 86 adults with knee osteoarthritis to see if injections of sugar-water (dextrose) or local anesthetic around the knee nerves provide better pain relief and function. Participants will be assessed for six months after their routine injection. The goal is to …

This study tests whether a short course of the steroid methylprednisolone, taken as pills after knee replacement surgery, can reduce pain, opioid use, and nausea. About 420 adults having knee replacement for osteoarthritis will receive either the steroid or a placebo. The goal is…

This study compares two pain-relief methods after total knee replacement: a single injection into the adductor canal versus a continuous nerve block in the thigh. The goal is to see which approach helps patients walk farther and recover faster without increasing fall risk. About …

This study tests a single injection called 4P004 for people with knee osteoarthritis and synovitis (inflammation). About 129 adults aged 40-80 will receive either the injection or a placebo. The goal is to see if it reduces daily knee pain and improves function over 12 weeks.

This study tests whether cannabidiol (CBD) can lower the need for opioid painkillers after knee replacement surgery. 380 adults with knee osteoarthritis will take CBD or a placebo before and after surgery. Researchers will measure total opioid use and pain over 28 days to see if …

This study compares two approaches for older adults with knee osteoarthritis and insomnia: personalized exercise coaching alone versus exercise plus a digital insomnia treatment. Researchers want to see if adding sleep therapy leads to greater pain relief. The trial involves 288 …

This study tests whether a group exercise program done over video calls is practical and helpful for Veterans with knee or hip arthritis. Fifty participants will exercise together online for 3 months, then get either text reminders or extra group sessions for 6 more months. Resea…

This study tests a procedure called transarterial microembolization (TAME) for people with knee osteoarthritis and long-lasting pain that hasn't improved with standard treatments. Doctors will inject tiny beads into blood vessels around the knee to block abnormal blood flow, aimi…

This pilot study tests whether wearing a knee extension brace for the first 72 hours after total knee replacement can reduce pain and improve recovery. 106 participants will be randomly assigned to either the brace or standard care with early movement. The main goal is to see if …

This study tests a new knee injection called ALLOHEAL for people with knee osteoarthritis. The injection contains natural substances to reduce friction in the joint and ease pain. About 286 adults aged 40 to 79 with knee pain will receive either ALLOHEAL or a similar approved tre…

This study looks at whether using cold and compression after total knee replacement surgery helps reduce pain more than standard care. About 90 adults aged 50 and older with knee osteoarthritis will be split into two groups. Their pain levels will be tracked before surgery, daily…

This study tests whether a hands-on technique called gastrocnemius myofascial release (a type of calf muscle massage) can reduce pain and improve physical function in women aged 45-55 with knee osteoarthritis. Thirty participants will receive either the real treatment or a sham v…

This study looks at how a person's background and their clinic visit affect knee osteoarthritis pain relief using topical diclofenac gel. 220 adults aged 50+ with knee OA will apply the gel for 8 weeks and answer questions about their pain. Researchers will also analyze blood sam…

This study is testing a device called the MISHA® Knee System to see if it safely relieves pain and improves function in people with medial knee osteoarthritis. About 120 adults aged 25 to 65 who have not gotten relief from other treatments will receive the implant and be followed…

This study compares two types of knee replacement implants designed to work with a newer, more natural surgical technique called kinematic alignment. The goal is to see which implant helps patients feel more like their knee is their own, with less stiffness and pain. About 120 pe…

This early-stage study tests a single injection of AVD275, a new form of the pain reliever celecoxib, in 15 adults with knee osteoarthritis. The goal is to check safety and how the drug spreads in the body. Participants will be monitored for 24 weeks after the shot.

This study tests whether taking creatine supplements for 12 weeks helps adults aged 65 and older regain muscle mass, strength, and physical function after total knee replacement surgery. Participants will take creatine or a placebo daily alongside standard rehabilitation. The goa…

This study tests if focused shockwave therapy can safely reduce knee pain and improve function in people with osteoarthritis who have bone marrow lesions. Fifteen adults with persistent knee pain will receive four weekly shockwave sessions or standard care (pain relievers and res…

This study tests whether remimazolam, a newer anesthesia drug, causes less confusion (delirium) after surgery than the standard drug propofol in elderly patients having hip or knee replacement. Researchers will monitor 82 participants for three days after surgery to check for del…

This study compares two types of computer-assisted knee replacement surgery: one using a navigation system (OrthoPilot) and one using a robotic arm (MAKO). The goal is to see if they provide similar improvements in knee function and pain relief one year after surgery. About 140 a…

This study looks at whether keeping or removing the posterior cruciate ligament during robotic knee replacement helps patients feel more natural after surgery. About 300 adults having their first robotic knee replacement will be randomly assigned to one of the two methods. The ma…

This study tests whether the BETY exercise program, which combines physical exercises with pain management and emotional support, can help people with knee osteoarthritis who recently received injections. Sixty adults with knee osteoarthritis will be enrolled. The goal is to see …

