DERMATOMYOSITIS

This study is testing whether a topical cream called ruxolitinib is safe and effective for treating severe skin symptoms in adults with dermatomyositis, an autoimmune disease. The cream is being studied in 15 participants whose skin symptoms have not improved with other standard …

This study is testing a one-time cell therapy called CABA-201 for adults and children with rare autoimmune diseases that cause severe muscle weakness and inflammation. The goal is to see if this treatment can safely reduce disease activity and improve muscle strength, potentially…

This study is testing the safety and effects of the immunotherapy drug nivolumab in people who have both advanced cancer and an autoimmune disease like lupus, rheumatoid arthritis, or Crohn's disease. It will enroll 300 adults to see if the drug can help control their cancer whil…

This early-stage trial is testing a new cell therapy for adults with severe, hard-to-treat autoimmune diseases like lupus, scleroderma, and muscle inflammation diseases. Doctors take a patient's own immune T-cells, genetically modify them to hunt and destroy harmful B-cells that …

This study is testing whether the drug tocilizumab can help control symptoms and lung problems in adults with a specific, serious form of dermatomyositis (anti-MDA5+). Researchers will compare the drug to a placebo (inactive substance) in 110 participants to see if it improves sk…

This study aims to understand the long-term safety and effectiveness of the drug dazukibart for adults with dermatomyositis or polymyositis, two rare diseases that cause painful muscle weakness and inflammation. The trial is open to people who previously completed a related 52-we…

This early-stage study is testing a new drug called SAR448501 in adults with moderate-to-severe lupus or rheumatoid arthritis who haven't gotten enough relief from their current treatments. The main goal is to find safe dose levels and see how the drug behaves in the body. About …

This study is testing whether injecting a medication called sodium thiosulfate directly into painful calcium deposits under the skin can shrink them and reduce pain. It will involve about 20 adults with connective tissue diseases like scleroderma or dermatomyositis who have these…

This study is creating a large collection of health information and biological samples from people with various rheumatic diseases, like rheumatoid arthritis and lupus. The goal is to help scientists compare different diseases to learn more about what causes them and how they pro…

This study aims to understand if certain environmental factors, like infections, chemicals, or stressful events, might trigger a rare autoimmune disease that weakens muscles and can affect the lungs. Researchers will compare the past exposures of 580 people—including those with t…

This study aims to understand what research topics are most important to people living with rare inflammatory muscle diseases called myositis. Researchers will gather opinions from about 700 patients and caregivers worldwide through online surveys, stories, and group discussions.…

This study aims to better understand the causes and effects of rare inflammatory muscle diseases like dermatomyositis and polymyositis. Researchers will observe up to 1,200 participants, including both patients and healthy volunteers, over time. The goal is to learn how these dis…

This study is tracking the long-term safety and effects of an experimental cell therapy called KYV-101 in people who have already received it. Researchers will follow 70 participants for up to 15 years to check for any delayed side effects and see how long the treatment's effects…

This study aims to understand why dermatomyositis, a rare autoimmune disease affecting skin and muscles, may be more severe in people of Caribbean descent. Researchers will observe 10 patients in Guadeloupe to identify factors linked to worse outcomes at diagnosis. The goal is to…

This study aims to better understand a rare skin condition called panniculitis in people who have dermatomyositis, a muscle and skin disease. Researchers will observe up to 20 patients to describe how this condition looks on the skin and under a microscope. The goal is to gather …