HEALTHY VOLUNTEERS

This study is testing a new vaccine designed to protect against four types of meningococcal bacteria (A, C, Y, W) that can cause serious meningitis and blood infections. It will involve about 1,602 healthy children and adolescents aged 2 to 17 in China. Researchers will compare t…

This study is testing a new version of a vaccine that protects against serious bacterial infections like pneumonia and meningitis. It will compare the safety and immune response of the new 21-strain vaccine against a currently licensed 20-strain vaccine in healthy infants. Babies…

This early-stage study is testing a new oral medication called RO7763505 to see if it's safe for people. Researchers will give the drug to healthy volunteers and people with stable coronary artery disease to check for side effects and how the body processes it. The study will hel…

This is an early-stage study to check the safety of a new drug called TAK-781. It will first be given to healthy volunteers to see how their bodies handle it. Then, a single dose will be given to a small group of people with a specific chronic liver disease called primary scleros…

This early-stage study is testing a new drug called BMS-986470 in healthy volunteers and people with sickle cell disease. Researchers want to understand if the drug is safe, how it moves through the body, and whether it can help increase healthy hemoglobin levels in sickle cell p…

This early-stage study is testing whether gentle electrical stimulation applied to the skin over nerves and the spinal cord can help improve arm, hand, or leg movements in people with paralysis or weakness. Researchers are recruiting 64 adults with conditions like stroke or spina…

This is the first time a new drug called BGB-45035 is being tested in people. The main goal is to check if it is safe and how the body processes it. The study will first give the drug to healthy volunteers at different doses. Later, a small group of adults with itchy skin conditi…

This is a very early-stage study testing an experimental drug called ALN-PNP in healthy adults and people with a common fatty liver disease (MASLD). The main goal is to check the drug's safety, how the body processes it, and see if it can reduce liver fat. Researchers will also s…

This study is testing whether a non-invasive brain stimulation technique can help control pain in people with fibromyalgia. Researchers will compare brain activity in people with fibromyalgia to healthy volunteers, then test if targeted stimulation can reduce a specific brain pat…

This is the first time a new drug called NNC4004-0002 is being given to people. The study aims to see if it is safe and how well the body tolerates it in adults with high uric acid levels but no symptoms. Researchers will also check if a single injection can lower uric acid in th…

This early-stage study aims to find out if a new drug called IGT-303 is safe for people. It will test single and multiple doses given as shots under the skin or into a vein. Researchers will compare the drug to a placebo in about 94 healthy volunteers and people with chronic kidn…

This is the first study in people to test the safety of an experimental oral drug called Leucettinib-21. It will first be given to healthy volunteers to check for side effects and how the body processes it. Later, a single dose will be given to a small group of men with Down synd…

This study is testing a new type of PET scan that uses much less radiation than current methods to detect and monitor neuroendocrine tumors. Researchers want to see if they can reduce radiation exposure by 10 to 100 times while still getting clear images. About 200 people, both w…

This study is testing a new device called the pneuRIP that monitors breathing without being invasive. It uses soft bands around the chest and belly to measure breathing patterns wirelessly. Researchers are comparing this new device to an older system in 10 healthy children and 10…

This study is testing a new, non-invasive device that uses light sensors on the skin to measure how fast a pulse wave travels through your arteries (pulse wave velocity). Researchers want to see if this measurement can be used to accurately estimate blood pressure. The goal is to…

This study is testing if a special elastic tape applied to the breathing muscles helps people get more benefit from high-intensity interval training (HIIT). Thirty trained adults will do an 8-week cycling workout program, with half also getting the tape before each session. Resea…

This study is testing whether a 12-week program combining modern dance with mindfulness practices can improve mental wellbeing in adults who dance for fun. About 160 participants will either take the weekly dance-mindfulness classes or continue their usual activities for comparis…

This study is testing whether taking a combination of antioxidant and multivitamin supplements for 12 weeks can improve skin health and how people feel about their overall physical health. It will involve 120 healthy Chinese adults who don't eat many fruits and vegetables. Partic…

