New hope for cancer patients with autoimmune conditions: immune checkpoint inhibitor trial expands access

NCT ID NCT03816345

Recruiting now Disease control Sponsor: National Cancer Institute (NCI) Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 31, 2026 · Updated 1 time

Summary

This study is for people who have both an autoimmune disease (like rheumatoid arthritis, lupus, or multiple sclerosis) and an advanced cancer that has spread or cannot be removed by surgery. It tests the safety and effectiveness of the immunotherapy drug nivolumab, given alone or with other treatments like ipilimumab, cabozantinib, or chemotherapy. The goal is to see if these combinations can shrink tumors while managing side effects in this specific patient group. About 300 adults will take part.

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Conditions

The condition(s) this trial relates to.

autoimmune disease cancer Crohn disease dermatomyositis hematopoietic and lymphoid cell neoplasm hematopoietic and lymphoid system neoplasm inflammatory bowel disease multiple sclerosis psoriasis psoriatic arthritis rheumatoid arthritis Sjogren syndrome systemic lupus erythematosus systemic sclerosis ulcerative colitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AUTOIMMUNE DISEASE CROHN DISEASE DERMATOMYOSITIS HEMATOPOIETIC AND LYMPHOID CELL NEOPLASM INFLAMMATORY BOWEL DISEASE MALIGNANT SOLID NEOPLASM MULTIPLE SCLEROSIS PSORIASIS PSORIATIC ARTHRITIS RHEUMATOID ARTHRITIS SJOGREN SYNDROME SYSTEMIC LUPUS ERYTHEMATOSUS SYSTEMIC SCLERODERMA ULCERATIVE COLITIS

Contacts and locations

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Locations

Dana-Farber Cancer Institute
RECRUITING

Boston, Massachusetts, 02215, United States
Emory University Hospital/Winship Cancer Institute
ACTIVE_NOT_RECRUITING

Atlanta, Georgia, 30322, United States
HaysMed
RECRUITING

Hays, Kansas, 67601, United States
Huntsman Cancer Institute/University of Utah
ACTIVE_NOT_RECRUITING

Salt Lake City, Utah, 84112, United States
Johns Hopkins University/Sidney Kimmel Cancer Center
RECRUITING

Baltimore, Maryland, 21287, United States
Laura and Isaac Perlmutter Cancer Center at NYU Langone
RECRUITING

New York, New York, 10016, United States

Contact Email: •••••@•••••
Lawrence Memorial Hospital
RECRUITING

Lawrence, Kansas, 66044, United States
Massachusetts General Hospital Cancer Center
RECRUITING

Boston, Massachusetts, 02114, United States
MedStar Georgetown University Hospital
RECRUITING

Washington D.C., District of Columbia, 20007, United States
Mercy Hospital Pittsburg
SUSPENDED

Pittsburg, Kansas, 66762, United States
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
RECRUITING

New York, New York, 10032, United States

Contact Email: •••••@•••••
NYP/Weill Cornell Medical Center
RECRUITING

New York, New York, 10065, United States
NYU Langone Hospital - Long Island
RECRUITING

Mineola, New York, 11501, United States

Contact Email: •••••@•••••
National Cancer Institute Developmental Therapeutics Clinic
RECRUITING

Bethesda, Maryland, 20892, United States
National Institutes of Health Clinical Center
ACTIVE_NOT_RECRUITING

Bethesda, Maryland, 20892, United States
Northwestern University
ACTIVE_NOT_RECRUITING

Chicago, Illinois, 60611, United States
Ohio State University Comprehensive Cancer Center
RECRUITING

Columbus, Ohio, 43210, United States
Rutgers Cancer Institute of New Jersey
RECRUITING

New Brunswick, New Jersey, 08903, United States
Salina Regional Health Center
RECRUITING

Salina, Kansas, 67401, United States
Siteman Cancer Center at Christian Hospital
RECRUITING

