SYSTEMIC SCLEROSIS

This early-stage study is testing a new cell therapy called CC-97540 for people with severe autoimmune diseases that haven't responded to multiple treatments. The therapy involves collecting a patient's own immune cells, engineering them to target specific immune cells (B cells),…

This study is testing a new combination treatment for people with severe autoimmune diseases like lupus and scleroderma who haven't responded well to standard therapies. It involves giving specially modified immune cells (AD-PluReceptor-NK cells) along with a drug called tafasita…

This early-stage study is testing a new type of cell therapy called anti-CD19/BCMA universal CAR-T cells in people with severe autoimmune diseases that have not improved with standard treatments. The main goals are to check if the treatment is safe and to see if it can help contr…

This early-stage study is testing a new type of cell therapy called RD06-05 for people with active autoimmune diseases. The therapy involves modifying a patient's own immune cells (CAR-T cells) to target and remove harmful immune cells, aiming to reset the immune system. The main…

This is an early safety study testing a single infusion of a new cell therapy called YTS109. It aims to see if the treatment is safe and shows any signs of helping adults with severe autoimmune diseases that have not responded to standard treatments. The study will enroll about 1…

This study is testing whether injections of a patient's own processed fat cells can help heal stubborn, painful finger ulcers caused by scleroderma. It will compare the cell injections to a placebo in 32 adults with systemic sclerosis who have ulcers that haven't healed with stan…

This study is testing a new cell therapy called CD19-BCMA CAR-T for people with severe autoimmune diseases that have not responded to standard treatments. It aims to see if this therapy is safe and can help control diseases like lupus affecting the kidneys, systemic sclerosis, an…

This study is testing a new cell therapy, originally developed for cancer, for people with severe autoimmune diseases that haven't responded to standard treatments. It uses modified immune cells (CAR-T) from umbilical cord blood to try to reset the body's faulty immune system. Th…

This study is testing a stem cell transplant procedure for people with severe systemic sclerosis (scleroderma) that hasn't responded to other treatments. Doctors will use the patient's own filtered stem cells to try to 'reset' their faulty immune system after strong chemotherapy.…

This study is testing a stem cell transplant procedure for children and young adults with severe, life-threatening forms of lupus or scleroderma that haven't responded to standard treatments. The goal is to use high-dose chemotherapy to wipe out the faulty immune system and then …

This is a first-in-human study testing the safety and early effectiveness of a new type of cell therapy called ALLO-329 in adults with severe autoimmune diseases like lupus, myositis, and scleroderma. The therapy involves giving patients specially engineered immune cells (CAR T c…

This early-stage trial is testing a new cell therapy for adults with severe, hard-to-treat autoimmune diseases like lupus, scleroderma, and muscle inflammation diseases. Doctors take a patient's own immune T-cells, genetically modify them to hunt and destroy harmful B-cells that …

This is an early-stage safety study testing a new type of personalized cell therapy called AZD0120. It aims to see if this treatment is safe and tolerable for adults with severe autoimmune diseases like systemic sclerosis, inflammatory myopathies, or difficult-to-treat rheumatoid…

This early-stage study is testing a new type of cell therapy called NKX019 in people with severe autoimmune diseases like systemic sclerosis, inflammatory muscle disease, and certain types of vasculitis. The main goals are to find a safe dose and see if the treatment is tolerable…

This study is testing whether a drug called itacitinib is safe and effective for treating adults with diffuse systemic sclerosis, a rare autoimmune disease that causes skin and organ scarring. It will enroll 74 participants to see if the drug can reduce skin thickening and contro…

This early-stage study is testing whether a type of cell therapy called CAR-T, which is used to treat some cancers, can help people with serious autoimmune diseases like lupus, scleroderma, and vasculitis. The therapy involves collecting a patient's own immune cells, modifying th…

This early-stage study is testing a single dose of an experimental cell therapy called CABA-201 for adults with active systemic sclerosis (scleroderma). The therapy, known as CAR T-cell therapy, is designed to target and remove a type of immune cell (B cells) thought to drive the…

This early-stage study is testing a new treatment called CTX112 for adults with severe autoimmune diseases like lupus, scleroderma, and inflammatory muscle disease that haven't responded to standard therapies. The treatment uses genetically modified immune cells from healthy dono…

This study is testing whether injections of donor stem cells can help heal painful, open sores on the fingers of people with scleroderma. It will involve 20 participants who have ulcers that haven't improved with standard treatments. The main goal is to first check if the treatme…

This study is testing whether a personalized home exercise program is practical and acceptable for people with scleroderma (systemic sclerosis) who have early lung disease. Fifteen participants will attend one supervised session and then follow a 3-month program of breathing and …

This study is creating a large collection of health information and biological samples from people with various rheumatic diseases, like rheumatoid arthritis and lupus. The goal is to help scientists compare different diseases to learn more about what causes them and how they pro…

This study aims to understand the natural progression of systemic sclerosis (scleroderma), a rare and serious autoimmune disease with no cure. Researchers will follow 500 patients for five years, collecting detailed health information and blood samples. The goal is to build a cle…

This study aims to understand if the types of bacteria in the gut are different in people with systemic sclerosis (scleroderma) compared to healthy people. Researchers will collect stool samples from 60 participants—some with scleroderma and some without—to analyze their gut bact…

This study aims to understand the complex biology of systemic sclerosis, a rare autoimmune disease that causes skin thickening and organ scarring. Researchers will analyze skin and blood samples from 40 adult patients to map the different types of cells involved and how they inte…