SYSTEMIC SCLEROSIS

This study tested whether a drug called nemolizumab could help people with systemic sclerosis, a rare disease that causes skin thickening and can affect internal organs. Six patients with moderate to severe skin symptoms received the drug for up to a year. Researchers measured ch…

This completed Phase 3 trial tested whether adding intravenous cyclophosphamide to standard prednisone treatment could better stabilize or improve lung function in people with scleroderma-related lung scarring. The study involved 40 adults whose lung function had recently worsene…

This study aimed to find the best initial treatment for people recently diagnosed with a severe, fast-moving form of scleroderma. It compared two approaches: an aggressive stem cell transplant right away versus starting with standard immunosuppressive drugs and saving the transpl…

This study tested whether a chest ultrasound, which is simple and radiation-free, can detect early signs of lung scarring in people with scleroderma. Researchers enrolled 30 scleroderma patients who did not yet show lung disease on standard CT scans. The goal was to see if ultras…

This study tested whether a self-guided phone app called RENEW is practical for people with scleroderma to use. Researchers wanted to see if people with the condition would sign up for the study, stick with it, and use the app. The app provides energy management and resilience-bu…

This study tested whether the drug rituximab could help reduce joint pain and swelling in people with systemic sclerosis (scleroderma) who had active arthritis. It involved 22 participants whose joint symptoms weren't controlled by standard medications. The main goal was to see i…

This study tested an online group program designed to help people with scleroderma (systemic sclerosis) better manage their disease and daily symptoms. The program included educational videos and live group video sessions led by trained peers, focusing on challenges like pain, fa…

This study aimed to understand if a type of white blood cell called an eosinophil plays a role in causing the scarring (fibrosis) seen in scleroderma. Researchers compared blood and skin samples from 70 people, including scleroderma patients and healthy volunteers. The goal was t…

This study aimed to understand how a severe lung complication, called diffuse infiltrating pneumonia, changes over time in people with systemic sclerosis (scleroderma). Researchers followed 56 patients for two years, measuring their lung function to see how it declined. The goal …

This study aimed to understand how common painful skin calcium deposits are in people with systemic sclerosis (scleroderma). Researchers used hand and foot X-rays to check 214 patients for these deposits. They also investigated whether having these calcium deposits is linked to d…

This study aimed to create a standard checklist to measure how systemic sclerosis (scleroderma) affects a person's daily life and function. Researchers worked with 113 patients and medical experts to identify the most important challenges people face. The goal was to develop a pr…

This study aimed to better understand the experiences of family members and friends who care for people with systemic sclerosis (scleroderma), a rare and serious autoimmune disease. Researchers surveyed 50 caregivers to learn about their quality of life, the challenges they face,…

This study aimed to understand how the body's own immune system might be involved in causing or worsening pulmonary arterial hypertension (PAH), a serious condition of high blood pressure in the lungs. Researchers compared blood samples from over 600 people, including patients wi…