HEALTHY VOLUNTEERS

This early-stage trial tests a new booster vaccine called CD40.Pan.CoV in 48 healthy adults in France. The goal is to see if it is safe and boosts the body's immune response against COVID-19. Participants receive one injection, and researchers monitor for side effects and measure…

This study tests a new drug called JUV-161 in healthy adults aged 40 to 65 who have one leg immobilized for about 6 weeks. The goal is to see if the drug can prevent muscle loss and is safe. Participants receive weekly injections of either JUV-161 or a placebo, and researchers me…

This study is testing whether a new drug called IGT-303 is safe for people with chronic kidney disease. It will involve 94 healthy volunteers and people with kidney disease, who will receive either the drug or a placebo. The main goal is to check for side effects and how the drug…

This early-stage study tests a new drug called BGB-45035 for safety and how the body processes it. First, healthy volunteers receive single or multiple doses. Then, people with autoimmune skin diseases like atopic dermatitis (eczema) or prurigo nodularis receive the drug to check…

This early-stage study tests a new medicine called BMS-986470 in healthy volunteers and people with sickle cell disease. The main goal is to check safety and how the body handles the drug. Up to 184 participants will receive either the drug or a placebo to find the right dose and…

This early-stage study tests an experimental oral drug, RO7795081, in 30 healthy Chinese adults who are overweight or have obesity. The main goal is to check the drug's safety and how the body processes it, not to prove weight loss yet. Participants will receive either the drug o…

This early-stage study tests a new drug called CPTX2309 in healthy people and those with moderate to severe rheumatoid arthritis (RA) or systemic lupus erythematosus (SLE). The main goal is to check if the drug is safe and tolerable. About 64 adults will take part, receiving the …

This early-stage study tests whether the drug TAK-781 is safe and tolerable. First, healthy volunteers receive either the drug or a placebo. Then, people with primary sclerosing cholangitis (PSC) receive the drug. The study also looks at how the body processes TAK-781. About 134 …

This study tests an experimental drug called ALN-PNP for metabolic dysfunction-associated steatotic liver disease (MASLD). It is the first time this drug is being tested in humans. The study includes healthy adults and people with MASLD who have a specific gene variant. The main …

This early-stage study is testing a new medicine called NNC0581-0001 for people with fatty liver and suspected liver inflammation. About 48 adults will receive either the drug or a placebo as a monthly injection for three months. The main goal is to check safety and how the drug …

This study explores whether suvorexant, a drug used for sleep problems, can help people with alcohol use disorder (AUD) by changing how the brain's dopamine system works. Researchers will compare suvorexant to a placebo in 180 adults (ages 18-75) with AUD who are undergoing detox…

This early-stage study tests a new drug called MTX-101 in healthy adults and people with type 1 diabetes. The main goal is to check for side effects and see how the drug moves through the body. Researchers will also look at how MTX-101 affects immune cells. The study involves up …

This early-stage study tests an experimental drug called NNC4004-0002 in 60 adults with high uric acid but no symptoms. The main goal is to check if a single injection under the skin is safe and well-tolerated. Researchers will also measure how well it lowers uric acid levels. Pa…

This is the first study in humans to test the safety and tolerability of a new oral drug called Leucettinib-21. It will involve healthy volunteers and a small group of people with Down syndrome or Alzheimer's disease. The main goal is to see how the body handles the drug and to c…

This study tests a new PET imaging method that uses 10 to 100 times less radiation than current scans to find neuroendocrine tumors. Researchers will scan 200 healthy volunteers and tumor patients using a special tracer that binds to tumor proteins. The goal is to see if the lowe…

This study tests a new, ultra-low radiation PET scan to detect Alzheimer's disease and other dementias. Researchers aim to reduce radiation exposure by 10 to 100 times compared to current scans. About 200 adults, including healthy volunteers and those with memory problems, will r…

This study tests a new vaccine (PCV21) in healthy infants to see if it safely helps their bodies build defenses against 21 types of pneumococcal bacteria, which can cause serious infections like pneumonia and meningitis. About 2,195 babies will receive four doses of either the ne…

