RHEUMATOID ARTHRITIS (RA)

This study is testing a live attenuated dengue vaccine (Butantan-DV) in people aged 12–59 with autoimmune rheumatic diseases (like rheumatoid arthritis or lupus) who are stable and on low or no immune-suppressing drugs. Researchers want to see if the vaccine triggers a good immun…

This study looks at the best way to give COVID-19 booster and flu shots to people with weakened immune systems (like those with rheumatoid arthritis, organ transplants, or HIV). It will compare getting both vaccines on the same day versus one month apart, and also test if getting…

This early-stage study is testing a new drug called KT501 in 24 adults with moderate-to-severe rheumatoid arthritis (RA). The main goal is to see if a single injection under the skin is safe and tolerable. Researchers will also measure how the drug moves through the body and whet…

This early-phase study tests a new drug called A-319 in 12 adults with active rheumatoid arthritis who haven't responded well to standard treatments. The main goal is to check if the drug is safe and tolerable. Researchers will also measure how the drug moves through the body and…

This early-stage study tests the safety of a new drug called CC312 in up to 18 adults with autoimmune diseases like lupus or rheumatoid arthritis that haven't improved with standard treatments. CC312 works like a bridge, guiding the body's immune cells to attack and destroy fault…

This early-stage trial tests an experimental treatment called QEL-005 in 16 adults with two serious autoimmune conditions: diffuse cutaneous systemic sclerosis and difficult-to-treat rheumatoid arthritis. QEL-005 is made from a patient's own white blood cells, which are genetical…

This study looks at whether following a Mediterranean or Paleolithic diet for 12 weeks can improve disease activity, nutrition, and quality of life in adults aged 40-60 with rheumatoid arthritis. Participants are randomly assigned to one of the two diets or their usual diet. The …

This early-phase study tests a new treatment called HBI0101 CAR T for people with severe autoimmune diseases like lupus, multiple sclerosis, and rheumatoid arthritis that haven't improved with standard care. The treatment uses a patient's own immune cells, modified to target and …

This study follows 10,000 Chinese adults with rheumatoid arthritis who are starting or already using methotrexate injections. Researchers want to see how well the drug works and how safe it is in everyday medical practice, including in patients with additional lung or heart probl…

This study tests a new oral drug, TollB-001, in 24 adults aged 18-70 with moderate to severe active rheumatoid arthritis who haven't responded well to standard treatments. Participants take the drug or a placebo daily for 4 weeks, with a 1-week follow-up. The goal is to check saf…

This study tests a non-invasive device that gently stimulates a nerve in the ear to reduce inflammation in people with moderate-to-severe rheumatoid arthritis who haven't improved with standard treatments. About 128 participants will use either the active device or a sham (inacti…

This study tests whether a 16-week plant-based diet can lower disease activity and improve quality of life in adults with rheumatoid arthritis. Participants receive weekly food boxes, diet guidance, and cooking classes, while a control group eats their usual diet. The goal is to …

This early study tests whether a single injection of special stem cells (hiSCs) into the knee is safe and can ease symptoms of rheumatoid arthritis. About 15 adults with active knee arthritis will take part. The goal is to see if the treatment reduces pain, swelling, and improves…

This study tests an experimental oral drug called AP1189, taken alongside methotrexate, for people recently diagnosed with rheumatoid arthritis who have not yet tried disease-modifying drugs. The goal is to see if AP1189 can better control joint inflammation and disease activity …

This study tests whether people with rheumatoid arthritis, psoriatic arthritis, or axial spondyloarthritis who are doing well on a JAK inhibitor can safely lower their dose without losing disease control. About 200 participants will either follow a guided dose-reduction plan or c…

This early-stage study tests an experimental oral drug called LPX-TI641 in 48 adults with rheumatoid arthritis or psoriatic arthritis. Participants will receive either the drug or a placebo daily for 28 days. The main goal is to check if the drug is safe and tolerable, and how it…

This early-stage study tests a new treatment called ADI-001 for people with rheumatoid arthritis that hasn't improved with standard therapies. ADI-001 uses specially engineered immune cells from a donor to target and destroy faulty immune cells that attack the joints. The main go…

This study tests a new treatment for people with certain autoimmune diseases (rheumatoid arthritis, Sjögren's disease, myositis, and scleroderma) that have not responded to standard therapies. The treatment combines AlloNK, a type of immune cell from donated cord blood, with ritu…

This study is observing 3000 people with rheumatoid arthritis who are starting peficitinib for the first time. Researchers are tracking side effects and how well the drug controls disease activity in real-world settings. The goal is to understand the drug's safety and effectivene…

This study tests a new medicine called cizutamig in 28 adults with severe rheumatoid arthritis that hasn't improved with other treatments. The goal is to see if it is safe and if it can help control the disease. Participants will receive the drug and be closely monitored for side…

This early-stage study tests a new drug, SAR448501/DR-0201, in 62 adults with lupus or rheumatoid arthritis. The goal is to find the safest and most effective dose by checking side effects and how the drug works in the body. Participants will be followed for about 13 months, and …

