Rare bone disease under the microscope: what causes melorheostosis?
NCT ID NCT02504879
First seen Jun 26, 2026 · Last updated Jul 23, 2026 · Updated 3 times
Summary
This study follows adults with melorheostosis, a rare disease that causes bone thickening, pain, and joint problems. Researchers will track how the disease progresses over time, collect genetic samples from patients and their relatives, and look for biomarkers. The goal is to better understand the disease's causes and natural course, not to test a new treatment.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- What this could lead to
- If successful, this study could reveal what causes melorheostosis and how it changes over time, pointing toward future treatments.
- What could go wrong
- This is an observational study, not a treatment trial. It may not lead directly to new therapies, and results depend on long-term participation.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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National Institutes of Health Clinical Center
RECRUITINGBethesda, Maryland, 20892, United States
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