National Institute Of Arthritis And Musculoskeletal And Skin Diseases (niams)

This study tests whether the drug anifrolumab can improve blood vessel health and reduce inflammation in people with lupus, who face higher risks of heart attacks and strokes. About 45 adults with lupus will receive either anifrolumab or a placebo through IV infusions over 8 mont…

This study looks at how treatments for eczema (atopic dermatitis) change the types and amounts of bacteria on the skin. Researchers will compare skin samples from people with eczema and healthy volunteers over one year. The goal is to understand how treatments affect the skin's m…

This study aims to learn more about spondyloarthritis, a group of disorders causing back and joint pain and stiffness. Researchers will observe 2000 people with the condition and their healthy relatives to find symptoms and tests that predict who may develop more severe disease. …

This study follows 350 adults with melorheostosis, a rare disease that causes bone thickening and pain, to learn how it changes over time and what genetic factors are involved. Participants undergo exams, scans, and tests over about one week, with follow-up visits every two years…

This study aims to understand the natural history, genetics, and causes of systemic juvenile idiopathic arthritis (sJIA) and adult-onset Still's disease (AOSD). Researchers will observe up to 2,000 people with these conditions over time, collecting medical history, blood samples,…

This study aims to better understand autoinflammatory diseases like juvenile dermatomyositis by observing up to 5,000 patients and healthy volunteers over time. Participants undergo medical exams, blood tests, and imaging to track disease activity and genetics. The goal is to fin…

This study aims to learn more about the causes of rheumatic diseases, such as arthritis, and why they often affect minority groups more severely. Researchers will observe up to 7,500 adults with known or suspected rheumatic disease, providing standard medical care and tests. No e…

This study surveys 100 women under 40 with lupus who received a chemotherapy-like drug called cyclophosphamide. Some also got a hormone drug (GnRHa) to protect their ovaries. Researchers want to see if GnRHa helps prevent early menopause and infertility. No new treatments are giv…

This study is following up to 4,000 people with vasculitis (a group of diseases that cause blood vessel inflammation) and healthy volunteers to learn more about the disease. Researchers will collect blood, urine, imaging, and genetic samples over time to find better ways to diagn…

This study aims to learn more about how lupus develops and changes over time by observing patients and their relatives. Researchers will collect medical history, blood, urine, and genetic samples from up to 2,000 participants aged 3 and older. The goal is to better understand the…

This study aims to collect blood, muscle, and skin samples from 500 people aged 12 and older with suspected or confirmed inflammatory muscle disease, plus healthy volunteers aged 18 and older. Researchers will use these samples and medical tests to better understand what causes t…

This study collects biological samples—like blood, skin, and saliva—from people with skin diseases, their family members, and healthy volunteers. The goal is to understand what causes different skin conditions and find better ways to treat them. Participants may provide samples d…