Lupus drug may harm ovaries – could a hormone shot help?
NCT ID NCT05567198
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study surveys women under 40 with lupus who are starting cyclophosphamide, a drug that can damage ovaries and cause infertility. Some received an additional drug called GnRHa to protect their ovaries. Researchers will compare menstrual health and fertility between those who got GnRHa and those who did not, using questionnaires and medical records. The goal is to see if GnRHa really helps preserve ovarian function.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
gonadotropin-releasing hormone agonist (GnRHa)
What this could lead to
If it works, this could point toward a way to preserve fertility in women with lupus who need cyclophosphamide.
What could go wrong
This is an observational survey, not a treatment trial. It cannot prove cause and effect, and results may not apply to all patients.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
RECRUITINGBethesda, Maryland, 20892, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••