HEALTHY VOLUNTEERS

This early-stage trial tests a new booster vaccine called CD40.Pan.CoV in 48 healthy adults in France. The goal is to see if it is safe and boosts the body's immune response against COVID-19. Participants receive one injection, and researchers monitor for side effects and measure…

This early-stage study tests whether the experimental drug TAK-781 is safe and tolerable. First, healthy volunteers receive either the drug or a placebo. Then, people with primary sclerosing cholangitis (PSC), a rare liver disease, receive the drug. The study also measures how th…

This study tests a new medicine called BMS-986470 in healthy people and those with sickle cell disease. The goal is to check if it is safe and how well it works. About 184 participants will take the drug or a placebo. The study is still recruiting.

This early-stage study tests a new oral drug called RO7795081 in 30 healthy Chinese adults who are overweight or obese. The main goal is to check the drug's safety and how the body processes it, not yet to prove weight loss. Participants are randomly assigned to receive either th…

This early-stage study is testing a new medicine called NNC0581-0001 for people with fatty liver and suspected liver inflammation. About 48 adults will receive either the drug or a placebo as a monthly injection for three months. The main goal is to check safety and how the drug …

This study explores whether suvorexant, a drug used for sleep problems, can help people with alcohol use disorder (AUD) by changing how the brain's dopamine system works. Researchers will compare suvorexant to a placebo in 180 adults (ages 18-75) with AUD who are undergoing detox…

This study tests a new drug called JUV-161 in healthy adults aged 40 to 65 to see if it can prevent muscle loss when a leg is immobilized. Participants will receive weekly injections of JUV-161 or a placebo for about 6 weeks. The main goals are to check safety and measure changes…

This early-stage study tests a new drug called CPTX2309 in healthy people and those with moderate to severe rheumatoid arthritis (RA) or systemic lupus erythematosus (SLE). The main goal is to see if the drug is safe and tolerable. About 64 participants will receive the drug by I…

This early-stage study tests an experimental drug called ALN-PNP in healthy adults and people with a type of fatty liver disease (MASLD) who have a specific gene variant. The main goal is to check safety and how the body processes the drug. Researchers will also measure changes i…

This early-stage study tests a new drug called MTX-101 in healthy adults and people with type 1 diabetes. The main goal is to check for side effects and see how the drug moves through the body. Researchers will also look at how MTX-101 affects immune cells. The study involves up …

This early-stage study tests an experimental drug called NNC4004-0002 in 60 adults with high uric acid but no symptoms. The main goal is to check if a single injection under the skin is safe and well-tolerated. Researchers will also measure how well it lowers uric acid levels. Pa…

This early-stage study aims to determine if the experimental drug IGT-303 is safe for people with chronic kidney disease. Researchers will give either IGT-303 or a placebo to 94 healthy volunteers and kidney disease patients, then monitor for side effects. The study will test dif…

This is the first study in humans to test the safety and tolerability of a new oral drug called Leucettinib-21. It will involve healthy volunteers and a small group of people with Down syndrome or Alzheimer's disease. The main goal is to see how the body handles the drug and to c…

This study tests a new, ultra-low radiation PET scan to detect Alzheimer's disease and other dementias. Researchers aim to reduce radiation exposure by 10 to 100 times compared to current scans. About 200 adults, including healthy volunteers and those with memory problems, will r…

This study tests a new PET imaging method that uses 10 to 100 times less radiation than standard scans to detect neuroendocrine tumors. Researchers will enroll 200 healthy volunteers and people with neuroendocrine tumors to see if the low-dose approach still produces clear images…

This study tests a new vaccine (PCV21) designed to protect babies against 21 types of pneumococcal bacteria, which can cause pneumonia, meningitis, and ear infections. About 2,195 healthy infants will receive four doses of either the new vaccine or a currently licensed vaccine st…

This study explores whether taking a combination of vitamin C, green tea, and multivitamin/mineral capsules for 12 weeks can improve skin health and how people feel about their overall health. It involves 120 healthy Chinese adults who eat few fruits and vegetables. Participants …

