HEALTHY VOLUNTEERS

This early-stage trial is testing a new experimental medicine called NNC1679-0001 for type 2 diabetes. Researchers want to see if it is safe and how well the body tolerates it. The study includes both healthy volunteers and people with type 2 diabetes, who will receive either a s…

This early-phase trial tests a new drug called PRO-203, given as a single shot under the skin. First, healthy volunteers will check safety; then, people with systemic sclerosis (a rare autoimmune disease that hardens skin and organs) will receive the drug. The main goal is to see…

This study tests whether suvorexant, a medicine used for sleep problems, can help people with alcohol use disorder (AUD) by changing how the brain's dopamine system works. About 180 adults (ages 18-75) with AUD and healthy volunteers will take either suvorexant or a placebo daily…

This study tests a new drug called BMS-986470 in healthy volunteers and people with sickle cell disease. The goal is to check its safety, how the body processes it, and whether it might help control the disease. The trial is in early phases and involves about 184 participants.

This early-stage study tests a new daily pill, RO7795081, in 30 healthy Chinese adults who are overweight or have obesity. The main goal is to check the drug's safety and how the body handles it. Participants will receive either the drug or a placebo, and researchers will monitor…

This early-stage trial tests a new drug called NNC0497-0040 in healthy people, those with overweight or obesity, and people with type 1 diabetes who are also overweight. The goal is to see if the drug is safe and tolerable when given as a weekly injection. About 146 participants …

This first-in-human trial tests an oral drug called SAR447971 (KT-485) in healthy volunteers and people with hidradenitis suppurativa (HS), a chronic skin condition causing painful lumps. The study has three parts: single and multiple doses in healthy people, and multiple doses i…

This early-stage study tests a new drug called MTX-101 in healthy adults and people with type 1 diabetes. The main goal is to check for side effects, see how long the drug stays in the body, and learn how it affects immune cells. About 96 participants will receive either a single…

This study tests an experimental drug called JUV-161 in healthy volunteers aged 40 to 65 who will have one leg immobilized for several weeks. The goal is to see if the drug can prevent muscle wasting (atrophy) and is safe. Participants receive weekly injections of either JUV-161 …

This study tests an experimental drug called ALN-PNP in healthy adults and people with a liver condition called MASLD who have a specific gene variant. The main goal is to check safety and how the body handles the drug. It is a first-in-human trial, so the drug is not yet approve…

This early-stage trial tests an experimental drug called NNC0581-0001 in 48 adults with fatty liver and suspected liver inflammation. Participants receive three monthly injections of either the drug or a placebo. The main goal is to check safety and how the drug moves through the…

This early-stage study tests a new drug, CPTX2309, to see if it is safe and tolerable. It involves 64 healthy adults and people with moderate to severe rheumatoid arthritis or lupus. Researchers will monitor side effects, lab results, and immune responses to determine the drug's …

This early-stage study tests whether the experimental drug TAK-781 is safe and tolerable in healthy volunteers and in people with primary sclerosing cholangitis (PSC), a chronic liver disease. The study also looks at how the body processes the drug. About 134 participants will be…

This early-stage trial tests a single dose of an inhaled drug called RJ026 in 42 healthy volunteers and 42 people with interstitial lung disease (ILD). The goal is to see how much drug reaches the lungs and blood, and whether it is safe. Researchers hope that inhaling the drug wi…

This study tests an experimental drug called NNC4004-0002 in 60 adults with high uric acid but no symptoms. Participants receive either the drug or a placebo as a single injection under the skin. The main goal is to check safety and how the body handles the drug, with a secondary…

This study tests whether artificial intelligence can plan cardiac MRI scans as accurately as expert radiographers. 150 adults will receive both an AI-planned and a standard scan, and doctors will compare the image quality and time taken. If successful, AI could help reduce long w…

This early-stage trial tests a radioactive imaging agent called RAD301 in 9 people: healthy volunteers and patients with pancreatic, lung, esophageal, cervical, endometrial, or ovarian cancer. The goal is to see how safe it is and how it travels through the body. If it works, it …

This study tests a special camera that takes detailed images of the retina using many wavelengths of light. Researchers hope it can find early signs of eye diseases like age-related macular degeneration, diabetic retinopathy, and glaucoma. About 1,000 adults in Melbourne, Austral…

