Inflammatory disease

This study tests a collaborative care model where pharmacists, doctors, and patient navigators work together to provide hepatitis C treatment to people who use drugs and live in supportive housing. 444 participants will be randomly assigned to either this model or usual care. The…

This early-stage trial tests a new vaccine called WGc0201 in 9 adults with chronic hepatitis B who are already on standard antiviral therapy. The vaccine is designed to boost the immune system to clear the virus, potentially leading to a functional cure. The main goal is to check…

This study tests whether platelet-rich fibrin (PRF) — a concentrate made from a patient's own blood — can improve gum healing after standard deep cleaning for periodontitis. Twenty adults with moderate to severe gum disease will receive deep cleaning on both sides of the mouth, w…

This study looks at how well an injection called Immunoglobulin-Histamine complex (IHC, brand name Histoglob) works for people with chronic urticaria, or long-term hives. Researchers will track 600 patients in India to see if the treatment reduces hives and the need for other all…

This early study tests baricitinib, a drug already approved for other immune conditions, in 20 people with Job syndrome who also have lupus-like disease or eczema. Participants take the pill daily for 6 months. The main goal is to see if it is safe and tolerable, while also check…

This early-stage study tests a new drug called IB-001 for chronic hepatitis B. It will first check safety in up to 60 healthy volunteers, then test multiple doses in about 30 people with chronic hepatitis B. The main goal is to see if the drug is safe and how the body handles it.

This Phase 2 trial tests an experimental inhaled medication called LTI-03 in about 120 people with idiopathic pulmonary fibrosis (IPF), a progressive lung disease that causes scarring and breathing difficulty. Participants will inhale LTI-03 or a placebo twice daily for 24 weeks.…

This study compares two common antibiotics, azithromycin and doxycycline, in adults hospitalized with community-acquired pneumonia who are also receiving a beta-lactam antibiotic. The goal is to see which combination helps patients leave the hospital sooner and reduces the need f…

This study looks at the long-term safety of an inhaled drug (AP01) for people with progressive lung scarring (pulmonary fibrosis). It is for those who already completed an earlier Avalyn Pharma study. About 340 participants will receive the drug and be monitored for side effects …

This study tests whether omega-3 fatty acid supplements from fish oil, combined with a healthy diet, can reduce disease activity in adults with dermatomyositis, a rare autoimmune disease causing muscle weakness and skin rashes. About 300 participants will take either fish oil cap…

This Phase 1 trial tests surovatamig, a bispecific T-cell engager, in 48 adults with rheumatoid arthritis or systemic lupus erythematosus. The study gives the drug as injections in increasing doses to check safety, side effects, and how the body processes it. It is too early to k…

This study tests whether an investigational drug called PLG0206 can prevent infections from coming back after knee replacement surgery. About 240 adults who need a special cleaning surgery (DAIR) for an infected knee joint will receive either PLG0206 or a placebo during the proce…

This study tests whether taking a low dose of niacin (vitamin B3) after meals can help reduce fat stored in the liver for people with metabolic fatty liver disease (MASLD). Researchers will compare niacin to a placebo in 36 adults aged 50 to 80. The goal is to see if niacin can r…

This study compares two treatments for acute cholecystitis (inflamed gallbladder) in patients aged 75 and older. One is the standard laparoscopic surgery to remove the gallbladder. The other is a newer, less invasive procedure called EUS-guided gallbladder drainage, where a small…

This early-stage trial is testing whether a gel containing beneficial bacteria (Staphylococcus hominis A9) can safely control eczema flares. About 86 adults and children aged 6 and older will apply the gel or a placebo twice daily for 14 weeks, along with a short course of steroi…

This study investigates whether a single infusion of a patient's own genetically modified immune cells (CD19 CAR-T cells) can safely control moderate-to-severe pemphigus vulgaris that hasn't responded to standard treatments. The therapy targets and depletes B cells, which are tho…

This study tests whether MK-8690, a drug given as a shot, can help people with moderate-to-severe ulcerative colitis achieve remission. About 100 adults who haven't responded well to other treatments will receive either MK-8690 or a placebo. The main goal is to see if more people…

This study tests whether combining two immune-suppressing drugs, rituximab and cyclosporine, can safely reduce protein leakage in the urine of people with membranous nephropathy, a kidney disease where the immune system attacks the kidneys. About 30 adults with persistent high pr…

This study tests an experimental drug called BAY 3401016 in 60 adults aged 18 to 45 with Alport syndrome, a rare genetic condition that damages kidneys, hearing, and eyes. The drug works by blocking a protein thought to cause kidney injury, with the goal of slowing the loss of ki…

This early study is testing whether giving a transplant of healthy gut bacteria (called IMT) through a feeding tube is safe and doable in 40 adults who have had part of their colon removed due to diverticulitis or sigmoid colon cancer. Participants get the transplant a couple of …

This study tests if the drug vorinostat is safe and can help people with moderate-to-severe Crohn's disease by reducing gut inflammation. Participants who respond well may then receive a maintenance treatment with ustekinumab for up to two years. The goal is to control symptoms a…

This study tests if obinutuzumab can help teens and children with lupus nephritis, a serious kidney complication of lupus. About 40 participants aged 5 to 17 will receive either the drug or a placebo. The goal is to see if the drug improves kidney function and reduces protein in …

This study will follow 100 people in Saudi Arabia with moderate to severe Crohn's disease or ulcerative colitis who are starting guselkumab. Researchers will measure how long patients continue the treatment in real-world clinics, along with early symptom improvements. No new drug…

This study tests a new drug called RO7790121 for people with moderate to severe ulcerative colitis, a condition that causes inflammation in the colon. About 350 adults who haven't responded well to other treatments will receive either the drug or a placebo. The main goal is to se…

This study tests an injectable drug called amlitelimab for people aged 12 and older with moderate-to-severe eczema that hasn't improved with other treatments. Participants will also use standard steroid creams. The goal is to see if the drug can clear or nearly clear the skin com…

This Phase 3 study tests whether the drug elafibranor can slow liver damage in adults with primary sclerosing cholangitis (PSC), a rare disease that scars the bile ducts. About 350 participants will receive either elafibranor or a placebo daily for several years. The main goal is…

This early-stage trial is testing whether a pill made from freeze-dried healthy donor stool (MTP-101P) is safe and can restore good bacteria in people having part of their colon removed. Forty adults aged 18-75 with colon polyps, early-stage cancer, or diverticulitis will take th…

This trial investigates whether pioglitazone, a drug used for diabetes, can help protect the kidneys in people with ANCA-associated vasculitis—a rare autoimmune disease that causes inflammation of blood vessels, often damaging the kidneys. Participants receive either pioglitazone…

This phase 3 trial tests a new antiviral pill, ibuzatrelvir, alone or with an IV drug (remdesivir) in 300 adults with weak immune systems who have mild-to-moderate COVID-19. The goal is to see if the combination prevents hospitalizations or worsening symptoms better than remdesiv…

This study follows adults who have received a Tipmed shoulder replacement to see how well the implant works and if any problems arise over the first year. Participants have conditions like severe arthritis, rotator cuff damage, or a broken shoulder bone. Researchers track shoulde…

This study tests an investigational drug called barzolvolimab in 240 adults who get hives from cold temperatures or from scratching their skin, and whose symptoms are not controlled by standard allergy pills. Participants receive either the drug or a placebo injection, and doctor…

This study looks at how the liver responds to food and a drug called semaglutide in people with non-alcoholic fatty liver disease (NAFLD). About 84 adults, including healthy volunteers, will take part. Researchers will check if semaglutide can reduce liver fat and damage over 30 …

This study tests a new medicine called ORKA-001 for adults with moderate-to-severe plaque psoriasis, a skin condition causing red, scaly patches. About 160 participants will receive either the drug or a placebo to see if it can completely clear the skin by week 16. The goal is to…

This study looks at whether taking coenzyme Q10 and vitamin C, alone or together, can improve healing and reduce dark gum color after surgical gum depigmentation. The trial involves 20 healthy adults with dark gums who undergo a simple scalpel procedure to remove pigmented tissue…

This study tests an experimental drug called SAR445399 in 144 adults with moderate to severe hidradenitis suppurativa (HS), a painful skin condition that causes abscesses and tunnels under the skin. Participants will receive one of two doses of the drug or a placebo for 32 weeks.…

This study tests an experimental pill called ISM5411 (Garutadustat) in 80 adults with active ulcerative colitis. Half receive the drug, half a placebo, and neither patients nor doctors know who gets what. The goal is to check if the drug is safe and helps control the disease.

This study is testing the safety and drug levels of glecaprevir/pibrentasvir, a hepatitis C treatment, in 30 pregnant women with or without HIV. The goal is to see how the drug works during pregnancy and to monitor the health of both mothers and their infants up to 10 weeks after…

This study is testing the long-term safety and effectiveness of a drug called ORKA-001 for people with moderate-to-severe plaque psoriasis. It is an open-label extension, meaning everyone gets the drug, and it includes 240 adults who already completed a previous trial with ORKA-0…

This phase 2 trial tests an oral drug called PIPE-791 in 324 adults with idiopathic pulmonary fibrosis (IPF), a disease that scars the lungs and makes breathing hard. Participants take either a low or high dose of PIPE-791 or a placebo daily for several months. The main goal is t…

This early-stage study tests a single dose of ABBV-519 in 30 adults with moderate lupus or rheumatoid arthritis. Researchers will check how the drug moves through the body, how it affects immune cells, and whether it is safe. Participants will be followed for about a year to moni…

This study tests a new tool called OPTIBIO that uses blood markers and patient data to help doctors decide if it's safe to reduce biological therapy in rheumatoid arthritis patients who are in remission. About 184 adults with RA in stable remission will be randomly assigned to ha…

This Phase 3 trial tests whether privosegtor, a neuroprotective drug, can improve vision recovery in people having their first episode of optic neuritis. About 210 adults aged 18 to 50 will receive either privosegtor or a placebo, both alongside standard steroid treatment. The ma…

This study tests a drug called surovatamig in 43 adults with primary membranous nephropathy, a kidney disease caused by antibodies attacking the kidneys. The drug is given as a shot under the skin. Researchers want to see if it is safe and can reduce protein in the urine, which i…

This study compares two types of partial knee replacements for people with arthritis on the inner side of the knee. One implant has a fixed bearing (the plastic piece stays still), while the other has a mobile bearing (the plastic piece can move slightly). Researchers will track …

This study tests a drug called H01 (hymecromone) in adults with interstitial lung disease, a condition that causes lung scarring and makes breathing hard. The goal is to see if H01 can lower a marker of lung damage and improve lung function. Participants take the drug as a tablet…

This early-phase trial is testing a new treatment called KITE-363 for people with certain autoimmune nerve diseases that have not responded to standard therapies. KITE-363 is a type of CAR T-cell therapy that uses a patient's own immune cells, modified to target and attack faulty…

This study tests an oral medication called ibuzatrelvir in adults and teens with COVID-19 who are not hospitalized but have a high risk of becoming severely ill. Participants will receive either the drug or a placebo for 5 days, and researchers will track whether it reduces emerg…

This study is for people with moderate-to-severe eczema who have already completed a previous APG777 trial. It aims to see if APG777 is safe and works well over a longer period. Participants will receive injections of the drug every 12 or 24 weeks and be monitored for side effect…

This study tests a drug called felzartamab in people with IgA nephropathy, a kidney disease where abnormal antibodies build up and damage the kidneys. The goal is to see if felzartamab can reduce protein in the urine, a sign of kidney damage. About 454 adults will receive either …