This study tests whether a new software called Motion Reset can prevent or reduce cybersickness—symptoms like nausea, dizziness, and headache—in healthy adults using virtual reality. About 150 volunteers aged 18 to 60 will be split into three groups: one using the anti-sickness s…

This study tests whether a 12-week program combining modern dance with mindfulness practices can improve psychological wellbeing, reduce stress, and enhance body awareness in healthy adults. About 160 recreational dancers will be randomly assigned to either the dance-mindfulness …

This early-stage study tests a new drug called ABCL635 in healthy people and in postmenopausal women with moderate-to-severe hot flashes. The goal is to see if it is safe and whether it can reduce the number and severity of hot flashes. About 136 participants will receive the dru…

This early study tests whether a device that sends mild electrical pulses to the spinal cord and muscles can improve arm, hand, or leg movement in people with paralysis from spinal cord injury, stroke, or other nerve damage. Up to 64 participants will attend up to 5 sessions per …

This early-stage study is testing three experimental drugs (DWJ1622, DWC202313, and DWC202314) in 36 healthy adults to see how the body processes them and if they are safe. Participants take the drugs after a meal, and researchers measure drug levels in the blood. The goal is to …

This early-stage study tests a new drug called RO7806881 in healthy volunteers to see if it is safe and how the body processes it. About 128 participants will receive either the drug or a placebo. The study does not aim to treat any disease, but to gather important safety informa…

This study collects blood samples from 1000 healthy adults aged 18 and older to help researchers study blood vessel and immune system diseases. Participants give about 10 tablespoons of blood per visit and can return for up to 10 years. The blood is used to develop lab tests and …

This study collects blood, bone marrow, and cheek cell samples from healthy volunteers ages 8 and older. Researchers use these samples to study blood cell formation, viral blood diseases, immune system problems, and genetic risks for conditions like aplastic anemia. The goal is t…

This study aims to create a detailed map of the bacteria and fungi living on the skin and in the gut of 5,000 healthy volunteers. Researchers will collect samples from different body sites and analyze how factors like diet, location, and medical history shape each person's unique…

This early-stage study tests a new drug called PBK_M2301 in 32 healthy adults aged 19 to 65. The goal is to measure how much of the drug gets into the blood and check for any safety issues. Participants will take the drug once and provide blood samples over time. This study does …

This study uses a new electrical stimulation technique called temporal interference to safely reach deep brain regions without surgery. Researchers will scan the brains of 30 healthy adults aged 18-50 to see how this method changes brain activity. The goal is to better understand…

This early-stage study tests the safety and how the body handles an experimental drug called BMS-986521. About 106 healthy adults will receive either the drug or a placebo. The goal is to check for side effects and measure drug levels in the blood, not to treat any disease.

This study looks at how healthy men absorb, break down, and get rid of a drug called E2086. Ten participants will receive a single dose with a radioactive tracer to track the drug in blood, urine, and stool. The goal is to understand the drug's metabolism and excretion, not to tr…

This study aims to improve current methods and develop new techniques for magnetic resonance imaging (MRI). Researchers will test different scanning parameters on healthy volunteers and current NIH participants aged 18 and older. Participants will undergo one or more MRI scans, e…

This study looks at how healthy adults use timing patterns in sounds and speech to predict what comes next. Researchers will use brain scans (EEG and MEG) and simple listening tasks to understand these processes. The goal is to learn more about language learning and comprehension…

This early-stage study tests the safety of a new drug called ARGX-124 in healthy adults. Researchers will also measure how the drug behaves in the body and how the immune system reacts. About 104 participants will be involved for up to 23 weeks. The goal is to gather important sa…

This study looks at how brain networks synchronize in people with fibromyalgia, a condition causing widespread pain. Researchers will compare brain activity in 150 participants (patients and healthy volunteers) and test a gentle, non-invasive brain stimulation technique called HD…

This study looks for better ways to measure what people eat, especially sugar. Researchers will give 60 healthy adults different amounts of sugar in soda and check if stable isotopes in blood, hair, and other samples can accurately track those sugar levels. Participants will stay…

This early-stage study tests a new drug called YN001 in 24 healthy adults aged 18 to 65. Researchers will measure how the drug moves through the body and check for side effects. The goal is to gather basic safety and drug-level information, not to treat any disease.