This study compares two methods of knee replacement surgery: traditional mechanical alignment (MA) and newer kinematic alignment (KA) that mimics the knee's natural position. About 95 adults with knee arthritis will be randomly assigned to one method and followed for 6 weeks. The…

This study compares two ways to recover after total knee replacement: standard outpatient physical therapy versus using a smart knee brace (FM2) at home. Eighty adults who need knee replacement will be randomly assigned to one of the two groups. Researchers will measure knee moti…

This study tests two ways to manage pain after hip replacement surgery. One group gets a nerve block plus a second nerve block; the other gets a nerve block plus wound numbing. The goal is to see which method reduces pain and the need for opioid painkillers. About 102 adults havi…

This study tests a procedure called genicular artery embolization (GAE) to see if it can reduce knee pain and inflammation in adults with knee osteoarthritis. Researchers will compare knee fluid samples and MRI scans before and after the procedure to see if changes in inflammatio…

This study tests whether a supplement called MyCondro can help people with knee osteoarthritis move better and feel less joint discomfort. Researchers will give two different doses to 240 adults aged 45 and older who have had knee problems for at least six months. The main goal i…

This study tests an investigational drug called ALT001 for people with knee osteoarthritis. The goal is to see if it can reduce pain, improve movement, and boost quality of life. About 30 adults aged 50 to 75 will receive injections into the knee every two weeks for 12 weeks. The…

This early-stage trial tests a new drug called HRS-2129 in 200 people with moderate to severe knee osteoarthritis pain. Participants will receive either HRS-2129, a placebo, or an active comparator (celecoxib) to see if it reduces pain and improves joint function. The study is do…

This study looks at whether adding core stabilization exercises to standard knee exercises can improve symptoms and function in women aged 40-65 with knee osteoarthritis. Forty participants will receive either knee exercises alone or knee exercises plus core exercises for six wee…

This study compares two treatments for chronic knee osteoarthritis: shock wave therapy and structured exercise. Forty adults aged 40 and older with persistent knee pain will be randomly assigned to one of the two groups. The goal is to see which approach better reduces pain and i…

This early-stage study tests whether people with knee osteoarthritis can stick to a daily routine of self-injecting recombinant human growth hormone (rHGH) for six weeks. Researchers will track how well participants follow the regimen, along with changes in knee strength, range o…

This phase 3 trial is testing whether adding metformin, a diabetes drug, to standard pain relief (celecoxib) can reduce pain and improve knee function in people with knee osteoarthritis. The study will enroll 70 adults aged 30-60 with moderate knee arthritis. Researchers will mea…

This early-phase study tests whether a non-invasive brain stimulation technique called rTMS can improve pain and depression in people with knee osteoarthritis. Thirty adults aged 50 and older with chronic knee pain and moderate to severe depression will receive rTMS while also ta…

This study tests whether a low dose of steroid injected into the knee works as well as the standard dose for reducing pain and improving function in obese people with knee arthritis. Forty participants will receive either a low or standard dose and report their pain levels and da…

Some people hear clicking or popping after knee replacement surgery, which can be bothersome. This study compares two different knee replacement designs to see if one causes less noise. Researchers will ask 170 patients about the sounds they hear and how much it bothers them over…

This study compares a special cold compression device (cryopressotherapy) to standard ice packs for people recovering from total knee replacement. Researchers will measure pain, mobility, swelling, and patient-reported outcomes 14 days after surgery. The goal is to see if the dev…

This study tests whether a program of exercise and ergonomics training can reduce muscle and joint pain in teachers. About 80 teachers who have had pain for at least three months will be randomly assigned to receive the training or not. Researchers will measure changes in pain, d…

This study tests a walking program for people with painful hip or knee osteoarthritis. Participants take a nonsteroidal anti-inflammatory drug (NSAID) only before planned walks to reduce pain while avoiding long-term side effects. The program also includes proper footwear, educat…

This study tests if freezing the nerves around the knee (cryoneurolysis) one day before total knee replacement surgery can lower pain and help patients move better afterward. About 100 adults with knee arthritis will be randomly assigned to get the freezing procedure plus surgery…

This study tests whether a 6-month mobile program can help 200 older adults (65+) with knee or hip arthritis pain become more active, lose weight, and feel less pain. Participants will join weekly group or individual coaching calls and track their steps. After the program, they w…

This study tests a new exercise program using a flywheel device to improve stair-climbing in people with knee osteoarthritis. The training focuses on the muscle-lengthening phase of movement, which may build better muscle and coordination. Researchers will measure changes in move…

This study tests whether a structured preparation program before hip or knee replacement surgery can help people recover faster. The program includes personalized exercise, nutritional advice, stress and pain support, and medication review. Researchers will compare recovery in 18…

This study tests whether a type of exercise called diagonal proprioceptive neuromuscular facilitation (PNF) can reduce pain and improve function in people with knee osteoarthritis. Researchers will compare PNF exercises to standard strength training in 150 adults aged 40-60. Both…