This early-stage study tests a new drug called ABCL635 in healthy people and in postmenopausal women with moderate-to-severe hot flashes. The goal is to see if it is safe and whether it can reduce the number and severity of hot flashes. About 136 participants will receive the dru…

This study tests a new drug called BGB-45035 for the first time in humans. It starts by giving the drug to healthy volunteers to check safety and how the body processes it. Then, it will be tested in people with autoimmune skin conditions like eczema and prurigo nodularis to see …

This early study tests whether a device that sends mild electrical pulses to the spinal cord and muscles can improve arm, hand, or leg movement in people with paralysis from spinal cord injury, stroke, or other nerve damage. Up to 64 participants will attend up to 5 sessions per …

This study tests a new software called Motion Reset that may prevent or reduce cybersickness (similar to motion sickness) in people using virtual reality. Healthy adults aged 18-60 will try different VR experiences and report any symptoms like nausea or dizziness. The goal is to …

This study tests whether a 12-week program combining modern dance with mindfulness exercises can improve psychological well-being, reduce stress, and increase happiness in recreational adult dancers. About 160 adults who already take dance classes will be randomly assigned to eit…

This study is testing whether a daily supplement made from a sugar found in human milk can increase the amount of helpful bacteria in the gut. Researchers will enroll 100 healthy adults who eat a typical Western diet. Participants will take the supplement powder twice a day for a…

This early-phase study tests the safety and how the body handles the experimental drug SEP-479 in 150 healthy adults aged 21 to 60. Participants receive single or multiple doses to check for side effects and measure drug levels in the blood. The study does not aim to treat any di…

This study aims to create a large collection of medical images (MRI and ultrasound) from 2400 healthy volunteers across France. Researchers will analyze the heart, blood vessels, and liver to understand how normal aging differs from disease. The goal is to improve early detection…

This early-stage study tests the safety and how the body processes an experimental drug called BMS-986521. About 106 healthy adults will receive either the drug or a placebo. The goal is to check for side effects and measure drug levels, not to treat any disease.

This early-stage study tests whether MRT-8102 is safe and how it works in the body. It involves 100 healthy adults and people with heart risk factors and high CRP levels. Participants receive either the drug or a placebo as single or daily doses for up to 28 days. The goal is to …

This early-stage study will give 10 healthy adults a combination of psilocybin (the active ingredient in magic mushrooms) and D-serine (an amino acid) to see if it is safe and how it affects the mind. The goal is to find out if D-serine can reduce the psychedelic effects of psilo…

This early-stage study tests a single dose of Alpha-0261 tablets in 60 healthy adults aged 18 to 55. The main goal is to check safety and how the drug moves through the body. No treatment is given for any disease; this is a first step to see if the drug is safe enough for future …

This early-stage study is testing new versions of experimental drugs called KarX and KarT in 72 healthy adults. The goal is to see how the body absorbs and processes these prototypes compared to the original drug, and whether food changes their effects. Participants will receive …

This study looks at whether putting a special tape on the diaphragm (the main breathing muscle) can make high-intensity interval training (HIIT) more effective. Thirty trained adults aged 18-35 will do an 8-week cycling program, with half also getting the tape. Researchers will m…

This study looks at how a new drug called repinatrabit interacts with several common medicines (birth control pills, metformin, carbamazepine, rosuvastatin, and methotrexate) in 48 healthy adults. The goal is to measure drug levels in the blood and check for side effects. Results…

This study collects blood samples from 1,000 healthy adults aged 18 and older to help researchers learn more about blood vessel and immune system diseases. Participants will have blood drawn once or up to several times over 10 years and receive $50 per visit. The samples will be …

This study collects blood plasma and white blood cells from healthy volunteers and patients using a procedure called apheresis. The samples are used in laboratory research on HIV and immune function. Participants must be 18 or older and enrolled in an NIH study or be a healthy vo…

This study aims to improve how MRI scans work by testing new techniques and settings. Healthy adults and current NIH participants aged 18 and older can join. Participants will have one or more MRI scans, possibly with a contrast agent, and blood samples may be taken. The goal is …