This early-stage study is testing a new drug, LAD106, in 93 healthy adults aged 18 to 45. The main goal is to check if the drug is safe and how the body processes it. Participants will receive either the drug or a placebo. This study does not aim to treat any disease, but to gath…

This study looks at how people use hearing versus physical sensation to monitor their speech. Healthy adults will complete speech tasks where their hearing is altered in real time, sometimes with a visual display of their speech. A computer model will estimate each person's relia…

This study is an early test to see if a new drug called LIFE-001 is safe for people. About 150 healthy adults will receive the drug and be monitored for side effects. Researchers will also measure how the drug moves through the body. This is a first step to see if the drug can be…

This study looks at whether longer or shorter training sessions help healthy adults better resist fatigue during prolonged exercise. Researchers will compare changes in cycling power output after a 4-hour ride between two groups: one doing long sessions and one doing short sessio…

This study looks at how energy drinks change the heart's electrical signals in healthy adults aged 18-40. Only 3 people will take part, and each will try 8 different drinks or capsules. The goal is to see if these drinks affect heart rhythm, not to treat any disease.

This early-stage study is testing an experimental drug called ABBV-243 in healthy adults to see if it is safe and how the body processes it. About 66 participants will receive either the drug or a placebo, given as an injection or IV. The study does not aim to treat any disease; …

This early-stage study is testing whether combining psilocybin (the active ingredient in magic mushrooms) with D-serine (an amino acid) is safe and how it affects the mind. Ten healthy adults aged 25-60 will receive one of two dose combinations. The goal is to see if D-serine can…

This study tests whether biotin (vitamin B7) can be used to label platelets so doctors can track how long they survive after a transfusion. Healthy volunteers donate their own platelets, which are treated with biotin and a small amount of radioactive material, then returned to th…

This early-stage study is testing a new drug, CLYM116, in 48 healthy adults aged 18 to 60. The main goal is to check if the drug is safe and how the body handles it. Participants will receive either the drug or a placebo as a shot under the skin. This study does not aim to treat …

This study aims to understand how psychological factors, such as expectations and emotions, influence the way we perceive pain. Healthy volunteers aged 18-50 will undergo brain scans (MRI) and pain tests (heat or electric shocks) while their heart rate, breathing, and other respo…

This study looks at how much of the drug KarXT gets into the breast milk and blood of healthy women who are breastfeeding. Eight mothers will take KarXT and provide milk and blood samples over 24 hours. The goal is to estimate how much of the drug a nursing baby might receive and…

This study tests whether taking vitamin and mineral supplements for 12 weeks can improve skin health and how healthy people feel overall. It involves 120 healthy Chinese adults who eat few fruits and vegetables. Participants are randomly assigned to take either the supplements or…

This early-stage trial is checking if a single inhaled dose of RCS-21 is safe and tolerable in 24 healthy adults aged 18 to 64. Participants receive one dose and are closely monitored for side effects. The study does not aim to treat any disease, just to gather initial safety and…

This study tests a new device called pneuRIP that measures breathing without needles or tubes. It uses special bands placed around the chest and belly. The study will include 10 healthy children and 10 children with mild breathing problems from muscle diseases. Researchers will c…

This early-stage study is testing a new drug called AKB-9090 for the first time in humans. The goal is to see if it is safe and how the body processes it. About 70 healthy adults will receive either the drug or a placebo, with doses given once or multiple times. This research is …

This study tests how a new drug called repinatrabit interacts with other common medications like birth control pills, metformin, and methotrexate. It involves 48 healthy adults and aims to measure drug levels in the blood. The results will help guide safe use of repinatrabit in f…

This study looks at substances in blood and tissues called biomarkers to better understand aging. Researchers will follow 900 healthy and frail adults over many years, collecting samples and doing tests. The goal is to find ways to improve quality of life as people get older.