This study is testing a new drug called ABCL635, given as an injection under the skin, to see if it can safely reduce hot flashes and night sweats in postmenopausal women. Researchers will first test it in healthy men and women, then specifically in women with moderate-to-severe …

This study is testing whether new software called Motion Reset can reduce motion sickness symptoms during virtual reality use. Healthy adults aged 18-60 will try different VR experiences and play a game while reporting any discomfort. Researchers want to see if this software help…

This study aims to understand the safety of energy drinks by measuring their effects on the heart. Three healthy volunteers will try different drinks and ingredients while researchers monitor their heart rhythm, blood pressure, and other health signs. The goal is to see if these …

This is the first study testing the experimental drug ABBV-277 in humans. Researchers will give single doses to 40 healthy volunteers to check for safety and see how the body processes the drug. The main goal is to understand side effects and how long the drug stays in the bloods…

This study aims to understand how the brain makes decisions about putting in effort for a reward. Researchers will use safe, non-invasive brain scans and stimulation techniques on 204 healthy volunteers to see which brain circuits are involved. The goal is to build knowledge that…

This is the first study in humans of an experimental drug called MTX-101. Researchers are testing it first in healthy adults and then in people with type 1 diabetes to understand its safety, how long it stays in the body, and how it affects specific immune cells. The main goal is…

This is the first study testing a new biologic therapy called MT-701 in humans. Researchers want to understand if it's safe and how the body processes it in 78 healthy volunteers. The study will check for side effects and how the drug moves through the body to decide if further t…

This study aims to understand how our internal body clock and sleepiness affect how we perceive time. Healthy adult volunteers will stay awake for about 36 hours in a controlled lab while taking regular tests on time perception, alertness, and mood. By measuring these changes alo…

This study aims to see how well emergency room doctors can use ultrasound machines to clearly see the layers of abdominal wall muscles. The goal is to understand if they could use this view to perform a specific type of pain-blocking injection called a TAP block. Researchers are …

This study aims to understand how sleep helps our brains learn visual patterns. Researchers will scan the brains of 10 healthy volunteers while they nap, measuring brain activity before and after visual training. The goal is to see if specific brain patterns during sleep are link…

This is the very first study in people for a new drug called MT-251. Its main goal is to check if the drug is safe and how the body processes it in 70 healthy volunteers. Researchers will give participants either the drug or a placebo and closely monitor them. The results will he…

This is the first study in humans to test a new inhaled compound called RCS-21. The main goal is to check if it is safe and how the body processes it. Healthy volunteers will inhale a single dose and be closely monitored for side effects. This is an early, basic safety study, not…

This study aims to see how reliable a simple grip strength test is for measuring a body's sense of position and movement (proprioception). Healthy volunteers aged 18-24 will squeeze a hand-held device to match specific force levels in two sessions one week apart. The goal is to v…

This is the first study in humans for a new oral medication called Alpha-0261. It will test the safety and how the body processes the drug in 60 healthy adult volunteers. The main goal is to see what side effects occur and how the drug moves through the body at different doses.

This early-stage study aims to check if an experimental drug called BMS-986278 affects the heart's electrical rhythm. Researchers will give the drug to 32 healthy adults and carefully monitor their heart activity. The main goal is to gather safety data before testing the drug in …

This research study aims to understand how our brains predict the timing of sounds and speech. Researchers will measure brain activity in healthy volunteers while they listen to different sounds and speech patterns. The goal is to learn how we use past patterns to anticipate what…

This is a very early, first-in-human study to understand how a new drug called YN001 moves through the body and how safe it is. It will involve 24 healthy adult volunteers who will receive a single dose. The main goal is to measure the drug's levels in the blood over time and che…

This is the first study in humans to test the safety of an experimental drug called ABBV-243. It will involve 66 healthy adult volunteers to see how their bodies process the drug and what side effects might occur. The study will test different doses given by injection and will in…

This study aims to understand how a wearable robotic hip exoskeleton changes the way people walk. Researchers will measure step length, walking speed, joint movement, and muscle activity in 15 healthy adults while they use the device. The goal is to gather basic knowledge about h…

