Regeneron Pharmaceuticals

This trial is testing a one-time gene therapy called DB-OTO in children and infants born deaf due to a specific genetic mutation (OTOF). The goal is to see if a single injection into the inner ear is safe and can restore hearing. Researchers will measure if children can hear soun…

This early-stage study is testing the safety and best dose of an experimental drug called linvoseltamab when it is given alongside other cancer drugs. It is for people with multiple myeloma, a blood cancer, that has come back or stopped responding to several prior treatments. The…

This study is testing two investigational drugs, pozelimab and cemdisiran, to see if they can slow down the progression of geographic atrophy, a late-stage form of age-related macular degeneration that causes permanent central vision loss. The trial will involve about 975 partici…

This study is testing whether injecting an immune-boosting drug directly into an early-stage skin cancer tumor works as well as surgery to remove it. Researchers will compare the drug, cemiplimab, to standard surgical removal in about 369 people with small skin cancers. The main …

This study is testing an experimental drug called linvoseltamab in people with AL amyloidosis that has returned or hasn't responded to prior treatments. The first phase will find the safest dose, and the second phase will see how well it works to reduce the harmful proteins and i…

This study is for adults with early-stage non-small cell lung cancer who are planning to have surgery. Researchers want to see if a three-drug combination (an immunotherapy drug plus chemotherapy plus a third new drug) works better than just the immunotherapy plus chemotherapy. T…

This program provides access to an experimental drug called odronextamab for people with advanced B-cell lymphomas that have come back or stopped responding to standard treatments. It is for patients who have run out of approved treatment options. The goal is to control the cance…

This study is testing a combination of two new drugs, pozelimab and cemdisiran, for people with PNH whose current standard treatment isn't fully controlling the disease. The goal is to see if this new combination can better reduce the destruction of red blood cells and improve sy…

This study is testing two experimental drugs, ubamatamab and REGN7075, for people with advanced non-small cell lung cancer that has spread and has not responded well to standard treatments. The main goal is to see if these drugs can shrink tumors and control the cancer. Researche…

This study is testing an investigational drug called REGN5093 for people with advanced non-small cell lung cancer that has a specific genetic change called a MET alteration. The first part of the study aims to find a safe dose, and the second part will see how well that dose work…

This is the first time researchers are testing an experimental drug called REGN7041 in people. The study aims to find out if the drug is safe and tolerable for adults with active, non-infectious inflammation inside the eye (uveitis). Researchers will also measure how much of the …

This study is testing a new investigational drug called marlotamig, both by itself and in combination with an existing immunotherapy drug (cemiplimab), for people with advanced solid tumors. The main goals are to find a safe and effective dose and to see how well the treatments w…

This program provides special access to an experimental drug called ubamatamab for patients with two rare and aggressive cancers: renal medullary carcinoma and epithelioid sarcoma. It is designed for individuals who have exhausted all standard treatment options and cannot join re…

This study is testing whether adding an experimental drug called fianlimab to an existing cancer drug (cemiplimab) works better for treating advanced head and neck cancer that has returned or spread. It will involve about 120 people whose cancer has not been treated for its advan…

This is an early-stage study to test the safety of an experimental drug called ALN-CIDEB in adults with fatty liver disease (MASLD and MASH). The main goal is to see what side effects occur and how the body processes the drug. Researchers will also check if the drug reduces liver…

This study is testing an experimental drug called REGN7999, given as an injection under the skin, for people with a genetic blood disorder called non-transfusion dependent beta-thalassemia. The main goal is to see if the drug can safely reduce dangerously high levels of iron that…

This early-stage study is testing the safety and initial effectiveness of an experimental treatment called 27T51, a type of CAR T-cell therapy, for women with recurrent or hard-to-treat ovarian, primary peritoneal, or fallopian tube cancers. The first part will find the safest do…

This study is testing two new experimental drugs, REGN7508 and REGN9933, which are injectable antibodies designed to prevent blood clots in people with atrial fibrillation (AFib). It will compare their safety, especially the risk of bleeding, against the commonly used blood thinn…

This is an early-stage study testing the safety and side effects of a new two-drug combination (REGN5837 plus odronextamab) for people with aggressive B-cell non-Hodgkin lymphoma that has come back or stopped responding to at least two prior treatments. The main goal is to find a…

This study is testing an experimental drug called REGN7544 in people with Postural Orthostatic Tachycardia Syndrome (POTS), a condition that causes a rapid heart rate upon standing. The main goal is to see if a single dose of the drug safely reduces the excessive heart rate incre…

This study is testing an experimental drug called mibavademab in adult women whose periods have stopped due to a brain signaling problem (functional hypothalamic amenorrhea). The main goals are to see if the drug can safely help the body restart the natural hormone cycle needed f…

This study is testing an investigational drug called mibavademab in people with generalized lipodystrophy, a rare disorder where the body cannot store fat properly. The main goals are to see if the drug can improve high blood sugar and high fat levels in the blood, reduce fat in …

This study is testing whether a new combination of two immunotherapy drugs (fianlimab and cemiplimab) works better than an already approved combination (Opdualag) for treating advanced melanoma that cannot be removed by surgery. It will involve 560 adults with this type of skin c…

This study is testing a one-time experimental gene therapy called REGV131-LNP1265 for people with hemophilia B, a genetic bleeding disorder. The therapy uses CRISPR technology to insert a working gene into a person's DNA, aiming to teach their body to produce its own blood clotti…

This study is testing an experimental drug designed to 'silence' a specific gene involved in a serious form of fatty liver disease called MASH. The goal is to see if the drug can reduce liver inflammation and scarring (fibrosis) in adults with MASH who have certain genetic risk f…