This study tests a new PET imaging method that uses 10 to 100 times less radiation than current scans to detect Alzheimer's disease and other dementias. Researchers will scan 200 adults (including healthy volunteers) after injecting a radioactive tracer, aiming to see if shorter …

This study tests a new PET imaging method that uses much less radiation to find neuroendocrine tumors. About 200 healthy volunteers and people with these tumors will get an injection of a radioactive tracer and be scanned on a high-sensitivity PET machine. The goal is to see if t…

This study tests a new vaccine (PCV21) designed to protect babies against 21 types of pneumococcal bacteria, which can cause pneumonia and other serious infections. About 2,200 healthy infants will receive four doses of either the new vaccine or an existing one starting at 2 mont…

This study tests a new software called Motion Reset that may prevent or reduce cybersickness—symptoms like nausea, dizziness, and headache—when using virtual reality. Healthy adults aged 18 to 60 will try different VR experiences and then play a commercial VR game while reporting…

This study tests the safety of a new drug called IGT-303 in healthy volunteers and people with chronic kidney disease (CKD). About 94 participants will receive either the drug or a placebo, given as a shot under the skin or into a vein. Researchers will monitor for side effects t…

This study tests if mulberry leaf extract capsules are safe for healthy people with slightly high blood sugar. 48 volunteers will take either the extract or a placebo three times a day for 8 weeks. Researchers will check blood counts, liver and kidney function, and blood sugar le…

This early study tests whether a device that sends electrical pulses to muscles and the spinal cord can improve arm, hand, or leg movement in people with paralysis from spinal cord injury, stroke, or other nerve damage. Up to 64 participants will attend sessions five times a week…

This study tests whether a 12-week program combining modern dance with mindfulness practices can improve psychological wellbeing, reduce stress, and increase happiness in recreational adult dancers. About 160 participants will be randomly assigned to the program or a waitlist. Th…

This early-stage study tests a new drug called CDR132L in 32 healthy adults. Researchers want to see how much of the drug gets into the blood when given as a shot under the skin compared to an IV drip. The goal is to find the best way to give this medicine to people with heart fa…

This study aims to understand what happens in the brain when someone thinks about or attempts suicide. Researchers will use brain scans, sleep monitoring, blood tests, and questionnaires to compare four groups: people with recent suicidal thoughts or attempts, those with past sui…

This study follows 1,500 children ages 8 to 17 over several years to learn how genes, sleep, mood, and environment affect eating behavior and overall health. Participants wear wrist monitors, answer smartphone surveys, and provide samples like blood and stool. The goal is to iden…

This study in 140 healthy adults tests how well different tablet versions of the drug BMS-986435 are absorbed into the body and whether taking it with food changes absorption. Participants will receive one or more doses of the drug in different tablet forms. The goal is to pick t…

This study collects white blood cells from healthy volunteers using a procedure called cytapheresis. The cells are used for lab research, not to treat any disease. Participants must be 18 or older and can donate every 56 days.

This study explores whether a single 20-minute session combining mindfulness with high-intensity interval training (HIIT) can improve executive function—skills like focus and flexibility—in children aged 10 to 12. Participants will try four conditions: mindfulness plus HIIT, mind…

This early-stage trial is testing a new drug called ABBV-313 in healthy adult volunteers. The main goal is to check if the drug is safe and how the body handles it, including how it is absorbed and broken down. Participants receive either the drug or a placebo as an injection or …

This study collects blood, bone marrow, urine, and tissue samples from up to 6,000 people with solid tumors, blood cancers, or non-cancerous blood disorders, as well as from their healthy family members who are stem cell donors. The samples are stored and used in research to bett…

This study looks at how social factors like race and ethnicity influence how people express pain and how others assess it. Researchers will measure pain responses and brain activity in healthy volunteers, then test whether feedback can improve accuracy in judging others' pain. Th…

This study looks at whether the artificial sweetener sucralose (found in many diet drinks and foods) changes how the body absorbs and processes certain medications. Researchers will give 150 healthy, overweight Black and Hispanic women either sucralose or a placebo capsule for 28…

