INFLUENZA

This study tests an experimental flu vaccine called BPL-1357, given as a shot or nasal spray, to see if it is safe and can protect against multiple flu types. About 129 healthy adults aged 18-55 will receive the vaccine or a placebo, then be exposed to a flu virus in a controlled…

This study compares a high-dose flu vaccine to the standard dose in 312 children aged 3-17 who have received a kidney, heart, or liver transplant within the past two years. The goal is to see if the high-dose vaccine triggers a stronger immune response and is just as safe. Partic…

This study tests a new program to help more children get their flu shot while in the hospital. The program brings together doctors, nurses, and families to make vaccination simple and routine. Researchers will track how many eligible kids receive the vaccine across 22,000 partici…

This large phase 3 trial is testing an experimental mRNA vaccine (mRNA-1018-H5) designed to protect against H5N1 pandemic influenza. Around 4,000 healthy adults aged 18 and older will receive two doses of the vaccine or a placebo. Researchers will measure immune responses and mon…

This study compares three different flu vaccines in 60 adults with blood cancers like leukemia or lymphoma. The goal is to see which vaccine triggers the strongest immune response in people with weakened immune systems. Participants will receive one of the vaccines and have their…

This study tests a new seasonal flu vaccine made from plants, called TVLP, in 728 adults aged 18 and older. The vaccine is compared to a standard flu shot to see if it is safe and triggers a strong immune response. The goal is to find the best dose for future development.

This study tests a new flu vaccine in 150 healthy pregnant women aged 18-39, between 20 and 32 weeks of pregnancy. Participants receive either the new vaccine or an existing one, and researchers check immune response and safety for both mother and baby. The goal is to see if the …

This early-stage trial tests a new influenza vaccine in 120 adults aged 60 and older. Participants receive either a high-dose vaccine, a standard-dose vaccine, or a placebo. The study focuses on safety and how well the vaccine triggers an immune response, with the goal of develop…

This early-stage study tests whether a new oral drug called VNT-101 is safe for people. About 78 healthy adults aged 18-59 will receive either the drug or a placebo. The goal is to check for side effects and how the body processes the drug, not yet to treat the flu.

This study looks at how well the flu drug baloxavir marboxil works in children under 12 and whether it stops the flu from spreading to family members. About 1,100 kids with flu symptoms will take the drug, and researchers will check for drug resistance and track infections in hou…

This study compares different antiviral drugs to see which one clears the flu virus fastest. It involves 3,000 adults aged 18-60 with early flu symptoms. Participants are randomly assigned to receive a drug or no treatment, and their viral levels are tracked daily for a week.

This study is testing whether a dietary supplement called IDP (Immune Defense Protein) can reduce the length and severity of cold and flu symptoms in people aged 60 and older. About 300 participants will take either a low or high dose of IDP or a placebo daily during cold and flu…

This phase 2 trial tests whether combining two antiviral drugs, baloxavir and oseltamivir, works better than oseltamivir alone for severe flu in people with weakened immune systems (such as blood cancer patients or stem cell transplant recipients). The study will measure how quic…

This study compares a high-dose flu vaccine to the standard dose in 270 lung transplant recipients who are 1 to 35 months post-transplant. The goal is to see if the high-dose vaccine triggers a stronger immune response and provides better protection against influenza. Participant…

This study looks at whether giving lung transplant recipients a high-dose flu vaccine for two years in a row provides better protection against the flu than the standard-dose vaccine. About 60 people who already took part in a previous flu vaccine study will be randomly assigned …

This study tests whether two antiviral drugs—suraxavir marboxil and oseltamivir (Tamiflu)—can prevent flu from spreading to uninfected roommates of flu patients in hospitals. About 384 people will take one of the drugs or a placebo for 5 days. Researchers will track how many get …

This study tests a new pill containing three ingredients (dipyrone, caffeine, and chlorpheniramine) to see if it works as well as a standard cold medicine for relieving stuffy nose and other cold and flu symptoms. About 620 adults with early cold or flu symptoms will take either …

This study tests whether a higher-dose version of the drug Ingavirin can help adults with the flu or other viral infections feel better faster. About 300 people will receive either the study drug or a placebo. The main goal is to see how quickly symptoms like fever, cough, and so…

This study tests a new medicine called JKN2301 for children aged 2 to 11 with the flu. It is a single-dose treatment compared to the standard 5-day oseltamivir (Tamiflu) course. The goal is to see if it safely reduces flu symptoms and fever faster. About 177 children will take pa…

