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Could CAR t cells tame scleroderma? new trial launches

NCT ID NCT06328777

Recruiting now Disease control Sponsor: Cabaletta Bio Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 23, 2026 · Updated 2 times

Summary

This early-stage study tests a new treatment called CABA-201 for people with systemic sclerosis (scleroderma), a disease that causes hardening of the skin and can damage organs. The treatment uses a patient's own immune cells, modified to target and destroy faulty B cells that drive the disease. The study will enroll 12 adults with active disease and significant organ involvement to check safety and how well the therapy works.

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Conditions

The condition(s) this trial relates to.

autoimmune disease diffuse scleroderma scleroderma systemic sclerosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SCLERODERMA SYSTEMIC SCLEROSIS

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

Locations

  • Columbia University Irving Medical Center

    RECRUITING

    New York, New York, 10032, United States

  • Duke University

    RECRUITING

    Durham, North Carolina, 27710, United States

  • Mayo Clinic Florida

    RECRUITING

    Jacksonville, Florida, 55905, United States

  • Mayo Clinic Rochester

    RECRUITING

    Rochester, Minnesota, 55905, United States

  • Northwestern Memorial Hospital

    RECRUITING

    Chicago, Illinois, 60611, United States

  • The University of Chicago Medical Center

    RECRUITING

    Chicago, Illinois, 60637, United States

  • University of Kansas Medical Center

    RECRUITING

    Kansas City, Kansas, 66160, United States

  • University of Michigan

    RECRUITING

    Ann Arbor, Michigan, 48109, United States

  • University of Rochester

    RECRUITING

    Rochester, New York, 14642, United States

  • Yale University

    RECRUITING

    New Haven, Connecticut, 06519, United States

More trials for these conditions

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