This study tests whether stimulating a nerve in the forehead at different speeds changes how the brain and the body's automatic systems (like breathing and heart rate) work together. Twenty-five healthy adults will receive mild electrical pulses at 2Hz, 120Hz, or a fake (sham) st…

This early-stage study is testing whether adding an enzyme called berahyaluronidase alfa changes how the body processes dupilumab (Dupixent), a drug used for conditions like eczema and asthma. Forty healthy adults will receive a single injection of dupilumab either with or withou…

This study aims to improve how MRI scans are done by testing new imaging techniques on up to 1,000 healthy volunteers and people with cardiac risk factors. Participants will have one or more MRI scans over a few years, with some receiving a contrast dye. The goal is to refine cur…

This study tests whether combining mindfulness with short bursts of high-intensity exercise (HIIT) can improve executive function—skills like focus, memory, and self-control—in children aged 8 to 12. Over 12 weeks, 352 kids will do brief sessions of mindfulness, HIIT, both, or se…

This study at the National Institute of Mental Health screens up to 16,000 people with mood or anxiety disorders, as well as healthy volunteers, to see if they can join other research studies. Participants undergo evaluations like psychiatric interviews, brain scans, and lab test…

The GESTALT study is recruiting 900 adults aged 20 and older to investigate biomarkers related to aging. Participants will undergo a range of tests every two years, including blood work, imaging, and physical exams. The goal is to better understand how genetic and epigenetic chan…

This early-stage trial is testing a new drug called RO7875913 in 40 healthy volunteers to see if it is safe and how the body processes it. Participants will receive either the drug or a placebo. The study aims to find the right dose for future trials, but offers no direct treatme…

This early-stage study is the first time LG-0317 is given to humans. It involves 100 healthy Chinese adults aged 18-45 to check the drug's safety and how the body processes it. Participants receive either the drug or a placebo in single or multiple doses. The goal is to gather sa…

This study looks at how transcranial magnetic stimulation (TMS) changes brain activity in healthy adults. TMS uses magnetic pulses to stimulate the brain and is already approved for depression. Researchers want to understand these brain changes to help design better treatments fo…

This study collects blood, bone marrow, and cheek cell samples from healthy volunteers to help researchers understand blood diseases like aplastic anemia. Participants must be 8 or older (18 for bone marrow). The samples are used for lab research only, not to treat any condition.…

This study looks at how the body handles the experimental drug BGB-58067 when taken with two common medicines that change liver enzyme activity. Thirty healthy adults will take BGB-58067 with either phenytoin (an enzyme booster) or itraconazole (an enzyme blocker). The goal is to…

This study investigates how a gentle electrical current applied to the forehead (trigeminal nerve stimulation) affects the brain and body. Researchers will numb the forehead skin with lidocaine in one session and leave it un-numbed in another, while using fMRI to watch brain acti…

This study aims to find better ways to measure what people eat, specifically sugar from soda. Researchers will have 60 healthy adults live in a clinic for 13 weeks, eating controlled diets with different amounts of soda. They will then test if stable isotopes in blood, hair, and …

This study tests a special camera that takes super-detailed pictures of the back of the eye (the retina). The goal is to see if this technology can find eye diseases earlier than standard methods. Up to 1,000 people aged 12 and older, with or without eye disease, will have their …

This study looks at how the body absorbs different versions of the drug emraclidine in 12 healthy adults. Participants take a single dose of each version and have their blood tested. The goal is to compare the drug levels and check for side effects, not to treat any disease.

This study aims to describe the physical and behavioral traits of overweight and obese adults compared to lean individuals. Researchers will measure hormones, metabolism, food preferences, fitness, sleep, and thinking patterns in 2,000 participants. The goal is to better understa…

This study collects blood samples from 1,000 healthy adults aged 18 and older to help researchers understand blood vessel and immune system diseases. Participants give about 10 tablespoons of blood at the NIH Clinical Center and may return for up to 10 years. The samples will be …

This early-stage study is testing a new drug called RO7806881 in healthy volunteers to see if it is safe and how the body processes it. About 128 healthy adults will receive either the drug or a placebo. The main goal is to check for side effects and measure drug levels in the bl…

This study is an early-stage trial to check the safety of a new drug called RO7763505. It involves 196 participants, first in healthy volunteers and then in people with stable coronary artery disease. The main goal is to see if the drug is safe and how the body processes it, not …