This early-stage study aims to understand how eating a standard meal affects how the body absorbs and processes a single dose of an investigational capsule called VV119. It will involve 16 healthy Chinese adult volunteers who will take the capsule either with or without food in a…

This is the first study in humans to test a new drug called KLA478. It aims to check if the drug is safe and how the body absorbs and processes it. The study will involve 40 healthy volunteers who will receive a single dose. The main goal is to gather initial safety data and unde…

This is a very early study to see if a new injection called RBD1119 is safe for people. It will be given to 32 healthy volunteers to check for side effects and to see how the body absorbs and processes it. The main goal is to gather basic safety information before testing it in p…

This study aims to understand how damage to a specific brain area affects vision and movement coordination in people with optic ataxia. Researchers will compare 160 participants—some with this condition and some healthy volunteers—using simple movement and perception tests. The g…

This study collects blood and urine samples from healthy adults and patients with heart, lung, or blood vessel conditions. Researchers will use these samples to develop new laboratory tests and study genes, proteins, and other substances in the body. The goal is to build a resour…

This study is testing a new, non-invasive brain stimulation technique called Temporal Interference (TI) on healthy volunteers. Researchers want to see if TI can safely and precisely activate deep brain areas without affecting the surface of the brain, using an MRI scanner to meas…

This study aims to collect blood, urine, saliva, and tissue samples from people with bladder or urinary tract cancer, as well as from healthy volunteers. Researchers will compare these samples to learn what genetic and cellular changes cause this cancer to develop. The goal is to…

This study aims to develop and improve MRI scanning techniques for better image quality. Researchers are recruiting 1,000 healthy volunteers and NIH patients to undergo MRI scans lasting 20 minutes to 2 hours. The goal is to refine scanning methods that could benefit future medic…

This study aims to find out if consuming the artificial sweetener sucralose changes how the body absorbs and processes certain medications. Researchers are enrolling 150 overweight or obese Black and Hispanic women to take either sucralose or a placebo pill for a month. They will…

This is the first study in humans for the investigational drug ALN-4285. It aims to test the safety and how the body processes a single injection of the drug in 76 healthy adult volunteers. The study will start with low doses and gradually increase them to find a safe range for f…

This is the first study testing a new drug called selonabant in people. Researchers want to see if it's safe and how the body handles it when given through an IV. They're enrolling 40 healthy adults aged 18-30 who will receive either the drug or a placebo. The main goal is to che…

This study is testing whether adding a natural compound called nitrate to common foods like cereal bars, porridge, and biscuits can help the body produce more nitric oxide, which may lower blood pressure. Thirty healthy volunteers will try all three fortified foods in a random or…

This early-stage study aims to check the safety of a new drug called ARGX-124 in healthy adults. Researchers will measure how much of the drug stays in the blood and how the body's immune system reacts to it. The study will involve about 104 healthy volunteers who will be monitor…

This early-stage study aims to understand how two common medications (itraconazole and rifampin) affect the body's processing of an experimental drug called AR-LDD. The research involves 42 healthy adult male volunteers who will take AR-LDD alone and then with each of the other m…

This is the first time researchers are testing the experimental drug SL-325 in humans. The study will enroll 72 healthy volunteers to check if the drug is safe and how the body processes it. Participants will receive either the drug or a placebo, and neither they nor the doctors …

This study collects blood, bone marrow, urine, and tissue samples from people with cancer, blood disorders, or their compatible family members. The samples are used for laboratory research to better understand these diseases, evaluate current treatments, and identify potential ne…

This study collects blood, saliva, stool, and swab samples from healthy volunteers to help researchers develop and improve medical tests. Participants ages 3-80 will provide samples during visits over 5 years, allowing scientists to track normal immune changes over time. The samp…

This study is not a treatment trial. Its main purpose is to screen a large number of people—including those with mood or anxiety disorders and healthy volunteers—to understand these conditions better and to find suitable participants for future research studies. Participants unde…

This early-stage study aims to understand how the body absorbs a new drug called ENX-104. It will test 12 healthy volunteers to see if taking the drug as a liquid or a pill, and with or without a high-fat meal, changes how much drug gets into the bloodstream. The main goals are t…

