INFLUENZA

This study tested new modified RNA vaccines that target both the flu and COVID-19. Healthy adults aged 18 and older received a single shot of either a flu vaccine, a COVID-19 vaccine, or a combination of both. The goal was to check safety and how well the body's immune system res…

This study tested a new flu vaccine in 2,772 healthy children aged 6 to 35 months. The children received two doses of either the new vaccine or a control vaccine, 28 days apart. Researchers checked for side effects and measured immune response through blood tests. The goal was to…

This study tested a new seasonal flu vaccine grown in cells (Vero cells) to see if it prevents the flu. Over 7,000 adults received either the vaccine or a placebo shot. Researchers tracked who got the flu over 6 months and checked for side effects. The goal was to see if the vacc…

This study looked at whether adding special ingredients called adjuvants to two standard flu vaccines (Fluzone and Flublok) could improve the body's immune response. About 240 healthy adults aged 18-45 received either a vaccine alone or a vaccine with an adjuvant. Researchers che…

This study tested whether a quadrivalent (four-strain) flu vaccine works as well as or better than a trivalent (three-strain) vaccine in over 7,000 people aged 6 months and older in China. The main goal was to see if the four-strain shot triggers a stronger immune response agains…

This study tested different doses of an H5N8 (bird flu) vaccine with immune-boosting ingredients (adjuvants) in 1,380 adults. The goal was to see if the vaccines are safe and trigger a strong immune response. Results will help decide the best dose for future protection against bi…

This early-stage study tested a new flu vaccine that includes an extra H3 virus strain to see if it is safe and boosts the immune system better than standard flu vaccines. About 400 healthy adults aged 18-49 and 60+ took part. The goal is to improve protection against influenza, …

This study tested a new combination vaccine (mRNA-1083) that targets both COVID-19 and influenza in one shot. It involved 2,457 healthy adults aged 50 and older in Japan, Taiwan, and South Korea. The goal was to see how well the vaccine triggers an immune response and to check fo…

This study compared two types of flu vaccines—one made using eggs and one not—to see which triggers a stronger immune response in adults aged 18 to 64. Researchers followed 366 participants over two flu seasons to measure antibody levels. The goal was to understand if egg-based v…

This early-phase study tested a new universal influenza vaccine in 144 healthy adults aged 18 to 40. The goal was to check the vaccine's safety and how well it triggers an immune response. Participants received either the vaccine or a placebo, and researchers monitored for side e…

This early-stage study tested an experimental flu vaccine called FluMos-v2 in 30 healthy adults aged 18 to 50. The vaccine is designed to protect against multiple flu strains at once, unlike current shots that target only one or two. Participants received two doses four months ap…

This study tested a new combination vaccine (mRNA-1083) that targets both influenza and COVID-19 in a single shot. About 1,320 healthy adults aged 18 to 64 took part. Researchers measured how well the vaccine boosted immunity and monitored for side effects. The goal is to simplif…

This study tested a new mRNA-based flu vaccine (mRNA-1010) in 172 healthy adults aged 18-50 and 65-80. The goal was to see if it is safe and triggers a strong immune response compared to standard flu vaccines. Results will help decide if larger studies are needed.

This study tested whether simple digital reminders sent through Denmark's official government email system could encourage more adults aged 18-64 with chronic diseases to get their flu shot. Over 300,000 participants were included, and the goal was to see if these behavioral nudg…

This study tested a new combination vaccine that aims to protect against both the flu and COVID-19 with a single shot. Researchers enrolled 1,758 healthy adults to check the vaccine's safety and how well it triggers the immune system. The goal is to simplify annual vaccinations b…

This early-stage study tested a single dose of an experimental mRNA flu vaccine in 50 healthy adults aged 18 to 49. The main goal was to check safety at three different dose levels. A small group also received a standard flu shot for comparison. The study is complete and helps pa…

This study tested a new seasonal flu vaccine made from animal cells instead of chicken eggs in over 3,200 adults aged 50 and older. Participants received either the new cell-based vaccine or a standard egg-based vaccine, and researchers measured their immune response and side eff…

This study tested a single shot vaccine that aims to protect against both COVID-19 and the flu. About 932 adults aged 50 to 64 received the experimental mRNA-1083 vaccine. Researchers checked for side effects and measured antibody levels one month after vaccination to see how wel…

This study tested two different doses of an experimental H7 bird flu vaccine, each combined with an immune booster (MF59), against a version without the booster. About 581 healthy adults aged 18 and older took part. The goal was to see which dose produced the strongest immune res…

This study tested a flu vaccine for the H1N1 virus in 110 pregnant women. The goal was to see if the vaccine is safe and helps the body fight the virus. Women received two doses and were monitored for side effects and immune response. Results help guide flu protection during preg…

This study tested a new method for making the seasonal flu vaccine in nearly 2,000 healthy adults aged 18 and older. The goal was to see if the new method produces a similar immune response and is as safe as the current method and a licensed flu vaccine. The study also checked th…

This study tested a new mRNA vaccine designed to protect against a future flu pandemic. 157 healthy adults received either the experimental vaccine, a licensed flu shot, or a placebo. Researchers monitored side effects and immune responses for 13 months to see if the vaccine is s…

This early-stage study tested a new way to make a flu vaccine that might protect against many different flu strains, not just one. Researchers gave an H5N1 flu shot to 32 adults, some of whom had previously received other experimental flu vaccines. The goal was to see if this 'pr…

This study tested a single combined vaccine that aims to protect against both COVID-19 and influenza. About 8,800 healthy adults received either the combo shot or separate vaccines. Researchers monitored safety and immune responses for 6 months to see if the combined approach is …

This study tested whether sending text message reminders to parents could increase flu vaccination rates among children. Over 228,000 kids aged 6 months to 18 years from the Children's Hospital of Philadelphia network took part. Researchers compared vaccination rates 30 days afte…

This study checked how well a new test called VitaSIRO solo™ detects COVID-19, flu, and RSV from nose swabs. Over 1,200 people with cold or flu symptoms took part. The test was compared to standard lab tests to see if it is accurate and reliable.