This early-stage trial tests a new biologic drug called MER511 in 100 adults with Graves' disease. The main goal is to check safety and side effects, and to see how the body handles the drug when given by IV or injection. Participants must be on stable thyroid medication. The stu…

This study tests a new treatment called LB-DTK-CMV for people with cytomegalovirus (CMV) retinitis that has not responded to standard antiviral medicines. The treatment uses a patient's own immune cells, specially trained to attack CMV, and is given as two infusions. The trial ai…

This study tests two different doses of an intravenous immune globulin (IGIV 10%) as maintenance therapy for adults with chronic inflammatory demyelinating polyneuropathy (CIDP), a nerve disorder causing weakness and numbness. About 161 participants will receive either a higher o…

This study tests an oral drug called povorcitinib in 40 adolescents aged 12 to 17 with moderate to severe hidradenitis suppurativa (HS), a chronic skin condition causing painful boils and tunnels. Over 54 weeks, researchers will check the drug's safety, how the body processes it,…

This study tests a drug called risankizumab in children with juvenile psoriatic arthritis, a condition causing joint pain and swelling. About 40 kids will receive either risankizumab or the standard drug adalimumab for 24 weeks, with responders continuing for up to 2 years. The g…

This study tests whether BHV-1300 can help adults with Graves' disease achieve normal thyroid function without antithyroid drugs. Participants receive either BHV-1300 or a placebo via injection. The main goal is to see if more people on BHV-1300 have normal thyroid hormone levels…

This trial tests a new antibiotic eye drop called SUM-191 for bacterial conjunctivitis (pink eye). It has three parts: first, healthy volunteers get a single dose to check safety; second, healthy volunteers get multiple doses for 6 days; third, patients with pink eye get the drop…

This study tests a drug called felzartamab in people who received a kidney transplant and later developed microvascular inflammation (MVI), a type of injury to small blood vessels in the new kidney that can lead to serious problems. The trial includes 81 participants who will rec…

This Phase 3 trial tests the drug benralizumab (Fasenra) in children aged 6 to 17 with two rare eosinophilic diseases: EGPA and HES. The study aims to see if the drug is safe, how it works in the body, and whether it can help control the disease. Fourteen children will receive in…

This early-phase trial is testing a new drug called MTS109, made with mRNA technology, for people with moderate to severe autoimmune diseases like lupus and scleroderma. Fifteen participants will receive several injections over a month to see if it is safe and tolerable. The goal…

This phase 3 study tests an intravenous C1 esterase inhibitor (C1-INH) in people with hereditary angioedema (HAE) to treat acute attacks and prevent attacks before medical procedures. About 124 participants, aged 2 and older, will receive either the drug or a placebo. The main go…

This study tests a drug called mosunetuzumab in 30 people with lupus, a disease where the immune system attacks the body. The goal is to see if the drug can put lupus into remission so that participants can stop most lupus medications for at least 6 months. However, some people m…

This study tests a new gene therapy, PS-002, for adults with IgA nephropathy, a kidney disease that can lead to kidney failure. The therapy aims to control the disease in people who are at high risk of getting worse despite current treatments. Participants receive a single dose a…

This early-stage trial tests an experimental treatment called QEL-005 for people with two serious autoimmune conditions: diffuse cutaneous systemic sclerosis and difficult-to-treat rheumatoid arthritis. QEL-005 is made from a patient's own white blood cells, which are genetically…

This study offers continued treatment with povorcitinib for up to 600 adults with hidradenitis suppurativa who completed a prior trial and saw benefit. The main goal is to track side effects over time, with a secondary focus on reducing skin abscesses, nodules, and tunnels. Parti…

This Phase 2 trial tests whether the oral drug RAP-103 can improve skin clearance and quality of life in people with moderate to severe psoriasis. About 90 adults aged 18 to 70 will take either a daily or twice-daily dose of RAP-103 or a placebo for 8 weeks. The study measures ho…

This study tests a new medicine called SBT777101 in 24 people with moderate-to-severe rheumatoid arthritis (RA). It is the first time this drug is given to humans, so the main goal is to check safety and side effects. Participants receive a single dose, and the dose is increased …

This trial tests whether giving the antiviral drug tenofovir disoproxil fumarate (TDF) to pregnant women with active hepatitis B can prevent the virus from spreading to their babies. The women take TDF from the 28th week of pregnancy until six weeks after giving birth, and all ne…

This study tests an experimental drug called Afimkibart (RO7790121) in 160 people with moderate to severe rheumatoid arthritis who did not get better with or could not tolerate standard treatments like TNF or JAK inhibitors. Participants will receive either the drug or a placebo …

This study tests whether adding alcohol use disorder treatments (acamprosate and counseling) to standard liver therapy improves outcomes for people with severe alcohol-associated hepatitis. It also compares a new drug, F-652, against prednisone for liver treatment. About 216 adul…

This study tests whether taking omega-3 fatty acids (fish oil) plus low-dose aspirin can improve gum disease treatment in smokers with advanced periodontitis. Participants receive these supplements or a placebo alongside standard deep-cleaning procedures. The trial measures chang…

This study tests a dog allergy immunotherapy called Alutard SQ Dog in 40 adults with moderate-to-severe dog allergy. Participants receive increasing doses over 13 weeks, then maintenance shots every 6-8 weeks for a year. Their symptoms and lung function are measured before and af…

This study tests whether taking a once-daily JAK inhibitor for rheumatoid arthritis in the evening works better than taking it in the morning. About 90 adults with RA who qualify for this medication will be randomly assigned to morning or evening dosing. Researchers will compare …

This Phase 2 trial tests PollenVax, a new immunotherapy for people with moderate-to-severe allergic rhinitis caused by mugwort pollen. The treatment is given as four weekly shots before the pollen season. Researchers will compare symptom scores and medication use between the Poll…

This Phase 3 study tests whether the oral drug zasocitinib (TAK-279) can improve symptoms of active psoriatic arthritis in people who have never used biologic treatments. About 1,088 adults will receive either zasocitinib, an active comparator, or a placebo for up to 60 weeks. Th…

This phase 3 study tests whether the experimental drug WD-890 can safely improve skin clearance in adults with moderate to severe plaque psoriasis. Participants are randomly assigned to receive either WD-890 or a placebo tablet daily for up to 52 weeks. The main goals are to see …

This study tests a new drug, povetacicept, against a standard treatment (calcineurin inhibitor) in 176 adults with primary membranous nephropathy, a kidney disease that can lead to kidney failure. The goal is to see if the new drug can put the disease into remission more safely a…

This Phase 2 trial is testing three long-acting antibodies, alone or in combination, for people with moderate-to-severe ulcerative colitis. The study will enroll 645 adults to see if these treatments can reduce inflammation and lead to remission. Participants receive the antibodi…

This study tests a new medicine called tulisokibart for people with active psoriatic arthritis, a condition causing joint pain and skin plaques. Researchers will compare different doses of the drug to a placebo in 140 adults to see if it improves symptoms like joint tenderness an…

This study tests whether switching from the current drug bulevirtide to a new drug called brelovitug can better control chronic hepatitis Delta. About 120 adults who have been on bulevirtide for at least 6 months will take brelovitug for 24 weeks. The main goal is to see if the v…

This study tests two different medicines placed inside root canals to kill bacteria in teeth with chronic infection. 24 adults with infected molars will receive either a bioceramic or a calcium hydroxide paste. Researchers measure bacterial levels before and after treatment to se…

This Phase 3 trial tests an oral drug called deucrictibant in adults with acquired angioedema due to C1 inhibitor deficiency, a rare condition causing sudden, painful swelling attacks. The study has three parts: one to see if a daily extended-release tablet can prevent attacks, a…

This study looks at teenagers aged 12 to 17 who have severe atopic dermatitis (eczema) with intense itching but only a mild to moderate rash. They are being treated with dupilumab (Dupixent), a standard medication. The goal is to see how well dupilumab controls itching, improves …

This early-stage trial tests a new treatment called AZD0120 for adults with three autoimmune diseases: systemic sclerosis, idiopathic inflammatory myopathies, or difficult-to-treat rheumatoid arthritis. AZD0120 is made from a patient's own immune cells, which are modified in a la…

This study follows 700 adults with moderate-to-severe plaque psoriasis who are already prescribed risankizumab by their doctor. Researchers will track changes in quality of life, including skin symptoms and daily impacts, over up to 2.5 years. The goal is to see how well the drug…

This Phase 3 trial tests whether the experimental drug zasocitinib (TAK-279) can reduce joint swelling and pain in people with active psoriatic arthritis. About 600 adults will receive either the drug or a placebo for up to 60 weeks. The main goal is to see if more people on the …

This Phase 2 study tests atacicept, a drug that may reduce immune system attacks on the kidneys. About 250 adults with various autoimmune kidney diseases (like IgA nephropathy or membranous nephropathy) will receive weekly injections. Researchers will check safety and measure cha…

This study is testing the long-term safety and effectiveness of a drug called afimkibart in people with moderate to severe rheumatoid arthritis. Participants have already taken afimkibart in a previous study and will continue taking it. The goal is to see if the drug remains safe…

This early-phase trial tests a new treatment called KN5501, which uses specially engineered immune cells (CAR NK cells) to target and destroy harmful B cells in people with relapsed or refractory immune nephropathy, a kidney disease caused by the immune system attacking the kidne…

This phase 2 trial tests the safety of brincidofovir, an antiviral drug, in 24 adults with progressive multifocal leukoencephalopathy (PML), a rare brain infection caused by the JC virus. Participants receive the drug intravenously twice a week for up to 12 weeks, with follow-up …

This study tests a drug called deucravacitinib in children aged 5 to 17 with active juvenile psoriatic arthritis, a condition causing joint pain and swelling. The trial aims to see if the drug can control the disease and prevent flare-ups. About 60 participants will receive eithe…

This study tests whether tofacitinib, a drug already used for rheumatoid arthritis, is safe and helpful for people with Sjogren's disease. About 60 adults with mild-to-moderate Sjogren's will take the pill twice daily for 28 weeks. Researchers will track side effects and measure …

This study compares a new plastic (PEEK) knee implant to a standard metal one in 200 people with severe knee osteoarthritis who need total knee replacement. The goal is to see if the plastic implant works just as well as metal in terms of pain relief, movement, and safety. Partic…

This phase 3 trial tests a drug called plozasiran in 288 adults with severe hypertriglyceridemia (very high blood fats) who have had at least two pancreatitis attacks. Participants receive either the drug or a placebo every three months. The main goal is to see if the drug can pr…

This study is testing the drug vedolizumab (Entyvio) in 400 adults with moderate to severe ulcerative colitis or Crohn's disease. Participants first receive the drug through an IV for 6 weeks, then switch to injections under the skin for the rest of the year. The main goal is to …

This study tests a new drug called RO7837195 for people with moderate to severe ulcerative colitis who haven't gotten better with other treatments. About 224 participants will receive either the drug or a placebo for 12 weeks to see if it can bring about remission. The goal is to…

This phase 3 trial tests whether a shorter, lighter course of corticosteroids (28 weeks) works as well as the standard longer course (52 weeks) for giant cell arteritis, a condition that inflames blood vessels. The study aims to reduce side effects from long-term steroid use. 150…

This study tests a daily pill called etrasimod in 24 children aged 2 to 12 with moderate to severe ulcerative colitis, a chronic inflammatory bowel disease. The goal is to see if the drug can safely help children reach remission (few or no symptoms) over 52 weeks. Participants wh…

