Can skin biopsies unlock new treatments for scleroderma?

NCT ID NCT06894654

Recruiting now Knowledge-focused Sponsor: Relation Therapeutics Source: ClinicalTrials.gov ↗

First seen Aug 14, 2026 · Last updated Aug 14, 2026

Summary

This study aims to understand the cellular and molecular mechanisms behind systemic sclerosis (SSc), a rare autoimmune disease that causes skin and organ fibrosis. Researchers will collect skin punch biopsies and blood samples from 500 participants, including those with SSc and healthy volunteers, to analyze gene expression and genetic variations. The goal is to identify novel therapeutic targets for SSc and related connective tissue diseases.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Skin punch biopsy and blood sampling for molecular and genetic analysis
What this could lead to: If successful, this could reveal new drug targets for systemic sclerosis and related autoimmune diseases, potentially leading to more effective, personalized treatments.
What could go wrong: This is an observational study, not a treatment trial, so it won't directly test a therapy. Findings may not translate into immediate clinical benefits.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

diffuse scleroderma systemic sclerosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SYSTEMIC SCLEROSIS (SSC)

Contacts and locations

Locations

Chapel Allerton Hospital
NOT_YET_RECRUITING

Leeds, LS7 4SA, United Kingdom
Royal Free Hospital
RECRUITING

London, NW3 2QG, United Kingdom

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