INFLAMMATORY BOWEL DISEASE

This study is observing how well the drug guselkumab works for adults with moderate-to-severe Crohn's disease or ulcerative colitis in real-world UK clinics. It will track 220 patients to see if the treatment reduces symptoms, improves quality of life, and helps them stop using s…

This study follows 400 people with Crohn's disease or ulcerative colitis who are starting treatment with guselkumab in real-world medical settings. The main goal is to see how well the drug controls symptoms like abdominal pain, diarrhea, and rectal bleeding, and to measure its i…

This study aims to find the best way to give COVID-19 booster shots and seasonal flu vaccines to adults with weakened immune systems. Researchers want to know if getting both shots on the same day works as well as getting them a month apart, and if getting COVID boosters every 3 …

This small pilot study is testing whether morning light therapy can help reduce inflammation and improve symptoms in adults with ulcerative colitis who also have poor sleep. Participants will use a wearable device to track sleep and receive one hour of morning light therapy daily…

This study is testing the safety and effects of the immunotherapy drug nivolumab in people who have both advanced cancer and an autoimmune disease like lupus, rheumatoid arthritis, or Crohn's disease. It will enroll 300 adults to see if the drug can help control their cancer whil…

This study is testing a new monitoring program for veterans with inflammatory bowel disease (IBD), a chronic gut condition. The program helps patients track their symptoms and share updates with their care team between clinic visits. Researchers want to see if this closer monitor…

This study is testing whether a special diet that mimics the effects of fasting can help people with mild to moderate ulcerative colitis. Researchers want to see if this diet reduces gut inflammation and improves symptoms and quality of life. About 75 participants will follow the…

This study is testing whether morning bright light therapy, delivered through special glasses, can help control Crohn's disease symptoms. Researchers want to see if this light treatment can strengthen the gut lining, reduce inflammation, and improve quality of life. The study wil…

This study aims to understand how Crohn's disease affects bone health in teenagers. Researchers will compare bone marrow and bone density in 46 teens recently diagnosed with Crohn's disease against 46 healthy teens using MRI scans and blood tests. The goal is to learn if increase…

This study aims to understand if tiny plastic particles in our environment affect gut bacteria and inflammation, potentially increasing the risk for Crohn's disease and other bowel conditions. Researchers will analyze stool samples from pregnant women with Crohn's, healthy women,…

This study aims to learn how the body's immune system causes inflammation in the gut of people with Crohn's disease and ulcerative colitis. Researchers will observe up to 1,000 patients and collect blood and tissue samples to understand the disease better. The study does not test…

This study is testing an educational tool designed to help melanoma patients who also have autoimmune diseases (like rheumatoid arthritis or Crohn's disease) understand their treatment options with immune checkpoint inhibitor drugs. Researchers want to see if the tool is easy to …

This study aims to understand the connection between inflammatory bowel disease (IBD) and depression by looking at gut bacteria and body chemicals. Researchers will compare samples from 120 people in three groups: those with both conditions, those with just IBD, and healthy indiv…