This study is a registry that will follow 300 people who receive the Freedom Total Knee System, a new artificial knee implant. The goal is to see how well the device holds up over time and how safe it is. Participants are adults with severe knee arthritis who have not gotten reli…

This study is monitoring the safety and effectiveness of the drug iptacopan (Fabhalta) in 21 Korean adults with paroxysmal nocturnal hemoglobinuria (PNH) or C3 glomerulopathy (C3G). Researchers will track side effects and lab results from routine medical records. The goal is to s…

This study tests a new, gentler way to clean deep gum pockets in people with advanced periodontitis. It compares a standard deep-cleaning method using larger tools to a minimally invasive approach using thinner, more delicate instruments. The goal is to see if the gentler method …

This study tests whether a single dose of an experimental immune cell therapy called agenT-797, given alongside standard care, can lower the risk of death in adults with severe pneumonia and breathing failure. About 90 people in intensive care will receive either agenT-797 or a p…

This study tests two different bone graft materials (GTO® and GenOs®) used with a new, less invasive surgical method called NIPSA to repair bone damage from advanced gum disease. Researchers will compare how well each material helps reattach gums and fill in bone defects over 6 m…

This study tests a freezing device called a cryoprobe to remove dead tissue from the pancreas in people with a serious complication of acute pancreatitis. Instead of using standard tools like forceps or snares, the cryoprobe freezes the dead tissue so it can be pulled out more ea…

This study tests whether upadacitinib, an oral tablet, can help adults with moderate to severe eczema (atopic dermatitis) who didn't get enough relief from dupilumab injections. About 200 participants will be randomly assigned to take upadacitinib or continue dupilumab for 8 week…

This Phase 3 trial tests whether a gel made from donated umbilical cord stem cells (CARTISTEM) can reduce pain and improve knee function better than a simple surgical cleanup (debridement) in people with knee cartilage damage and osteoarthritis. About 300 adults aged 18-75 with m…

This Phase 3 trial tests whether mezagitamab, an injectable drug, can reduce protein in the urine and preserve kidney function in adults with IgA nephropathy, a condition where immune complexes damage the kidneys. About 347 participants will receive either mezagitamab or a placeb…

This study is the first time REGN20423 is being tested in humans. It will enroll 144 adults, first healthy volunteers and then people with atopic dermatitis (eczema). The goal is to check safety, side effects, how the drug moves through the body, and whether it helps eczema sympt…

This study compares two mouthwashes used alongside standard gum disease treatment. One contains a higher dose of chlorhexidine (0.2%), while the other combines a lower dose of chlorhexidine (0.12%) with cetylpyridinium chloride. The goal is to see if the lower-dose combination wo…

This study follows 142 Canadian adults with moderate-to-severe hidradenitis suppurativa who are prescribed secukinumab as part of their regular care. Researchers will track changes in disease severity over 12 months using a standard scoring system. The goal is to understand how w…

This Phase 3 trial is testing a new gel called SNP-ACTH (1-39) against the standard drug rituximab in 148 adults with primary membranous nephropathy, a rare kidney condition. The goal is to see if the gel can better reduce protein in the urine and protect kidney function over 24 …

This phase 3 trial tests survodutide, a weekly injection, in 1800 adults with MASH and moderate to advanced liver fibrosis. Participants receive either the drug or a placebo for up to 7 years, alongside diet and exercise advice. The goal is to see if survodutide can improve or re…

This phase 2 trial tests a one-time treatment called CC-97540, made from a patient's own immune cells engineered to target and calm the overactive immune system in lupus. The study enrolls 89 adults with active lupus (including kidney inflammation) who have not responded well to …

This study tests whether giving patients special donor immune cells (called CD45RA-depleted DLI) can treat viral infections that persist after a stem cell transplant. The trial involves 30 participants who have not improved with standard antiviral drugs. Researchers will measure …

This study follows 40 children with Crohn's disease or ulcerative colitis who developed severe psoriasis from anti-TNF drugs and switched to ustekinumab. Researchers will check if their digestive symptoms stay controlled and if their skin improves after 3-6 months. The goal is to…

This study tests whether Miebo eye drops, used for one month before and 1.5 months after LASIK surgery, can reduce dry eye symptoms in people who already have dry eye disease. One hundred adults will use the drops four times daily. The goal is to see if eye dryness after surgery …

This phase 3 trial tests whether adding tirzepatide (a weight-loss drug) to mirikizumab (an anti-inflammatory drug) helps people with moderate-to-severe ulcerative colitis who are also overweight or obese. The goal is to see if the combination can reduce both gut symptoms and bod…

This Phase 2 study tests a new drug called ADX-038, alone or with another drug (telitacicept), in 30 Chinese adults with kidney diseases caused by an overactive complement system (IgA nephropathy, C3G, or IC-MPGN). The goal is to see if the treatment is safe and can help control …

This study tests the long-term safety of the drug nerandomilast in people with idiopathic pulmonary fibrosis (IPF) or progressive pulmonary fibrosis (PPF). All 1,700 participants have already taken the drug in a previous study. They will take nerandomilast tablets for up to 1 yea…

This study tests a new medicine called afimkibart in children aged 2 to 17 with moderate to severe ulcerative colitis, a disease that causes inflammation and sores in the colon. The goal is to see if the drug can safely help children feel better and achieve remission (no symptoms…

This study tests whether taking oral vancomycin while on other antibiotics can prevent a repeat Clostridioides difficile infection (CDI) in people who had one in the last 120 days. Researchers will compare vancomycin to a placebo in 300 adults. Participants take the study drug tw…

This phase IIb study tests three doses of AZD8965 against a placebo in 359 adults with idiopathic pulmonary fibrosis (IPF), a lung-scarring disease. The main goal is to see if AZD8965 can slow the decline in lung function over 24 weeks. Participants may also be taking standard IP…

This study tests an oral drug called LY4268989 (MORF-057) in adults with moderate-to-severe ulcerative colitis. About 1,431 participants will receive either the drug or a placebo for up to 108 weeks. The goal is to see if the drug can safely help control the disease and improve s…

This Phase 1 trial tests the safety and tolerability of a new drug called AZD5492 in 72 adults with lupus, myositis, or rheumatoid arthritis. Participants receive one or two doses under the skin and are monitored for side effects and how the drug moves through the body. The study…

This study compares two surgical treatments for thumb base osteoarthritis: total joint replacement with the TOUCH prosthesis and trapeziectomy (removing a bone at the thumb base). Researchers want to see if joint replacement provides better grip strength and fewer complications. …

This study tests the long-term safety and effectiveness of mirikizumab in 150 children and adolescents with moderate-to-severe ulcerative colitis or Crohn's disease. Participants who completed earlier mirikizumab studies can join. The trial lasts about 172 weeks and aims to see i…

This study tests an experimental drug called AZD1163 in 320 people with moderate-to-severe rheumatoid arthritis who haven't gotten enough relief from standard treatments. Participants receive either AZD1163 or a placebo as an injection, along with their usual care. The main goal …

This study tests an experimental tablet, BI 764198, in adults and some teens with four types of kidney disease that cause protein in the urine. Participants take the drug or a placebo daily for 20 weeks while continuing their usual care. The main goal is to see if the drug lowers…

This study compares two methods for disinfecting root canals in teeth with apical periodontitis (an infection at the tooth root). Fifty adults with infected molars will receive either a laser-based disinfection or a standard protocol. The goal is to see which method reduces bacte…

This study tests whether baricitinib, a daily pill, is safe and works for children aged 1 to under 18 with systemic juvenile idiopathic arthritis (sJIA), a chronic inflammatory disease. About 58 children will receive either baricitinib or a standard injected drug (tocilizumab) to…

This trial tests a new drug called IMVT-1402 for adults with Graves' disease, a condition where the thyroid is overactive. The study will include 210 participants who still have high thyroid levels despite taking standard medications. Participants will receive either one of two d…

This study tests whether a minimally invasive procedure called endoscopic sleeve gastroplasty (ESG), which reduces stomach size by 70%, can help reverse fatty liver disease (MASH) in people with obesity. Researchers will compare ESG plus lifestyle changes to lifestyle changes alo…

This study tests a drug called zigakibart in 32 adults with IgA nephropathy, a kidney disease. The goal is to see if it can reduce signs of kidney damage and slow disease progression. Participants must have a recent kidney biopsy and persistent protein in their urine despite stan…

This early-stage study tests a new drug called LY4213663 in healthy volunteers and people with rheumatoid arthritis (RA). The main goal is to see if the drug is safe and what side effects it may cause. Researchers will also measure how the body processes the drug. The study lasts…

This study tests a new medicine called MH002, which contains live bacteria meant to restore gut health in people with mild-to-moderate ulcerative colitis. About 204 adults whose current treatment isn't working well enough will receive either a low dose, high dose, or placebo caps…

This study is testing whether teaching people with periodontitis (gum disease) to follow an anti-inflammatory diet can improve the results of standard non-surgical gum treatment. One hundred adults with a pro-inflammatory diet will be split into groups; some will get diet educati…

This study looks at the long-term safety and effectiveness of the drug baricitinib for children aged 1 to 17 with juvenile idiopathic arthritis (JIA). It includes 190 participants who have already taken baricitinib in a previous study. Researchers will monitor side effects and ho…

This study tests a one-time treatment called Obe-cel, made from a patient's own immune cells, for severe lupus nephritis that hasn't improved with standard care. About 35 people aged 12 to 65 will receive the infusion and be monitored for up to 24 months. The main goal is to see …

This early-stage trial tests whether BHV-1400 is safe and tolerable for people with IgA nephropathy, a kidney disease. About 20 participants with confirmed IgA nephropathy will receive the drug subcutaneously. The main goal is to check for side effects and lab abnormalities.

This Phase III trial in sub-Saharan Africa tests whether giving higher doses of rifampicin plus linezolid, along with aspirin, can reduce deaths from tuberculous meningitis (TBM) in both HIV-positive and HIV-negative people. About 768 adolescents and adults will receive either th…

This early-stage study tests an experimental drug called LY4298445 in healthy volunteers and people with lupus or rheumatoid arthritis. The main goal is to check safety and how the body handles the drug. Participants will receive either the drug or a placebo, and the study lasts …

This study tests whether a 6-week gait retraining program using real-time feedback can improve walking patterns and reduce early signs of knee osteoarthritis in people who have had ACL reconstruction. Seventy participants will be randomly assigned to receive either real-time biof…

This early-stage study tests a new drug (GSK5926371) in people with lupus and similar autoimmune diseases. The drug is designed to target and calm specific immune cells that attack the body. The main goal is to check if the drug is safe and how the body handles it, with 54 adults…

This phase 2 study tests two experimental drugs, lutikizumab and ravagalimab, alone or together, in about 180 adults with moderate-to-severe rheumatoid arthritis who have not improved with other treatments. The goal is to see if these drugs can reduce joint pain and swelling bett…

This study tests an experimental drug called SAR441566 in about 204 adults with moderate-to-severe ulcerative colitis, a chronic bowel disease causing inflammation and symptoms like diarrhea and bleeding. Participants will receive either the drug or a placebo for up to 52 weeks t…

This study tests a new medicine called BI 765423 in 71 adults with idiopathic pulmonary fibrosis (IPF), a lung disease that causes scarring and breathing problems. Participants receive either the drug or a placebo by infusion every four weeks for about 3 months. The main goal is …

This pilot study tests whether the steroid prednisone can prevent recurrent pleural effusions (fluid buildup around the lungs) in people with non-specific pleuritis. Forty adults will be randomly assigned to take prednisone daily for 4 weeks or receive no steroid. The study lasts…

