DERMATOMYOSITIS

This study is for people who have both an autoimmune disorder (like rheumatoid arthritis, lupus, or multiple sclerosis) and advanced cancer that has spread or cannot be removed. It tests a drug called nivolumab, which helps the immune system fight cancer, given alone or with othe…

This study looks at the long-term safety and effectiveness of a medicine called dazukibart for people with dermatomyositis or polymyositis, which are rare diseases that cause muscle weakness and inflammation. About 211 adults who were in a previous dazukibart study will receive t…

This study tests a new treatment called CABA-201 for people with active idiopathic inflammatory myopathy, a group of rare diseases that cause muscle inflammation and weakness. The treatment uses a patient's own immune cells, modified to target and destroy faulty B cells. The goal…

This study tests a new treatment using specially engineered immune cells (CAR-T cells) to target and destroy faulty B cells in people with severe autoimmune diseases like lupus, rheumatoid arthritis, and scleroderma. About 72 adults aged 18-70 will receive a single infusion of th…

This study tests a new treatment using a patient's own immune cells, modified to target and destroy faulty B cells that drive autoimmune diseases like lupus, scleroderma, and myositis. Up to 24 adults with active disease will receive the therapy after a short chemotherapy course.…

This study tests whether tocilizumab, an anti-inflammatory drug, can improve symptoms and breathing in adults with anti-MDA5-positive dermatomyositis, a rare autoimmune disease affecting muscles, skin, and lungs. About 110 participants will receive either the drug or a placebo ev…

This early-stage study tests a new drug, SAR448501/DR-0201, in 62 adults with lupus or rheumatoid arthritis. The goal is to find the safest and most effective dose by checking side effects and how the drug works in the body. Participants will be followed for about 13 months, and …

This study is testing whether injecting sodium thiosulfate directly into painful calcium deposits under the skin can shrink them and ease symptoms. It includes 20 adults with scleroderma, dermatomyositis, or mixed connective tissue disease who have calcium buildup. Participants r…

This study tests a cream called ruxolitinib for skin symptoms in people with dermatomyositis, a rare autoimmune disease. The cream is applied directly to the skin. Researchers will check if it is safe and reduces skin activity after 8 and 12 weeks. The study involves 15 adults wh…

This study looks at a rare condition called panniculitis, which is inflammation of the fat under the skin, in people who already have dermatomyositis. Researchers want to describe what this looks like and how it differs from similar conditions. About 20 people aged 1 and older wi…

This study aims to learn more about myositis, a group of diseases that cause muscle inflammation and damage. Researchers will study up to 1,200 children and adults with or without myositis to understand its causes, immune system changes, and related health problems. Participants …

This study is building a large database and sample bank from 5,000 adults with various rheumatic diseases like rheumatoid arthritis, lupus, and psoriatic arthritis. Researchers will use this information to find links between patient outcomes and biological markers. The goal is to…

This study tracks 70 people who have already received an infusion of KYV-101, a CAR T cell therapy, for autoimmune diseases like lupus, multiple sclerosis, and rheumatoid arthritis. The goal is to watch for delayed side effects, new cancers, or other health problems over up to 15…

This study looks at whether certain environmental exposures—like infections, stress, or sun exposure—are more common in people with anti-synthetase syndrome (a type of myositis with lung involvement) compared to other myositis patients and healthy volunteers. Researchers will col…

This study looks at what makes dermatomyositis more severe in Caribbean patients. Researchers will track 10 adults in Guadeloupe to see how often the disease affects muscles, lungs, heart, or is linked to cancer. The goal is to learn more about this rare autoimmune disease in thi…

This study asks people living with rare myositis diseases (and their caregivers) what research questions matter most to them. Researchers will collect ideas through online surveys and forums. The goal is to create a patient-driven list of priorities to guide future studies and fu…

This study collects information from 300 adults with dermatomyositis to track skin symptoms, treatments, and quality of life over 5 years. Researchers use a special skin severity index and surveys to understand how the disease changes and responds to therapies. The goal is to imp…