This early-stage study is testing a single inhaled dose of a new drug called RJ026 in 42 healthy volunteers and 42 people with interstitial lung disease (ILD), a condition that causes lung scarring. The main goal is to see how the drug moves through the body and whether it is saf…

This study looks at whether a gentle chest massage technique, called intercostal mobilization, can help healthy young adults breathe better and walk farther. Researchers will measure lung function and walking performance in 90 sedentary volunteers aged 18-30. Participants are ran…

This study aims to create a detailed map of the bacteria and fungi living on the skin and in the gut of 5,000 healthy volunteers. Researchers will collect samples from different body sites and analyze how factors like diet, location, and medical history shape each person's unique…

This study collects blood and urine samples from 1,000 healthy volunteers and patients with heart or lung conditions. Researchers will analyze genes, proteins, and other substances to develop new lab tests and better understand diseases. Participants must be 18 or older and can p…

This study looks at how healthy brains process social information, like understanding others' feelings (empathy) and thoughts (mentalizing). Researchers will use brain scans (fMRI) and brain wave recordings (EEG) in 200 healthy volunteers to see which brain areas are active durin…

This study collects blood, bone marrow, urine, and tissue samples from people with cancer or blood disorders, as well as from their healthy family members who are stem cell donors. The samples are used in lab research to better understand diseases, improve treatments, and find ne…

This early-stage study is testing a single dose of an experimental drug called VV913 in 56 healthy Chinese men aged 18 to 45. The main goal is to check if the drug is safe and how the body processes it. Participants are randomly assigned to receive either the drug or a placebo, a…

This early-stage study tests whether ARGX-124 is safe in healthy adults aged 18 to 65. Researchers will also measure how the drug moves through the body and how the immune system reacts. About 104 participants will receive either the drug or a placebo and be followed for up to 23…

This study aims to learn more about biomarkers—substances in blood and tissues—and how they relate to aging. Researchers will follow 900 healthy and frail adults over time, collecting blood, urine, and tissue samples, along with memory tests and scans. The goal is to find ways to…

This study aims to understand what happens in the brain when someone has thought about or attempted suicide. Researchers will use interviews, blood tests, brain scans, and sleep monitoring to compare four groups: people who recently had suicidal thoughts or attempts, those with p…

This study aims to describe the physical and behavioral traits of overweight and obese adults compared to healthy-weight individuals. Researchers will measure hormones, metabolism, food preferences, fitness, sleep, and thinking patterns in 2,000 participants over 18. The goal is …

This early-stage study tests a single oral dose of VV261 tablets in 58 healthy adults aged 18-45. The goal is to check safety, side effects, and how the drug moves through the body. Participants are randomly assigned to receive either VV261 or a placebo. This study does not aim t…

This study looks at how healthy men absorb, break down, and eliminate a drug called E2086. Ten participants will receive a single dose with a radioactive tracer to track the drug's path through the body. The goal is to understand the drug's metabolism and excretion, not to treat …

This study uses brain scans (fMRI) to understand how healthy people make decisions and how aging changes this process. Researchers will recruit 150 healthy adults to complete thinking tests and brain imaging. The goal is to create a baseline for future studies on decision-making …

This early-stage study is testing a new drug, AKB-9090, in healthy adults to see if it is safe and how the body processes it. About 70 participants will receive either the drug or a placebo in single or multiple doses. The goal is to gather safety information, not to treat any di…

This study aims to understand how sleep improves visual learning. Researchers will use MRI and sleep monitoring to watch brain activity in 10 healthy adults while they sleep. Participants will also do a visual task to measure changes in their eyesight.

