Can a new pill ease the hardening skin of systemic sclerosis?
NCT ID NCT07745725
First seen Aug 04, 2026 · Last updated Aug 05, 2026 · Updated 1 time
Summary
This phase II trial is testing an experimental tablet called TollB-001 in adults with systemic sclerosis, a rare autoimmune disease that causes skin thickening and can affect internal organs. The study aims to see whether the drug can improve skin symptoms and overall well-being compared to a placebo. Participants will be randomly assigned to receive either TollB-001 or a placebo, and researchers will monitor safety and how the drug behaves in the body.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- TollB-001 tablets
- What this could lead to
- If TollB-001 proves effective, it could offer a new treatment option to slow or reduce skin thickening and improve quality of life for people with systemic sclerosis.
- What could go wrong
- This is an early-phase study with a small number of participants, so results may not hold up in larger trials. The drug may also cause side effects or prove no better than a placebo.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Peking Union Medical College Hospital, Chinese Academy of Medical Sciences
Beijing, Beijing Municipality, 102206, China
-
Toll Biotech, 2108-B007, No. 9 West Beisihuan Road, Haidian District, Beijing, People's Republic of China
Beijing, Beijing Municipality, 100083, China
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