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New immune cell combo tackles tough autoimmune diseases

NCT ID NCT06991114

Recruiting now Disease control Sponsor: Artiva Biotherapeutics, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 2 trial tests a therapy called AlloNK, made from donor cord blood immune cells, combined with the drug rituximab. It aims to see if this combination is safe and can help people with severe forms of rheumatoid arthritis, Sjögren's disease, myositis, or scleroderma that haven't responded to other treatments. About 90 participants will receive the therapy in a step-by-step dosing plan.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

AlloNK (a donor immune cell therapy) combined with rituximab

What this could lead to

If it works, this could offer a new treatment option for people with hard-to-treat autoimmune diseases like rheumatoid arthritis or scleroderma.

What could go wrong

This is an early phase 2 trial with only 90 people, so results may not apply widely. The therapy involves strong immune suppression, which carries risks of infection and other side effects.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

acquired idiopathic inflammatory myopathy diffuse scleroderma juvenile dermatomyositis myositis disease rheumatoid arthritis scleroderma Sjogren syndrome systemic sclerosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

IDIOPATHIC INFLAMMATORY MYOPATHIES (IIMS) IIM MYOSITIS REFRACTORY RHEUMATOID ARTHRITIS (RA) RHEUMATOID ARTHRITIS (RA SCLERODERMA SJOGREN SYNDROME SJOGRENS DISEASE SYSTEMIC SCLEROSIS (SSC)

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Artiva Investigational Site Arlington

    RECRUITING

    Arlington, Texas, 76012, United States

  • Artiva Investigational Site Belgrade

    RECRUITING

    Belgrade, Belgrade, Serbia

  • Artiva Investigational Site Bellaire

    RECRUITING

    Bellaire, Texas, 77401, United States

  • Artiva Investigational Site Bonn

    RECRUITING

    Bonn, Bonn, Germany

  • Artiva Investigational Site Brasília

    RECRUITING

    Brasília, Brasília, Brazil

  • Artiva Investigational Site Brescia

    RECRUITING

    Brescia, 25125, Italy

  • Artiva Investigational Site Bucharest

    RECRUITING

    Bucharest, 50474, Romania

  • Artiva Investigational Site Bucuresti

    RECRUITING

    Bucharest, 20125, Romania

  • Artiva Investigational Site Bydgoszcz

    RECRUITING

    Bydgoszcz, Bydgoszcz, Poland

  • Artiva Investigational Site Charleston

    RECRUITING

    Charleston, South Carolina, 29407, United States

  • Artiva Investigational Site Charlotte

    RECRUITING

    Charlotte, North Carolina, 28207, United States

  • Artiva Investigational Site Charlotte

    RECRUITING

    Charlotte, North Carolina, 28625, United States

  • Artiva Investigational Site Chula Vista

    RECRUITING

    Chula Vista, California, 92108, United States

  • Artiva Investigational Site Covina

    RECRUITING

    Covina, California, 91723, United States

  • Artiva Investigational Site Cuiabá

    RECRUITING

    Cuiabá, Cuiabá, Brazil

  • Artiva Investigational Site Gainesville

    RECRUITING

    Gainesville, Georgia, 30501, United States

  • Artiva Investigational Site Hixson

    RECRUITING

    Hixson, Tennessee, 37343, United States

  • Artiva Investigational Site Iowa

    RECRUITING

    Iowa City, Iowa, 52242, United States

  • Artiva Investigational Site Iowa Great Falls

    RECRUITING

    Great Falls, Montana, 59405, United States

  • Artiva Investigational Site Irving

    RECRUITING

    Irving, Texas, 75061, United States

  • Artiva Investigational Site Jackson

    RECRUITING

    Jackson, Tennessee, 38305, United States

  • Artiva Investigational Site Jupiter

    RECRUITING

    Jupiter, Florida, 33458, United States

  • Artiva Investigational Site Katy

    RECRUITING

    Katy, Texas, 77494, United States

  • Artiva Investigational Site Los Alamitos

    RECRUITING

    Los Alamitos, California, 90720, United States

  • Artiva Investigational Site Los Angeles

    RECRUITING

    Los Angeles, California, 90027, United States

  • Artiva Investigational Site Marseille

    RECRUITING

    Marseille, 13005, France

  • Artiva Investigational Site Mesquite

    RECRUITING

    Mesquite, Texas, 75150, United States

  • Artiva Investigational Site Miami

    RECRUITING

    Miami, Florida, 33143, United States

  • Artiva Investigational Site Montpellier

    RECRUITING

    Montpellier, 34090, France

  • Artiva Investigational Site Munchen

    RECRUITING

    München, 80336, Germany

  • Artiva Investigational Site Norcross

    RECRUITING

    Norcross, Georgia, 30092, United States

  • Artiva Investigational Site Phoenix

    RECRUITING

    Phoenix, Arizona, 85037, United States

  • Artiva Investigational Site Plantation

    RECRUITING

    Plantation, Florida, 33324, United States

  • Artiva Investigational Site Plovdiv

    RECRUITING

    Plovdiv, Plovdiv, Bulgaria

  • Artiva Investigational Site Porto Alegre

    RECRUITING

    Porto Alegre, Porto Alegre, Brazil

  • Artiva Investigational Site Red Oak

    RECRUITING

    Red Oak, Texas, 75154, United States

  • Artiva Investigational Site Rio Grande

    RECRUITING

    Rio Grande, Porto Alegre, Brazil

  • Artiva Investigational Site Roanoke

    RECRUITING

    Roanoke, Virginia, 24016, United States

  • Artiva Investigational Site Santa Ana

    RECRUITING

    Santa Ana, California, 92706, United States

  • Artiva Investigational Site Sao Paulo

    RECRUITING

    São Paulo, São Paulo, Brazil

  • Artiva Investigational Site Sevila

    RECRUITING

    Seville, 41701, Spain

  • Artiva Investigational Site Sofia

    RECRUITING

    Sofia, 1612, Bulgaria

  • Artiva Investigational Site Statesville

    RECRUITING

    Statesville, North Carolina, 27103, United States

  • Artiva Investigational Site São Paulo

    RECRUITING

    São Paulo, São Paulo, Brazil

  • Artiva Investigational Site Toulouse

    RECRUITING

    Toulouse, 31059, France

  • Artiva Investigational Site Tucson

    RECRUITING

    Tucson, Arizona, 85748, United States

  • Artiva Investigational Site Tuscaloosa

    RECRUITING

    Tuscaloosa, Alabama, 35406, United States

  • Artiva Investigational Site Tustin

    RECRUITING

    Tustin, California, 92780, United States

  • Artiva Investigational Site Vila Nova De Gaia

    RECRUITING

    Vila Nova de Gaia, 4434, Portugal

  • Artiva Investigational Site Warszawa

    RECRUITING

    Warsaw, Warszawa, Poland

  • Artiva Investigational Site Willowbrook

    RECRUITING

    Willowbrook, Illinois, 60527, United States

  • Artiva Investigational Site Woodland

    RECRUITING

    Woodland, Texas, 77382, United States