This early-stage study is testing a new drug called MT-701 in 78 healthy adults aged 19 to 55. The main goal is to see if the drug is safe and how the body handles it. Participants will receive either the drug or a placebo, and researchers will monitor for side effects and measur…

This study checks whether a single dose of balinatunfib changes the heart's electrical activity in healthy adults aged 18 to 55. Researchers will compare it to a placebo and another drug to see if it causes any heart rhythm issues. The results will help determine if the drug is s…

This study looks at how a brain region called the posterior parietal cortex (PPC) helps us combine vision and body awareness to guide hand movements. People with optic ataxia, caused by damage to this area, have trouble reaching for objects and may also have perception issues. Re…

This study tests whether the experimental drug BMS-986278 changes the heart's electrical activity in 32 healthy adults aged 18 to 55. Participants receive the drug, a placebo, and a positive control in random order. The goal is to check for heart rhythm risks, not to treat any di…

This study looks at how the brain's electrical activity differs in people with fibromyalgia compared to healthy volunteers. It also tests whether a gentle, non-invasive brain stimulation technique called HD-tDCS can reduce chronic pain. About 150 adults with fibromyalgia and heal…

This early-stage study is testing a new drug, LAD106, in 93 healthy adults aged 18 to 45. The goal is to check its safety, how the body processes it, and any side effects. Participants receive either the drug or a placebo in single or multiple doses. This research helps determine…

This study tests whether biotin (vitamin B7) can be used to label platelets so doctors can track how long they survive after a transfusion. Healthy volunteers donate their own platelets, which are labeled with biotin and a small amount of radioactive material, then returned to th…

This early-phase study tests the safety and tolerability of a new drug called CLYM116 in 48 healthy adults aged 18 to 60. Participants receive either the drug or a placebo by injection, and researchers monitor for side effects and how the drug moves through the body. The goal is …

This study collects samples like blood, stool, saliva, and skin swabs from 600 healthy volunteers aged 3 to 80. The samples are used to develop and improve research tests, not to treat any disease. Participants may be asked to give samples over 5 years, with visits lasting about …

This early-stage study is testing a new drug, ME3241, in healthy adults to see if it is safe and how the body processes it. About 104 people aged 18 to 55 will receive either the drug or a placebo. The study does not aim to treat any disease, but to gather important safety inform…

This early-stage study is testing how safe three experimental drugs (DWJ1622, DWC202313, and DWC202314) are and how they move through the body after a meal. It involves 36 healthy adults who will receive single doses in a random order. The goal is to gather basic safety and drug-…

This early-stage study tests whether a single inhaled dose of RCS-21 is safe and tolerable in 24 healthy adults aged 18 to 64. Participants receive either the drug or a placebo and are closely monitored for side effects and how the drug moves through the body. The study does not …

This study tests a special imaging technique called adaptive optics to take super-detailed pictures of the retina. Researchers want to see if this method can detect eye diseases earlier than standard exams. About 1000 people aged 12 and older, with or without eye conditions, will…

This study looks at how transcranial magnetic stimulation (TMS) changes brain activity in healthy adults. TMS is a non-invasive method that uses magnetic pulses to stimulate the brain. Researchers want to understand these effects to design better treatments for drug addiction. Ab…

This study looks at how quickly the body breaks down a drug called KarXT based on a person's CYP2D6 metabolism type. Healthy adults aged 18-55 with specific metabolizer types (normal, intermediate, poor, or ultrarapid) can join. The goal is to measure drug levels and safety, not …

This study looks at how healthy adults absorb and process kaempferol, a natural compound found in many plants. Researchers will give participants kaempferol and collect blood and urine samples to measure its levels in the body. The goal is to better understand how kaempferol work…

This study uses a non-invasive technique called temporal interference (TI) to stimulate deep brain regions in 30 healthy adults aged 18-50. Researchers will use fMRI to see how brain activity changes during different stimulation patterns. The goal is to better understand how deep…

This study looks at whether adding nitrate—a natural compound found in leafy greens and beetroot—to common foods like cereal bars, porridge, and biscuits can help the body produce more nitric oxide, which may lower blood pressure. Thirty healthy adults will eat these fortified fo…

This study is for healthy adults to test different tablet versions of a drug called BMS-986435. Researchers want to see how well each tablet works and if eating food changes how the drug is absorbed. The study involves 140 participants and includes checkups like heart tests and b…

This early-stage study is testing a new drug called ABBV-243 in healthy adults to see if it is safe and how the body processes it. About 66 participants will receive either the drug or a placebo, and researchers will monitor for side effects and measure drug levels in the blood. …