This study looks at whether emergency medicine doctors can use ultrasound to clearly see the muscle layers of the belly wall, which is needed for a type of pain block called a TAP block. About 118 healthy adults will have an ultrasound scan of their abdomen. The goal is to see if…

This study uses a technique called temporal interference (TI) to stimulate deep brain regions in healthy adults without surgery. Researchers will use MRI scans to see how brain activity changes during different types of stimulation. The goal is to better understand how deep brain…

This study tests a special camera called adaptive optics to take detailed pictures of the retina, the light-sensitive part at the back of the eye. Researchers want to see if this method can find eye diseases earlier than standard exams. About 1,000 people aged 12 and older, inclu…

This study aims to make sure a questionnaire that measures motion sickness in virtual reality (VR) works correctly in Turkish. Researchers will ask 42 healthy volunteers to use VR and then fill out the questionnaire. The goal is to create a reliable tool for Turkish speakers to r…

This study is testing a new device that uses light to measure pulse waves and estimate blood pressure. Researchers want to see if this method is as reliable as current standard devices. The study involves 27 healthy adults and aims to improve how we monitor heart health without n…

This study looks at how changing what you eat—like the amount of protein, fat, carbs, and total calories—affects the energy your body uses to digest food. Healthy adults aged 18 to 60 will stay in a clinic for about 35 days, eating only provided meals and spending 24-hour periods…

This early-stage study is testing a new drug, MT-251, in 70 healthy adults aged 19 to 55. The main goal is to check if the drug is safe and how the body processes it. Participants will receive either the drug or a placebo, and researchers will monitor for side effects. This study…

This early-stage study tests whether a single dose of the experimental drug Alpha-0261 is safe and tolerable in healthy adults. About 60 volunteers aged 18 to 55 will receive either the drug or a placebo. The goal is to check for side effects and how the drug moves through the bo…

This early-stage study is testing an experimental drug called RO7763505 to see if it is safe and how the body processes it. The trial involves about 196 participants, first in healthy volunteers and then in people with stable coronary artery disease. Researchers will monitor side…

This study looks at how healthy adults absorb and process kaempferol, a natural compound found in many plants. Researchers will give kaempferol to 120 volunteers and collect blood and urine samples to measure its levels in the body. The goal is to understand how kaempferol works …

This study looks at how sleep improves visual learning. Researchers will use MRI and sleep monitoring to see what happens in the brain during sleep. Ten healthy adults aged 18-30 will take part. The goal is to understand the process, not to test a treatment.

This study aims to collect medical images (MRI and ultrasound) from 2,400 healthy adults across France to create reference charts for the heart, liver, and fat tissue. By linking these images with health data, researchers hope to better distinguish normal aging from early disease…

This study tests whether a new experimental drug called B-3E07 works like the approved drug Forsteo in the body. It involves 48 healthy adult women aged 18-45. Participants receive a single dose of each drug in random order, and researchers measure drug levels and safety. The goa…

This study looks at how the drug KarXT is broken down in healthy adults who have different types of a liver enzyme called CYP2D6. About 56 participants will be grouped by their metabolism speed (normal, intermediate, poor, or ultrarapid). The goal is to measure drug levels and sa…

This study uses brain scans (fMRI and EEG) to understand how healthy people process social information like empathy and reading others' thoughts. Researchers will look at brain activity in 200 healthy adults to see which areas are involved and how this changes with age. The goal …

This study aims to understand what happens in the brain when someone has thought about or attempted suicide. Researchers will use interviews, blood tests, brain scans, and sleep monitoring to compare four groups: people who recently had suicidal thoughts or attempts, those with p…

This study looks at how a standard meal changes the way a new drug, VV119, is processed in the body. It involves 16 healthy Chinese adults who will take the drug once with and without food. The goal is to see if food affects drug levels and to check for any side effects.