This study tests a portable, seated leg dexterity trainer designed to improve knee control and reduce pain in people with knee osteoarthritis. About 82 adults aged 40-85 with knee OA will use either the new device or a wobble board at home for 8 weeks. The goal is to see if the d…

This study tests a web-based app called IAMABLE that provides evidence-based rehabilitation strategies for people with chronic conditions like heart disease, arthritis, or neurological disorders. Fifty adults aged 45 to 75 will use the app for 4 months to set goals and learn abou…

This study tests whether a combination of platelet-rich plasma (PRP) and hyaluronic acid injections works better than either treatment alone for knee osteoarthritis. About 288 adults aged 40 to 75 with knee pain will receive one of three treatments. The goal is to see if the comb…

This study tests whether doing supervised exercise and learning about recovery before total knee replacement helps patients feel better and function better one year after surgery. About 110 adults with knee osteoarthritis awaiting surgery will be randomly assigned to either the p…

This study compares two ways to manage pain after total knee replacement in 80 adults aged 65 and older. Both methods use a nerve block in the thigh (adductor canal block) plus either a block near the sacrum or one behind the knee. The goal is to see which combination provides lo…

This study is testing whether low-impact group exercise classes can help reduce pain in people with knee, hip, or ankle osteoarthritis. Participants attend one-hour group sessions three times a week for six months, led by a physical therapist or trainer. The study also includes s…

This study tests a minimally invasive treatment for chronic knee pain from osteoarthritis or after knee replacement. Doctors guide a thin tube to knee arteries and inject a temporary agent to reduce blood flow to inflamed tissue. The goal is to see if this procedure safely reduce…

This study compares two common additives (dexamethasone and dexmedetomidine) mixed with a numbing drug to see which one reduces pain and the need for strong painkillers after total knee replacement. About 96 people aged 65 and older will take part. The goal is to find a safer, mo…

This study tests whether a single injection of collagen into the knee joint can reduce pain and improve function in people with knee osteoarthritis. Researchers will compare the collagen injection to a placebo (saline) injection in 204 adults. The main goal is to see if collagen …

This study tests two different methods of a nerve block (iPACK) to manage pain after total knee replacement. The goal is to find which approach provides better pain relief and reduces the need for strong painkillers. 120 adults having knee replacement will be randomly assigned to…

This study tests whether adding probiotic supplements to standard treatment can reduce pain, stiffness, and improve daily function in people with knee osteoarthritis. About 146 adults with symptomatic knee OA will take probiotics or a placebo for a set period. The goal is to see …

This study looks at whether a 6-month thermal spa treatment program can meaningfully reduce pain and improve daily function in people with knee osteoarthritis. Researchers will compare results from 76 participants aged 50-80 who receive the spa therapy against an external group r…

This study tests whether a supplement made from boswellia, turmeric, and grape extracts can reduce pain and stiffness in people with knee or hip osteoarthritis. Thirty adults will take the supplement or a placebo for four weeks each, then switch. Researchers will measure changes …

This study compares a special cold-and-compression device to regular ice packs for managing pain after total knee replacement. About 138 adults having knee surgery will be randomly assigned to one of the two treatments. The main goal is to see if the device reduces pain more than…

This study tests whether using virtual reality for relaxation exercises can reduce pain and improve sleep better than traditional relaxation methods in people recovering from hip or knee replacement surgery. About 82 adults who speak Turkish and have no mental or sleep disorders …

This study tests different types and doses of vitamin K in 55 adults aged 60 and older with knee osteoarthritis. Researchers want to see if vitamin K can improve knee health by measuring changes in blood markers. The goal is to find the best form and dose for future larger studie…

This study tests a new injection called CartiPRO to see if it can safely reduce knee pain in people with osteoarthritis. About 194 adults will receive either CartiPRO or another approved injection, and then get a second shot 24 weeks later. Researchers will measure pain and knee …

This study tests whether teaching patients about nutrition and following a specific fasting plan before knee replacement surgery can help reduce thirst, nausea, and vomiting afterward. About 72 adults having knee replacement will be split into two groups: one gets the special edu…

This study compares two ways of giving platelet-rich plasma (PRP) injections for chronic knee osteoarthritis: one into the joint only, and another that also targets tissues around the knee. Researchers want to see if the combined approach better reduces pain, improves daily funct…

This study tests whether injecting a steroid and numbing medicine into muscle trigger points can relieve knee osteoarthritis pain as well as injecting into the knee joint itself. About 1,000 adults with knee arthritis and at least one tender muscle spot will receive either a trig…

This study looks at using different amounts of steroids injected into the knee during total knee replacement surgery to control pain. Researchers want to find the safest and most effective dose to help patients recover faster and feel better. The trial involves 120 adults having …

This study tests whether frozen platelet-rich plasma (PRP) injections can reduce pain and improve knee function in people with knee osteoarthritis. About 60 adults aged 40-85 with mild to moderate knee arthritis will receive either frozen PRP or fresh PRP injections. The goal is …

