Finger injections aim to loosen stiff hands in scleroderma
NCT ID NCT07697274
First seen Jul 13, 2026 · Last updated Jul 14, 2026 · Updated 1 time
Summary
This early-phase trial investigates whether monthly injections of hyaluronidase into the fingers can improve stiffness and hand function in people with systemic sclerosis who have sclerodactyly (tight, thickened skin on the fingers). The study enrolls 10 adults aged 18 to 60 and measures feasibility, safety, and preliminary effects on finger movement and hand function. Researchers believe that adding hyaluronidase may counteract the fibrosis that causes stiffness.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- hyaluronidase (Hylenex)
- What this could lead to
- If it works, this could point toward a treatment for finger stiffness in systemic sclerosis, improving hand function and quality of life.
- What could go wrong
- This is a very small early-phase trial with only 10 participants, so results may not apply broadly. The injections are monthly and may cause side effects like pain or allergic reactions.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Medical University of South Carolina
Charleston, South Carolina, 29425, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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