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Experimental CAR-T shot targets three tough autoimmune diseases

NCT ID NCT07470151

Recruiting now Disease control Sponsor: Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This early study is testing an experimental therapy called EVM18001 in 12 people with active, hard-to-treat lupus, myasthenia gravis, or scleroderma. The main goal is to see if it is safe and to find the right dose. Researchers will also look at how the body processes the therapy and whether it shows any signs of helping control the disease.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
EVM18001 injection (a type of CAR-T cell therapy)
What this could lead to
If it works, this could point toward a new treatment option for people with hard-to-control autoimmune diseases like lupus, myasthenia gravis, or scleroderma.
What could go wrong
This is a very early, small study with only 12 people, so results may not apply broadly. The therapy is new and its safety and effectiveness are not yet known.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

autoimmune disease diffuse scleroderma myasthenia gravis scleroderma systemic lupus erythematosus systemic sclerosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MYASTHENIA GRAVIS (MG) SCLERODERMA SYSTEM LUPUS ERYTHEMATOSUS(SLE)

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Union hospital Tongji medical college Huazhong university of science and technology

    RECRUITING

    Wuhan, Hubei, 430022, China

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

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