This study aims to understand how psychological factors like expectations and emotions change how we feel pain. Researchers will recruit 500 healthy volunteers to undergo brain scans and simple tests involving mild, brief pain or other sensations. The goal is to map how the brain…

This is the first study testing a new drug called ZP9830 in humans. Researchers will give the drug to 124 healthy volunteers to check for side effects and see how the body handles it. The study will compare people who get the real drug to those who get a placebo (inactive substan…

This study aims to create normal reference scores for French-language tests that diagnose spatial neglect, a common attention disorder after stroke. Researchers will test 210 healthy French-speaking volunteers, grouped by age and gender, to establish what typical test results loo…

This study aims to collect blood samples from healthy adults to help researchers better understand and test for blood vessel and immune system diseases. Researchers will use these samples to establish what 'normal' looks like, which helps them develop more accurate tests and stud…

This study aims to develop new at-home rehabilitation methods for people with 'unilateral neglect,' a common condition after a stroke where individuals have difficulty noticing one side of their space. Researchers are testing whether virtual reality or mental imagery exercises ca…

This is the first time researchers are testing a new drug called ABCL575 in people. The study will check if the drug is safe and how the body handles it in 40 healthy volunteers. Participants will receive either the drug or a placebo (inactive substance) in gradually increasing d…

This is a first-in-human study to understand how a new inhaled drug, RJ026, moves through the body and how safe it is. It will enroll 84 people, including healthy volunteers and patients with interstitial lung disease (ILD), a condition that causes lung scarring. Researchers will…

This is the first study in humans to test the safety and how the body processes a new tablet called HW241045. The trial involves 56 healthy volunteers who will receive either the tablet or a placebo. Researchers will monitor for side effects and measure how the drug moves through…

This study is preparing for future research by testing different brain and heart scan procedures. It involves 150 healthy volunteers and patients with Parkinson's disease or paralysis. The goal is to figure out the best way to run these scans so future studies on these conditions…

This study aims to understand what causes various skin diseases by collecting biological samples from participants. Researchers will gather skin, blood, saliva, and other samples from people with skin conditions, their family members, and healthy volunteers. The collected samples…

This is the first study in humans to test a new drug called LAD106. It aims to find out if the drug is safe, how the body processes it, and what side effects it might cause. The study will involve about 93 healthy adult volunteers who will receive either the drug or a placebo. Th…

This study aims to understand the many factors that influence body weight by observing and measuring physical and behavioral traits in adults. Researchers are recruiting 2,000 healthy adults of all body sizes—lean, overweight, and obese—to participate. The study involves detailed…

This is the very first study to give the experimental drug MRT-8102 to people. Its main goal is to check if the drug is safe and how the body processes it. The study will involve 100 healthy adults and adults with risk factors for heart disease who have a specific blood marker (C…

This is an early safety study to see if a single dose of an investigational drug called balinatunfib affects the electrical timing of the heart in healthy people. It will involve 44 healthy adult volunteers who will receive the drug, a placebo, and a comparison drug in a specific…

This study aims to create detailed reference images of what healthy hearts and livers look like at different ages and between sexes. Researchers will use MRI and ultrasound scans on 2,400 healthy French adults to establish normal ranges for heart function, liver fat, and body fat…

This is an early safety study for a new pill called PBK_M2301, which combines two ingredients for cough. It aims to see how the drug moves through the body and if it's safe. Researchers will give the pill to 32 healthy adults and compare it to two separate reference drugs. The ma…

This study aims to understand how a new drug called KarXT changes the way the body processes three other common medications: midazolam (a sedative), fexofenadine (an allergy medicine), and digoxin (a heart medicine). It will involve 60 healthy adult volunteers. Researchers will m…

This early-stage study aims to understand how eating food and taking a common stomach acid medicine (rabeprazole) affect how the body absorbs a new drug called ZN-A-1041. It will involve 48 healthy volunteers who will take the drug under different conditions (like with a high-fat…

This is a very early, first-in-human study to check if a new drug called RO7806881 is safe for people and to see how the body handles it. The study will give single and multiple doses to 128 healthy volunteers and compare them to people who receive a placebo. The main goal is to …

