RHEUMATOID ARTHRITIS (RA)

This early-stage study is testing the safety and tolerability of a new oral drug called LPX-TI641 in people with rheumatoid arthritis or psoriatic arthritis. About 48 participants will take the drug or a placebo pill daily for 28 days. The main goal is to see how well the drug is…

This early-stage study is testing a single injection of stem cells (hiSCs) directly into the knee joint of people with rheumatoid arthritis (RA). The main goal is to see if the injection is safe and well-tolerated. Researchers will also check if it helps reduce knee pain, stiffne…

This study is testing a new at-home ultrasound device that aims to reduce inflammation in people with moderate to severe rheumatoid arthritis. The device delivers gentle ultrasound waves to the spleen, which may help calm the overactive immune system. About 60 adults who haven't …

This early study is testing the safety of a new drug called CC312 in adults with severe autoimmune diseases that have not improved with standard treatments. The drug works by engaging the body's own immune T cells to attack harmful B cells, using a mechanism similar to some advan…

This early study is testing the safety of a new drug called A-319 for people with active rheumatoid arthritis (RA) who haven't gotten enough relief from at least two other standard treatments. The drug works by guiding the body's own immune T-cells to find and destroy harmful B-c…

This study is testing whether adding a new type of immune cell therapy (called AlloNK) to an existing drug (rituximab) can better control several autoimmune diseases that have come back after standard treatments. The trial will enroll 90 adults with rheumatoid arthritis, Sjögren'…

This study aims to find the best way to give COVID-19 booster shots and seasonal flu vaccines to adults with weakened immune systems. Researchers want to know if getting both shots on the same day works as well as getting them a month apart, and if getting COVID boosters every 3 …

This study is testing a new, non-drug treatment for people with moderate-to-severe rheumatoid arthritis (RA) who haven't gotten enough relief from standard medications. The treatment is a special headset that delivers gentle electrical pulses to a nerve in the outer ear, aiming t…

This early-stage study is testing a new drug called LY4213663 to see if it's safe and how the body handles it. The research involves both healthy volunteers and people with rheumatoid arthritis to check for side effects and measure drug levels in the blood. This is the first step…

This study is testing whether switching to a 100% plant-based diet for 16 weeks can help reduce symptoms and improve quality of life for people with rheumatoid arthritis. 180 participants will either receive weekly food boxes and diet coaching to follow the plant-based diet, or c…

This early-stage study is testing a new drug called SAR448501 in adults with moderate-to-severe lupus or rheumatoid arthritis who haven't gotten enough relief from their current treatments. The main goal is to find safe dose levels and see how the drug behaves in the body. About …

This is the first time researchers are testing a new drug called KT501 in people with rheumatoid arthritis. The main goal is to check if it's safe and see how the body processes it. About 24 adults with active RA will receive one injection and be monitored for 12 weeks, with some…

This study aims to see how well and how safely an injected form of the drug methotrexate works for people with rheumatoid arthritis in everyday medical practice. It will follow 10,000 adult patients in China who are already starting this treatment. The main goal is to measure how…

This study is monitoring the safety and effectiveness of the drug peficitinib in people with rheumatoid arthritis during routine medical care in Japan. It will enroll 3000 patients who are starting this medication for the first time. The goal is to understand how well the drug wo…

This study is testing a new oral medication called TollB-001 for adults with moderate to severe rheumatoid arthritis (RA) who haven't gotten enough relief from standard treatments. Participants will take the pill or a placebo daily for four weeks to see if it safely reduces arthr…

This is an early-stage study testing a new type of cell therapy called ADI-001 for adults with rheumatoid arthritis that hasn't improved with standard treatments. The main goal is to check the safety and side effects of the treatment. Researchers will give participants specially …

This early-stage study is testing a new drug called cizutamig in people with rheumatoid arthritis that hasn't responded to standard treatments. The research aims to see if the drug is safe and shows signs of helping control the disease. About 28 participants will receive the drug…

