SCLERODERMA

This early study tests an experimental treatment called EVM18001 in 12 people with active, hard-to-treat lupus, myasthenia gravis, or scleroderma. The treatment uses a type of cell therapy (CAR-T) to target and possibly reset the immune system. The main goals are to check safety …

This study tests an experimental drug called tibulizumab in 80 adults with systemic sclerosis (scleroderma), a disease that causes skin thickening and can damage internal organs. For the first 24 weeks, some participants get the drug and some get a placebo, without knowing which.…

This study tests a new treatment for people with certain autoimmune diseases (rheumatoid arthritis, Sjögren's disease, myositis, and scleroderma) that have not responded to standard therapies. The treatment combines AlloNK, a type of immune cell from donated cord blood, with ritu…

This study tests several new medicines to see if they can improve lung function in people with scleroderma-related lung scarring. About 400 adults will receive either an experimental drug or a placebo for one year. The main goal is to measure changes in breathing capacity.

This early-stage study tests a new treatment called HN2301 in 30 people with lupus, scleroderma, or rheumatoid arthritis. The main goal is to check safety and find the right dose. Researchers will also see if the therapy can reduce disease activity by targeting immune cells.

This early-stage trial tests a treatment called CABA-201, made from a patient's own immune cells (CAR T cells), for people with systemic sclerosis (scleroderma). The goal is to see if it is safe and can help control the disease by targeting and reducing certain immune cells. Abou…

This early-stage study tests a new drug, SAR448501/DR-0201, in 62 adults with lupus or rheumatoid arthritis. The goal is to find the safest and most effective dose by checking side effects and how the drug works in the body. Participants will be followed for about 13 months, and …

This study tests whether sildenafil (a drug that relaxes blood vessels) can improve exercise ability in people with scleroderma who have mildly elevated blood pressure in their lungs. About 30 participants will receive either sildenafil or a placebo for 4 months. The main goal is…

This study tests a biopsychosocial exercise program called BETY in 48 children and adults with scleroderma. The goal is to see if it improves physical function, skin health, and overall well-being. Participants are randomly assigned to BETY or standard care, and outcomes are meas…

This study looks at why people with interstitial lung disease (ILD) often feel short of breath and have trouble exercising. Researchers think leg muscle problems might be a cause. They will measure leg muscle strength and structure in 40 adults with ILD, and test whether extra ox…

This study is creating a registry of 1,000 pregnant women with autoimmune diseases like lupus and rheumatoid arthritis. Researchers will track their health and pregnancy outcomes to identify risk factors and ways to improve care for both mothers and babies. The study does not tes…

This study looks at skin cells called fibroblasts from people with scleroderma and compares them to cells from healthy people. The goal is to find which genes are turned on or off, especially those linked to aging. No treatment is tested—just observation to better understand the …

This study is building a large database and sample bank from 5,000 adults with various rheumatic diseases like rheumatoid arthritis, lupus, and psoriatic arthritis. Researchers will use this information to find links between patient outcomes and biological markers. The goal is to…

This study looks at how scleroderma affects chewing and swallowing in both children and adults. Researchers will measure things like mouth opening, swallowing ability, and eating performance using simple tests and questionnaires. The goal is to better understand these problems an…

This study collects tissue and blood samples from 300 people with autoimmune diseases like Crohn's, multiple sclerosis, and celiac disease. Researchers will look for T cells that are active in inflamed tissues to find their targets. The goal is to discover new targets for future …

This study follows 500 adults with systemic sclerosis (a rare disease causing skin and organ hardening) for 5 years. Researchers will collect health data and blood samples to track how the disease naturally progresses. The goal is to better understand the disease, not to test a n…

This study looks at how physical, mental, and social factors affect movement and daily activities in people with scleroderma. Researchers will test walking, stair climbing, and other tasks in 50 children and adults. The goal is to find better ways to measure physical function and…

This study is creating a registry of 300 adults with scleroderma to collect medical information and samples over time. The goal is to learn more about the disease's features, genetics, and biology, which could lead to future treatments. Participants will provide skin scores and c…

This study aims to create a large collection of blood and tissue samples from people with autoimmune diseases like lupus and scleroderma. Researchers will use these samples to learn more about how these diseases work, identify markers for diagnosis, and discover clues for future …