This early-stage study tests the safety and tolerability of a new drug called ALN-4285 in 76 healthy adults. Participants receive a single injection of either the drug or a placebo, and researchers monitor for side effects and how the drug moves through the body. The goal is to g…

This study looks at how different parts of the brain work together when people decide whether to put in effort for a reward. Researchers will use safe, non-invasive brain stimulation and brain scans in 204 healthy adults aged 18-40. The goal is to understand the brain circuits be…

This study looks at how a robotic hip brace (exoskeleton) changes the way healthy adults walk. Researchers will measure step length, speed, muscle activity, and foot pressure while people walk with different levels of assistance from the device. The goal is to understand how the …

This early-stage study is testing a new drug called ABCL575 for the first time in people. It involves 40 healthy adults who will receive either a single dose of ABCL575 or a placebo. The main goal is to check if the drug is safe and how the body handles it. No treatment benefit i…

This study tests whether virtual reality and mental imagery can replace traditional prism adaptation therapy for people with unilateral neglect after a brain injury. Researchers will first work with 480 healthy volunteers to see if these new methods work similarly to the standard…

This early-stage study tests a single inhaled dose of RJ026 in 42 healthy volunteers and 42 people with interstitial lung disease (ILD), a type of lung scarring. The goal is to measure how much drug gets into the blood and lungs, and to check for side effects over 7 days. No trea…

This study looks at how a new drug called KarXT affects the levels of three other medicines (midazolam, fexofenadine, and digoxin) in the blood of healthy adults. Researchers want to see if taking KarXT changes how these drugs are processed by the body. The results will help guid…

This study looks at whether a gentle hands-on technique called intercostal mobilization can make breathing easier and improve walking performance in healthy young adults. Researchers will divide 90 sedentary volunteers aged 18-30 into three groups: one receiving the actual techni…

This study follows 100 healthy adults aged 18 to 29 who have had Epstein-Barr virus (EBV) in the past. Researchers will collect blood and saliva samples over 6 to 12 months to see when and how the virus becomes active again. No treatments or vaccines are given—the goal is simply …

This study is a practice run for future clinical trials. Researchers are testing brain and heart monitoring equipment on healthy volunteers, people with Parkinson's disease, and those with paralysis. The goal is to make sure the tests work well and are comfortable for participant…

This early-phase study is testing a new substance called RAD301 in 9 healthy volunteers and people with certain cancers (pancreatic, lung, esophageal, cervical, endometrial, or ovarian). The goal is to see how the body absorbs and handles the radiation from RAD301, and whether it…

This study tests an experimental drug called MRT-8102 for the first time in humans. It aims to see if the drug is safe and how the body processes it. The trial includes 100 healthy adults and people with high inflammation (elevated CRP) who are at risk for heart disease. Particip…

This study screens healthy adults aged 18 and older to see if they qualify for future vaccine or treatment trials for infectious diseases. Volunteers provide basic health information and may be invited to join other studies. The goal is to make recruitment faster and easier for r…

This study is the first time ZP9830 is being tested in humans. It aims to check the drug's safety and how the body processes it in 124 healthy adults aged 18-45. Participants will receive either the drug or a placebo, and researchers will monitor for side effects and measure drug…

This early-stage study tests a single dose of an experimental drug, VV913, in 56 healthy Chinese men aged 18 to 45. The goal is to check how safe the drug is and how the body processes it, not to treat any disease. Participants are randomly assigned to receive either the drug or …

This study looks at how well different tablet versions of the drug BMS-986435 are absorbed by the body in healthy adults. It also checks if eating food changes how the drug is absorbed. The study involves 140 healthy volunteers and aims to gather important information for future …

This study tests whether a synbiotic supplement (a powder containing a sugar from human milk plus probiotics) can increase helpful gut bacteria in healthy adults. One hundred participants will take the supplement twice daily for 8 weeks. Researchers will measure changes in gut ba…

This study looks at how transcranial magnetic stimulation (TMS) changes brain activity in healthy adults. Researchers want to understand these effects to design better treatments for drug addiction. Participants will have brain scans before, during, and after TMS. The study invol…

This study looks at how laser light bounces off different parts of the eye, like the cornea and retina. The goal is to make eye exams and laser treatments safer. Twenty healthy volunteers aged 18 to 40 will have their eyes tested with low-level lasers at different angles and colo…

This study checks whether a single dose of the experimental drug balinatunfib changes the heart's electrical activity in 44 healthy adults aged 18 to 55. Participants will receive the drug, a placebo, and another control drug in random order. The goal is to ensure the drug is saf…

This study looks at whether a simple handgrip device can reliably measure how well people sense their own grip strength—a part of body awareness called proprioception. About 55 healthy volunteers aged 18 to 24 will perform grip tasks twice to see if the results are consistent. Th…

This study explores whether training your motor skills (like hand movements) can also improve your ability to learn a language. Researchers believe that when the brain changes to learn a new motor skill, it might also boost other functions that use the same brain areas, like lang…

This study collects white blood cells from healthy volunteers using a procedure called cytapheresis. The cells are used for lab research only, not to treat any disease. Participants must be at least 18 years old and can donate up to six times per year.