This early-stage study is testing a new drug, ABCL575, for the first time in people. It will give a single dose to 40 healthy volunteers to see if it is safe and how the body handles it. The goal is to check for side effects and measure drug levels in the blood, not to treat any …

This study is a preparation step for future clinical trials. Researchers will test brain and heart imaging methods on 150 healthy volunteers, people with Parkinson's disease, and those with paralysis. The goal is to make sure the equipment and procedures work well before launchin…

This study looks at whether the length of your training sessions changes how well your body resists fatigue during long endurance exercise. Researchers will compare two groups of healthy volunteers who do either long or short training sessions. The goal is to see which group main…

This early-phase study tests the safety and tolerability of a single dose of HW241045 in 56 healthy adults aged 18-55. Participants are randomly assigned to receive either the drug or a placebo, and researchers monitor for side effects. The goal is to gather initial safety data b…

This small study looks at how energy drinks change the heart's electrical signals in healthy adults aged 18-40. Three participants will try eight different drinks and have their heart activity measured by ECG. The goal is to see if energy drinks cause any temporary changes in hea…

This study is testing a new device that uses light to measure pulse waves and estimate blood pressure. Researchers want to see if this method is as reliable as current standard devices. The study involves 27 healthy adults and aims to improve how we monitor heart health without n…

This early-stage study tests the safety of a new drug called CHF6467 given as a nasal spray. It involves 68 healthy adults to see how the drug behaves in the blood and spinal fluid, and whether it causes side effects. The study has two parts: one with a single dose and one with m…

This study collects white blood cells from healthy volunteers for laboratory research. Participants must be at least 18 years old and healthy. The procedure, called cytapheresis, removes only white blood cells and returns the rest of the blood to the donor. Donations can be made …

This study aims to establish normal scores on tests for spatial neglect—a common attention problem after stroke—by testing 210 healthy French-speaking volunteers aged 20 to 89. Participants will complete simple paper-and-pencil tasks, like crossing out apples on a page. The resul…

This early-stage study is testing a new drug called PBK_M2301 in 32 healthy adults aged 19 to 64. The goal is to see how the drug is absorbed and processed in the body, and to check for any safety issues. Participants will receive the drug and two reference drugs in a random orde…

This study looks for better ways to measure what people eat, especially sugar, without relying on memory or food diaries. Researchers will give 60 healthy adults different amounts of sugar in soda and then check if stable isotopes in blood, hair, and fat can accurately track thos…

This study looks at how much of the drug KarXT (xanomeline and trospium) gets into the breast milk and blood of healthy women who are breastfeeding. About 8 participants will take KarXT and provide milk and blood samples over 24 hours. The goal is to estimate how much of the drug…

This study looks at whether a common grip strength device can reliably measure a person's sense of force, known as proprioception. Researchers will test 55 healthy volunteers aged 18-24 twice to see if the results are consistent. The goal is to provide an easy, accessible way for…

This early-phase study is testing the safety and how the body processes three experimental drugs (DWJ1622, DWC202313, and DWC202314) in 40 healthy adults. Participants take a single dose on an empty stomach and are monitored closely. The goal is to gather basic safety and drug-le…

This study looks at how your internal body clock changes the way you perceive time, think, and feel when you stay awake for 36 hours. Thirty healthy adults aged 23 to 45 will stay in a controlled lab, awake the whole time, with constant light, posture, food, and activity. Every t…

This study looks at how thoughts, expectations, and emotions change the way we feel pain. Researchers will use brain scans and other tests on 500 healthy adults aged 18 to 50. The goal is to understand pain better, not to test a new treatment.