This study tests whether a daily supplement called Cardiosyn can increase helpful gut bacteria in healthy adults who eat a typical Western diet. The supplement contains a natural sugar found in human milk along with probiotics. One hundred participants will take the powder for ab…

This early-phase trial is testing the safety and tolerability of a single dose of ALN-4285 in 76 healthy adults. Participants receive either the drug or a placebo, and researchers monitor for side effects and how the drug moves through the body. The study does not aim to treat an…

This early-phase trial is testing the safety and tolerability of a new drug called ALN-4915 in 44 healthy adults. Participants receive a single injection of either the drug or a placebo, and researchers monitor for side effects and how the drug moves through the body. Since this …

This early-stage study involves 18 healthy men to see how well the experimental drug MSP-2020 attaches to serotonin receptors in the brain. Researchers will also measure how much drug stays in the blood and check for side effects. The goal is to understand the drug's activity in …

This study looks at how changing the amount and type of food you eat affects the energy your body uses to digest and process that food. Healthy adults aged 18 to 60 will stay in a clinic for about 35 days, eating only provided meals and spending multiple 24-hour periods in a seal…

This study investigates how sleep improves visual learning by scanning the brains of 10 healthy volunteers aged 18-30. Participants will undergo visual training and then have their brain activity measured with MRI and sleep monitors. The goal is to understand what happens in the …

This early-stage study is testing whether KarXT, a new drug for schizophrenia, changes how the body processes three other common medications (midazolam, fexofenadine, and digoxin). Sixty healthy adults will take KarXT along with each of these drugs to see if their levels in the b…

This early-stage study is testing how the drug BMS-986435 behaves in the body and whether it is safe for people with mild to moderate liver problems compared to those with healthy livers. 24 adults will receive a single dose, and researchers will measure drug levels and monitor f…

This study is testing new magnetic resonance imaging (MRI) techniques to get clearer pictures of the heart and blood vessels without using radiation. Researchers will compare these new MRI methods to standard tests like angiography and CT scans. Up to 4,000 adults—including healt…

This study aims to see if completely inactive people can train for 18 months to complete a 100 km mountain ultra-marathon. Researchers will track how many participants stick with the program and finish the race, as well as monitor injuries and overall health. The goal is to under…

This study collects blood plasma and white blood cells from healthy volunteers and people with HIV using a procedure called apheresis. The samples are used for laboratory research on infectious diseases and immune function. Up to 3,000 participants aged 18 and older will be enrol…

This study tests whether adding a safe amount of nitrate—a natural compound found in leafy greens and beetroot—to common oat-based foods like biscuits, cereal bars, and porridge can improve nitric oxide levels and lower blood pressure. Thirty healthy adults will try each fortifie…

This study is testing a new, more comfortable brain scanner that uses special sensors to measure brain activity. Researchers will compare this new device to a standard scanner in 80 healthy volunteers and athletes who have had a mild concussion. The goal is to see if the new scan…

This early-stage study tests a new drug called ZE74-0282 in 40 healthy adults aged 18-55. The main goal is to check its safety and how the body handles it, not to treat any disease. Participants receive either the drug or a placebo, and researchers monitor side effects and drug l…

This study collects biological samples—like blood, skin biopsies, and swabs—from people with or at risk for skin diseases, as well as healthy volunteers. Researchers will use these samples to study the causes of skin conditions and explore potential treatments. Up to 700 particip…

This study looks at how the body absorbs a drug called empasiprubart when given as a shot under the skin using an autoinjector compared to through an IV. It involves 130 healthy adults aged 18 to 65. The goal is to understand the drug's behavior and safety, not to treat any disea…

This study looks at whether taking cold showers regularly can improve how people cope with stress. About 120 healthy adults will either take a warm shower with a 30-second cold blast at the end, or just a warm shower. Some will be told the showers are beneficial, others won't get…

This early-stage study tests a new drug called KLA578-1 in 48 healthy volunteers aged 18 to 45. The main goal is to check if the drug is safe and how the body processes it. Participants will receive either a single dose or multiple doses, and researchers will monitor for side eff…

This study tests a single dose of ITI-1284 in 42 healthy adults aged 18-55. Researchers will use brain scans to see how much of the drug attaches to certain brain receptors. The goal is to gather safety and drug-level information, not to treat any disease.