This study collects blood plasma and white blood cells from healthy volunteers and patients using a procedure called apheresis. The samples are used in laboratory research on HIV and immune function. Participants must be 18 or older and enrolled in an NIH study or be a healthy vo…

This study collects blood and urine samples from 1,000 healthy volunteers and patients with heart or lung conditions. Researchers will analyze genes, proteins, and other substances to develop new lab tests and better understand diseases. Participants must be 18 or older and can p…

This early-phase study tests the safety and how the body handles the experimental drug SEP-479 in 150 healthy adults aged 21 to 60. Participants receive single or multiple doses to check for side effects and measure drug levels in the blood. The study does not aim to treat any di…

This early-stage study is testing a new drug called CHF6467, given as a nasal spray, in 68 healthy adults. The main goal is to see if it is safe and how the body handles it, including measuring drug levels in blood and spinal fluid. Participants will receive either single or mult…

This study looks at whether the artificial sweetener sucralose (found in many diet foods and drinks) affects how the body absorbs and breaks down certain medicines. Researchers will give healthy, overweight Black and Hispanic women either sucralose or a placebo for four weeks and…

This early-stage study is testing a new drug called ME3241 in healthy adults aged 18 to 55. The main goal is to check if it is safe and how the body processes it. About 104 participants will receive either the drug or a placebo. This study does not aim to treat any disease.

This early-stage study is testing new versions of experimental drugs called KarX and KarT in 72 healthy adults. The goal is to see how the body absorbs and processes these prototypes compared to the original drug, and whether food changes their effects. Participants will receive …

This study looks at whether putting a special tape on the diaphragm (the main breathing muscle) can make high-intensity interval training (HIIT) more effective. Thirty trained adults aged 18-35 will do an 8-week cycling program, with half also getting the tape. Researchers will m…

This study collects blood, bone marrow, urine, and tissue samples from people with cancer or blood disorders, as well as from their healthy family members who are stem cell donors. The samples are used in lab research to better understand diseases, improve treatments, and find ne…

This study aims to describe the physical and behavioral traits of overweight and obese adults compared to healthy-weight individuals. Researchers will measure hormones, metabolism, food preferences, fitness, sleep, and thinking patterns in 2,000 participants over 18. The goal is …

This early-stage study tests a single oral dose of VV261 tablets in 58 healthy adults aged 18-45. The goal is to check safety, side effects, and how the drug moves through the body. Participants are randomly assigned to receive either VV261 or a placebo. This study does not aim t…

This study uses brain scans (fMRI) to understand how healthy people make decisions and how aging changes this process. Researchers will recruit 150 healthy adults to complete thinking tests and brain imaging. The goal is to create a baseline for future studies on decision-making …

This early-stage study is testing a new drug called MT-701 in 78 healthy adults aged 19 to 55. The main goal is to see if the drug is safe and how the body handles it. Participants will receive either the drug or a placebo, and researchers will monitor for side effects and measur…

This study looks at how a brain region called the posterior parietal cortex (PPC) helps us combine vision and body awareness to guide hand movements. People with optic ataxia, caused by damage to this area, have trouble reaching for objects and may also have perception issues. Re…

This study tests whether the experimental drug BMS-986278 changes the heart's electrical activity in 32 healthy adults aged 18 to 55. Participants receive the drug, a placebo, and a positive control in random order. The goal is to check for heart rhythm risks, not to treat any di…

This study collects samples like blood, stool, saliva, and skin swabs from 600 healthy volunteers aged 3 to 80. The samples are used to develop and improve research tests, not to treat any disease. Participants may be asked to give samples over 5 years, with visits lasting about …

This study looks at whether adding nitrate—a natural compound found in leafy greens and beetroot—to common foods like cereal bars, porridge, and biscuits can help the body produce more nitric oxide, which may lower blood pressure. Thirty healthy adults will eat these fortified fo…

