Can an extra shot boost COVID protection in autoimmune patients?
NCT ID NCT05000216
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether an additional dose of a COVID-19 vaccine can improve immune protection in adults and children with autoimmune diseases like rheumatoid arthritis, lupus, multiple sclerosis, and others who are taking immunosuppressive medications. Participants who had a weak or negative antibody response to their initial vaccines receive one extra dose of Moderna, Pfizer/BioNTech, or Janssen vaccine. The goal is to see if this booster helps them reach a protective antibody level.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
COVID-19 vaccines (Moderna, Pfizer/BioNTech, or Janssen)
What this could lead to
If successful, this could show that an additional vaccine dose helps protect people with autoimmune conditions who had a weak response to the initial COVID-19 vaccine series.
What could go wrong
This is a mid-stage trial, so results are not yet proven. The definition of a protective antibody response was not established for the assay used, and effectiveness may vary with new virus variants.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Benaroya Research Institute at Virginia Mason: Internal Medicine
Seattle, Washington, 98101, United States
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Boston Children's Hospital: Department of Pediatrics, Rheumatology Program
Boston, Massachusetts, 02115, United States
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Brigham & Women's Hospital: Department of Medicine, Rheumatology, Immunology
Boston, Massachusetts, 02115, United States
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Cleveland Clinic
Cleveland, Ohio, 44195, United States
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Columbia University Irving Medical Center: Department of Neurology, Multiple Sclerosis Center
New York, New York, 10032, United States
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Duke University Medical Center: Division of Rheumatology and Immunology
Durham, North Carolina, 27710, United States
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Feinstein Institute for Medical Research
Manhasset, New York, 11030, United States
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Feinstein Institute for Medical Research: Center for Autoimmune and Musculoskeletal Diseases
Manhasset, New York, 11030, United States
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Hospital for Special Surgery
New York, New York, 10021, United States
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Indiana University Medical Center, Riley Hospital for Children
Indianapolis, Indiana, 46202, United States
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Massachusetts General Hospital: Rheumatology, Allergy and Immunology, Center for Immunology and Inflammatory Diseases
Boston, Massachusetts, 02114, United States
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Medical University of South Carolina, Nexus Research Center
Charleston, South Carolina, 29425, United States
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Medical University of South Carolina, Shawn Jenkins Children's Hospital
Charleston, South Carolina, 29425, United States
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Nationwide Children's Hopspital
Columbus, Ohio, 43205, United States
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New York University Langone Medical Center: Department of Medicine, Division of Rheumatology
New York, New York, 10016, United States
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Oklahoma Children's Hospital-Pediatrics Specialties Clinic
Oklahoma City, Oklahoma, 73104, United States
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Oklahoma Medical Research Foundation: Arthritis and Clinical Immunology Research Program
Oklahoma City, Oklahoma, 73104, United States
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Stony Brook University Hospital
Stony Brook, New York, 11794-8111, United States
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Temple Health: Rheumatology
Philadelphia, Pennsylvania, 19104, United States
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The Emory Clinic: Division of Rheumatology
Atlanta, Georgia, 30322, United States
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UCLA Medical Center: Division of Rheumatology
Los Angeles, California, 90095, United States
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UT Southwestern (Peds)
Dallas, Texas, 75325, United States
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University of Michigan Health System: Department of Internal Medicine, Division of Rheumatology
Ann Arbor, Michigan, 48109, United States
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University of North Carolina Children's Hospital
Chapel Hill, North Carolina, 27599, United States
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University of Pennsylvania Perelman Center for Advanced Medicine
Philadelphia, Pennsylvania, 19104, United States
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University of Rochester Medical Center
Rochester, New York, 14642, United States
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University of Texas Houston Medical School: Division of Rheumatology and Clinical Immunogenetics
Houston, Texas, 77030, United States
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Washington University School of Medicine in St. Louis: Division of Rheumatology
St Louis, Missouri, 63110, United States
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Yale University School of Medicine: Rheumatology, Allergy & Immunology
New Haven, Connecticut, 06519, United States