This early-stage study tests a single dose of an experimental drug called KL0011034 in 76 healthy Chinese volunteers aged 18-45. The main goal is to check for side effects and how the drug moves through the body. Participants are randomly assigned to receive the drug, a placebo, …

This early-stage study tests whether a single dose of KLA478 is safe and how the body processes it. About 40 healthy adults aged 18-45 will receive the drug and be monitored for side effects and drug levels in the blood. No treatment benefit is expected; the goal is to gather saf…

This study tests a non-invasive brain stimulation method called temporal interference (TI) in 30 healthy adults. Using scalp electrodes, TI aims to safely reach deep brain areas like the dorsal anterior cingulate cortex without affecting the surface. Researchers will measure brai…

This study looks at how taking itraconazole (a common antifungal) changes the way the body processes an experimental drug called ABBV-722. It involves 12 healthy adults and focuses on safety and drug levels in the blood. The goal is to gather information, not to treat any disease…

This study looks at how thoughts and expectations change the way we feel pain. Healthy volunteers aged 18-50 will have brain scans and receive mild pain (heat or electric shocks) while researchers measure their heart rate, sweat, and brain activity. The goal is to understand pain…

This early-stage trial is testing whether a new drug called B-3E07 works the same as the approved osteoporosis drug Forsteo. 48 healthy adult women will receive a single injection of each drug in random order. The main goal is to compare how the body absorbs and processes the dru…

This early-stage study is testing a new drug called LAD106 in 93 healthy adults aged 18 to 45. The main goal is to see if it is safe and how the body processes it. Participants will receive either LAD106, a similar drug (lebrikizumab), or a placebo. This research is a first step …

This study checks if a Turkish version of the Cybersickness in Virtual Reality Questionnaire (CSQ-VR) is valid and reliable. It involves 42 healthy volunteers who will answer questions about symptoms like nausea or eye strain after using VR. The goal is to ensure the tool works w…

This study looks at how people use their sense of hearing versus physical feeling when they speak. Healthy adults aged 18 to 45 will do speech tasks with altered audio feedback, sometimes with a visual display. Researchers will use a computer model to see if individual difference…

This study uses brain scans (fMRI) to understand how healthy people make decisions and how aging changes this process. Researchers will recruit 150 healthy adults to complete thinking tasks and brain imaging. The goal is to gather baseline data, not to treat any disease.

This study looks at how 200 healthy adults make decisions, such as how they weigh potential losses against gains. Researchers want to see if decision-making stays stable over time and if age plays a role. The goal is to create a baseline that can help doctors spot changes in deci…

This study looks at how healthy brains process social information, like understanding others' feelings. Researchers will use brain scans (fMRI) and brain wave recordings (EEG) to see which brain areas are active during social thinking tasks. The goal is to create a baseline of no…

This early-stage trial is testing how the experimental drug repinatrabit interacts with several common medications, including birth control pills, metformin, and methotrexate. The study involves 48 healthy volunteers and will measure drug levels in the blood to see if combining t…

This early-stage study is testing a single dose of an experimental drug called VV913 in 56 healthy Chinese men aged 18 to 45. The goal is to see if the drug is safe and how the body processes it. Participants are randomly assigned to receive either VV913 or a placebo, and no dire…

This early-stage study is testing whether a new drug called ABBV-722 changes how the body processes several common medications. Twelve healthy adults will take ABBV-722 along with a 'cocktail' of other drugs (midazolam, digoxin, pitavastatin, metformin, and sitagliptin) to see if…

This study is testing a new imaging method called 4D-MRI that creates 3D movies of the lungs and liver as a person breathes. The goal is to help doctors better track tumor movement during radiation therapy, making treatment more precise. Researchers will test this in healthy volu…

This study is testing how a new drug called atumelnant interacts with other medications in 46 healthy adults. Participants will receive atumelnant along with drugs like carbamazepine, midazolam, digoxin, and metformin to see how the body processes them. The goal is to gather safe…

This early-phase trial is testing a single injection of GenSci161 in 44 healthy adults aged 18 to 45. The main goal is to check for side effects and how the drug moves through the body. No one expects a medical benefit—this is purely about safety and dosing information.