St Louis, Missouri, 63136, United States

Contact Email: •••••@•••••
Siteman Cancer Center at Saint Peters Hospital
RECRUITING

City of Saint Peters, Missouri, 63376, United States

Contact Email: •••••@•••••
Siteman Cancer Center at West County Hospital
RECRUITING

Creve Coeur, Missouri, 63141, United States

Contact Email: •••••@•••••
Siteman Cancer Center-South County
RECRUITING

St Louis, Missouri, 63129, United States

Contact Email: •••••@•••••
Smilow Cancer Center/Yale-New Haven Hospital
RECRUITING

New Haven, Connecticut, 06510, United States

Contact Email: •••••@•••••
Stanford Cancer Institute Palo Alto
ACTIVE_NOT_RECRUITING

Palo Alto, California, 94304, United States
The University of Kansas Cancer Center - Olathe
RECRUITING

Olathe, Kansas, 66061, United States

Contact Email: •••••@•••••
Thomas Jefferson University Hospital
ACTIVE_NOT_RECRUITING

Philadelphia, Pennsylvania, 19107, United States
UPMC Hillman Cancer Center
RECRUITING

Pittsburgh, Pennsylvania, 15232, United States
UT MD Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States
UT Southwestern Clinical Center at Richardson/Plano
RECRUITING

Richardson, Texas, 75080, United States
UT Southwestern Simmons Cancer Center - RedBird
RECRUITING

Dallas, Texas, 75237, United States

Contact Email: •••••@•••••
UT Southwestern/Simmons Cancer Center-Dallas
RECRUITING

Dallas, Texas, 75390, United States

Contact Email: •••••@•••••
UT Southwestern/Simmons Cancer Center-Fort Worth
RECRUITING

Fort Worth, Texas, 76104, United States

Contact Email: •••••@•••••
University Health Network-Princess Margaret Hospital
SUSPENDED

Toronto, Ontario, M5G 2M9, Canada
University Health Truman Medical Center
RECRUITING

Kansas City, Missouri, 64108, United States
University of Alabama at Birmingham Cancer Center
ACTIVE_NOT_RECRUITING

Birmingham, Alabama, 35233, United States
University of California Davis Comprehensive Cancer Center
RECRUITING

Sacramento, California, 95817, United States
University of Chicago Comprehensive Cancer Center
ACTIVE_NOT_RECRUITING

Chicago, Illinois, 60637, United States
University of Kansas Cancer Center
RECRUITING

Kansas City, Kansas, 66160, United States
University of Kansas Cancer Center - Lee's Summit
RECRUITING

Lee's Summit, Missouri, 64064, United States
University of Kansas Cancer Center - North
RECRUITING

Kansas City, Missouri, 64154, United States
University of Kansas Cancer Center at North Kansas City Hospital
RECRUITING

North Kansas City, Missouri, 64116, United States
University of Kansas Cancer Center-Overland Park
RECRUITING

Overland Park, Kansas, 66210, United States
University of Kansas Clinical Research Center
RECRUITING

Fairway, Kansas, 66205, United States
University of Kansas Health System Saint Francis Campus
RECRUITING

Topeka, Kansas, 66606, United States
University of Kansas Hospital-Indian Creek Campus
RECRUITING

Overland Park, Kansas, 66211, United States
University of Kansas Hospital-Westwood Cancer Center
RECRUITING

Westwood, Kansas, 66205, United States
University of Kentucky/Markey Cancer Center
RECRUITING

Lexington, Kentucky, 40536, United States
VCU Massey Comprehensive Cancer Center
RECRUITING

Richmond, Virginia, 23298, United States
Washington University School of Medicine
RECRUITING

St Louis, Missouri, 63110, United States

Contact Email: •••••@•••••
Wayne State University/Karmanos Cancer Institute
ACTIVE_NOT_RECRUITING

Detroit, Michigan, 48201, United States
Yale University
RECRUITING

New Haven, Connecticut, 06520, United States

Contact Email: •••••@•••••

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