Can a blood flow drug ease painful finger ulcers in scleroderma?
NCT ID NCT01395732
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested the drug bosentan in 18 adults with systemic sclerosis who had reduced blood flow in their hands and a history of digital ulcers. The goal was to see if bosentan could improve hand blood flow measured by laser imaging and how blood flow relates to ulcer severity. The trial is already completed.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Bosentan (a drug taken as tablets to improve blood flow)
What this could lead to
If successful, this could show that bosentan improves hand blood flow and helps manage digital ulcers in systemic sclerosis patients.
What could go wrong
This is a small, completed Phase 4 study with only 18 participants, so results may not apply broadly. The drug may not significantly improve blood flow or ulcer outcomes.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Erasmus MC
Rotterdam, 3015CE, Netherlands
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Isala Klinieken
Zwolle, 8011JW, Netherlands
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LUMC
Leiden, 2333ZA, Netherlands
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MCL
Leeuwarden, 8934AD, Netherlands
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MUMC
Maastricht, 6229HX, Netherlands
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Maasstad Ziekenhuis
Rotterdam, 3078HT, Netherlands
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Sint Franciscus Gasthuis
Rotterdam, 3045PM, Netherlands
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UMC Groningen
Groningen, 9700RB, Netherlands
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UMC St Radboud
Nijmegen, 6525GA, Netherlands
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VUmc
Amsterdam, 10811HV, Netherlands