This Phase 3 trial tests whether survodutide, a weekly injection, can improve liver outcomes in 1590 adults with NASH or MASH cirrhosis. Participants are randomly assigned to receive survodutide or a placebo, along with diet and exercise counseling. The study will track serious l…

This study tests a new medicine called BI 3802876 in adults with compensated cirrhosis caused by MASH (a type of fatty liver disease). The main goal is to see if the drug is safe and how the body handles it. Participants receive either the drug or a placebo as an infusion, and ar…

This phase 3 trial tests whether the anti-inflammatory drug ketorolac can improve outcomes in 360 people undergoing emergency surgery for a life-threatening aortic dissection. Participants receive either ketorolac or a placebo before and after surgery, alongside standard care. Re…

This Phase 2 trial tests whether adding belimumab to standard rituximab treatment helps more people with primary membranous nephropathy achieve remission. The study enrolls 58 adults with confirmed disease. Belimumab targets new immune cells, while rituximab depletes existing one…

This early-stage trial tests a new approach for chronic granulomatous disease (CGD), a genetic condition that leaves people vulnerable to severe infections. Researchers take a participant's own white blood cells, use mRNA to correct the genetic defect, and infuse the cells back. …

This study tests whether a weekly under-the-skin antibody treatment (XEMBIFY) provides similar blood levels as a standard IV infusion (Gamunex-C) given every 3 weeks in people with CIDP, a chronic nerve disorder. About 40 adults who are stable on IVIG will first receive Gamunex-C…

This phase II trial tests whether a 12-week course of higher-dose antibiotics combined with a urinary antiseptic (methenamine hippurate) can better control chronic UTI than standard low-dose antibiotics or antiseptic alone. About 192 adults with daily UTI symptoms for at least 3 …

This study compares two types of wrist fusion surgery for people with post-traumatic wrist arthritis. One surgery fuses four wrist bones and removes the scaphoid. The other fuses three or two bones and also removes the triquetrum. The goal is to see which approach gives better gr…

This study tests whether a drug called tralokinumab, given as a shot along with steroid cream, can safely control moderate-to-severe eczema in children aged 6 months to under 12 years. About 195 participants will receive either the drug or a placebo for 16 weeks, then all will ge…

This early study tests a new medicine, MK-1045, in about 21 people with lupus or rheumatoid arthritis. The main goal is to see if it is safe and tolerable at different dose levels. Participants receive the drug through an IV infusion, and researchers monitor for side effects.

This study tests whether a special medical food called LH VIOLA, taken as a partial replacement for regular meals, can help people with Crohn's disease or ulcerative colitis who are at risk of malnutrition maintain or regain weight and muscle strength. About 146 participants will…

This Phase 3 study tests a drug called efruxifermin in 1,650 people with non-cirrhotic NASH/MASH and moderate liver scarring (stage 2 or 3). Participants receive either the drug or a placebo as a weekly injection. The goal is to see if the drug can reverse liver inflammation and …

This early-stage trial is testing an experimental drug called GIGA-2339 in 48 adults with chronic hepatitis B. The main goal is to check if the drug is safe and how the body processes it. Participants will receive either GIGA-2339 or a placebo by IV infusion, and researchers will…

This study tests a new medicine called MAS825 for people with Still's disease, a rare inflammatory condition causing fever, rash, and joint pain. About 20 children and adults with active disease will receive the drug to see if it safely controls symptoms. The goal is to improve d…

This study tests an experimental drug called LY4005130 in 60 adults with non-segmental vitiligo, a condition that causes white patches on the skin. Participants receive either the drug or a placebo by IV every few weeks for 24 weeks. The goal is to see if the drug can reduce the …

This phase 3 study tests the drug risankizumab in about 120 children aged 2 to 18 with moderate to severe ulcerative colitis. The trial has three parts: an initial 12-week IV treatment period, a 52-week maintenance phase where patients get one of two doses by injection, and a lon…

This study tests whether a balloon coated with the drug paclitaxel, used during standard sinus surgery, can reduce the need for additional procedures or medications in adults with chronic sinusitis. About 300 participants will receive either the drug-coated balloon or a plain bal…

This Phase 3 trial will test whether children and teens with mild rheumatic heart disease (RHD) can safely stop taking long-term penicillin. About 922 participants aged 5-20 who have stable or normalized RHD after at least 2 years of antibiotics will be randomly assigned to eithe…

This study compares two ways of giving the drug bimekizumab to people with active psoriatic arthritis or axial spondyloarthritis: as an IV infusion or as a shot under the skin. The goal is to see if the IV method works just as well as the shot. About 392 adults who are suitable f…

This study tests whether artificial intelligence can help doctors personalize rituximab doses for people with membranous nephropathy, an autoimmune kidney disease. About 120 adults with active disease will receive either standard rituximab or AI-guided dosing to keep drug levels …

This large platform trial is testing new antifungal drug combinations for cryptococcal meningitis, a severe brain infection that is fatal without treatment and common in people with HIV. The study will enroll 2,000 participants across multiple sites to compare a newer oral drug, …

This study tests an experimental drug called GIA632 in 210 adults with non-segmental vitiligo, a condition that causes white patches on the skin. The goal is to see if the drug can safely restore skin color and to find the best dose for future studies. Participants will receive e…

This study looks at how well etrasimod works for people with moderate to severe ulcerative colitis when used in normal doctor visits. About 360 adults aged 18 to 65 will take etrasimod as prescribed by their doctor and fill out health questionnaires online. Researchers will track…

This trial investigates whether adding the antibiotic rifampicin to standard treatment improves outcomes for people with prosthetic joint infections caused by Cutibacterium acnes bacteria. These infections are hard to treat because the bacteria form a protective biofilm. The stud…

This study compares two common antibiotics, daptomycin and vancomycin, to see which one works better for adults with MRSA bloodstream infections. About 300 participants will be randomly assigned to one of the two drugs. The goal is to find which treatment leads to fewer complicat…

This study tests a drug called bimekizumab in children aged 2 to 17 with specific types of juvenile arthritis (enthesitis-related arthritis and juvenile psoriatic arthritis). The goal is to see how the drug moves through the body and if it is safe. About 40 children will take par…

This phase 3 trial tests whether the drug bimekizumab can clear or nearly clear the pustules and skin lesions of palmoplantar pustulosis (PPP) on the hands and feet. About 320 adults with moderate to severe PPP will receive either bimekizumab or a placebo for 16 weeks, with an op…

This Phase 2 trial tests an experimental oral drug called D-2570 in 75 adults with moderate to severe plaque psoriasis. Participants are randomly assigned to receive either D-2570 or a placebo tablet for 12 weeks. The main goal is to see if the drug can achieve at least a 90% imp…

This study tests whether a 20-day fasting schedule before hip replacement surgery can reduce complications like infections. 130 adults will either follow the fasting plan or receive standard care. Researchers will measure changes in gut bacteria and immune markers to see if fasti…

This study tests a drug called bimekizumab in teenagers (ages 9 to 17) with moderate to severe hidradenitis suppurativa, a painful skin condition that causes boils. The goal is to see how the drug moves through the body and if it is safe. About 40 participants will receive the dr…

This study tests the drug lenalidomide in 42 adults with Behçet's syndrome who have stubborn mouth ulcers. Participants take 10 mg of lenalidomide daily for 12 weeks, then stop for 4 weeks of observation. The main goal is to see if the ulcers completely disappear by week 12.

This trial tests a gene therapy for chronic granulomatous disease (CGD), a rare immune disorder that leaves patients vulnerable to severe infections. Ten patients will receive their own stem cells modified with a lentivirus to correct the faulty gene. The goal is to restore immun…

This study tests if guselkumab can help people with Hailey-Hailey disease, a genetic condition causing painful blisters and sores in skin folds. Ten adults with moderate to severe disease will receive the drug and be monitored for changes in skin severity and quality of life. The…

This study tests a new medicine called galvokimig in 160 adults with moderate-to-severe atopic dermatitis (eczema). The goal is to see if different doses can reduce skin redness, itching, and rash better than a placebo. Participants will receive injections and be monitored for 16…

This study looks at the long-term safety of a drug called vedolizumab given as a shot under the skin to children and teenagers with ulcerative colitis or Crohn's disease. About 70 participants who did well on the drug in an earlier study will keep getting it, while those who didn…

This study tests a new drug called KPL-387 in 80 people with well-controlled recurrent pericarditis (inflammation around the heart). The goal is to see if patients can safely switch from their current treatments to KPL-387 alone and still prevent flare-ups. The trial will measure…

This study tests if a new drug called cenerimod can help people with lupus who have active kidney disease (lupus nephritis). About 300 adults will take either cenerimod or a placebo daily for 76 weeks, on top of their usual treatments. The main goal is to see if cenerimod improve…

This study tests whether taking pentoxifylline and vitamin E during chemoradiation can prevent lung injury (pneumonitis) in stage III non-small cell lung cancer patients. 150 participants will receive either the drug combo or a placebo for 6 months. The goal is to see if this red…

This study tests whether removing a small part of the shoulder bone (coracoid) during reverse total shoulder replacement helps patients rotate their arm inward better after surgery. Sixty adults needing shoulder replacement will be randomly assigned to get the standard surgery or…

This study tests whether the drug avacopan can help children aged 6 to 18 with a rare autoimmune disease called ANCA-associated vasculitis, which causes inflammation of blood vessels. About 20 participants will receive avacopan alongside standard treatments like rituximab or cycl…

This study is checking the long-term safety of a drug called avacopan for people with ANCA-associated vasculitis, a rare disease where the immune system attacks blood vessels. About 300 adults who need treatment for a new diagnosis or flare-up will take avacopan or a placebo. The…

This study tests whether canakinumab, an anti-inflammatory drug, can reduce blood vessel inflammation in people with coronary artery disease. Some participants have a genetic change called TET2 clonal hematopoiesis, which may increase inflammation. 120 adults will receive either …

This study tracks 40 children aged 2 to 12 with hereditary angioedema (HAE) who are taking lanadelumab to prevent sudden, painful swelling attacks. Researchers will look at medical records to see how long kids stay attack-free and how the drug performs in daily life. No new treat…

This study tests a daily pill called deucravacitinib in teenagers aged 12 to 18 with moderate to severe plaque psoriasis. About 366 participants will receive either the drug or a placebo. The main goals are to see if the drug improves skin clearance by at least 75% and reduces ov…

This pilot study tests a new procedure for people with Crohn's disease who have anal fistulas that haven't healed with standard treatments. Doctors take a small amount of fat from the patient's belly, process it mechanically in the same surgery, and inject it into the fistula tra…

This study compares two treatments after surgery for stage III-IVA head and neck cancer: radiation alone versus radiation plus the chemotherapy drug cisplatin. The goal is to see which approach better prevents the cancer from returning, especially in patients with certain TP53 ge…

This early-stage study tests a new treatment called ALLO-329 for people with lupus, myositis, or scleroderma. The therapy uses specially engineered immune cells from a donor to target and calm the overactive immune system. The main goals are to check safety and see if it can impr…

This study tests an experimental drug called ALXN1920 in 30 adults with primary membranous nephropathy, a rare kidney disease that can lead to kidney failure. Participants are at high risk for their disease getting worse. The study compares the drug to a placebo to see if it redu…

This phase 3 trial tests whether zasocitinib, an oral medication, can safely and effectively treat moderate-to-severe plaque psoriasis in children and teens aged 4 to 17. The study involves 110 participants and lasts up to 4 years. In the first part, some receive the drug and oth…