This study checks if emergency medicine doctors can get clear ultrasound images of the abdominal wall muscles, which is needed for a type of pain block called a TAP block. About 118 healthy adults will have an ultrasound scan, but no medicine is given. The goal is to see if body …

This early-stage study will give a single dose of the experimental drug YN001 to 24 healthy adults aged 18 to 65. Researchers will measure how the drug moves through the blood, how long it stays, and whether it causes any side effects. The goal is to gather safety and drug-level …

This study looks at how unconscious factors, like how information is presented, affect decision-making in healthy people. Researchers will test 200 volunteers to see if these factors change with age. The goal is to create a baseline to better understand decision-making problems i…

This study aims to develop better MRI techniques for imaging the heart and blood vessels, avoiding the radiation used in standard X-ray tests. Researchers will compare these new MRI methods with traditional angiography and CT scans in up to 4,000 adults, including healthy volunte…

This study looks at whether the artificial sweetener sucralose changes how the body absorbs and processes certain medicines, as well as its effects on hormones, gut bacteria, and fat cells. About 150 healthy overweight Black and Hispanic women will take either sucralose or a plac…

This study looks at how healthy people's brains predict the timing of sounds and speech. Researchers will use EEG and MEG to measure brain activity while volunteers listen to different sounds. The goal is to understand how we process natural speech rhythms, which could help impro…

This study aims to understand how laser light bounces off different parts of the eye, like the cornea and retina. Researchers will measure the reflected light at various angles and colors in 20 healthy volunteers aged 18-40. The goal is to make laser-based eye exams safer and mor…

This early-stage study tests an experimental drug called RO7875913 in 40 healthy adults. The main goal is to check for side effects and see how the drug moves through the body. Participants will not receive any treatment for a disease, but the results will help decide safe doses …

This early-stage study is testing a new drug, ZP9830, in healthy volunteers to see if it is safe and how the body handles it. About 124 people aged 18 to 45 will receive either the drug or a placebo. The goal is to check for side effects and learn how the drug moves through the b…

This study looks at how different parts of the brain work together when people decide whether to put in effort for a reward. Researchers will use safe, non-invasive brain stimulation on 204 healthy volunteers aged 18-40 to see how changing brain connections affects motivation. Th…

This study collects biological samples—like blood, skin, and saliva—from people with skin diseases, their family members, and healthy volunteers. The goal is to understand what causes different skin conditions and find better ways to treat them. Participants may provide samples d…

This study collects blood, bone marrow, and cheek cell samples from healthy volunteers to help researchers understand blood diseases like aplastic anemia and viral blood infections. Participants must be 8 or older for blood and cheek samples, and 18 or older for bone marrow. The …

This early-stage study tests the safety and tolerability of a new drug called RBD1119 in 32 healthy adults aged 18 to 65. Participants receive a single injection under the skin, and researchers monitor for side effects and how the drug moves through the body. The goal is to gathe…

This early-stage study is testing an experimental drug called RO7806881 in healthy volunteers to see if it is safe and how the body processes it. About 128 healthy adults will receive either the drug or a placebo, with doses increased gradually. The main goal is to check for side…

This study explores whether training your motor skills (like hand movements) can also improve your ability to learn a language. Researchers believe that when the brain changes during motor learning, it might also help language functions that use the same brain areas. The study wi…

This study looks at how a person's background—like race or ethnicity—affects how they feel and show pain, and how others judge that pain. Researchers will measure pain responses in healthy volunteers and then test if people can learn to assess pain more accurately. The goal is to…

This study looks at how two other drugs (itraconazole and rifampin) change the amount of AR-LDD in the blood of healthy adult men. It involves 42 participants and is only for research, not treatment. The goal is to understand drug interactions for future use.

This early-phase study is testing a new substance called RAD301 in 9 healthy volunteers and people with certain cancers (pancreatic, lung, esophageal, cervical, endometrial, or ovarian). The main goal is to see how RAD301 moves through the body and how much radiation reaches orga…

This study looks at how taking VV119 with or without a standard meal changes the way the body processes the drug. It involves 16 healthy Chinese volunteers who will take a single dose of VV119 under different conditions. The goal is to measure side effects and drug levels in the …

This study looks at how people use hearing versus physical sensation when they speak. Healthy adults aged 18 to 45 will complete speech tasks where their hearing is altered through headphones, sometimes with a visual display of their speech. A computer model will estimate each pe…

This study aims to understand how genes and the environment shape children's eating behavior and health over time. Researchers will follow 1,500 children ages 8-17 for up to 6 years, using wrist monitors, smartphone surveys, and yearly checkups that include blood tests, X-rays, a…

