Should you get your COVID and flu shots together? new study aims to find out for immunocompromised patients

NCT ID NCT06599658

Recruiting now Knowledge-focused Sponsor: McGill University Health Centre/Research Institute of the McGill University Health Centre Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study is testing whether giving the COVID-19 booster and flu vaccine at the same time is as good as giving them a month apart for people with weakened immune systems. It also compares getting a COVID-19 booster every 3 months versus every 6 months. The trial involves 660 adults with conditions like rheumatoid arthritis, lupus, inflammatory bowel disease, HIV, or who have had an organ transplant. Researchers will measure immune responses through blood tests and track side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: COVID-19 booster vaccine and seasonal influenza vaccine
What this could lead to: If successful, this could show the best way to time vaccines for immunocompromised people, improving protection against COVID-19 and flu.
What could go wrong: This is a Phase 2 trial, so results are still early. The findings may not apply to all immunocompromised groups, and vaccine responses can vary widely.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

COVID-19 HIV infectious disease immunodeficiency disease inflammatory bowel disease influenza rheumatoid arthritis systemic lupus erythematosus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COVID-19 IMMUNOCOMPROMISED HOST INFLAMMATORY BOWEL DISEASE INFLUENZA PEOPLE LIVING WITH HIV RHEUMATOID ARTHRITIS (RA) SOLID ORGAN TRANSPLANT RECIPIENTS SYSTEMIC LUPUS ERTHEMATOSUS

Contacts and locations

Locations

Centre hospitalier de l'Université de Montréal (CHUM)
RECRUITING

Montreal, Quebec, H2X 0C1, Canada
Maisonneuve -Rosemont Installation
RECRUITING

Montreal, Quebec, H1T2M4, Canada
Research Institute of McGill University Health Centre
RECRUITING

Montreal, Quebec, H4A 3J1, Canada

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