This study tests whether hyaluronic acid injections into the knee can reduce pain and improve function in people with knee osteoarthritis. Researchers will also measure changes in inflammation-related substances in blood and joint fluid. 50 adults aged 45-75 with moderate knee os…

This study tests whether teaching older adults to press specific points on their body (self-administered acupressure) can reduce knee osteoarthritis pain. About 368 Chinese adults aged 60+ with knee pain will learn the technique in two sessions and practice at home. Researchers w…

This study tests two approaches to help people with knee osteoarthritis stay active after physical therapy: a game-like reward system with social support, and health coaching. About 254 veterans will use a Fitbit and smartphone app to track their progress. The goal is to see if t…

This study tests whether a faster rehabilitation program helps people recover better after total knee replacement surgery. Researchers will compare the accelerated program to standard rehab in 32 adults aged 50-80. The goal is to see if the faster approach improves knee function …

This study tests whether nurse-led telehealth visits can detect complications and support recovery as well as in-person visits after total knee replacement. About 98 adults who had their first knee replacement will receive follow-up care either through a mobile app or at the clin…

This study tests whether injecting a mix of hyaluronic acid and fibrinogen into the knee can reduce pain and improve function in people with knee osteoarthritis. About 31 adults aged 45 to 75 will receive the injection as part of routine care. Researchers will track changes in pa…

This study tests a device that uses focused sound waves to block pain signals in the knee, offering a needle-free option for people with chronic osteoarthritis pain. Ten adults with moderate to severe knee pain will receive a one-hour treatment and be followed for six months. The…

This study tests whether supplements made from agar-agar (a seaweed extract) and undenatured type II collagen can reduce knee pain in people with osteoarthritis. Eighty adults aged 40 to 70 with mild to moderate knee pain will take capsules daily for several weeks. The goal is to…

This study tests whether combining functional electrical stimulation (FES) with exercise can improve quadriceps muscle strength and reduce pain in people with knee osteoarthritis. Researchers will measure muscle strength, pain levels, and quality of life in 52 participants aged 5…

This study tests whether injecting a person's own bone marrow cells or a mix of fat cells and platelet-rich plasma into the knee can reduce pain from osteoarthritis. About 148 adults with moderate knee arthritis will receive either the real treatment or a placebo (salt water) inj…

This study tests whether the antidepressant duloxetine can help reduce opioid painkiller use after knee replacement surgery. About 150 adults with knee osteoarthritis will receive either duloxetine or a placebo before and after surgery. The goal is to see if duloxetine lowers opi…

This study tests whether an 8-week yoga program can improve physical function and reduce pain in people with knee osteoarthritis. Researchers will compare yoga to standard therapeutic exercises in 90 adults aged 45 and older. The goal is to see if yoga offers extra benefits for m…

This study tests whether taking GlyNAC (a mix of two natural amino acids) before and after knee replacement surgery can reduce chronic pain. 148 adults with knee osteoarthritis will take either GlyNAC or a placebo for 4 weeks before surgery and 6 weeks after. Researchers will tra…

This study tests whether adding a fall prevention program to standard physical therapy can reduce falls and improve balance in older adults who have had a total knee replacement. About 90 women aged 60 and older will be followed for 24 weeks. The program includes guidance on avoi…

This study tests whether a manual therapy called Mobilization with Movement (MWM) can reduce pain and inflammation in people with knee osteoarthritis. Forty adults with moderate to severe knee OA will receive either MWM or a sham treatment twice a week for four weeks, plus standa…

This study looks at whether doing physical therapy exercises through a video game can improve knee function and keep people more engaged than standard exercises. About 60 adults with knee osteoarthritis will do 10 weeks of exercises, some using a special game with sensors and oth…

This study is testing whether extracorporeal shockwave therapy (ESWT) can reduce pain and improve function in athletes who developed knee osteoarthritis after ACL reconstruction. Researchers will treat 70 participants with a device that delivers pressure waves to the knee. The go…

This study tests whether adding a sugar solution (dextrose) to numbing injections around the knee nerves provides better pain relief than numbing medicine alone for people with chronic knee osteoarthritis. Sixty adults with knee arthritis will receive a series of three injections…

This study compares two common knee injections—platelet-rich plasma (PRP) and hyaluronic acid (HA)—for treating osteoarthritis behind the kneecap. About 166 adults aged 30–65 will receive a single injection and be followed for 12 months to see which provides better pain relief an…

This study tests whether a special light (810 nm) can reduce knee pain and swelling in people with chronic knee pain and synovitis. About 80 adults aged 40-80 will receive either real light therapy or a sham treatment twice a week for five weeks. Researchers will measure pain, ul…

This study tests three different doses of a long-acting numbing medicine (liposomal bupivacaine) injected into a nerve block in the thigh to control pain after total knee replacement. About 177 adults having robotic knee surgery will be randomly assigned to receive one of the dos…