This study collects blood, urine, saliva, and tumor tissue from people with or at risk for urothelial cancer, as well as from healthy volunteers. The goal is to analyze DNA and other molecular changes to learn what causes this cancer and how it responds to treatment. Participants…

This study screens up to 16,000 people aged 3 to 99 with mood or anxiety disorders, as well as healthy volunteers, to see if they can join other research studies at the National Institute of Mental Health. Participants undergo interviews, medical tests, and brain scans to collect…

This study is an early test of a new medicine called RO7763505. It will check if the drug is safe and how the body processes it. The trial includes about 196 people, first healthy volunteers and then patients with stable coronary artery disease. Participants will receive either t…

This study aims to measure how quickly proteins in the body are replaced (protein turnover) in healthy adults of different ages. Participants will drink small amounts of safe heavy water for 21 days and undergo tests including muscle and fat biopsies, imaging scans, and strength …

This study tests a new device called pneuRIP that measures breathing without touching the body. It uses special bands placed around the chest and belly. The study will include 10 healthy children and 10 children with mild breathing problems from muscle diseases. Researchers want …

This study looks at how taking a new medicine (ZN-A-1041) with food or with a common stomach-acid drug (rabeprazole) changes the amount of medicine in the blood. About 48 healthy adults will take the medicine under different conditions to measure absorption. The results will help…

This study looks at how a new drug called KarXT changes the levels of three other drugs (midazolam, fexofenadine, and digoxin) in the body. It involves 60 healthy adults and is done in three parts. The goal is to understand potential drug interactions, not to treat any disease.

This early-stage study tests a new drug called ALN-4285 in healthy adults to see if it is safe and how the body processes it. Participants receive a single injection of the drug or a placebo. The study aims to gather basic safety information before testing the drug in patients wi…

This study looks at how eating more calories changes the energy your body uses to digest food. Healthy adults aged 18 to 60 will stay in a clinic for about 35 days and eat 8 different diets. Researchers will measure their energy use in a special room to understand how protein, fa…

This early-stage study tests the safety and tolerability of a new drug called MT-251 in 70 healthy adults aged 19 to 55. Participants receive either the drug or a placebo, and researchers monitor for side effects and how the drug moves through the body. The study does not aim to …

This study screens healthy adults aged 18 and older to see if they qualify for future vaccine or treatment trials for infectious diseases. It collects basic information like race, ethnicity, and gender, and tracks how many people go on to join other studies. The goal is to make i…

This study aims to create a large database of healthy Caucasian knee anatomy and function using advanced imaging techniques like CT scans and ultrasound. Researchers will enroll 200 healthy volunteers aged 20-35 to measure knee shape, alignment, and ligament balance. The goal is …

This study looks at how a wearable robotic hip device changes the way healthy adults walk. Researchers will measure step length, speed, muscle activity, and foot pressure under different levels of assistance. The goal is to understand how the device affects natural movement, whic…

This early-stage study aims to determine if a new compound called LIFE-001 is safe for healthy adults. Researchers will enroll 150 healthy volunteers to test different doses and monitor how the body processes the drug. The main goal is to understand side effects and how the compo…

This study is developing new ways to help people recover from 'unilateral neglect,' a common problem after a stroke where patients ignore one side of their space. Researchers are testing if virtual reality goggles or even just mental practice can retrain the brain, similar to cur…

This is a first-in-human study to check the safety and see how the body processes a new drug called KLA478. It will involve 40 healthy adult volunteers. Researchers will give single, increasing doses to see how much is safe and how the drug moves through the body.

This early-stage study aims to check if a new drug called ARGX-213 is safe for people. Researchers will give the drug to 80 healthy adults and closely monitor them for side effects. They'll also measure how long the drug stays in the blood and how the body responds to it. Partici…

This study is testing a new, non-invasive brain stimulation technique called temporal interference (TI) on healthy volunteers. Researchers want to see if TI can safely and precisely activate deep brain areas without affecting the surface of the brain, which is measured using an M…