This study tests whether a non-invasive device that gently stimulates a nerve in the ear can help people with psoriatic arthritis. The device, called taVNS, is used for 20 minutes daily over 10 days. Researchers will measure changes in disease activity, pain, quality of life, and…

This study compares two antibiotic approaches for a serious heart valve infection caused by staph bacteria. One group gets a standard treatment that includes the drug rifampin, while the other group gets a treatment without it. The goal is to see if skipping rifampin is just as e…

This early-stage trial is testing two experimental drugs, vonsetamig and odronextamab, in people with lupus nephritis that has not responded to standard treatments. The main goal is to check safety and side effects over the long term. Researchers will also see if the drugs can he…

This study tests the drug dupilumab in children as young as 6 months who have active eosinophilic esophagitis (EoE), a condition that causes inflammation in the esophagus and can make eating difficult. The goal is to see if the drug is safe and effective over 24 weeks. About 20 c…

This Phase 3 study tests a new drug called felzartamab in 180 people with primary membranous nephropathy (PMN), a kidney disease where the body's immune system attacks the kidneys. Felzartamab is a lab-made antibody designed to stop that attack. The study compares felzartamab to …

This early study tests a new treatment called azercabtagene zapreleucel (azer-cel) for people with B-cell mediated autoimmune disorders like multiple sclerosis and neuromyelitis optica. The treatment uses a patient's own immune cells that are modified in a lab to target and destr…

This study tests whether adding a new oral drug, LY4268989, to the existing treatment mirikizumab works better than mirikizumab alone for adults with moderate-to-severe ulcerative colitis. About 252 participants will receive either the combination or mirikizumab plus a placebo fo…

This study is for people who have both an autoimmune disease (like rheumatoid arthritis, lupus, or multiple sclerosis) and an advanced cancer that has spread or cannot be removed by surgery. It tests the safety and effectiveness of the immunotherapy drug nivolumab, given alone or…

Most older Americans eat too much salt, which can raise blood pressure and harm the kidneys. This study tests whether a ketone supplement (a substance the body makes during fasting or exercise) can block those harmful effects. Thirty-five adults aged 60-85 will follow a high-salt…

This study tests whether nicorandil, a drug usually used for heart conditions, can reduce inflammation and improve symptoms in people with active rheumatoid arthritis. 46 participants will take nicorandil tablets for 3 months. Researchers will measure joint disease activity and p…

This study looks at how well risankizumab works for people with moderate to severe ulcerative colitis in real-world settings. About 200 adults in Germany and Austria will take the drug as prescribed by their doctor and be followed for up to 52 weeks. The goal is to see if symptom…

This study tests the long-term safety and effectiveness of an oral drug called zasocitinib (TAK-279) in adults with active psoriatic arthritis, a condition causing joint pain and skin patches. About 1,182 participants who completed a one-year parent study will take either a lower…

This study tests a non-invasive device that uses ultrasound to stimulate the spleen and reduce inflammation in people with moderate to severe rheumatoid arthritis. About 60 adults who haven't responded well to standard medications will use the device at home for 12 weeks, with so…

This study tests a drug called FB825 in adults with moderate-to-severe atopic dermatitis (eczema). Participants receive five injections over 12 weeks, either FB825 or a placebo, to see if it improves skin symptoms like redness and itching. The goal is to find a new treatment opti…

This phase 3 trial is testing whether atorvastatin, a common cholesterol drug, is safe and can reduce inflammation in children with Kawasaki disease who also have coronary artery abnormalities. The study will enroll 9 children and give them different doses of atorvastatin for 6 w…

This study tests the long-term safety of deucravacitinib compared to ustekinumab in about 3,040 adults with moderate-to-severe plaque psoriasis who also have heart risk factors like smoking, high blood pressure, or diabetes. Participants will receive one of the two medications an…

This study tests a daily pill called vibegron to see if it safely improves bladder control in children aged 2 to 18 with neurogenic detrusor overactivity (NDO), a condition where the bladder contracts too often due to nerve damage. Participants must already use a catheter to empt…

This phase 3 trial is testing an experimental drug called ADX-324 in 90 adults with hereditary angioedema (HAE) types 1 or 2. HAE causes sudden, painful swelling in the body. ADX-324 uses a technology called siRNA to lower levels of a protein involved in triggering these attacks.…

This study tests NOV05, a water-free tacrolimus eye drop, in 20 adults with active non-infectious anterior uveitis. Participants receive either a high or low dose for 6 weeks. The goal is to see if it safely controls inflammation and reduces the need for steroid eye drops.

This study tests a new treatment called CART19 for teens and young adults (ages 12-29) with severe lupus that hasn't improved with standard treatments. CART19 uses a patient's own immune cells, modified in a lab to target and calm the overactive immune system causing lupus. The g…

This study tests a new gel called OCF001 for treating acute yeast infections in women. About 36 women with a confirmed yeast infection will use the gel or a placebo for 7 days. Researchers will check if the infection clears up and if the gel is safe and well-tolerated.

This study tests a new drug called tarperprumig in 75 adults with ANCA-associated vasculitis, a rare disease where the immune system attacks blood vessels. The goal is to see if the drug is safe and can help control the disease by reducing inflammation. Participants will receive …

This Phase 2 study is testing a new drug called ADX-038 in 45 adults with complement-mediated kidney diseases, such as IgA nephropathy and C3G. The drug is an siRNA that targets the complement system, which is overactive in these conditions. Researchers are checking if it is safe…

This phase 3 trial compares a new drug, brelovitug, to an existing treatment (bulevirtide) for chronic hepatitis delta, a serious liver infection. About 172 adults with the infection will receive either drug to see which better controls the virus and normalizes liver enzymes. The…

This early-stage trial tests a new drug called TRB-061 in healthy adults and people with moderate-to-severe atopic dermatitis (eczema). The study checks for safety, side effects, and how the drug moves through the body. Participants receive either TRB-061 or a placebo as injectio…

This study is for people with hereditary angioedema (HAE) who have already completed a previous trial of the drug ADX-324. ADX-324 is an RNA-based medicine designed to lower a protein involved in swelling attacks. The goal is to see if long-term use is safe and can reduce the num…

This early-stage trial tests a single infusion of CRISPR-edited immune cells (CTX112) from a healthy donor in 80 adults with severe lupus, scleroderma, or myositis that hasn't responded to standard treatments. The goal is to see if the cells are safe and can reduce disease activi…

This study tests a new drug called riliprubart against standard IVIg treatment in 160 adults with chronic inflammatory demyelinating polyneuropathy (CIDP), a nerve disorder causing weakness and numbness. Participants currently on IVIg will be randomly assigned to receive either r…

This trial investigates whether montelukast, a common asthma medication, can reduce inflammation and prevent cartilage breakdown after anterior cruciate ligament (ACL) reconstruction. The study enrolls adults aged 25 to 50 who also have a meniscus tear, a group at high risk for r…

This study tests whether infliximab (Remicade), a drug used for arthritis and other inflammatory conditions, can shrink a specific type of brain aneurysm called a dolichoectactic vertebrobasilar (DVB) aneurysm. These aneurysms are difficult to treat with surgery or stents, and th…

This study tests whether a steroid mouthwash (clobetasol propionate 0.05%) and low-level laser therapy, alone or together, can heal painful mouth sores in people with pemphigus vulgaris—a chronic autoimmune disease that causes blisters on skin and mucous membranes. Thirty partici…

This early-stage trial tests BDHK-2009, an experimental tablet for inflammatory bowel diseases like ulcerative colitis and Crohn's disease. The study involves 68 healthy adults aged 18 to 55 to see if the drug is safe and how the body handles it. Participants receive either a sin…

This study compares muscle thickness around the shoulder blade in people with early ankylosing spondylitis (an inflammatory condition) versus those with mechanical shoulder blade movement problems. Researchers use ultrasound and electromyography (EMG) to see if they can tell the …

This study tests whether a simple esophageal string test (EST) can diagnose eosinophilic esophagitis (EoE) in people who have trouble swallowing. Participants swallow a capsule with a nylon string that collects fluid from the esophagus, which is then analyzed. The results will be…

This study aims to create and test a clinical prediction score called FUNGAL-P to help doctors identify fungal pneumonia early in adults who come to the hospital with pneumonia. Researchers will analyze medical records from past patients and then test the score on new patients to…

This study tests whether adding advanced molecular tests (like PCR and DNA sequencing) to standard blood cultures helps doctors identify the cause of infective endocarditis—a serious heart valve infection—more quickly. The goal is to see if this leads to more patients receiving t…

This study tests a portable ultrasound system to measure the position of the shoulder blade (scapula) in patients with shoulder arthritis while they stand. The goal is to see if this non-radiation method can give results similar to CT scans taken when lying down. Thirty adults sc…

This study looks at whether a protein in the blood, called I-FABP, can tell doctors if a child's IgA vasculitis is affecting their stomach or intestines. Researchers will take blood samples from 100 children at diagnosis and again 2-4 weeks later. If I-FABP levels are linked to g…

This study explores whether measuring heart rate variability—the natural ups and downs in heartbeat timing—can help detect complications like leaks or abscesses after planned colorectal surgery. Researchers will monitor patients for a week after surgery and compare heart rate pat…

This study looks at whether a new set of international criteria can accurately diagnose optic neuritis—a condition that causes sudden vision loss—in Chinese patients. Researchers will enroll 500 people with acute or subacute vision loss and compare the criteria's results against …

This study is testing a new type of PET/CT scan that uses a special tracer to see if it can better detect and monitor chronic inflammatory and fibrotic diseases like rheumatoid arthritis, liver fibrosis, and lupus. About 390 adults with these conditions will get the scan to measu…

This study tests a software called Glandy HYPER that uses artificial intelligence to detect thyrotoxicosis—a dangerous overactive thyroid state—in people with Graves' disease. The AI analyzes resting heart rate data from wearable devices like smartwatches and compares it with sta…

This study tests whether Aquamin, a natural mineral supplement from seaweed, can prevent pouchitis—a painful inflammation of the J-pouch—in people with ulcerative colitis who have had their colon removed. About 52 participants will take Aquamin or a placebo for up to 8 months. Th…

This phase 3 trial tests whether a gradual taper of vancomycin is as good as a 10-day course of fidaxomicin at preventing another C. difficile infection. About 500 adults with a first or second C. diff episode will be randomly assigned to one of the two treatments. The main goal …

This study tests a new drug called AZD5148 to see if it can prevent repeat C. diff infections in adults. About 230 people will get either the drug or a placebo as a single injection. The goal is to stop the infection from coming back after standard treatment.

This study tests whether a dexamethasone mouthwash can prevent moderate to severe mouth sores caused by chemotherapy in adults with cancer. Participants use the mouthwash four times daily during chemo for up to 8 weeks. Researchers compare their outcomes to a historical group to …

This study is testing a gel called OSTENIL TENDON to see if it safely reduces pain and improves movement in people with tendon problems. Researchers will enroll 84 adults with one of four types of tendinopathy. The main goal is to measure pain changes three months after treatment…

This study tests whether a mobile app that provides psychological tools can improve quality of life for people with eczema, psoriasis, or chronic hives. Participants use the app over 32 weeks to learn coping strategies and wellness tips. The goal is to see if this digital approac…

This study tests a new eye drop called HUC1-394 in 150 adults with moderate to severe dry eye disease. Participants will use the drops or a placebo for a period to see if the drug reduces eye surface damage and improves symptoms. The goal is to find the best dose and frequency.