This large study tested whether a high-dose flu vaccine works better than the standard-dose version in adults aged 65 and older. Over 330,000 participants were randomly assigned to receive either the high-dose or standard-dose shot. The main goal was to see which vaccine better p…

This study combined data from two large trials in Denmark and Spain involving over 466,000 older adults to compare the effectiveness of a high-dose flu vaccine versus a standard-dose flu vaccine. The goal was to see which vaccine better prevents severe outcomes like hospitalizati…

This study tested whether a high-dose flu vaccine works better than the standard-dose shot in adults aged 50 to 64. About 1,180 participants received either the high-dose or standard vaccine, and researchers measured their antibody levels 28 days later. The goal is to see if the …

This study tested a new medicine called CD388, given as a single set of shots, to see if it can prevent the flu in healthy adults aged 18 to 64. Over 5,000 participants received either the study drug or a placebo. The goal was to find the right dose that safely reduces flu cases …

This study tested a single dose of baloxavir marboxil against a 5-day course of oseltamivir in 100 Chinese children aged 1 to 12 with flu symptoms. The main goal was to check safety and how quickly symptoms like fever and cough improved. Results help doctors understand if a one-t…

This study looked at over 230,000 adults treated for lower respiratory tract infections (like pneumonia or bronchitis) in French primary care from 2015 to 2024. Researchers used anonymous electronic health records to describe patient characteristics and track antibiotic prescribi…

This study tracked 289 healthcare workers in short-stay hospital wards to find out how often they catch the flu, even without symptoms. Researchers compared flu rates between vaccinated and unvaccinated workers. The goal is to better understand the risk of unknowingly spreading f…

This study examined 30 ICU patients on ventilators for severe H1N1 flu. Researchers analyzed lung fluid and blood to understand how the virus and the body's immune response interact. The goal was to find better ways to treat severe flu and prevent lung damage.

This study looked at whether a community-designed program could help more people from minority ethnic groups, low-income households, and underserved migrants get vaccinated against COVID-19 and the flu. About 5,900 adults in East London took part. The main goal was to see if the …

This study looked at how adults' immune systems respond to the live attenuated flu vaccine given as a nasal spray. Researchers want to understand why this vaccine is less effective in adults than in children. By measuring antibodies and other immune markers in 51 participants, th…

This study looked at 241 adults hospitalized with the flu to understand how the infection can harm the heart. Researchers checked for problems like heart failure, heart attacks, and abnormal heart function. The goal was to learn more about the link between flu and heart complicat…

This study collected blood samples from 90 people—children aged 6 months to under 9 years and adults 65 and older—before and after they received their flu vaccine. The samples were sent to health experts to analyze immune responses and guide recommendations for future flu vaccine…

This study gave a nasal flu vaccine to 33 healthy adults to mimic a mild flu infection. Researchers then collected nose samples to measure how the virus grows and how the immune system reacts. The goal was to create a safe way to study flu infections in people, not to test a new …

This study looked for a substance in the blood (called HLA-G5) that might help doctors predict which flu patients in the intensive care unit (ICU) are at higher risk of severe breathing problems or death. Researchers studied 227 adults and children with severe flu. They also coll…

This study looked at 32 adults in the ICU on ECMO (a heart-lung machine) who had severe influenza or COVID-19 and a serious fungal lung infection called aspergillosis. Researchers measured how the antifungal drug voriconazole moved through their bodies to find the best dose. The …

This study explored how the flu virus affects the types of bacteria living in the nose and throat, and how the body's immune system reacts. Researchers gave 17 healthy adults either a flu vaccine nasal spray or a saltwater mist, then tracked changes over time. The goal was to und…

This study followed 38 adults who survived severe H1N1 flu that caused lung failure. Researchers compared those who needed a machine to add oxygen to their blood with those who did not. They measured lung function, quality of life, and mental health at least 9 months after leavin…

This study looked at how bacteria living in the nose and gut affect the immune response to a nasal flu vaccine in 201 children and teens aged 6 to 17. Participants received the vaccine either right away or after a delay, and researchers collected samples to measure antibodies and…

This completed pilot study tested whether measuring a protein called MxA in the blood can help doctors decide when to stop antiviral treatment for flu or COVID-19. 86 adults with these infections were randomly assigned to either MxA-guided treatment or standard care. The goal was…

This study gave a specific H3N2 flu virus to 11 healthy adults aged 18-50 to learn how the immune system reacts during and after infection. Participants stayed in a clinic so researchers could closely monitor symptoms and virus spread. The goal was to confirm the virus dose neede…

This study aimed to understand how the immune system responds to seasonal and H1N1 flu vaccines in healthy adults. Researchers collected blood and nasal samples from 203 NIH employees before and after vaccination over two months. The goal was to learn more about the body's defens…

This study followed 919 pregnant women in Paris to see how often they caught H1N1 flu and how it affected their pregnancy. Researchers measured infection rates and checked for any impact on the baby. They also looked at the safety of the flu vaccine during pregnancy.