This study aims to understand how a non-invasive brain stimulation technique called TMS affects brain activity in healthy people. Researchers will use MRI scans to watch brain changes while applying magnetic pulses to the forehead area. The knowledge gained could help design bett…

This study aims to understand how three new drugs are absorbed and processed by the body and to check their safety. It involves 36 healthy adult volunteers who will take the drugs after a meal. This is an early-stage trial to gather basic information before testing in patients wi…

This is the first study in humans for a new oral drug called AN2-502998. The main goal is to check if the drug is safe and to see how the body absorbs and processes it. The study will involve 72 healthy adults, who will receive either the drug or a placebo. Researchers will monit…

This study is testing a new, non-invasive brain stimulation technique called temporal interference (TI) on healthy volunteers. The goal is to see if TI can safely and precisely target deep brain areas without affecting the surface, using brain scans (fMRI) to measure its effects.…

This study aims to develop better tools for measuring what people eat by testing if stable isotopes in blood, hair, and fat can track sugar intake from soda. For 13 weeks, 60 healthy adults will live at the NIH and follow controlled diets with different amounts of soda. Researche…

This study aims to understand how the number of calories you eat changes the energy your body uses to digest and process food. Healthy volunteers will live in a clinic for about 35 days, eating controlled diets while researchers measure their metabolism in special rooms. The goal…

This study aims to understand how the body's natural process of breaking down and rebuilding proteins changes as we age. Researchers will enroll 75 healthy adults over age 20. Participants will drink safe, labeled water for three weeks and provide small tissue samples to measure …

This is an early safety study to see if a new drug called LIFE-001 is safe for healthy adults and how their bodies process it. Researchers will give increasing doses to small groups of volunteers and closely monitor for any side effects. The study will help determine if the drug …

This study aims to measure how much KarXT medication passes into breast milk when taken by healthy nursing mothers. Researchers will track medication levels in both breast milk and blood over time to understand potential infant exposure. The study involves 8 healthy lactating par…

This study is testing a new, very detailed camera system called adaptive optics to take pictures of the retina at the back of the eye. Researchers want to see if these super-clear images can help doctors find and understand eye diseases much earlier than is currently possible. Th…

This study is testing a new idea: that training your brain with a physical skill, like a motor task, might make it easier to learn a new language. Researchers are recruiting over 1,100 healthy French-speaking adults to see if the brain changes from motor training can boost langua…

This study aims to collect white blood cells from healthy volunteers to supply researchers studying the immune system and aging. Up to 10,000 participants will donate cells using a safe machine that separates and returns most of their blood. The goal is to provide high-quality ce…

This early-stage study aims to check if a new drug called ARGX-213 is safe for people. It will involve 80 healthy adults who will receive either the drug or a placebo. Researchers will track side effects and measure how the drug moves through the body over about 21 weeks.

This early-stage study aims to see if combining the psychedelic compound psilocybin with a supplement called D-Serine is safe for healthy people. Researchers will give the combination to 10 healthy volunteers to check for side effects and measure how it changes their thoughts, fe…

This study collects blood, cheek cell, and bone marrow samples from healthy volunteers to help researchers better understand how blood cells form, how the immune system works, and what causes certain blood diseases. The samples will be used in laboratory research projects at the …

This study aims to develop better MRI scanning methods to see the heart and arteries in more detail without using radiation. Researchers will compare these new MRI techniques to standard heart tests in up to 4000 adults, including both healthy volunteers and people with or at ris…

This long-term study aims to understand why some children develop unhealthy eating patterns and weight gain by following 1,500 kids aged 8-17 for up to six years. Researchers will track factors like sleep, mood, genetics, and brain activity to see how they influence eating behavi…

This early-stage study aims to understand how the body processes new versions of the drug combination KarXT. It will involve 72 healthy adult volunteers to measure drug levels in the blood and check for safety. Researchers will compare new pill forms to existing ones and see if t…

This research aims to understand why pain is assessed and treated differently across racial groups, contributing to healthcare disparities. The study involves healthy volunteers who will experience mild pain while researchers measure their responses, then have other participants …