This study is testing whether following a Mediterranean or Paleolithic diet for 12 weeks can help adults with rheumatoid arthritis. Researchers will compare these two specific eating plans to see which one better reduces joint inflammation, improves quality of life, and affects b…

This early-stage study is testing the safety of a new drug called F8IL10, which is injected directly into an inflamed joint. Researchers want to find the highest dose that is safe and well-tolerated in adults with rheumatoid arthritis who still have flare-ups despite their regula…

This study is testing if a new oral drug called AP1189, when added to the standard medication methotrexate, can better control disease activity in people recently diagnosed with rheumatoid arthritis. It will involve 240 participants who have not yet tried other powerful arthritis…

This study is testing whether a daily at-home ultrasound device can safely reduce inflammation and symptoms in adults with moderate rheumatoid arthritis. Up to 40 participants will use either a real or a dummy device for 8 weeks to see if it helps control their disease. The goal …

This study is testing whether patients with rheumatoid arthritis, psoriatic arthritis, or axial spondyloarthritis can safely reduce their JAK inhibitor medication doses while still keeping their disease under control. Researchers will compare 200 patients who gradually lower thei…

This study is testing a new blood test designed to predict which arthritis medications will work best for individual patients before they start treatment. Researchers will analyze blood samples from 120 people with various autoimmune rheumatic diseases to see if the test can accu…

This study is testing whether a new artificial intelligence (AI) tool can help doctors more completely diagnose the many complications that can occur with rheumatoid arthritis (RA), such as lung, heart, or thyroid problems. Researchers will give doctors AI-generated predictions a…

This study is testing if weekly coaching sessions with a peer who also has rheumatoid arthritis (RA) can help reduce feelings of anxiety and depression. It will involve 250 adults with RA who report significant anxiety or depression. Researchers will compare the peer coaching gro…

This study aims to understand the link between nutrition and disease activity in people with rheumatic diseases like rheumatoid arthritis and lupus. Researchers will assess the nutritional status of 460 patients using questionnaires and blood tests. The goal is to see if poor nut…

This study is exploring whether taking common probiotic supplements affects symptoms in people with rheumatoid arthritis. For 6 weeks, 50 adults with RA will take a daily probiotic and provide regular stool samples. Researchers will check if the probiotic bacteria survive in the …

This study aims to find better ways to spot people with rheumatoid arthritis who are at high risk for heart disease before they have any symptoms. Researchers will test 120 participants with rheumatoid arthritis using two heart health markers: a blood test and a special heart sca…

This is the first study in humans for a potential new rheumatoid arthritis drug called CIGB-814. Researchers are testing it on 70 healthy volunteers to check if it's safe, see how the body processes it, and observe its early effects on the immune system. The goal is to gather bas…

This study aims to understand what causes swallowing difficulties (dysphagia) in people with rheumatoid arthritis (RA) and how severe these problems are. Researchers will examine 137 adult RA patients using a small, flexible camera to look at the throat and swallowing process. Th…

This study aims to understand if certain medications taken by people with rheumatoid arthritis increase their risk of breaking a bone. Researchers will follow 100 adult patients with RA for about a year, tracking their medications and calculating their future fracture risk. The g…

This study aims to see if a quick, simple test called the Four Square Step Test is a reliable way to measure balance in people with rheumatoid arthritis (RA). Researchers will have 50 participants with RA perform the test and compare the results to other standard measures of bala…

This study is tracking the long-term safety and effects of an experimental cell therapy called KYV-101 in people who have already received it. Researchers will follow 70 participants for up to 15 years to check for any delayed side effects and see how long the treatment's effects…

This is a very early, first-in-human study to check if a new potential drug called SHR-3045 is safe and how it behaves in the body. It will be given as a single injection to 16 healthy volunteers, not people with rheumatoid arthritis. The main goal is to see what side effects mig…