INFLUENZA

This early-stage trial is testing a new mRNA flu vaccine in 50 healthy adults aged 18 to 49. The vaccine uses mRNA technology to target a specific flu strain. Researchers will compare its safety and immune response to a standard seasonal flu shot. The goal is to see if the new va…

This early-stage trial tests a single dose of a new mRNA flu vaccine (VRC H1ssF-3928) in 50 healthy adults aged 18 to 49. The vaccine aims to teach the body to fight a stable part of the flu virus. Researchers are checking for side effects and measuring immune responses, comparin…

This study tested a new mRNA-based flu vaccine in over 1,100 adults aged 50 and older. The vaccine targets multiple flu virus proteins to potentially provide stronger protection. Researchers compared it to standard flu shots and monitored safety and immune response for six months…

This completed Phase 3 trial tested whether an adjuvanted flu vaccine (FLUAD Quadrivalent) triggers a stronger immune response than a standard flu vaccine (FluQuadri) in 192 healthcare workers in Lima, Peru. Participants received one dose of either vaccine, and researchers measur…

This completed Phase 4 trial tested whether the Butantan Institute's seasonal flu vaccine is as safe and effective as the Sanofi vaccine. A total of 632 Brazilian adults aged 18 to 69 received one of the two vaccines. Researchers measured immune response through blood tests and t…

This early-stage trial tested a new universal influenza vaccine called fH1/DSP-0546LP in 144 healthy adults aged 18 to 40. The goal was to check safety and how well the vaccine triggers an immune response. Participants received two shots three weeks apart, with different doses or…

This study tested a new mRNA vaccine designed to protect against a future flu pandemic. Healthy adults aged 18-49 and 65-84 received either the experimental vaccine, a licensed flu shot, or a placebo. Researchers monitored safety and immune responses for about 13 months to see if…

This study tested new modified RNA vaccines that target both influenza and COVID-19, given as a single shot. Over 2,600 healthy adults aged 18 and older took part, receiving either a flu vaccine, a COVID-19 vaccine, or a combination of both. The main goal was to check safety and …

This study tested two different H5N8 bird flu vaccines in 1380 healthy adults to see how safe they are and how well they trigger the immune system. Participants received different doses of the vaccine with either AS03 or MF59 adjuvant. The goal is to find the best dose and adjuva…

This early-stage study tested an experimental flu vaccine called FluMos-v2 in 30 healthy adults aged 18 to 50. The vaccine is designed to protect against multiple flu strains at once, unlike current vaccines that target only one. Participants received two shots four months apart …

This study tested a new seasonal flu vaccine made from animal cells instead of eggs in over 3,200 adults aged 50 and older. Participants received either the new vaccine or a standard egg-based flu shot, and researchers measured their immune response and side effects. The goal was…

This large Phase 3 trial tested a new quadrivalent flu vaccine in over 2,700 healthy children aged 6 to 35 months. The study compared two doses of the experimental vaccine against a standard flu vaccine to see how well it triggers an immune response and whether it is safe. Resear…

This early-stage trial tested several experimental mRNA vaccines that aim to protect against both influenza and SARS-CoV-2 in a single injection. About 1,758 healthy adults aged 18 to under 80 took part. The main goals were to check safety and measure the immune response, with re…

This phase 2 study tested a non-adjuvanted H1N1 flu vaccine in 110 pregnant women to see if it is safe and triggers a good immune response. Participants received two doses of the vaccine and were monitored for side effects. The goal is to protect both mothers and their babies fro…

This study tested a single combined vaccine that aims to protect against both COVID-19 and influenza. About 8,800 healthy adults received either the combo shot or separate vaccines. Researchers checked for side effects and measured immune responses over six months to see if the c…

This study tested a new combination vaccine called mRNA-1083 that aims to protect against both COVID-19 and the flu with a single shot. It involved 2,457 healthy adults aged 50 and older in Japan, Taiwan, and South Korea. The main goals were to check how well the vaccine triggers…

This study tested a new mRNA-based flu vaccine (mRNA-1010) in 172 healthy adults aged 18-50 and 65-80. The goal was to check its safety and how well it triggers the immune system compared to standard flu vaccines. Results help determine if the vaccine is safe and effective enough…