This study tests if using an ultrasound device at home is safe and practical for people with rheumatoid arthritis (RA). About 40 adults with moderate RA will use the device daily for 8 weeks. The goal is to see if it reduces inflammation and joint pain, and to gather information …

This study is testing a non-invasive, at-home ultrasound device that stimulates the spleen to reduce inflammation in people with moderate-to-severe rheumatoid arthritis. The research involves 60 adults who haven't responded well to standard arthritis medications. Participants wil…

This study is testing a new blood test that may help doctors choose the most effective drug for each person with rheumatic diseases like rheumatoid arthritis or lupus. The test looks at how a person's immune cells react to different medications before treatment starts. The goal i…

This early-stage study tests a new drug called F8IL10 for people with rheumatoid arthritis. The drug is injected directly into an inflamed joint to see if it is safe and to find the best dose. About 42 adults with arthritis flares will take part. The goal is to measure side effec…

This study tests whether a single steroid injection works as well as a 3-week course of steroid pills for treating rheumatoid arthritis flares. Researchers will track symptom relief, daily function, and patient satisfaction in 220 adults. The goal is to help patients and doctors …

This study tests whether a ketogenic (low-carb, high-fat) or carnivore (meat-only) diet can improve quality of life and reduce symptoms in 160 adults with inflammatory bowel disease (Crohn's or ulcerative colitis) or rheumatoid arthritis. Participants are randomly assigned to one…

This study looks at how three different levels of physical activity (45, 90, or 150 minutes per week) affect arthritis symptoms like pain and physical function. Researchers will enroll 285 adults with arthritis, rheumatoid arthritis, gout, fibromyalgia, osteoarthritis, or lupus. …

This study tests whether talking with a peer coach (someone who also has rheumatoid arthritis) can lower anxiety and depression in adults with RA. 250 participants will meet weekly for 9 weeks and complete surveys. The goal is to see if this approach improves mental well-being co…

This study looks at whether taking a daily probiotic for 6 weeks can help adults with rheumatoid arthritis. Fifty participants will take the probiotic and provide stool samples to track gut bacteria changes. The goal is to see if probiotics can ease joint pain and swelling.

This early-stage study tests a new drug called LY4213663 in healthy volunteers and people with rheumatoid arthritis (RA). The main goal is to see if the drug is safe and what side effects it may cause. Researchers will also measure how the body processes the drug. The study lasts…

This study aims to understand the link between nutrition and disease activity in people with rheumatic diseases like rheumatoid arthritis, lupus, and psoriatic arthritis. Researchers will assess the nutritional status of 460 participants using various scores and check if better n…

This study looks at why some people with rheumatoid arthritis have trouble swallowing. Researchers will use a small camera to examine the throat and see if joint problems are the cause. About 137 adults with RA will take part to help identify early warning signs.

This study looks at whether generative AI can help doctors better diagnose complications of rheumatoid arthritis (RA), such as lung disease or heart problems. Researchers will use AI to analyze patient records and suggest possible complications, then see if doctors find these sug…

This study monitors up to 36 people who previously received an experimental gene-modified Treg therapy for rheumatoid arthritis or hidradenitis suppurativa. Researchers will watch for delayed side effects, how long the modified cells last in the body, and any serious health event…

This early-stage study is testing a new drug called CIGB-814 in 70 healthy adults aged 18 to 45. The main goal is to see if the drug is safe and how the body processes it. This is the first step before testing it in people with rheumatoid arthritis.

This study tracks 70 people who have already received an infusion of KYV-101, a CAR T cell therapy, for autoimmune diseases like lupus, multiple sclerosis, and rheumatoid arthritis. The goal is to watch for delayed side effects, new cancers, or other health problems over up to 15…

This study aims to find better ways to predict heart disease in people with rheumatoid arthritis (RA), who face twice the risk of heart attack. Researchers will measure calcium in heart arteries and a protein called troponin in 120 adults aged 40-79 with RA and at least one other…

This study aims to see if a blood test can predict how well a lower dose of the drug rituximab works for people with rheumatoid arthritis. Researchers will enroll 30 adults who already respond well to standard-dose rituximab and switch them to a single 1000 mg dose. The goal is t…

This study looks at whether drugs with anticholinergic effects increase fracture risk in people with rheumatoid arthritis. Researchers will track 100 adults, recording their medications, bone density, and blood tests. The goal is to understand how the total anticholinergic load f…

This large observational study will follow at least 10,000 people with rheumatoid arthritis (RA), including those with hard-to-treat RA or related lung disease. Researchers will collect data on symptoms, treatments, and side effects from both Traditional Chinese and Western medic…

This early-stage study tests a single injection of an experimental drug called SHR-3045 in 16 healthy adults aged 18-55. The main goal is to check for side effects and see how the drug moves through the body. This study does not aim to treat any disease; it is a first step to gat…

This study looks at 200 adults with autoimmune joint diseases like rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis. Researchers will measure certain blood markers of oxidative stress at three points over a year. The goal is to see if these markers can help d…

This study is testing whether the Four Square Step Test (FSST) is a valid and reliable way to measure balance in people with rheumatoid arthritis. Researchers will compare FSST results with other measures like disease activity, pain, and muscle strength. The study involves 50 adu…