A simple blood test for lupus kidney damage?

NCT ID NCT07763821

Not yet recruiting Diagnosis Sponsor: Assiut University Source: ClinicalTrials.gov ↗

First seen Aug 13, 2026 · Last updated Aug 14, 2026 · Updated 1 time

Summary

This study investigates whether levels of a protein called RNASE1 in the blood can serve as a biomarker for lupus nephritis, a serious kidney complication of systemic lupus erythematosus (SLE). Researchers will compare RNASE1 levels in 128 adults with SLE, some with lupus nephritis and some without, to see if the protein is elevated in those with kidney involvement. The goal is to determine if this blood test could help identify or monitor lupus nephritis.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: A blood test measuring levels of the protein ribonuclease 1 (RNASE1)
What this could lead to: If RNASE1 levels reliably distinguish lupus nephritis from lupus without kidney involvement, it could become a simple blood test to help diagnose and monitor this serious complication.
What could go wrong: This is an early, observational study, so the biomarker may not prove accurate enough for clinical use. Also, RNASE1 levels could be influenced by other factors, limiting its specificity.

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Conditions

The condition(s) this trial relates to.

lupus nephritis systemic lupus erythematosus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SYSTEM LUPUS ERYTHEMATOSUS(SLE)

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