This study looks at whether taking ibuprofen (a common painkiller) along with dextrose prolotherapy injections affects pain and function in people with knee osteoarthritis. Researchers will give 68 adults either ibuprofen or a placebo for 7 days after each of three injections. Th…

This study compares a new procedure called genicular artery embolization (GAE) using Nexsphere-F microspheres against standard steroid injections for knee osteoarthritis. About 126 people with knee pain will be randomly assigned to one of the two treatments. The goal is to see if…

This study tests whether combining the Bowen technique (a gentle hands-on therapy) with walking backward can improve hamstring flexibility, reduce pain, and boost mobility in people with knee osteoarthritis. Researchers will enroll 36 adults aged 40-60 with mild to moderate knee …

This study is testing a new procedure called musculoskeletal embolization using NBGM200 to treat knee osteoarthritis. The goal is to reduce pain and improve function and quality of life. The trial will enroll 72 adults with knee OA confirmed by MRI. Participants will receive the …

This study tests a technique called ischemic preconditioning, where blood flow to one thigh is briefly and repeatedly restricted using a device. Over two weeks, 24 adults with knee osteoarthritis and low back pain will receive either the full treatment or a sham (low pressure) ve…

This study looks at two different methods of giving a nerve block (adductor canal block) to control pain after total knee replacement surgery. About 78 adults with knee osteoarthritis will take part. The goal is to see which approach provides better pain relief and helps patients…

This study tests whether eating freeze-dried wild blueberry powder every day for 12 weeks can improve gut health, reduce inflammation, and ease joint pain in adults with arthritis. Fifty participants will take either the blueberry powder or a placebo, with a 2-week break between …

This study tests whether extra support for case managers helps veterans leaving the military better manage pain and reduce risky substance use. About 1800 veterans will take part. The program focuses on non-drug pain treatments and counseling.

This study compares myofascial release (a type of massage) and cupping therapy to see which better improves quality of life in people with restless leg syndrome and knee osteoarthritis. 54 adults aged 40-70 with moderate to severe knee arthritis will receive 12 sessions over 4 we…

This pilot study tests whether a culturally tailored program of muscle strengthening exercises and physical activity, delivered via video calls, can help Hispanics with knee osteoarthritis. Participants bring a family member or close friend for support. The study will measure how…

This study tests whether high-intensity pulsed electromagnetic field (HI-PEMF) therapy can reduce pain and improve strength in older adults with knee osteoarthritis. 64 participants will receive HI-PEMF on the knee alone or on both the knee and thigh muscle, plus a home exercise …

This study tests whether using mild electrical pulses on the thigh muscle can help people regain strength and movement faster after total knee replacement. About 3,250 patients will be randomly assigned to receive either standard physical therapy or standard therapy plus electric…

This study tests whether a special navigation system (NextAR) helps surgeons better balance the soft tissues during total knee replacement. The goal is to make the new knee feel more natural so patients can forget about it. About 100 adults with severe knee arthritis will be rand…

This study compares two ways to perform total knee replacement: the standard manual technique versus one guided by computer-assisted navigation. Researchers will enroll 160 patients and measure pain, function, blood loss, and costs. The goal is to see if the computer-assisted met…

This study looks at whether low-level laser therapy, combined with a home exercise program, can help people with knee osteoarthritis. It will measure pain, knee function, and muscle thickness in 62 participants over 3 months. The goal is to see if adding laser treatment improves …

This study tests whether taking cannabidiol (CBD) extract under the tongue three times a day can safely ease knee osteoarthritis pain and reduce the need for NSAID painkillers. Thirty adults with moderate to severe knee pain will receive either CBD or a placebo for several weeks.…

This study tests whether methotrexate, a drug used for rheumatoid arthritis, can reduce pain and swelling in people with knee osteoarthritis who also have joint inflammation (synovitis). Seventy adults aged 40–70 will receive either methotrexate or a placebo for 6 months. Researc…

This study tests whether a new, concentrated version of a patient's own blood platelets (called self-repair factor) works better than standard platelet-rich plasma (PRP) injections for knee osteoarthritis. 90 adults with mild to moderate knee arthritis will receive either the new…

This pilot study tests a new pain-numbing injection called IPSA, given by the surgeon directly into the back and inner side of the knee during total knee replacement. 60 adults undergoing knee replacement will be randomly assigned to receive either the new IPSA block plus standar…

This study tests whether a special heat wrap can reduce knee pain in people with moderate osteoarthritis. About 80 adults aged 19 to 69 will wear the wrap for 8 hours a day over 7 days. Researchers will measure pain changes after 3 days using a simple pain scale.

