Can engineered immune cells tame stubborn autoimmune diseases?
NCT ID NCT07729995
First seen Jul 28, 2026 · Last updated Jul 29, 2026 · Updated 1 time
Summary
This phase 1 trial tests an experimental cell therapy called LMY-922 (BAFF CAR-T cells) in people aged 16 to 75 with refractory autoimmune diseases, including rheumatoid arthritis, lupus, dermatomyositis, and systemic sclerosis. The therapy uses donor immune cells engineered to target BAFF, a protein involved in autoimmune attacks. The study aims to find a safe dose and see if this approach can reduce disease activity in patients who have not responded to other treatments.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- an experimental cell therapy called BAFF CAR-T cells (LMY-922), made from donor immune cells engineered to target BAFF
- What this could lead to
- If it works, this could offer a new treatment option for people with autoimmune diseases that do not respond to standard therapies.
- What could go wrong
- This is an early phase 1 trial, so safety and effectiveness are not yet known. CAR-T cell therapies can cause serious side effects, including cytokine release syndrome and neurological issues.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Boston Children's Hospital
Boston, Massachusetts, 02115, United States
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