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Engineered immune cells take on autoimmune diseases in first human trial

NCT ID NCT07085104

Recruiting now Disease control Sponsor: Allogene Therapeutics Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 24, 2026 · Updated 1 time

Summary

This early-stage study tests a new treatment called ALLO-329 for people with lupus, myositis, or scleroderma. The therapy uses specially engineered immune cells from a donor to target and calm the overactive immune system. The main goals are to check safety and see if it can improve disease symptoms.

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Conditions

The condition(s) this trial relates to.

autoimmune disease dermatomyositis diffuse scleroderma idiopathic inflammatory myopathy lupus nephritis myositis disease systemic lupus erythematosus systemic sclerosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

IDIOPATHIC INFLAMMATORY MYOPATHY SYSTEMIC LUPUS ERYTHEMATOSUS (WITH AND WITHOUT NEPHRITIS) SYSTEMIC SCLEROSIS

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Astera Cancer Care

    RECRUITING

    East Brunswick, New Jersey, 08816, United States

    Contact

  • Duke University Medical Center

    RECRUITING

    Durham, North Carolina, 27710, United States

    Contact

  • Hôpital Maisonneuve Rosemont

    RECRUITING

    Montreal, Quebec, H1T 2M4, Canada

    Contact

  • Icahn School of Medicine at Mount Sinai

    RECRUITING

    New York, New York, 10029, United States

    Contact

  • LDS Hospital - lntermountain Health

    RECRUITING

    Salt Lake City, Utah, 84143, United States

    Contact

  • Loma Linda University Medical Center

    RECRUITING

    Loma Linda, California, 92354, United States

    Contact

  • Mayo Clinic

    RECRUITING

    Phoenix, Arizona, 85054, United States

    Contact

  • Mayo Clinic

    RECRUITING

    Jacksonville, Florida, 32224, United States

    Contact

  • Medical University of South Carolina

    RECRUITING

    Charleston, South Carolina, 29605, United States

    Contact

  • Norton Cancer Institute, St. Matthews Campus

    RECRUITING

    Louisville, Kentucky, 40207, United States

    Contact

  • Prisma Health

    RECRUITING

    Greenville, South Carolina, 29425, United States

    Contact

  • The University of Chicago Medical Center

    RECRUITING

    Chicago, Illinois, 60637, United States

    Contact

  • University of Colorado Denver

    RECRUITING

    Aurora, Colorado, 80045, United States

    Contact

  • University of Iowa

    RECRUITING

    Iowa City, Iowa, 52242, United States

    Contact

More trials for these conditions

Other studies related to the condition(s) this trial covers.