This study in 12 healthy volunteers tests whether biotin (vitamin B7) can be used to label platelets so they can be tracked after transfusion. Platelets are collected, labeled with biotin, stored for 3 days, then a small radioactive tag is added before returning them to the donor…

This study collects blood and urine samples from healthy adults and patients with heart, lung, or blood vessel conditions. Researchers will use these samples to study genes, proteins, and other substances in the lab. The goal is to support basic and translational research that co…

This study collects biological samples like blood, stool, saliva, and skin swabs from 600 healthy volunteers aged 3 to 80. Researchers at the National Institutes of Health will use these samples to design and improve laboratory tests for other studies. Participants may be asked t…

This early-stage study is testing a new drug, SEP-479, in 150 healthy adults aged 21 to 60. The main goal is to check if the drug is safe and how the body processes it. Participants will take single or multiple doses of the drug or a placebo. This study does not aim to treat any …

This study tests whether virtual reality or mental imagery can replace the standard prism adaptation therapy used for people with unilateral neglect after a brain injury. Researchers will compare these new methods to the traditional approach in 480 healthy volunteers. The goal is…

This study looks at whether longer or shorter training sessions help healthy adults maintain their endurance during a 4-hour cycling test. Researchers will measure changes in power output and heart rate. 40 volunteers who exercise up to 2 hours per week will participate.

This early-stage study is testing a new drug, AKB-9090, in about 70 healthy adults to see if it is safe and how the body processes it. Participants will receive either the drug or a placebo, given through a vein, in either a single dose or multiple doses over time. The main goal …

This study aims to create a detailed map of the bacteria and fungi living on the skin and in the gut of 5,000 healthy volunteers. Researchers will collect samples from different body sites and analyze how factors like diet, location, and medical history shape each person's unique…

This study screens healthy adults aged 18 and older to see if they qualify for future infectious disease research at Beth Israel Deaconess Medical Center. It collects basic information like race, ethnicity, and gender, and tracks how many screened volunteers later join other stud…

This early-stage trial is testing a new drug called ME3241 in 104 healthy adults to see if it is safe and how the body handles it. Participants will receive either the drug or a placebo by infusion, and researchers will monitor for side effects and measure drug levels in the bloo…

This study collects blood, urine, saliva, and tumor tissue from 500 adults with urothelial cancer (bladder, ureter, or urethra) and healthy volunteers. Researchers will analyze the samples to find genetic differences between normal and cancer cells. The goal is to better understa…

This study looks at how healthy adults absorb and process kaempferol, a natural compound found in many plants. Researchers will give kaempferol to 120 volunteers and collect blood and urine samples over a short period. The goal is to understand how the body handles this compound,…

This study looks at how quickly proteins in the body are replaced, a process called protein turnover, in healthy adults aged 20 and older. Participants drink heavy water for 21 days and undergo tests including muscle, skin, and fat biopsies, imaging scans, and strength tests. The…

This study checks if the experimental drug BMS-986278 affects the heart's electrical activity in 32 healthy adults aged 18 to 55. Participants receive multiple doses of the drug, a placebo, and a positive control in a crossover design. The main goal is to measure changes in heart…

This early-stage study tests whether LIFE-001 is safe and tolerable in 150 healthy adults aged 18 to 65. Participants receive single or multiple doses, and researchers monitor side effects and how the drug moves through the body. There is no expected treatment benefit for volunte…

This study is creating a large database of healthy Caucasian knees using advanced CT scans, X-rays, and ultrasound. Researchers will analyze knee shape, ligament balance, and bone structure in 200 volunteers aged 20-35. The goal is to provide a reference for better understanding …

This early-stage study tests whether ARGX-124 is safe in healthy adults aged 18 to 65. Researchers will also measure how the drug moves through the body and how the immune system reacts. About 104 participants will receive either the drug or a placebo, and the study lasts up to 2…

This study looks at how a wearable robotic hip device affects the way healthy adults walk. Fifteen volunteers will walk with different levels of assistance from the exoskeleton. Researchers will measure step length, speed, muscle activity, and foot pressure to understand the devi…

This study looks at how brain networks synchronize in people with fibromyalgia, a condition causing widespread pain. Researchers will use EEG and fMRI to measure brain activity and test a gentle brain stimulation technique called HD-tDCS. The goal is to understand pain processing…

