INFLAMMATORY BOWEL DISEASE

This study looks at the best way to give COVID-19 booster and flu shots to people with weakened immune systems (like those with rheumatoid arthritis, organ transplants, or HIV). It will compare getting both vaccines on the same day versus one month apart, and also test if getting…

This study is for people who have both an autoimmune disorder (like rheumatoid arthritis, lupus, or multiple sclerosis) and advanced cancer that has spread or cannot be removed. It tests a drug called nivolumab, which helps the immune system fight cancer, given alone or with othe…

This study tests a program called Measurement-Based Care (MBC) for veterans with inflammatory bowel disease (IBD). The program uses regular patient surveys to help doctors spot problems early and adjust treatment between clinic visits. Researchers will compare quality of life and…

This study tracks 220 adults with moderate-to-severe ulcerative colitis or Crohn's disease who are starting guselkumab, a biologic drug. Researchers will measure how many patients achieve remission (symptom control) and whether they can stop using steroids. The goal is to see how…

This study follows 400 people with Crohn's disease or ulcerative colitis who are starting guselkumab, a biologic drug. Researchers will measure how many achieve remission and how the drug affects fatigue, quality of life, and daily activities. The goal is to see how well the trea…

This study tests whether morning bright light therapy can improve gut health and quality of life in people with Crohn's disease or ulcerative colitis. Researchers will measure changes in intestinal barrier function, inflammation, and gut bacteria. The study enrolls 30 adults with…

This study tests whether morning light therapy can improve sleep and reduce inflammation in 30 adults with ulcerative colitis who have active inflammation and poor sleep. Participants wear a sleep tracker, complete surveys, and receive one hour of light therapy each morning for f…

This study tests whether a five-day diet that tricks the body into a fasting state can reduce inflammation and improve quality of life in people with mild to moderate ulcerative colitis. Participants will follow the diet for three cycles while researchers track symptoms like stoo…

This study looks at bone health in teenagers recently diagnosed with Crohn's disease compared to healthy teens. Researchers use MRI and other scans to measure bone marrow fat and bone density. The goal is to understand how Crohn's disease affects bones early on, which could help …

This study is testing a new educational tool designed for people with melanoma who also have an autoimmune disease (like rheumatoid arthritis or Crohn's disease) and may receive immune checkpoint inhibitor drugs. Researchers want to see if the tool is easy to use and helpful for …

This study looks at how tiny plastic particles (microplastics) in our environment might affect gut health and inflammation, especially in pregnant women and their families. Researchers will measure microplastics in stool samples and study the gut bacteria of 46 participants. The …

This study looks at how the immune system controls inflammation in the gut for people with Crohn's disease or ulcerative colitis. Up to 1,000 participants, from newborns to age 75, will receive standard medical care while researchers collect blood, tissue, and other samples. The …

This early-stage study is testing a new drug called SPH7854 in 111 healthy volunteers to see if it is safe and how the body processes it. The drug is being developed for inflammatory bowel disease, but this trial does not involve people with the condition. The main goal is to che…

This study looks at gut bacteria and related chemicals in 120 adults to understand why inflammatory bowel disease (IBD) and depression often occur together. Researchers will compare three groups: people with both IBD and depression, people with IBD only, and healthy volunteers. T…