This study tests whether giving dexamethasone through a vein can improve pain control after total hip replacement. About 198 adults having hip surgery will receive either no dexamethasone, 4 mg, or 8 mg, along with standard anesthesia and a nerve block. The main goal is to see ho…

This study tests whether injecting ozone gas into the knee joint, combined with exercise, can reduce pain and improve function in people aged 40-75 with moderate knee osteoarthritis. Participants receive three weekly ozone injections at different concentrations (10, 15, or 20 µg/…

This study will compare three pain management methods after hip surgery in 108 adults aged 65 and older. The methods are a nerve block (PENG block), a local anesthetic injection around the joint (periarticular injection), or both combined. The goal is to see which approach reduce…

This early-stage study tests a new drug called BBT001 in healthy volunteers and adults with moderate-to-severe atopic dermatitis (eczema). The main goal is to check safety and how the drug moves through the body. About 198 participants will receive either BBT001 or a placebo, wit…

This study tests whether a numbing injection called a PENG block can reduce inflammation and pain in older adults having hip replacement surgery. Sixty patients will receive either the numbing drug ropivacaine or a placebo (salt water) after spinal anesthesia. The goal is to see …

This study compares two manual therapy techniques—myofascial release and instrument-assisted soft tissue mobilization—for treating plantar fasciitis in pregnant women. Forty-four women in their second or third trimester will receive one of the two treatments over four weeks, alon…

This study investigates whether drinking nitrate-rich beetroot juice twice a day for three days can improve exercise capacity in people with idiopathic pulmonary fibrosis (IPF), a lung scarring disease that limits activity. Researchers will compare the juice to a placebo in a sma…

This study compares three different over-the-counter lubricating eye drops in people with dry eye disease. Researchers will measure how well each drop is tolerated, how much it improves symptoms like discomfort and blurry vision, and its effect on daily visual function. The trial…

This study tests whether a cream made with Helichrysum italicum (Immortelle) extract can help heal irritated skin and restore the skin barrier better than a plain moisturizer. Healthy volunteers will have a small patch of skin irritated with a mild soap, then apply the Immortelle…

This study tests whether injecting the steroid dexamethasone near the tooth ligament or under the gum helps numb the tooth better and reduces pain during root canal treatment. It includes 84 adults with severe, irreversible pulpitis in a lower molar. Participants receive one of t…

This Phase 3 trial tests whether the drug Raphamin can help adults with acute bronchitis recover faster. About 308 participants will take either Raphamin or a placebo for 5 days. Researchers will track symptoms like cough and chest pain to see if Raphamin reduces illness duration…

This study tests a modular, powered leg brace (exoskeleton) designed to assist knee movement and reduce pain in people with knee osteoarthritis. The brace provides a small amount of torque to help the joint, potentially lowering muscle effort and painful loads on the knee. Resear…

This study tests whether a team of pharmacists and physiotherapists can help people with early knee osteoarthritis manage their condition. Participants will get one-on-one pharmacist care, including medication review and education, plus individual or group physiotherapy sessions.…

This study compares two minimally invasive procedures—cryoneurolysis (freezing nerves) and radiofrequency (using electric pulses)—to relieve knee pain in adults with osteoarthritis who haven't responded to standard treatments like painkillers or physical therapy. Sixty participan…

This study tests a new eye drop called DFL24498 in people with dry eye disease. About 417 adults will use the drops four times a day for 12 weeks. Researchers will check if the drops improve eye surface health and reduce dryness symptoms compared to a placebo.

This study tests whether starting an accelerated shoulder rehabilitation program immediately after reverse total shoulder replacement leads to better pain relief and function than the standard rehab approach. About 74 people with shoulder osteoarthritis will be randomly assigned …

This study compares two methods of removing the gallbladder during laparoscopic (keyhole) surgery: through a port near the belly button or one below the breastbone. The goal is to see which approach causes less pain and fewer wound problems like infection. The trial will involve …

This study tests whether adding a beta-glucan moisturizing cream to standard skin care helps heal incontinence-associated dermatitis faster and reduces symptoms like pain, itching, and burning. Sixty adults with this skin condition will receive either the cream plus standard care…

This Stanford study tests whether people with knee osteoarthritis can learn to change how they activate their calf muscles while walking, using a vibrating feedback device. The goal is to reduce the force on the knee joint. Thirty-one participants will train on a treadmill or ove…

This study is testing whether a time-restricted eating plan (eating only during an 8-10 hour window each day) combined with a healthy plant-based diet is safe and doable for people with liver cancer, cirrhosis, or fatty liver disease. Fifty overweight or obese adults will either …

This study compares two types of nerve blocks to see which provides better pain relief after total hip replacement. Fifty adults having hip surgery will receive one of the two blocks. Researchers will measure pain scores and how much extra morphine is needed. The goal is to impro…

This study tests whether taking vitamin C around the time of knee replacement surgery can reduce long-term pain. About 400 adults having knee replacement will be randomly assigned to receive vitamin C or a placebo for 8 weeks. The main goal is to see if a larger study is possible…

This study tests whether injecting Botox or hyaluronic acid into the knee joint can reduce pain in people with knee osteoarthritis. Fifty adults aged 50 and older with moderate to severe knee arthritis will receive three weekly injections of one of the two treatments. The main go…

This study tests whether giving lactulose, a mild laxative, after complex appendix surgery helps the bowels start working again sooner. 150 adults will receive either lactulose or a placebo for a few days after their operation. The main goal is to see how quickly they can pass st…

This study compares two exercise programs for people with knee osteoarthritis: supervised cycling on a stationary bike and a land-based therapeutic exercise program with strengthening and balance training. The goal is to see which approach better reduces pain sensitivity during a…

This clinical trial tests whether a doxepin solution spray can relieve severe breakthrough pain when swallowing, a common side effect of radiation therapy for nasopharyngeal carcinoma. About 178 patients will be randomly assigned to receive either the doxepin spray or a placebo s…

This study tests two experimental drugs (REGN5713 and REGN5715) given alone or together to reduce eye allergy symptoms caused by birch pollen. About 350 adults with birch pollen allergy will receive the drugs or a placebo and then be exposed to pollen in a controlled setting. The…

This study tests whether a combination of special joint mobilizations, pain education, and core exercises can reduce pain and improve shoulder function in people with frozen shoulder. Thirty-six adults with the condition will be randomly assigned to either this new program or sta…

This Phase 3 study tests a once-weekly injection called eloralintide in 900 adults with osteoarthritis of the knee who are also overweight or obese. The goal is to see if it reduces knee pain and helps with weight loss compared to a placebo. Participants will be in the study for …

This study tests whether a gentle brain stimulation technique called tDCS, applied before eccentric knee exercises, can improve pain and function more than exercise alone in people with patellar tendinopathy (jumper's knee). Forty-two adults with chronic knee pain will be randoml…

This study tests a single injection called SL1002 to see if it safely reduces knee pain in people with osteoarthritis. About 150 adults aged 40 and older with mild to moderate knee arthritis will receive either the study drug or a placebo. The main goal is to measure pain relief …

This study tests an oral drug called vapendavir in 180 adults with COPD who catch a rhinovirus (common cold). The goal is to see if it can reduce the severity and length of breathing symptoms compared to a placebo. Participants are randomly assigned to one of two doses or a place…

This phase II trial tests whether adding BMX-001 to standard symptom management can reduce severe mouth sores in head and neck cancer patients receiving chemoradiation. About 98 participants will receive either BMX-001 or a placebo alongside usual care. The goal is to see if BMX-…

This study tests a hydrogel wound dressing (Emanate Perio PODS) to see if it helps gums heal better after scaling and root planing, a deep cleaning for stage 3 periodontitis. 72 adults will use the gel at home twice a day for 30 minutes, or receive no extra treatment. The main go…

This Phase 2 trial is testing four experimental drugs (taken orally or by IV) against placebo in 10,000 people with chronic pain from knee osteoarthritis, diabetic nerve damage, or low-back pain. The goal is to see if any of these drugs can safely reduce pain. The study uses a fl…

This study tests an ointment called HL-300 in people with mild-to-moderate atopic dermatitis (eczema). About 156 adults will apply the ointment or a placebo twice daily for 4 weeks. Researchers will check if the ointment reduces eczema severity and improves symptoms.

This study tests whether adding hyaluronic acid to a standard corticosteroid injection works better for shoulder tendonitis pain than the steroid alone. About 132 adults with confirmed supraspinatus tendinopathy will receive either the combo or a placebo injection. Pain levels ar…

This early-phase study tests a 4-week training program that uses mixed reality to guide precise movements, like stacking virtual objects. The goal is to see if this can improve walking speed, balance, and thinking in people with multiple sclerosis. Thirty adults with MS will part…

This study is testing whether giving one dose of methadone just before total knee replacement surgery can help control pain afterward and reduce the amount of other painkillers needed. About 192 adults aged 21-75 having a knee replacement will be randomly assigned to receive meth…

This study looks at whether a special version of clamshell exercises can help people with moderate hip osteoarthritis feel less pain and move better. Researchers will compare three exercise programs in 54 adults aged 45 to 60. The goal is to find the best way to improve hip funct…

This study tests whether a protein-based eye drop (rhPRG4) can safely relieve dry eye symptoms in people with Sjögren's syndrome. About 80 adults will receive either the active drops or a placebo for 28 days. The main goal is to see if the drops can clear corneal staining, a sign…

This study tests whether daily cannabis extracts (CBD or THC) can reduce pain interference in people with hip or knee osteoarthritis. One hundred adults aged 40-80 will take either CBD, THC, or a placebo capsule daily for 8 weeks and track their symptoms remotely. The goal is to …

This study tests whether an enhanced recovery after surgery (ERAS) protocol helps people recover faster after total knee replacement. About 120 patients aged 50-70 will either get standard care or the ERAS plan, which includes pre-surgery exercise, shorter fasting, and early walk…

This phase 3 study tests lebrikizumab, an injectable drug, in 450 adults with perennial allergic rhinitis (year-round allergies). The goal is to see if it reduces nasal symptoms like congestion and sneezing compared to a placebo. Participants will be followed for up to 29.5 month…

This study tests an experimental drug called Allocetra, given as a shot into the knee joint, for people aged 64+ with moderate-to-severe knee osteoarthritis. The goal is to see if it reduces pain and improves function better than a placebo. About 270 participants will be followed…

This trial tests whether a short, temporary nerve stimulation can reduce pain in people with moderate to severe knee osteoarthritis. About 100 adults aged 30 to 70 who have not found relief from oral pain medications or physical therapy will receive a brief electrical pulse to sp…

This study compares two types of balance and strength exercises added to standard physical therapy for knee osteoarthritis. Sixty adults aged 40-70 with mild to moderate knee arthritis will be randomly assigned to one of two exercise programs. The goal is to see which approach be…

This study tests a powered boot-like device (exoskeleton) to see if it can help people with knee osteoarthritis walk more easily. Nine adults with knee pain who have trouble walking will try the device in a lab. The goal is to see if the device is comfortable and can reduce strai…

This study tests an experimental daily pill, ritlecitinib, for adults with chronic spontaneous urticaria (long-term itchy hives and swelling) that antihistamines don't fully control. About 200 participants will receive either 50 mg, 100 mg, or a placebo for 12 weeks, then all wil…

This study tests a new lotion (ZYG24002) in 48 adults with mild to moderate seborrheic dermatitis, a common skin condition causing redness and flaking. Participants will apply the lotion daily for 28 days to see if it is safe and tolerable. The goal is to find the best dose for f…

This study is testing two versions of Tears Naturale lubricating eye drops—one with preservatives and one without—in 120 people with mild to moderate dry eye disease. Participants will stop using their usual artificial tears and use only the study drops for the duration of the tr…

