New mRNA flu shot shows promise in older adults

NCT ID NCT06744205

Completed ⭐️ VACCINE ⭐️ Sponsor: Sanofi Pasteur, a Sanofi Company Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a new mRNA-based flu vaccine in over 1,100 adults aged 50 and older. The vaccine targets multiple flu virus proteins to potentially provide stronger protection. Researchers compared it to standard flu shots and monitored safety and immune response for six months.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: hexavalent influenza mRNA vaccine (mRNA HA + mRNA NA)
What this could lead to: If successful, this could lead to a more effective flu vaccine that offers broader protection for older adults.
What could go wrong: This is an early-phase trial (Phase 1/2) with a limited number of participants. The vaccine may not prove more effective than existing flu shots, and side effects are still being evaluated.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

influenza prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEALTHY VOLUNTEERS INFLUENZA

Contacts and locations

Locations

AMR - Chicago- Site Number : 8400012

Oak Brook, Illinois, 60532, United States
AMR Las Vegas - Site Number : 8400016

Las Vegas, Nevada, 89119, United States
AMR Miami- Site Number : 8400021

Coral Gables, Florida, 33134, United States
AMR Mobile- Site Number : 8400022

Mobile, Alabama, 36608, United States
Accel Research Site - NeuroStudies.net, LLC - ERN - PPDS- Site Number : 8400001

Decatur, Georgia, 30030-2627, United States
Accel Research Sites - Maitland- Site Number : 8400007

Maitland, Florida, 32751, United States
Accel Research Sites Network - Birmingham- Site Number : 8400008

Birmingham, Alabama, 35216, United States
Accel Research Sites Network - DeLand Clinical Research Unit- Site Number : 8400003

DeLand, Florida, 32720, United States
ActivMed Practices & Research- Site Number : 8400005

Methuen, Massachusetts, 03110, United States
Alliance for Multispeciality Research - Clinical Research Consortium- Site Number : 8400015

Tempe, Arizona, 85281, United States
Alliance for Multispeciality Research - Fort Myers- Site Number : 8400013

Fort Myers, Florida, 33912, United States
Alliance for Multispeciality Research - Kansas City- Site Number : 8400019

Kansas City, Missouri, 64114, United States
Alliance for Multispeciality Research - Knoxville- Site Number : 8400017

Knoxville, Tennessee, 37920, United States
Alliance for Multispeciality Research - Lexington- Site Number : 8400018

Lexington, Kentucky, 40509, United States
Alliance for Multispeciality Research - Newton- Site Number : 8400020

Newton, Kansas, 67114, United States
Alliance for Multispeciality Research - Wichita East- Site Number : 8400014

Wichita, Kansas, 67207, United States
Boston Clinical Trials- Site Number : 8400009

Boston, Massachusetts, 02131, United States
Charlottesville Medical Research- Site Number : 8400004

Charlottesville, Virginia, 22911, United States
Coastal Carolina Research Center - North Charleston- Site Number : 8400002

North Charleston, South Carolina, 29405, United States
Innovation Medical Research Center - Palmetto Bay- Site Number : 8400011

Palmetto Bay, Florida, 33157, United States
Investigational Site Number : 0360001

Botany, New South Wales, 2019, Australia
Investigational Site Number : 0360002

Melbourne, Victoria, 3124, Australia
Investigational Site Number : 0360003

Bayswater, Victoria, 3153, Australia
Quest Research Institute- Site Number : 8400010

Farmington Hills, Michigan, 48334, United States

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