This study screens up to 5,000 healthy adults aged 18-65 to see if they can join future research on infectious diseases like flu and Zika. Volunteers undergo a 3-5 hour checkup including blood tests, heart exam, and chest X-ray. The goal is to build a pool of eligible participant…

This study enrolls healthy adults who are already part of a respiratory virus challenge study at the NIH. Participants wear a smartwatch and use a smartphone to track temperature, heart rate, coughs, and other health signals. The goal is to see if these devices can detect subtle …

This early-stage study tests a new combination capsule (Ingavirin Forte) that contains two active ingredients against the standard single-ingredient Ingavirin. The goal is to see how the body processes each version and whether the combination is safe. Thirty-six healthy adults wi…

This study looks at how serious respiratory infections (like flu, COVID-19, and RSV) affect the ability of adults aged 60 and older to live independently. Researchers will follow 1,600 hospitalized seniors across multiple countries to track changes in daily activities such as bat…

This study tests whether a web-based educational program can improve pregnant women's knowledge about influenza and Tdap vaccines and increase their intention to get vaccinated. Researchers will compare the program to standard antenatal care in 351 pregnant women in Malaysia. Par…

This study looks at how breathing in woodsmoke changes the way your nose's immune system responds to the flu virus. Healthy adults aged 18-49 will be exposed to woodsmoke and then given a live but weakened flu vaccine to mimic infection. Researchers will measure immune markers an…

This study will compare immune responses in 36 healthy adults aged 18-55 who either receive a nasal spray flu vaccine or are deliberately infected with a controlled dose of influenza A (H3N2) virus. Researchers will track symptoms and measure immune markers in the blood and respi…

This study looks at whether drinking pasteurized milk containing harmless, inactive flu virus particles could lead to a positive flu test from a nose or throat swab. Researchers want to help the CDC improve how flu is tracked. About 30 healthy adults aged 18-64 will drink the mil…

This study follows 150 NIH staff members for about a year to see how their immune systems respond to flu and COVID-19 vaccines. Participants give monthly blood and nasal samples to measure antibodies in both the body and the nose. The goal is to understand how long immunity lasts…

This study aims to find the safest and most effective dose of a specific flu virus to give to healthy adults in a controlled setting. About 90 volunteers aged 18 to 55 will be exposed to the virus or a placebo and closely monitored. The goal is to create a reliable model for test…

This study aims to collect blood, nose, and saliva samples from up to 20,000 people aged 3 and older who have or may have a respiratory virus infection like flu or COVID-19. The samples will be stored and used in future research to better understand these viruses and how the immu…

This study gives healthy adults a controlled dose of flu virus to see how their immune system responds and how the virus travels through the air. Researchers will track who gets mild to moderate flu symptoms and monitor safety. The goal is to learn more about flu infection, not t…

This study looks at how the immune system of adults over 75 responds to the annual flu shot. Researchers want to know if a common virus called CMV affects how well the vaccine works. Participants will receive the flu shot for free and provide blood samples over several weeks. The…

This study tracks the immune response of 300 people with confirmed flu or COVID-19, comparing those who were recently vaccinated to those who were not. Participants provide blood, saliva, and nasal samples over 6 months, and some may opt for a lung fluid sample via bronchoscopy. …

This study is testing whether giving the COVID-19 booster and flu vaccine at the same time is as good as giving them a month apart for people with weakened immune systems. It also compares getting a COVID-19 booster every 3 months versus every 6 months. The trial involves 660 adu…

This study trains community health workers to create and share personal stories and infographics on social media to promote flu, COVID-19, and other respiratory virus vaccines. Researchers will survey the health workers' social media followers to see if the messages change their …

This study gives healthy adults aged 18-49 a controlled dose of the H3N2 flu virus via nasal spray to observe how the immune system fights it and how the virus spreads. Participants stay in the hospital for 8-12 days for close monitoring, with follow-up visits over 5 months. The …

This study reviews medical records from up to 400,000 U.S. Veterans to see how COVID-19 treatments like Paxlovid and remdesivir are used and how well they work. It also looks at RSV and flu patterns. The goal is to improve treatment strategies for respiratory viruses in the VA he…

This study follows 10,000 pregnant women in Nagpur, India, from early pregnancy through 42 days after birth. Researchers want to learn if catching flu or COVID-19 raises the risk of problems like preterm labor or severe pre-eclampsia. The goal is to provide clear evidence to help…