This study tests a new pill containing three ingredients (dipyrone, caffeine, and chlorpheniramine) to see if it works as well as a standard cold medicine for relieving stuffy nose and other cold and flu symptoms. About 620 adults with early cold or flu symptoms will take either …

This study looks at whether people with COPD and chronic bronchitis who switch from regular cigarettes to a tobacco heating system feel better and breathe easier. About 290 adults aged 40 and older who have smoked for at least 10 years will take part. Researchers will measure cou…

This study tests two ways to guide a treatment called cooled radiofrequency ablation for knee osteoarthritis pain. The treatment uses heat to calm nerves around the knee. Researchers want to see if using ultrasound is better than the standard X-ray method for targeting the right …

This study compares two noninvasive treatments—shock wave therapy and low-level laser therapy—for tennis elbow (lateral epicondylitis). Fifty adults with at least six weeks of elbow pain will receive one of the treatments plus a brace and exercises. Researchers will measure pain,…

This trial compares two injection treatments for knee osteoarthritis: a combination of platelet-rich plasma (PRP) and hyaluronic acid versus hyaluronic acid alone. Researchers want to see if the combined approach provides better pain relief and function after one year. The study …

This study investigates knee osteoarthritis and cartilage degeneration by combining MRI scans with gait analysis. Researchers aim to better understand how the disease affects both the structure and function of the knee joint. The study involves 25 participants with knee pain or c…

This study collects blood stem cells and immune cells from healthy volunteers and patients with primary immune deficiencies or blood disorders. The cells are used in the lab to develop new gene and cell therapies. Up to 850 adults aged 18-70 will participate. The goal is to advan…

This study aims to learn more about Hyper IgE syndrome, a rare immune disorder that causes skin and lung infections. Researchers will follow 600 patients and their relatives over time, examining their health and genetics. The goal is to better understand the disease and improve c…

This completed observational study at a single hospital in China enrolled 16 adults with sepsis in the ICU. Researchers measured specific memory CD8+ T cells in the blood at several time points to see if their numbers or activity relate to how severe the sepsis is or whether pati…

This study aims to learn more about liver diseases like hepatitis B, C, and D by observing up to 8,050 participants over time. Participants will have yearly check-ups, blood and urine tests, and liver ultrasounds. Some may be offered experimental treatments if they qualify. The g…

This study aims to learn more about how lupus (SLE) develops and changes over time by observing patients and their relatives. Up to 2000 people aged 3 and older with known or suspected lupus, along with their family members, will provide medical history, blood and urine samples, …

This study looks at how people's immune systems react to infections from parasitic worms, which can cause serious health problems like swelling, blindness, or heart disease. Researchers will evaluate and treat up to 500 participants aged 3 to 100 using standard medical tests and …

This study aims to understand the causes and progression of systemic juvenile idiopathic arthritis (sJIA) and adult-onset Still's disease (AOSD) by observing up to 2,000 participants over time. Researchers will collect medical history, blood samples, and genetic data to identify …

This study tests whether bundling key tests like scans and lung function tests into a single, fast-tracked appointment can help people with suspected interstitial lung disease get a diagnosis sooner. About 92 adults will be randomly assigned to either the usual step-by-step testi…

This study examines how common eczema treatments, including antibiotics and bleach baths, change the types and amounts of bacteria on the skin. Researchers will compare people with eczema to healthy volunteers. The goal is to understand the skin microbiome better, not to test a n…

This study aims to uncover genetic changes that cause autoimmune diseases in people native to Peru. Researchers will collect blood, urine, and stool samples from 300 participants, including patients with conditions like lupus and rheumatoid arthritis, their family members, and he…

This registry study follows about 100 people with FOP, a rare disease where soft tissue turns to bone. Some participants take palovarotene (an approved treatment), while others do not. Researchers will track side effects, flare-ups, and daily function over time to see how well th…

This study looks at people with smell loss caused by chronic rhinosinusitis. Participants will undergo a 3-month smell training program. Researchers will measure changes in smell function, mental health, and immune markers in blood and tissue samples. The goal is to understand th…

This study is observing up to 3,500 people with immune system problems, including rare genetic conditions like chronic granulomatous disease and severe combined immunodeficiency. Researchers will track how these diseases change over time through blood tests, imaging, and checkups…

This pilot study investigates how a gel made from hyaluronic acid and polynucleotides affects early healing of gum defects after surgery. Researchers will measure molecular markers in gum fluid and use laser imaging to track blood flow changes. The study includes 24 adults with a…

This study follows up to 2000 people with immune-related kidney diseases, such as nephrotic syndrome and lupus nephritis. Researchers will collect medical history, lab tests, and blood or urine samples to better understand these conditions. The goal is to learn more about causes …

This study follows 300 adults with lupus nephritis who are already taking belimumab as part of their routine care. Researchers will track kidney function for up to 5 years to see how well the drug preserves renal health and prevents the need for dialysis or transplant. The goal i…

This study tests a 20-step recovery plan (ERAS) for children aged 5-18 having laparoscopic appendix surgery. The goal is to see if the plan can be followed closely and safely in a hospital. Researchers will track how well the steps are followed and check for any major problems or…

This study aims to learn more about heart and blood vessel diseases by observing people who have them or are at risk. Researchers will collect samples and perform tests like imaging and stress tests on up to 5,000 participants, including healthy volunteers and relatives of affect…

This pilot study aims to see if a new method can safely measure how tired patients get during a special type of exercise after total knee replacement. Twenty adults recovering from knee surgery will try cycling while blood flow to their legs is partially restricted. The results w…

This study looks at the causes and effects of food allergies and related conditions like eczema and eosinophilic esophagitis. Researchers will collect blood, skin, and genetic samples from up to 1,800 people over many years. The goal is to find biomarkers and pathways that explai…

This study looks at how the types of bacteria in the mouth change in people with severe gum disease as they go from having some teeth left to having no teeth, and then after getting dental implants. Researchers will collect microbial samples and analyze DNA to see if different im…

This study looks at whether isotretinoin, a common acne medicine, changes how well people can smell. Researchers will test the sense of smell in 54 adults before and after at least 4 weeks of treatment. The goal is to understand if the drug's drying effect on the nose can reduce …

This study investigates how changes in kidney cell metabolism relate to the rate of kidney function decline in people with ANCA vasculitis and other kidney diseases. Researchers will analyze kidney biopsy samples and blood/urine tests from 146 participants over one year. The goal…

This study is creating a large collection of medical data and blood samples from 450 adults with autoimmune diseases (rheumatoid arthritis, lupus, or scleroderma) and 50 healthy volunteers. Researchers will use advanced lab techniques to find unique biological markers that could …

This study is creating a large collection of microbiome samples—like stool, saliva, and skin swabs—from 600 people of all ages, including healthy volunteers and those with various illnesses. The goal is to build a resource for future research on how the microbiome affects health …

This study aims to learn more about diseases that affect the salivary glands, which produce saliva. Researchers will collect medical data, blood, saliva, and tissue samples from people with these conditions, their relatives, and healthy volunteers. The goal is to better understan…

This study aims to learn more about myositis, a group of diseases that cause muscle inflammation and damage. Researchers will observe up to 1,200 children and adults with myositis, along with healthy volunteers, to track changes in the immune system and other health problems over…

This study looks at how genetic immune system problems might lead to gum disease and other mouth issues. Researchers will collect samples like saliva, plaque, and blood from 700 people, including those with immune defects, healthy adults with gum disease, and healthy adults witho…

This study follows up to 2,000 people with spondyloarthritis (a group of inflammatory joint and spine conditions) and their healthy relatives. Researchers aim to identify symptoms, genetic factors, and medical tests that predict who will develop more severe forms of the disease. …

This observational registry will follow 1,500 adolescents aged 12–15 with moderate-to-severe atopic dermatitis (eczema) across North America and Europe. Researchers aim to document the disease's natural history, how it's managed, and long-term outcomes. Participants will be under…

This study explores whether a substance called thromboxane A2, which is involved in blood clotting and fat metabolism, also plays a role in osteoarthritis. Researchers will measure thromboxane levels in blood and joint fluid from 20 people with knee osteoarthritis and look for a …

This study looks at two types of fat tissue in people with knee osteoarthritis: one inside the knee joint (Hoffa's fat pad) and one inside the thigh muscle. Researchers want to see if these fat deposits are different in size, fat content, and scar tissue. The goal is to better un…

This study follows 100 adults with healthy gums or various stages of gum disease over two years. Researchers will collect saliva and plaque samples at yearly visits to measure specific biomarkers. The goal is to see if these markers can predict who will develop or worsen gum dise…

This study is gathering health information from 2,000 adults with primary sclerosing cholangitis (PSC) to build a real-world data comparator group. The goal is to help design and run future drug trials more efficiently by providing a control group from real patient experiences. P…

This study follows 200 adults and children with eosinophilic esophagitis (EoE) in Italy to learn how the disease progresses over time and how well current treatments work. EoE is an allergic condition that causes swallowing problems and can lead to scarring if not treated. The re…

This study follows 500 adults with lupus to see if blood and urine tests can reliably detect kidney inflammation (lupus nephritis). Participants give samples during routine visits, and doctors track their kidney health over time. The goal is to find simple, non-invasive markers t…

This study at Hashemite University looks at how people with and without tennis elbow feel pressure pain and how their bodies briefly turn down pain after a cold stimulus. Participants answer short questionnaires and have their pressure-pain threshold tested with a handheld device…

This study looks at how children with Crohn's disease or ulcerative colitis burn energy at rest. Researchers will measure resting energy expenditure using a special breathing test and compare it to standard formulas. The goal is to see if energy use is linked to disease activity …

This study looks at gum disease in people with rare kidney disorders like Alport syndrome, Fabry disease, and tuberous sclerosis, as well as lupus. Researchers will compare 100 participants to those with chronic kidney disease and healthy controls. They aim to understand how comm…

This study aims to collect medical information and tissue samples from 500 people with suspected or confirmed inflammatory muscle diseases, as well as healthy volunteers. Researchers will use blood, muscle, and skin samples to study what causes these diseases and how they progres…

This study looks at whether high uric acid levels (hyperuricemia) are linked to more severe gum disease and bone loss. Researchers will measure inflammation and oxidative stress markers in gum fluid and blood from 80 adults. Participants are grouped by gum health and uric acid st…

This study looks at 200 people aged 3–21 with eczema and high IgE levels who may have milk or peanut allergies. Researchers will use oral food challenges to find better ways to predict true allergies. The goal is to make allergy tests more accurate and reduce unnecessary food res…

This study follows 700 people with progressive multifocal leukoencephalopathy (PML), a rare brain infection caused by the JC virus. Researchers will collect blood, spinal fluid, and brain scans over time to understand how the disease progresses. No treatment is given; the goal is…

This study is testing a new device called BloodTrackR that lets people with rheumatoid arthritis collect a small blood sample at home using a finger prick and a smartphone app. Twenty participants will try the device and answer questions about how easy it is to use. The goal is t…

This study aims to learn more about the causes of rheumatic diseases—conditions that cause joint pain, stiffness, and swelling—and why they often affect minority groups more severely. Researchers will observe up to 7,500 adults with known or suspected rheumatic disease, providing…

This study looks at whether severe gum disease (periodontitis) is linked to stiffer arteries, which is a sign of heart risk. Researchers will compare 206 adults aged 40-69—half with advanced gum disease and half with healthy gums—using a simple test that measures artery stiffness…

