Can a blood flow drug ease painful finger ulcers in scleroderma?

NCT ID NCT01395732

Completed Disease control Sponsor: Actelion Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested the drug bosentan in 18 adults with systemic sclerosis who had reduced blood flow in their hands and a history of digital ulcers. The goal was to see if bosentan could improve hand blood flow measured by laser imaging and how blood flow relates to ulcer severity. The trial is already completed.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Bosentan (a drug taken as tablets to improve blood flow)
What this could lead to: If successful, this could show that bosentan improves hand blood flow and helps manage digital ulcers in systemic sclerosis patients.
What could go wrong: This is a small, completed Phase 4 study with only 18 participants, so results may not apply broadly. The drug may not significantly improve blood flow or ulcer outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

digital ulcers systemic sclerosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DIGITAL ULCERS SYSTEMIC SCLEROSIS

Contacts and locations

Locations

Erasmus MC

Rotterdam, 3015CE, Netherlands
Isala Klinieken

Zwolle, 8011JW, Netherlands
LUMC

Leiden, 2333ZA, Netherlands
MCL

Leeuwarden, 8934AD, Netherlands
MUMC

Maastricht, 6229HX, Netherlands
Maasstad Ziekenhuis

Rotterdam, 3078HT, Netherlands
Sint Franciscus Gasthuis

Rotterdam, 3045PM, Netherlands
UMC Groningen

Groningen, 9700RB, Netherlands
UMC St Radboud

Nijmegen, 6525GA, Netherlands
VUmc

Amsterdam, 10811HV, Netherlands

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