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Could a simple injection dissolve painful calcium lumps in rare diseases?

NCT ID NCT03582800

Recruiting now Disease control Sponsor: University Hospital, Limoges Source: ClinicalTrials.gov ↗

First seen Jul 20, 2026 · Last updated Jul 21, 2026 · Updated 1 time

Summary

This study tests whether injecting sodium thiosulfate directly into abnormal calcium deposits can shrink them and reduce pain. It includes people with three rare conditions: systemic sclerosis, dermatomyositis, and a genetic disorder called iPPSD2. Participants receive up to 11 injections over six months, and doctors measure changes in deposit size using CT scans.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
sodium thiosulfate injected under the skin
What this could lead to
If it works, this could offer a non-surgical option to shrink painful calcium deposits in rare diseases like systemic sclerosis and dermatomyositis.
What could go wrong
This is a small, early-phase pilot study with no placebo group, so results may not be definitive. The injections may not shrink deposits or could cause side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

alpha-heavy chain disease dermatomyositis Ossification, Heterotopic pseudohypoparathyroidism type 1A systemic sclerosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DERMATOMYOSITIS IPPSD2 SYSTEMIC SCLEROSIS

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • ApHp - Hôpital Bicêtre

    RECRUITING

    Le Kremlin-Bicêtre, 94270, France

    Contact Email: •••••@•••••

    Contact

  • ApHp - hôpital Lariboisière

    RECRUITING

    Paris, 75000, France

    Contact Email: •••••@•••••

    Contact

  • CHU de BORDEAUX

    RECRUITING

    Bordeaux, 33000, France

    Contact Email: •••••@•••••

    Contact

  • CHU de Limoges

    RECRUITING

    Limoges, 87042, France

    Contact

    Contact Email: •••••@•••••

    Contact

    Contact

    Contact Email: •••••@•••••

    Contact

  • CHU de ROUEN

    NOT_YET_RECRUITING

    Rouen, 76031, France

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • CHU de Toulouse

    RECRUITING

    Toulouse, 31000, France

    Contact Email: •••••@•••••

    Contact

  • Hospice Civil de Lyon

    NOT_YET_RECRUITING

    Bron, 69500, France

    Contact Email: •••••@•••••

    Contact

  • Hôpital de la Pitié Salpétriêre

    NOT_YET_RECRUITING

    Paris, 75651, France

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

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