This study compares robotic-assisted total knee replacement to the standard manual procedure in 86 adults aged 40-85 with severe knee arthritis. Participants will receive the same knee implant, but one group's surgery is guided by a robotic system. Researchers will measure pain, …

This study tests whether a mobile app can help patients do simple in-bed exercises after orthopedic surgery for spine, hip, or knee problems. About 100 participants will use the app or receive usual care. Researchers will measure how well patients recover their ability to move an…

This phase 2 trial is testing whether daily doses of THC, CBD, or both can reduce pain and improve symptoms in people with knee osteoarthritis. About 200 participants will take one of the study drugs or a placebo for 16 weeks, with regular pain assessments, blood tests, and brain…

This study investigates knee osteoarthritis and cartilage degeneration by combining MRI scans with gait analysis. Researchers aim to better understand how the disease affects both the structure and function of the knee joint. The study involves 25 participants with knee pain or c…

This pilot study aims to see if a new method can safely measure how tired patients get during a special type of exercise after total knee replacement. Twenty adults recovering from knee surgery will try cycling while blood flow to their legs is partially restricted. The results w…

This study looks at two types of fat tissue in people with knee osteoarthritis: one inside the knee joint (Hoffa's fat pad) and one inside the thigh muscle. Researchers want to see if these fat deposits are different in size, fat content, and scar tissue. The goal is to better un…

This study aims to learn more about rare skeletal disorders by collecting medical records, blood samples, and genetic data from 100 participants. People with known or suspected bone conditions, as well as their healthy family members, can join either remotely or in person. The go…

This study will follow 78 people aged 50 to 85 who need a total knee replacement to see how well a newer all-polyethylene (plastic) knee implant holds up over 5 years. Researchers want to know if this design, which may be cheaper and have fewer mechanical problems, works as well …

This study looks at whether sulfasalazine, a drug for inflammatory arthritis, makes the standard diabetes blood test (HbA1c) falsely low. That could mean diabetes goes undiagnosed or is undertreated in these patients. Researchers will use continuous glucose monitors and fasting b…

This study looks at whether a person's expectations before starting physical therapy can predict how much they will benefit from it. Researchers will track 84 adults over 50 with knee osteoarthritis as they go through 15 sessions of standard physical therapy. The goal is to see i…

This registry will follow 10,000 people receiving various pain treatments for knee osteoarthritis, such as injections, nerve blocks, or knee replacement. Researchers will track pain levels, function, sleep, and side effects over time. The goal is to learn which approaches work be…

This study translates and tests several health questionnaires—covering pain, arm and leg function, mood, and daily activities—for use with Albanian-speaking people. Researchers will check if the translated versions are reliable and accurate by giving them to about 300 participant…

This study is creating a collection of blood, urine, and leftover surgical tissue from 350 patients with bone, calcium, and growth plate disorders. The goal is to better understand how these diseases progress and to find markers that could predict outcomes. No new treatments are …

This study tests a new tool called the PRISM Dashboard, which gives physiotherapists feedback on how their decisions compare to their peers. The goal is to see if this feedback helps reduce differences in care for people with muscle and joint pain. About 60 physiotherapists and t…

This study aims to develop a better way to locate painful inflammation in the knee joint for people with patellofemoral osteoarthritis. Researchers will use a special PET/MRI scan to see how inflammation changes when the knee is under pressure. About 50 adults, including both pat…

This study looks at how the alignment of the knee joint, seen on X-rays, relates to pain, daily function, quality of life, and fear of movement in people with knee osteoarthritis. Researchers will measure alignment and joint space width in 100 adults with knee osteoarthritis and …

This study compares two ways of tracking recovery after knee replacement surgery: traditional paper questionnaires filled out at the clinic versus digital surveys sent to a patient's smartphone. Researchers will enroll 50 adults aged 18-78 who own a smartphone, tablet, or compute…

This study tests whether taking a collagen peptide supplement before and after total knee replacement surgery can improve tissue healing, strength, and recovery. Researchers will measure changes in knee ligaments, bone density, and wound healing in 44 adults aged 50-75. Participa…

This study is creating a registry to track how well a procedure called genicular artery embolization (GAE) works for knee osteoarthritis pain over time. Up to 100 adults with mild to moderate knee arthritis that hasn't improved with standard treatments will be enrolled. The goal …

This study is creating a large collection of joint fluid and blood samples from 500 people with different types of arthritis. Researchers will use these samples to test new biomarkers that could help diagnose arthritis earlier and monitor how the disease changes over time or with…

This study is looking at how the shape and alignment of the kneecap joint relate to knee pain. Researchers will take 3D CT scans of the knee while people stand (weight-bearing) to see the joint in a natural position. They hope to find links between specific bone measurements and …

This study aims to find out if brain-based tests can predict who will get pain relief from common knee osteoarthritis treatments. About 180 adults with knee pain will be randomly assigned to take duloxetine, celecoxib, or a placebo for 20 weeks. Researchers will use brain MRIs, k…

This pilot study is testing whether increasing daily steps can improve knee cartilage health in people who have had ACL reconstruction. Fifty-six participants will wear a Fitbit and receive daily step goals via text for 16 weeks. Researchers will use MRI scans to measure changes …

This study is a long-term check on the safety and performance of the MADISON total knee replacement system. It will follow 1,000 adults in France who need knee replacement surgery for up to 15 years. The goal is to track how often the implant needs to be revised or causes problem…

