New RNA drug targets fatty liver in people with specific gene

NCT ID NCT05648214

Recruiting now Disease control Sponsor: Regeneron Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests an experimental drug called ALN-PNP in healthy adults and people with a liver condition called MASLD who have a specific gene variant. The main goal is to check safety and how the body handles the drug. It is a first-in-human trial, so the drug is not yet approved for any use.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ALN-PNP (an experimental RNA-based drug)
What this could lead to: If successful, this could point toward a treatment that reduces liver fat in people with MASLD who have a specific gene variant.
What could go wrong: This is a very early, first-in-human study, so safety and effectiveness are not yet known. The drug may not work or could cause side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

fatty liver disease Fibrosis metabolic dysfunction-associated steatotic liver disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEALTHY VOLUNTEERS METABOLIC DYSFUNCTION-ASSOCIATED STEATOTIC LIVER DISEASE (MASLD)

Contacts and locations

Locations

California Clinical Trials Medical Group
COMPLETED

Glendale, California, 91206, United States
Genoma Research Group, Inc
RECRUITING

Miami, Florida, 33173, United States
Med Research of Florida, LLC
RECRUITING

Miami, Florida, 33186, United States
Pioneer Research Solutions
RECRUITING

Houston, Texas, 77099, United States
Tandem Clinical Research
RECRUITING

Marrero, Louisiana, 70072, United States
Velocity Clinical research
RECRUITING

Los Angeles, California, 90057, United States

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