This early-phase study tests the safety and tolerability of a single dose of HW241045 in 56 healthy adults aged 18-55. Participants are randomly assigned to receive either the drug or a placebo, and researchers monitor for side effects. The goal is to gather initial safety data b…

This study aims to establish normal scores on tests for spatial neglect—a common attention problem after stroke—by testing 210 healthy French-speaking volunteers aged 20 to 89. Participants will complete simple paper-and-pencil tasks, like crossing out apples on a page. The resul…

This early-phase study is testing the safety and how the body processes three experimental drugs (DWJ1622, DWC202313, and DWC202314) in 40 healthy adults. Participants take a single dose on an empty stomach and are monitored closely. The goal is to gather basic safety and drug-le…

This study looks at how your internal body clock changes the way you perceive time, think, and feel when you stay awake for 36 hours. Thirty healthy adults aged 23 to 45 will stay in a controlled lab, awake the whole time, with constant light, posture, food, and activity. Every t…

This study looks at how unconscious factors, like how information is presented, affect decision-making in healthy people. Researchers will test 200 volunteers to see if these factors change with age. The goal is to create a baseline to better understand decision-making problems i…

This study aims to develop better MRI techniques for imaging the heart and blood vessels, avoiding the radiation used in standard X-ray tests. Researchers will compare these new MRI methods with traditional angiography and CT scans in up to 4,000 adults, including healthy volunte…

This early-stage study tests an experimental drug called RO7875913 in 40 healthy adults. The main goal is to check for side effects and see how the drug moves through the body. Participants will not receive any treatment for a disease, but the results will help decide safe doses …

This study collects biological samples—like blood, skin, and saliva—from people with skin diseases, their family members, and healthy volunteers. The goal is to understand what causes different skin conditions and find better ways to treat them. Participants may provide samples d…

This early-stage study tests the safety and tolerability of a new drug called RBD1119 in 32 healthy adults aged 18 to 65. Participants receive a single injection under the skin, and researchers monitor for side effects and how the drug moves through the body. The goal is to gathe…

This study looks at how a person's background—like race or ethnicity—affects how they feel and show pain, and how others judge that pain. Researchers will measure pain responses in healthy volunteers and then test if people can learn to assess pain more accurately. The goal is to…

This study looks at how two other drugs (itraconazole and rifampin) change the amount of AR-LDD in the blood of healthy adult men. It involves 42 participants and is only for research, not treatment. The goal is to understand drug interactions for future use.

This study aims to understand how genes and the environment shape children's eating behavior and health over time. Researchers will follow 1,500 children ages 8-17 for up to 6 years, using wrist monitors, smartphone surveys, and yearly checkups that include blood tests, X-rays, a…

This study collects blood, urine, saliva, and tumor tissue from people with or at risk for urothelial cancer, as well as from healthy volunteers. The goal is to analyze DNA and other molecular changes to learn what causes this cancer and how it responds to treatment. Participants…

This study screens up to 16,000 people aged 3 to 99 with mood or anxiety disorders, as well as healthy volunteers, to see if they can join other research studies at the National Institute of Mental Health. Participants undergo interviews, medical tests, and brain scans to collect…

This study aims to measure how quickly proteins in the body are replaced (protein turnover) in healthy adults of different ages. Participants will drink small amounts of safe heavy water for 21 days and undergo tests including muscle and fat biopsies, imaging scans, and strength …

This study looks at how taking a new medicine (ZN-A-1041) with food or with a common stomach-acid drug (rabeprazole) changes the amount of medicine in the blood. About 48 healthy adults will take the medicine under different conditions to measure absorption. The results will help…

This study aims to create a large database of healthy Caucasian knee anatomy and function using advanced imaging techniques like CT scans and ultrasound. Researchers will enroll 200 healthy volunteers aged 20-35 to measure knee shape, alignment, and ligament balance. The goal is …

This is a first-in-human study to check the safety and see how the body processes a new drug called KLA478. It will involve 40 healthy adult volunteers. Researchers will give single, increasing doses to see how much is safe and how the drug moves through the body.