This study aims to understand the biological process of aging by tracking changes in blood, tissue, and body function over many years. It will enroll 900 adults, including healthy individuals, those with some health issues, and frail individuals, to compare how they age different…

This is an early safety study testing a new drug called BB-025, both by itself and after another drug called BB-031. The main goal is to see how safe these drugs are and how they move through the body in 72 healthy volunteers. Participants will be monitored for 28 days to check f…

This study aims to understand how HIV behaves in different body tissues, not just the blood. Researchers will collect small tissue samples from the tonsils, lymph nodes, intestines, and lungs of HIV-positive patients, patients with a rare immune condition (ICL), and healthy volun…

This early-stage study is testing whether a daily supplement containing a natural sugar from human milk can increase beneficial gut bacteria and improve markers linked to heart health. It will enroll 100 healthy adults who eat a typical Western diet. Participants will take the su…

This study is investigating whether suvorexant, a medication approved for sleep problems, can change brain chemistry related to addiction in people with alcohol use disorder (AUD). Researchers will compare brain scans, sleep patterns, and cravings in people with AUD receiving eit…

This early-stage study aims to understand how the body breaks down and eliminates the experimental drug E2086. Ten healthy male volunteers will receive a single, traceable dose. Researchers will measure how much of the drug is absorbed, how long it stays in the body, and how it i…

This study is testing whether a specific hands-on therapy for the muscles between the ribs can improve breathing strength and walking endurance in healthy young adults. Researchers will compare the technique against a fake treatment and no treatment in 90 participants aged 18-30 …

This study aims to understand how the body absorbs and processes Kaempferol, a natural substance found in many fruits and vegetables. Researchers will give Kaempferol to 120 healthy adults and measure its levels in blood and urine over time to learn about its safety and how it mo…

This study aims to understand how a person's genetic makeup affects how their body processes an experimental drug called KarXT. Researchers will enroll 56 healthy adults who have different genetic profiles related to drug metabolism. The main goal is to measure drug levels in the…

This early-stage study aims to understand how the body absorbs different tablet versions of an experimental drug called BMS-986435. It will also test if eating food affects how the chosen tablet works. The study involves 140 healthy adult volunteers to gather basic safety and abs…

This is the first study in humans to test the safety and drug levels of a new oral medication called BMS-986521. Healthy adult volunteers will take single and multiple doses to see how their bodies handle the drug and check for side effects. The study will also examine whether ta…

This is the first time a new antibody drug called CLYM116 is being tested in people. The main goal is to check if it is safe and how the body processes it. The study will involve up to 48 healthy volunteers who will receive injections of the drug or a placebo. Researchers will mo…

This study aims to gather basic information about how laser light interacts with different parts of the healthy human eye. Researchers will shine safe, low-power lasers into the eyes of 20 healthy volunteers and measure how the light reflects. The goal is to improve the safety an…

This early-stage study aims to understand the safety and imaging properties of an experimental radioactive tracer called RAD301. The research involves 9 participants, including both healthy volunteers and people with specific cancers like pancreatic, lung, or ovarian cancer. Part…

This study collects blood samples from healthy volunteers and people with HIV to support laboratory research on infectious diseases and immune function. Participants undergo a special blood collection procedure called apheresis, which allows researchers to obtain larger quantitie…

This is the first study in people for a new drug called VV261. Its main purpose is to check the safety and see how the body absorbs and eliminates the drug. The study will enroll 58 healthy volunteers in China who will receive a single dose of either the drug or a placebo. Resear…

This early-stage study aims to understand how the body processes and tolerates three new drug compounds (DWJ1622, DWC202313, and DWC202314). It will enroll 40 healthy adult volunteers to measure drug levels in the blood and check for side effects. The main goal is to gather basic…

This study aims to understand what happens in the brain when someone thinks about or attempts suicide. Researchers will compare brain scans, sleep patterns, and blood tests from people with different levels of suicidal thoughts to healthy volunteers. Some participants currently i…

This is an early safety study testing an experimental nasal spray called CHF6467 in 68 healthy adults. Researchers want to see if the spray is safe and how the body processes it, including whether it reaches the fluid around the brain and spinal cord. The study will test single d…