This study is building a library of information and samples from 60 adults with suspected autoimmune myopathy, a rare muscle disease. Researchers will collect blood, urine, stool, and muscle tissue, along with medical data, to better understand the condition. The goal is to impro…

This study follows 300 adults with systemic lupus erythematosus (SLE) who are seen by a team of specialists at a hospital in Brest, France. Researchers will collect data on disease patterns, symptoms, and test results over time. The goal is to better understand lupus and improve …

This study enrolls up to 400 people with known or suspected infections or inflammatory diseases that are not covered by other research protocols. The goal is to evaluate patients using standard medical practices, generate new ideas for future studies, and train doctors. No experi…

This study aims to understand why some people are more prone to fungal infections, especially from Candida yeast. Researchers will collect blood, saliva, urine, and tissue samples from people with immune disorders, their family members, and healthy volunteers. No treatment is giv…

This study is collecting blood, urine, and fecal samples from 100 people with ANCA-associated vasculitis, a rare autoimmune disease. Researchers will follow participants for up to 5 years, tracking relapses and complications. The goal is to identify factors that predict disease f…

This study will follow 78 people aged 50 to 85 who need a total knee replacement to see how well a newer all-polyethylene (plastic) knee implant holds up over 5 years. Researchers want to know if this design, which may be cheaper and have fewer mechanical problems, works as well …

This study looks at joint tissue from people with early osteoarthritis to find different patterns of inflammation. Researchers will take small samples using a needle under local anesthetic, along with blood tests. The goal is to better understand how the disease starts and progre…

This study looks at whether certain genes make some people more likely to develop eye damage from the drug Plaquenil, which is used for autoimmune diseases like lupus and rheumatoid arthritis. Researchers will compare people who have had eye damage from Plaquenil with those who h…

This early-phase study is testing whether afimkibart, an experimental drug for ulcerative colitis, changes how the body processes common medications like caffeine, warfarin, and omeprazole. About 25 people with moderate to severe active ulcerative colitis will receive afimkibart …

This study looks at how ANCA-associated vasculitis affects the eyes. Researchers will use a special imaging test called OCT angiography to examine blood vessels in the eyes of 70 participants. The goal is to better understand and detect eye involvement early, which could help pre…

This study is observing 40 adults with multiple sclerosis to see how clinical tests of balance and walking relate to detailed motion-capture measurements. Participants will attend one session where they walk on force plates and perform balance tasks while cameras track their move…

This study is a registry that will follow 1,000 adults and teens with atopic dermatitis (eczema) who are starting or switching systemic treatments. Researchers will track which treatments people use, how long they take them, and why they change or stop. The goal is to better unde…

This study looks at whether sulfasalazine, a drug for inflammatory arthritis, makes the standard diabetes blood test (HbA1c) falsely low. That could mean diabetes goes undiagnosed or is undertreated in these patients. Researchers will use continuous glucose monitors and fasting b…

This study tests whether taking a broccoli sprout extract (sulforaphane) for four days, doing high-intensity interval running, or combining both can improve how immune cells use energy and reduce inflammation. Twenty healthy adults aged 18-35 will try each approach in random orde…

This observational study will follow 800 adults with IgA nephropathy, a common kidney disease, to see how well current treatments control protein in the urine and preserve kidney function over 12 months. Researchers want to understand why some patients do not respond to standard …

This study adds a heart-focused PET scan to a standard cancer imaging test (Gallium-68-DOTATOC) in 99 adults with neuroendocrine tumors. The goal is to see if the scan can detect heart inflammation linked to age and cardiovascular risk factors. Researchers will also compare scan …

This study looks at medical records of 514 adults in India with acute cholangitis (a bile duct infection and blockage) who had a drainage procedure. The goal is to create a new composite index that combines factors like death, need for organ support, ICU stay, complications, hosp…

This study is collecting joint fluid and tissue samples from 50 adults with inflammatory or non-inflammatory bone and joint diseases. Researchers will use both standard and advanced lab techniques to find new biomarkers that could help diagnose rheumatic diseases more accurately …

This study follows 500 people with neurocysticercosis, a brain infection caused by the pork tapeworm. Participants receive standard antiparasitic drugs and anti-inflammatories. Researchers will track their health over many years to understand what factors lead to better or worse …

This study looks at the tiny organisms living on our skin—like bacteria and fungi—and how they might differ in people with eczema (atopic dermatitis). Researchers will collect skin samples from healthy volunteers and patients aged 2 to 40 with moderate to severe eczema, as well a…

This study aims to learn more about alkaptonuria, a rare genetic disease that causes a pigment to build up in bones and tissues, leading to arthritis and other problems. Researchers will evaluate 300 patients over several years using advanced medical tests. The goal is to better …

This study looks at bile acid profiles in children with ulcerative colitis (UC) who also have a C. difficile infection. Researchers want to see if changes in bile acids and gut bacteria make these children more vulnerable. They will compare three groups: children with UC flare-up…

This study aims to find out how often people with chronic hepatitis B also have hepatitis D, and which types of the virus are most common. Researchers will interview about 2,400 participants and take blood samples to look for links with vaccination history, lifestyle, and other f…

This international study observes how people with atopic dermatitis (eczema) access healthcare, what treatments they receive, and how the disease affects their daily lives. Researchers will collect data from routine medical records of about 9,600 participants across multiple coun…

This study looks at whether certain proteins in saliva can signal the start of gum disease. Researchers will collect saliva from 240 adults with healthy gums, gingivitis, or periodontitis and measure specific biomarkers linked to bone loss. The goal is to find a simple, non-invas…

This study looks at how gut bacteria produce certain chemicals that might worsen fatty liver disease (MASLD). Researchers will collect stool, blood, and urine samples from 24 people with the condition and healthy volunteers. They aim to identify which bacteria are responsible for…

This study uses a device called FibroScan to measure liver stiffness and fat content in people with liver disease. The scan is non-invasive, like an ultrasound, and takes only a few minutes. Researchers aim to build a large database of these measurements to help improve future di…

This study looks at proteins in lung fluid from 750 people with pneumonia to find biomarkers that could reveal what's causing the lung inflammation. Participants undergo a standard bronchoscopy with lung washings, plus a blood draw. The goal is to better understand different type…

This international study observes how people with hidradenitis suppurativa (a chronic skin condition) access healthcare, what treatments they receive, and how the disease affects their quality of life. Researchers collect data from routine medical records across multiple countrie…

This study is collecting blood, urine, and kidney tissue samples from 144 children and adults with a kidney condition called nephrotic syndrome. The goal is to build a large database and sample collection to study how the immune system and kidney cells interact. Researchers hope …

This study is looking for clues to predict how well different rheumatoid arthritis (RA) drugs will work in individual patients. Researchers will give 400 adults with RA one or more standard medications and track their response over 16 weeks. The goal is to find genetic or other f…

This early-phase study tests a new way to use PET scans to measure inflammation in both the liver and brain at the same time. Researchers will scan 12 adults with fatty liver disease using two different tracers (18F-FDG and 18F-DPA-714) to see if the new method can reliably detec…

This study collects small tissue samples (biopsies) from people undergoing routine endoscopy and grows them into mini-organs called organoids in the lab. These organoids mimic the real intestine and help researchers understand diseases like Crohn's and ulcerative colitis. The goa…

This study will test whether using essential oils (by smelling, applying to skin, or swallowing capsules) can improve immune health in healthy adults aged 18 to 45. Forty participants will use either the oils or a placebo for 30 days. Researchers will measure changes in blood, sa…

This study in South-East Austria looks at past lab results to find people with hepatitis B, C, or D who may not know they have it. Researchers will invite these individuals to a clinic to discuss treatment options. The goal is to connect them to care and track how many get cured,…

This study looks at liver inflammation (hepatitis) that can occur in cancer patients treated with immune checkpoint inhibitors, a type of immunotherapy. Researchers aim to describe the different patterns of liver injury and how they respond to treatment. By collecting real-world …

This study follows 100 women with neuroimmune diseases (like multiple sclerosis or myasthenia gravis) through pregnancy and up to five years after. Researchers will track disease activity, pregnancy complications, and baby health to learn how these conditions affect fertility and…

This study surveys women under 40 with lupus who are starting cyclophosphamide, a drug that can damage ovaries and cause infertility. Some received an additional drug called GnRHa to protect their ovaries. Researchers will compare menstrual health and fertility between those who …

This study looks at how common chemicals in personal care products, processed foods, and synthetic materials affect skin, gut, and airway health. One hundred twenty healthy adults will stay in a controlled hospital room for two 7-day periods—one with filtered air and pure product…

This study looks at 800 healthy adults who have cryptococcosis, a fungal infection that usually only harms people with weak immune systems. Researchers want to learn why these otherwise healthy people get sick, how their immune system responds, and how the disease progresses over…

This study looks at whether an artificial intelligence (AI) tool can predict if lung scarring (pulmonary fibrosis) will get worse over time. Researchers will analyze CT scans from 200 people with either idiopathic pulmonary fibrosis (IPF) or other types of interstitial lung disea…

This study reviews medical records from 3,000 patients who had emergency surgery at a Swedish hospital between 2009 and 2019. Researchers want to understand what factors increase risks and how patients fare in the long run, including complications, repeat surgeries, and survival.…

This study follows 950 people with idiopathic CD4+ lymphocytopenia (ICL), a rare condition where low CD4+ white blood cells raise infection risk. Researchers will track participants for up to 10 years, collecting medical history, blood samples, and infection data. The goal is to …

This study watches how people with eosinophilic esophagitis (EoE) use the medicine Dupixent in everyday care. Researchers will collect information from about 350 patients to learn more about the disease and how treatment affects symptoms and quality of life. No new treatments are…

This study looks at whether dry eye disease affects the accuracy of corneal measurements needed for cataract surgery planning. 400 cataract patients will be divided into those with and without dry eye. Those with dry eye will use sodium hyaluronate eye drops for two weeks. Resear…

This study aims to learn how the immune system controls inflammation in the gut for people with Crohn's disease or ulcerative colitis. Up to 1,000 participants aged 0 to 75 will receive standard medical care and may provide blood, tissue, or white blood cell samples. No experimen…

This study follows up to 4,000 people with vasculitis (a group of diseases that cause blood vessel inflammation) and healthy volunteers over many years. Researchers collect blood, urine, imaging, and genetic samples to learn how the disease develops and changes. The goal is to fi…

This study will use a new, more sensitive total-body PET scanner to measure inflammation in the skin, joints, and blood vessels of people with psoriasis. Researchers want to see if switching from a typical Western diet to a more balanced diet for 6 weeks can reduce that inflammat…

This study follows about 100 adults who received a Tipmed hip replacement during routine care. Researchers track complications and hip function over two years to see how well the device performs in real life. The goal is to gather practical evidence on safety and effectiveness, n…

This study follows 645 patients hospitalized with infectious endocarditis, a serious heart infection. Researchers will track hospital deaths and long-term survival to identify factors that influence prognosis. The goal is to better understand how the disease progresses and what a…

This study looks at how certain white blood cells (neutrophils and monocytes) sense signals in the body and what substances they release, especially when they might cause inflammation. Healthy adults aged 18 to 65 who weigh at least 110 pounds can join by donating blood up to six…

This study looks at whether new MRI techniques can spot NASH, the serious form of fatty liver disease, without needing a liver biopsy. Researchers will scan 110 adults who already need a biopsy to see if the MRI can match the biopsy results. If successful, it could lead to a safe…

This registry follows 5000 people who have received Dezawa MuseCells as part of their routine care for conditions like osteoarthritis, pain, and wound healing. Participants report their symptoms and any side effects through online surveys over five years. The goal is to understan…