This study is an early safety check for a new drug called HW241045, which may one day help treat a lung disease called IPF. Researchers are giving a single dose to 56 healthy adults to see if it is safe and how the body processes it. No treatment benefit is expected for participa…

This study explores whether training your motor skills (like hand movements) can also improve your ability to learn a language. Researchers believe that when the brain changes to learn a new physical skill, it might also boost nearby brain areas used for language. The study will …

This early-stage study gives 10 healthy men a single dose of the experimental drug E2086 with a radioactive tracer. Researchers will measure how much of the drug appears in blood, urine, and stool over time. The goal is to understand how the body breaks down and eliminates E2086,…

This early-stage trial is testing a single oral dose of VV261 tablets in 58 healthy Chinese adults to see if it is safe and how the body processes it. Participants are randomly assigned to receive either VV261 or a placebo. The study does not aim to treat any disease, but to gath…

This early-phase trial is testing a new drug, MT-251, in 70 healthy adults aged 19 to 55. The main goal is to check if the drug is safe and how the body handles it. Participants will receive either MT-251 or a placebo, and researchers will monitor for side effects and measure dru…

This early-stage study tests the safety of a new drug, CLYM116, in 48 healthy adults aged 18-60. Participants receive either the drug or a placebo by injection, and researchers monitor for side effects and how the drug moves through the body. The study is not designed to treat an…

This early-stage study looks at how different versions of a liver enzyme (CYP2D6) affect the breakdown of xanomeline, one part of the drug KarXT. About 56 healthy volunteers with four different metabolism types will take KarXT and have their blood tested. The goal is to see if pe…

This early-stage trial tests the safety and tolerability of a new drug called ZP9830 in 124 healthy adults aged 18-45. Participants receive either the drug or a placebo, given as an injection under the skin or into a vein. The study aims to understand how the drug behaves in the …

This study tests a new method called temporal interference (TI) that uses electrical currents to stimulate deep brain areas without surgery. Thirty healthy adults aged 18-50 will receive TI stimulation while their brain activity is measured with fMRI. The goal is to understand ho…

This study tests a new, non-invasive brain stimulation technique called temporal interference (TI) that uses scalp electrodes to safely reach deep brain regions without affecting the surface. Researchers will measure brain activity changes in 30 healthy volunteers using fMRI. The…

This study looks at whether putting elastic tape on the diaphragm (the main breathing muscle) before high-intensity interval training (HIIT) can improve fitness. Thirty trained adults will do an 8-week cycling program, with half also getting the tape. Researchers will measure cha…

This study aims to establish normal scores for four paper-and-pencil tests that detect spatial neglect, a common attention problem after stroke. Researchers will test 210 healthy French-speaking adults aged 20 to 89, divided by age and sex. The results will help doctors know what…

This early-stage study will give 10 healthy adults a single dose of psilocybin (the active ingredient in magic mushrooms) combined with D-serine, an amino acid. Researchers want to see if D-serine can tone down the psychedelic effects and improve safety. The goal is to find the r…

This study looks at whether taking vitamin and mineral supplements for 12 weeks can improve skin health and how healthy people feel overall. About 120 healthy Chinese adults with low fruit and vegetable intake will take either the supplements or a placebo. Researchers will measur…

This study looks at how healthy people's brains predict the timing of sounds, especially in speech. Researchers will use EEG and MEG to record brain activity while participants listen to various sounds and press buttons. The goal is to understand how we process natural rhythms in…

This study will use MRI and ultrasound to create detailed reference images of the heart, liver, and blood vessels in 2,400 healthy adults across France. By linking these images with health data, researchers hope to better understand normal aging versus disease, especially for con…

This study looks at how a brain area called the posterior parietal cortex (PPC) helps us move and perceive the world. Researchers will compare people with optic ataxia, a condition caused by PPC damage, to healthy volunteers. Participants will perform simple tasks like pointing a…

This study looks at how different parts of the brain work together when people decide whether to put in effort for a reward. Researchers will use safe, non-invasive brain stimulation and brain scans in 204 healthy adults aged 18-40. The goal is to understand the brain networks be…

