INFLAMMATORY BOWEL DISEASE

This study is for people who have both an autoimmune disease (like rheumatoid arthritis, lupus, or multiple sclerosis) and an advanced cancer that has spread or cannot be removed by surgery. It tests the safety and effectiveness of the immunotherapy drug nivolumab, given alone or…

This study follows 50 people with moderate to severe Crohn's disease or ulcerative colitis to see how long they stay on guselkumab in real-world settings. Researchers will measure treatment persistence and early symptom improvements using patient diaries. The goal is to understan…

This study will follow 500 people with Crohn's disease or ulcerative colitis who are starting guselkumab, a biologic drug. Researchers will measure how many achieve remission and how the treatment affects daily life, including fatigue and work productivity. The goal is to underst…

This study tracks 220 adults with moderate-to-severe ulcerative colitis or Crohn's disease who are starting guselkumab, a biologic drug. Researchers will measure how many achieve remission (symptom control) and whether they can stop steroids. The goal is to see how well the drug …

This study tests whether a program of weekly surveys can help veterans with inflammatory bowel disease (IBD) feel better and avoid flare-ups. About 250 veterans at four VA hospitals will either get the usual care or also complete short weekly check-ins for 12 months. The goal is …

This study tests whether morning bright light therapy can help people with Crohn's disease or ulcerative colitis by reducing gut leaks and inflammation. About 30 adults with stable medication will use a light box each morning for 8 weeks. Researchers will check changes in gut bar…

This study tests whether one hour of morning light therapy each day for four weeks can improve sleep quality and reduce inflammation in adults with ulcerative colitis who have active inflammation and poor sleep. Thirty participants will wear a sleep tracker, complete surveys, and…

This study tests whether a special 5-day diet that mimics fasting can lower inflammation and improve quality of life in people with mild to moderate ulcerative colitis. Participants will follow the diet for three cycles while researchers track symptom changes. The goal is to see …

This study aims to learn how the immune system controls inflammation in the gut for people with Crohn's disease or ulcerative colitis. Up to 1,000 participants aged 0 to 75 will receive standard medical care and may provide blood, tissue, or white blood cell samples. No experimen…

This study looks at whether a protein in the blood called LRG can accurately show how active Crohn's disease or ulcerative colitis is in the gut. Researchers will compare LRG levels with standard endoscopic and symptom scores in 100 European adults. If successful, LRG could becom…

This study is testing an educational tool designed for people with melanoma who also have an autoimmune disease and are considering treatment with immune checkpoint inhibitors. Researchers want to see if the tool is easy to use and helpful for both patients and healthcare provide…

This study looks at how the gut and kidneys work together in people with enteric hyperoxaluria, a condition that raises the risk of kidney stones. Researchers will give participants a high-oxalate diet (like spinach) and measure oxalate levels in urine and stool. The goal is to u…

This early-phase study tests the safety of a new drug called SPH7854 in 111 healthy adults. Participants receive either the drug or a placebo, and researchers monitor side effects and how the drug moves through the body. The goal is to see if it is safe enough to test in people w…

This study is testing whether giving the COVID-19 booster and flu vaccine at the same time is as good as giving them a month apart for people with weakened immune systems. It also compares getting a COVID-19 booster every 3 months versus every 6 months. The trial involves 660 adu…

This study looks at whether removing a urinary catheter one day after colorectal surgery is as safe as the standard three days. About 176 adults having certain pelvic surgeries will be randomly assigned to early or standard removal. The goal is to see if shorter use lowers infect…

This study looks at gut bacteria and related chemicals in 120 adults to understand why inflammatory bowel disease (IBD) and depression often occur together. Researchers will compare people with both conditions, those with IBD only, and healthy volunteers. The goal is to find uniq…

The PLANET study is looking at whether tiny plastic particles in our environment can trigger gut inflammation and raise the risk of inflammatory bowel disease (IBD). Researchers will measure microplastics in stool samples from pregnant women, their healthy relatives, and people w…

This study uses MRI scans to look at bone marrow fat in teenagers newly diagnosed with Crohn's disease, comparing them to healthy teens. The goal is to understand if Crohn's affects bone health early on. Researchers will also measure bone density using other imaging methods. The …

This observational study will follow 1,000 pregnant women with inflammatory bowel disease (IBD) who are taking newer medications (non-anti-TNF biologics or targeted small molecules). Researchers will track serious infections and other adverse events in mothers and their children …