This study tested whether a new flu vaccine made in cells (instead of eggs) can prevent the flu. About 7,250 adults received either the vaccine or a placebo shot. Researchers then checked for flu infections over 6 months. The goal was to see if the vaccine protects against flu st…

This study compared how well egg-based and non-egg-based flu vaccines trigger the immune system in adults aged 18 to 64. Researchers wanted to see if egg adaptation weakens the vaccine's effectiveness. Over two flu seasons, 366 participants received one of three vaccines: a stand…

This study tested a new combination vaccine called mRNA-1083 that aims to protect against both flu and COVID-19 in a single shot. About 1,320 adults aged 18 to 64 took part. Researchers measured the immune response and checked for side effects to see if the combo vaccine works as…

This study looked at whether adding special ingredients called adjuvants to two standard flu vaccines (Fluzone and Flublok) could make them work better. About 240 healthy adults aged 18 to 45 received either a regular flu shot or one with an adjuvant. Researchers checked for side…

This study tested a single shot that aims to protect against both COVID-19 and the flu. About 932 adults aged 50 to 64 received the experimental mRNA-1083 vaccine. Researchers checked for side effects and measured antibody levels one month after vaccination to see how well the va…

This study tested two different doses of an experimental H7 flu vaccine with an added booster (adjuvant) against a version without the booster. About 581 healthy adults aged 18 and older took part. The goal was to see which dose produced the strongest immune response and was safe…

This early-stage study tested a 'prime-boost' approach for a universal flu vaccine. Researchers gave an inactivated H5N1 flu shot to 32 healthy adults, some of whom had previously received other experimental flu vaccines. The goal was to see if this method could trigger broad imm…

This study tested a seasonal flu vaccine made with a modified manufacturing process in healthy adults aged 18 and older. The goal was to see if the new process produces a vaccine that works as well as the current version and is as safe as a licensed flu vaccine. About 1,928 parti…

This completed Phase 1 trial tested a new flu vaccine that includes an extra H3 strain, aiming to improve protection against influenza. The study involved 400 healthy adults aged 18-49 and 60+, comparing the new vaccine to standard flu shots. Researchers checked for side effects …

This completed Phase 2/3 trial tested whether adding baloxavir to standard oseltamivir treatment helps hospitalized flu patients clear the virus faster. Fifteen adults with confirmed influenza were randomly assigned to receive either the combination or oseltamivir alone. The main…

This study checked how well a new test called VitaSIRO solo™ detects COVID-19, flu, and RSV in people with respiratory symptoms. Over 1,200 participants provided nose and throat swabs. The test's accuracy was compared to standard lab methods.

This study tested a new medicine called CD388, given as a single set of three shots, to see if it can prevent the flu in healthy adults aged 18 to 64. Over 5,000 participants received either CD388 or a placebo. Researchers measured how many people got the flu over the next 24 wee…

This study tested whether a high-dose flu vaccine works better than the standard dose in adults aged 50 to 64. About 1,180 participants received either the high-dose or standard-dose shot, and researchers measured their immune response 28 days later. The goal is to see if the str…

This study tested whether sending a one-time text reminder to parents could increase flu vaccination rates among children. Over 228,000 patients aged 6 months to 18 years at Children's Hospital of Philadelphia were included. Researchers compared vaccination rates 30 days after th…

This phase 3 study tested a quadrivalent (four-strain) influenza vaccine against two trivalent (three-strain) vaccines in over 7,100 Chinese participants aged 6 months and older. The goal was to see if the quadrivalent vaccine triggers a stronger immune response and provides broa…

This study combines data from two large trials in Denmark and Spain involving over 466,000 older adults. It compares the high-dose flu vaccine (Efluelda/Fluzone High-Dose) to the standard-dose flu shot to see which better prevents severe outcomes like hospitalization for flu or p…

This completed study tested whether sending behavioral nudges through Denmark's official electronic letter system could increase flu vaccination among adults aged 18-64 with chronic diseases. Over 300,000 participants were randomly assigned to receive different types of letters o…

This large study tested whether a high-dose flu vaccine works better than the standard-dose shot in adults 65 and older. Over 332,000 participants were randomly assigned to receive either the high-dose or standard-dose vaccine. Researchers tracked hospitalizations for flu, pneumo…