This study looks at whether a simple hand-grip device can reliably measure proprioception—your body's ability to sense force and position—in 55 healthy volunteers aged 18-24. Participants will squeeze the device at a target force and try to repeat it, with researchers checking ho…

This early-stage study is testing a new drug called ABBV-243 in healthy adults to see if it is safe and how the body processes it. About 66 participants will receive either the drug or a placebo, given as an injection or IV. The study does not aim to treat any disease, but to gat…

This early-stage study tests an experimental drug called BMS-986521 in healthy adults to see if it is safe and how the body processes it. About 106 participants will receive either the drug or a placebo. The study does not aim to treat any disease; it is designed to gather import…

This study looks at how taking a new drug (VV119) with or without a standard meal changes its levels in the blood. Sixteen healthy Chinese adults will receive a single dose of VV119 under both conditions. The goal is to understand food's effect on drug absorption and safety, not …

This study looks at how two other drugs (itraconazole and rifampin) change the amount of AR-LDD in the blood of healthy adult men. 42 participants will take AR-LDD alone and then with each of the other drugs to see the difference. This is a phase 1 trial with no direct treatment …

This study looks at how the body's internal clock changes our perception of time when we stay awake for 36 hours. Thirty healthy adults will remain awake in a controlled lab, with constant light, posture, and food. Every two hours, they complete tests on time estimation, reaction…

This early-phase trial is testing a new drug called YN001 in 24 healthy adults. Researchers want to see how the drug moves through the body, how long it stays, and whether it causes any side effects. Participants receive a single dose by IV and are monitored closely. This study d…

This early-stage study is testing new forms of two drugs, KarX and KarT, in 72 healthy adults. Researchers want to see how the body absorbs and processes these new versions compared to the original drugs, and whether food changes their effects. The goal is to gather safety and do…

This study looks at whether emergency room doctors can use ultrasound to clearly see the muscle layers in the belly wall, which is needed for a type of pain block called a TAP block. About 118 healthy adults will get an ultrasound scan of their abdomen. The goal is to see if body…

This early-stage trial is testing the safety and how the body handles three experimental drugs—DWJ1622, DWC202313, and DWC202314—in 40 healthy adults. Participants take a single dose of each drug under fasting conditions. The study aims to measure drug levels in the blood and che…

This early-phase study is testing three experimental drugs (DWJ1622, DWC202313, and DWC202314) in 36 healthy adults. The goal is to see how the body absorbs and processes these drugs and to check for any safety issues. Participants will take the drugs by mouth after eating. This …

This study looks at how energy drinks change the heart's electrical signals in healthy adults aged 18 to 40. Only 3 people will take part, and each will try 8 different drink combinations. The goal is to see if these drinks cause any heart rhythm changes, not to treat or cure any…

This study tests a new device called pneuRIP that measures breathing without needles or tubes. It uses special bands placed around the chest and belly. Researchers will compare it to an existing monitor in 20 children—10 healthy and 10 with mild breathing problems from muscle or …

This early-stage study tests whether a single inhaled dose of RCS-21 is safe and tolerable in 24 healthy volunteers aged 18 to 64. Participants receive either the drug or a placebo and are closely monitored for side effects and how the drug moves through the body. The study does …

This study looks at how laser light bounces off different parts of the eye, like the cornea and retina. Researchers will measure the reflected light at various angles and colors in 20 healthy volunteers aged 18-40. The goal is to make laser-based eye exams and surgeries safer and…

This early-stage trial is testing a new drug called CHF6467, given as a nasal spray, in 68 healthy adults. The main goal is to check if it is safe and how the body processes it, including how it moves into the blood and spinal fluid. The study will give either single or repeated …

This early-phase trial is testing a new combination drug called PBK_M2301, which contains two ingredients: levodropropizine (a cough suppressant) and Pelargonium sidoides extract (a herbal remedy). The study involves 32 healthy adults aged 19 to 64. Each person will take the comb…

This study is a practice run to see how well different brain and heart scans (MEG, MRI, EEG, ECG) work in healthy volunteers, people with Parkinson's disease, and those with paralysis. Researchers want to make sure the equipment and procedures are ready for larger future studies.…

This study tests a new device that uses light to measure pulse waves, which might help estimate blood pressure. Researchers will compare it to a standard device in 27 healthy adults. The goal is to see if this simpler method is reliable.