Could your environment trigger this rare muscle disease?

NCT ID NCT01276470

Recruiting now Knowledge-focused Sponsor: National Institute of Environmental Health Sciences (NIEHS) Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study investigates whether certain environmental exposures—like infections, stress, or sun exposure—are more common in people with anti-synthetase syndrome, a rare autoimmune condition that causes muscle weakness and lung disease. Researchers will compare 580 participants, including myositis patients with and without the syndrome, and healthy volunteers. Participants complete questionnaires and provide blood, urine, and house dust samples to identify potential triggers.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this could help identify environmental triggers for anti-synthetase syndrome, potentially guiding future prevention strategies.
What could go wrong: This is an observational study, not a treatment trial. It may not find clear links, and results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

autoimmune disease dermatomyositis juvenile dermatomyositis juvenile polymyositis myositis disease polymyositis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DERMATOMYOSITIS JUVENILE DERMATOMYOSITIS JUVENILE POLYMYOSITIS MYOSITIS POLYMYOSITIS

Contacts and locations

Locations

Brigham and Women's Hospital
COMPLETED

Boston, Massachusetts, 02115, United States
Johns Hopkins University
COMPLETED

Baltimore, Maryland, 21205, United States
Mayo Clinic, Rochester
COMPLETED

Rochester, Minnesota, 55905, United States
Mid-Atlantic Kaiser Permanente
COMPLETED

Rockville, Maryland, 20853, United States
NIEHS Clinical Research Unit (CRU)
RECRUITING

Research Triangle Park, North Carolina, 27709, United States
National Institutes of Health Clinical Center
RECRUITING

Bethesda, Maryland, 20892, United States
University of Miami Hospital
WITHDRAWN

Miami, Florida, 33101, United States
University of Pittsburgh
COMPLETED

Pittsburgh, Pennsylvania, 15261, United States

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