This study compared a single dose of baloxavir marboxil to a 5-day course of oseltamivir in 100 Chinese children aged 1 to 12 with flu symptoms. The main goal was to check safety, including side effects. Researchers also measured how quickly symptoms like cough and fever improved…

This Phase 3 trial tested whether a single pill containing paracetamol (pain reliever/fever reducer), fexofenadine (antihistamine), and phenylephrine (decongestant) works better than a placebo for treating cold and flu symptoms. 567 adults in Brazil took the combo pill or a place…

This study aimed to understand how the immune system responds to seasonal and H1N1 flu vaccines in healthy adults. Researchers collected blood and nasal samples from 203 NIH employees before and after vaccination. The goal was to analyze immune responses to improve future vaccine…

This study followed 241 adults hospitalized with the flu to see how the infection impacts the heart. Researchers tracked heart complications like new or worsening heart failure, heart attacks, and cardiac arrest. The goal was to better understand the link between influenza and he…

This completed study gave 11 healthy adults a specially made H3N2 flu virus via nasal spray to see how their immune systems reacted. Participants were quarantined for at least 8 days in a hospital-like setting. The goal was to learn more about flu infection and immune response, n…

This study looked at how bacteria living in the nose and gut influence the immune response to a nasal flu vaccine in 201 children aged 6 to 17. Half got the vaccine right away, half waited 28 days. Researchers collected samples before and after vaccination to measure antibodies a…

This study looked at why the live attenuated influenza vaccine (LAIV), given as a nasal spray, is less effective in adults than in children. Researchers measured antibody levels in 51 healthy adults after vaccination to understand the immune response. The goal is to use these ins…

This study tested whether measuring a protein called MxA in the blood can help doctors decide when to stop antiviral drugs in patients with flu or COVID-19. Researchers enrolled 86 adults and compared standard care to MxA-guided treatment. The goal was to see if the test could re…

This study gave healthy adults a nasal flu vaccine to safely mimic a mild flu infection. Researchers then measured virus levels and immune responses in nasal samples. A small group also had lung function tests. The goal was to create a reliable model for studying flu without caus…

This completed study analyzed over 230,000 adults in France who had lower respiratory tract infections like pneumonia, bronchitis, or flu. Researchers used anonymous electronic health records from 2015 to 2024 to describe patient characteristics, how often antibiotics were prescr…

This study looked at how the flu virus changes the types of bacteria living in the nose and throat, and how the body's immune system reacts. Researchers gave 17 healthy adults either a flu vaccine nasal spray or a saltwater mist, then tracked bacterial changes and immune response…

This study looked at 32 adults in the ICU on ECMO life support who had severe influenza or COVID-19 and a serious fungal lung infection called aspergillosis. Researchers measured how the antifungal drug voriconazole behaves in the body to find the best dose for these very ill pat…

This study tracked 289 healthcare workers in short-stay hospital wards to see how often they caught the flu, both with and without symptoms. Participants gave blood samples and nasal swabs to confirm infections. The goal is to understand how many silent flu cases occur among staf…

This study followed 919 pregnant women in Paris to see how often they caught H1N1 flu during the 2009 pandemic and what happened to their pregnancies. Researchers also checked if the flu vaccine was safe. The goal was to better understand the risks of flu during pregnancy.

This study looked at 30 people in the ICU with severe H1N1 flu who needed a breathing machine. Researchers collected fluid from the lungs to study the virus and the body's immune response. The goal was to learn more about what causes severe illness, not to test a new treatment.

This completed study looked at 227 adults and children in the intensive care unit with severe flu. Researchers wanted to see if a specific blood marker (soluble HLA-G5) could predict which patients would develop severe breathing failure. They also collected respiratory samples to…

This study followed 38 adults who survived severe breathing failure from the 2009 H1N1 flu. Researchers compared those who needed a machine to oxygenate their blood (ECMO) with those who did not. They measured lung function, quality of life, and mental health at least 9 months af…

This study tested a patient engagement tool (PET) designed to encourage COVID-19 and flu vaccination among underserved populations in East London, including minority ethnic groups, migrants, and low-income individuals. Over 5,900 adults from six GP practices were randomly assigne…

This study collected blood samples from 90 children (6 months to under 9 years) and adults 65 and older after they received the 2019-2020 flu vaccine. The samples were sent to health agencies like the WHO and CDC to help them decide which flu strains to include in future vaccines…