This study uses small wearable sensors to measure how people with severe knee osteoarthritis move before and after total knee replacement surgery. Researchers will track 20 patients over age 60 to see if these sensors can detect changes in knee motion and pain. The goal is to fin…

This study looks at two different methods of placing a total knee prosthesis: mechanical alignment (standard, fixed angles) and kinematic alignment (customized to each patient's anatomy). Researchers want to see which technique leads to better knee movement and function during ac…

This pilot study tests a smartphone app that collects movement data and patient questionnaires to create a score that predicts satisfaction after knee or hip replacement. Researchers will enroll 1,250 people, including patients before or after surgery and healthy volunteers. The …

This study checks if a standardized ultrasound scoring system for knee osteoarthritis works well in Turkish patients. Researchers will compare ultrasound findings with pain and function questionnaires in 100 adults aged 45 and older. The goal is to see if this method is reliable …

This pilot study is measuring prednisolone levels in 120 people with inflammatory diseases like thyroid eye disease, vasculitis, COPD, asthma, and others. Participants take high-dose prednisolone as part of their routine care, and researchers take timed blood samples to see how t…

This study follows 252 adults with muscle, bone, or joint problems (like arthritis, back pain, or after surgery) to see how well they do their prescribed home exercises. Researchers will track who sticks with the program and why, looking at factors like pain, mood, and support. T…

This study tests whether platelet-rich plasma (PRP) injections into the knee can change certain proteins in the blood of people with knee osteoarthritis. About 60 participants aged 18-70 will receive either PRP or a saltwater placebo, and researchers will compare protein levels t…

This study compares general anesthesia (being fully asleep) with spinal anesthesia (numbing only the lower body) for people having hip or knee replacement surgery. Researchers will track recovery time, pain, nausea, infections, and other complications in about 2,400 participants.…

This study looks at whether a 3-month virtual program called Choose to Move Replacement Ready is feasible for people waiting for hip or knee replacement surgery due to osteoarthritis. About 60 participants will answer surveys and some will be interviewed. The goal is to see if th…

This study looks at whether brain scans can predict if someone will be satisfied after knee replacement surgery. Up to 1 in 5 patients still have pain or trouble moving after surgery, and doctors can't currently predict who. Researchers will scan the brains of 50 adults before an…

This study aims to improve total knee replacement surgery for people with severe knee arthritis and a bow-legged (varus) deformity. Researchers will use advanced CT scans to compare the angle of the affected leg with the healthy leg, helping surgeons decide how much to correct th…

This study tests whether using a virtual reality (VR) headset during shoulder exercises helps patients feel more engaged and motivated. Fifty adults with shoulder problems will do rehab exercises in a VR environment and then answer questionnaires about how easy and immersive the …

This study aims to see if artificial intelligence can use a patient's genetics, biomechanics, and psychology to predict how well they will recover after total knee replacement. Researchers will enroll 197 adults with severe knee osteoarthritis and follow them for a year. The goal…

This study compares two ways of closing the wound after hip or knee replacement surgery: barbed sutures (a newer type) versus conventional sutures. About 90 adults having hip or knee replacement will be randomly assigned to one method. Researchers will track wound healing, compli…

This study looks at whether muscle power and control can predict falls better than muscle strength in people aged 65-80 with knee osteoarthritis. Fifty participants will undergo muscle tests, walking analysis, and MRI scans. The goal is to develop a fall-risk assessment tool for …

This study looks at 320 adults who are about to start strong immune-suppressing therapy and have already had at least two COVID-19 shots. Researchers want to find out if giving a COVID-19 booster right before starting therapy or waiting six months provides better protection. Part…

This study follows 50 people who had knee realignment surgery (high tibial osteotomy) for early knee arthritis. Researchers want to see how the surgery affects the kneecap joint and arthritis progression over the long term. Participants are under 65 and had the surgery at least 5…

This study follows 600 people with hip or knee osteoarthritis for one year to understand how their symptoms and daily function change over time. Participants fill out online questionnaires every two weeks and try different self-care programs through a web app called ArtroseCoach.…

This study looks at how bone density in the thigh bone changes after knee replacement surgery. Researchers will compare two ways of fixing the new joint: with cement or without. They will also compare surgery done by hand versus with a robot. 100 people aged 55 and older will tak…

This study will follow 300 people with knee osteoarthritis or chronic inflammatory arthritis for up to 10 years. Researchers will collect blood, joint fluid, and platelet-rich plasma samples to look for biomarkers linked to pain, joint damage, and the need for knee replacement. T…

This study follows 432 golfers who have hip, knee, or shoulder replacement surgery to see when and how they return to golf. Participants are active golfers who want to play again after surgery. The goal is to learn about the recovery process, not to test a new treatment.

