Could your environment trigger this rare muscle disease?
NCT ID NCT01276470
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study investigates whether certain environmental exposures—like infections, stress, or sun exposure—are more common in people with anti-synthetase syndrome, a rare autoimmune condition that causes muscle weakness and lung disease. Researchers will compare 580 participants, including myositis patients with and without the syndrome, and healthy volunteers. Participants complete questionnaires and provide blood, urine, and house dust samples to identify potential triggers.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
What this could lead to
If successful, this could help identify environmental triggers for anti-synthetase syndrome, potentially guiding future prevention strategies.
What could go wrong
This is an observational study, not a treatment trial. It may not find clear links, and results may not apply to all patients.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Brigham and Women's Hospital
COMPLETEDBoston, Massachusetts, 02115, United States
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Johns Hopkins University
COMPLETEDBaltimore, Maryland, 21205, United States
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Mayo Clinic, Rochester
COMPLETEDRochester, Minnesota, 55905, United States
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Mid-Atlantic Kaiser Permanente
COMPLETEDRockville, Maryland, 20853, United States
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NIEHS Clinical Research Unit (CRU)
RECRUITINGResearch Triangle Park, North Carolina, 27709, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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National Institutes of Health Clinical Center
RECRUITINGBethesda, Maryland, 20892, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Miami Hospital
WITHDRAWNMiami, Florida, 33101, United States
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University of Pittsburgh
COMPLETEDPittsburgh, Pennsylvania, 15261, United States