This pilot study tests two different exercise programs in 20 people with knee osteoarthritis to see how cartilage responds. One group exercises with rest breaks, the other without. The goal is to understand the mechanical and molecular effects of exercise on cartilage, not to tre…

This study aims to create a secure national database for muscle and joint (musculoskeletal) conditions by collecting routine data from community clinics and GP practices. About 22,000 adults will have their information anonymously gathered to help develop a dashboard that tracks …

This observational study looks at why some people with knee osteoarthritis have worse pain than others, even when their knee damage looks similar on X-rays. Researchers will study 300 adults aged 45-80 with chronic knee pain. Participants will complete surveys, physical tests, kn…

This study is testing whether special insoles that measure how you walk can predict your recovery after knee replacement surgery. 200 adults with knee osteoarthritis will wear the insoles before surgery and complete questionnaires about their symptoms. Researchers will use comput…

This study aims to find out how many people with knee osteoarthritis also have nerve-related pain, and whether that type of pain makes their symptoms and daily function worse. Researchers will measure pain and physical ability in 102 participants using standard questionnaires. Th…

This study watches 2000 people having hip or knee replacement surgery to see how long spinal anaesthesia lasts. The goal is to learn how the amount of anaesthetic affects timing, helping doctors decide if patients can safely go home the same day. No new treatments are tested—just…

This observational study looks at hip and knee tissue from 1000 adults with osteoarthritis who are scheduled for joint replacement surgery. Researchers want to measure levels of rare metals and immune markers in the joint tissue and blood. The goal is to find imbalances that coul…

This study looks at how often people can return to sports at least three years after total knee replacement. It compares three different types of knee prostheses to see if one type leads to better sports participation. The study will include 660 adults who had their first knee re…

This study looks at how well a particular type of knee replacement works in 960 adults who had surgery between 2013 and 2024. Researchers will check knee function and X-ray results at least one year after surgery. The goal is to see how the prosthesis performs and compare it to o…

This study looks at how changing the heel cushion on an ankle-foot brace (AFO) affects walking in people who use one daily. Forty adults with leg injuries or nerve problems will try four different heel wedges—tall or short, soft or firm—while walking at controlled speeds. Researc…

This study aims to create and test an Italian version of a standard knee questionnaire, the New Knee Society Knee Scoring System. Researchers will translate the English survey into Italian, check its accuracy, and then ask about 300 Italian patients with knee osteoarthritis to fi…

This study looks at how 3D computer simulation and printing can help surgeons better plan and perform bone correction surgeries. Researchers will compare the planned corrections to the actual results in 100 children and young adults with rare bone deformities. The goal is to make…

This study aims to create a model that predicts how long patients will need inpatient rehabilitation after hip or knee replacement for osteoarthritis. Researchers will collect data from 400 patients to validate the model. The goal is to personalize care and improve quality of lif…

This study is testing whether a smart knee implant that tracks movement like steps and walking speed can help people recover better after knee replacement surgery. Researchers will also see if the device can reduce the number of follow-up clinic visits. About 150 adults having kn…

This study looks at how oxytocin, a natural hormone, affects the part of your nervous system that controls rest and digestion. Researchers will give a single injection of oxytocin or a placebo to 38 people (some with knee arthritis, some healthy) and measure tiny changes in pupil…

This study looks at whether having total knee replacement surgery as an outpatient (going home the same day) leads to better recovery compared to staying in the hospital. Researchers will review medical records of 440 patients who had knee replacement between 2020 and 2023 at a F…

This study from the University of Pittsburgh is looking at how well people recover after total knee replacement surgery. It compares two types of surgery: one done with a robot's help and one done by hand. Researchers will follow 30 people who are already scheduled for knee repla…

This study tests a new tool to help surgeons balance knee ligaments during total knee replacement. The goal is to see if the tool makes the procedure more accurate and repeatable. About 40 adults with knee arthritis will take part. The study focuses on measuring how much the liga…

This study follows 4,000 children who receive orthopedic implants (like rods or screws) during standard care for bone fractures, deformities, or hip problems. Researchers will track how long the implants last, any complications, and how well they work over time. The goal is to ga…

This study is building a registry of people with rare bone diseases (skeletal dysplasias) in Italy. Researchers will collect medical history, genetic data, and treatment details over time to better understand how these conditions progress. No experimental treatments are given; th…

This study follows 144 adults with muscle or bone problems who are already scheduled to receive treatment with Chattanooga Intelect devices (like TENS or ultrasound). Researchers will measure pain, muscle strength, and movement range to confirm the devices are safe and work as ex…

This study looks at whether the routine one-year follow-up visit and X-ray after total hip or knee replacement is really needed. Researchers will compare patients who have a check-up only when they have concerns versus those who follow the standard yearly schedule. The goal is to…

This study follows 700 people with chronic diseases like arthritis, diabetes, or heart disease for 4 years. Participants wear a small movement sensor for 5 days, three times a year, to track their physical activity and sedentary time. Researchers want to see if a person's unique …

This study adds a return-to-sports test to an existing knee replacement recovery study. The test uses a stepwise approach to assess athletic readiness, starting with low-level sports and progressing only if safe. Researchers hope to provide an objective way to guide patients back…