This study is testing an experimental drug called mibavademab for people with a rare, severe form of obesity caused by a specific genetic mutation that disrupts the body's ability to feel full. The main goal is to see if the drug can help control body weight and is safe to use. R…

This study is testing a new injectable medication called olatorepatide for weight management in people who are overweight or have obesity but do not have diabetes. Researchers will compare the drug to a placebo (inactive substance) in about 120 participants to see how safe it is,…

This is an early-stage study testing the safety of an experimental drug called pozelimab, given as an injection into the eye. It involves about 54 people with geographic atrophy, a condition that causes progressive vision loss. The main goal is to see how well people tolerate the…

This is a very early-stage study testing an experimental drug called ALN-PNP in healthy adults and people with a common fatty liver disease (MASLD). The main goal is to check the drug's safety, how the body processes it, and see if it can reduce liver fat. Researchers will also s…

This program provides special access to an investigational drug called REGN4461 for patients with rare diseases where the body's leptin signaling is deficient. It is for conditions like lipodystrophy (abnormal fat distribution) and monogenic obesity (a genetic form of obesity). A…

This study is testing an experimental drug called ALN-CFB in people with Paroxysmal Nocturnal Hemoglobinuria (PNH) who still have anemia despite being on standard C5 inhibitor therapy. The main goals are to check the drug's safety, how the body processes it, and see if it can hel…

This study is testing whether a new drug combination works better than the current standard treatment for two types of lymphoma that have returned or stopped responding to prior therapy. It will involve about 470 adults with relapsed or hard-to-treat follicular lymphoma or margin…

This study is testing whether an experimental drug called odronextamab works better than the current standard treatment for people newly diagnosed with follicular lymphoma, a type of blood cancer. About 822 participants will be randomly assigned to receive either the new drug or …

This early-stage study is testing a new drug called linvoseltamab in people with advanced multiple myeloma that has come back or stopped responding to other treatments. The main goals are to find a safe dose, check for side effects, and see if the drug can effectively fight the c…

This study is testing two experimental drugs, ALN-ANG3 and evinacumab, to see if they can help control diabetic kidney disease. The main goal is to see if the drugs safely reduce protein in the urine, a key sign of kidney damage. The trial will involve about 270 adults with type …

This Phase 3 study is testing the long-term safety and effectiveness of a two-drug combination (pozelimab + cemdisiran) for people with paroxysmal nocturnal hemoglobinuria (PNH), a rare and serious blood disease. The trial will follow 202 patients who previously participated in r…

This study is testing an experimental drug called ubamatamab for women with advanced ovarian cancer that has stopped responding to standard platinum-based chemotherapy. Researchers want to see how safe and effective the drug is when given alone and when combined with other cancer…

This early-stage study is testing two new antibody drugs for people with lupus nephritis, a serious kidney complication of lupus. The main goal is to check how safe and tolerable these experimental treatments are when given for a short period. The study will enroll 90 participant…

This study is testing a new experimental drug, REGN5668, alone and in several combinations with other cancer drugs, for people with advanced ovarian, fallopian tube, peritoneal, or uterine cancers that have progressed after standard treatments. The main goals are to find the safe…

This is the first study to test an experimental drug called ALN-SOD in people with ALS caused by a specific change in the SOD1 gene. The main goal is to check the drug's safety and how well it's tolerated when given via spinal injection. Researchers will also measure how the drug…

This study is testing whether an experimental drug called vonsetamig can safely lower harmful antibodies in people with chronic kidney disease who need a transplant. These antibodies make it extremely difficult to find a compatible donor kidney. The research will enroll about 56 …

This study is testing a new experimental drug called REGN5678, which is designed to help the body's immune system find and attack cancer cells. It is being tested alone and in combination with an existing immunotherapy drug (cemiplimab) in patients with advanced prostate cancer o…

This study is for adults whose asthma remains poorly controlled despite using a standard medium-strength inhaler. It aims to find out which next step works better: adding a new injectable drug (dupilumab) to the current inhaler, or simply switching to a higher-dose inhaler. The m…

This study aims to learn more about how well and how safely a cancer drug called cemiplimab (Libtayo) works for people with advanced non-small cell lung cancer in everyday medical practice. It will follow about 500 patients in Europe who are already prescribed this drug by their …

This study is checking the safety of an experimental drug called pozelimab in young children (ages 1-5) with a very rare and serious genetic condition called CHAPLE disease. CHAPLE can cause life-threatening stomach and heart problems. Researchers will closely monitor the childre…

This is a very early safety study testing an experimental drug called linvoseltamab, given alongside an existing allergy drug (dupilumab), in adults with severe, life-threatening food allergies. The goal is to see if this combination is safe and can reduce the levels of the speci…

This large, late-stage study is testing whether new drug treatments can better control multiple myeloma that has come back or stopped responding to prior therapies. It will compare two approaches using an investigational drug called linvoseltamab—given alone or combined with carf…

This study is testing new immunotherapy drugs for men with advanced prostate cancer that has spread and stopped responding to standard hormone treatments. The goal is to find safe doses and see if these drugs, which aim to activate the body's own immune cells to attack cancer, ca…

This program provides emergency access to an experimental three-antibody treatment called REGN-EB3 for people sick with Ebola virus disease. It is for patients in outbreak regions who are not eligible for the main clinical trials, including children and pregnant women. The goal i…

This is the first study in people to test an experimental drug called ALN-SNCA for early Parkinson's disease. The main goal is to check if the drug is safe and well-tolerated when given as a single injection into the spinal fluid. Researchers will also measure if the drug can low…

This study is testing an experimental drug called odronextamab for people with an aggressive type of blood cancer (B-cell non-Hodgkin lymphoma) that has come back or stopped responding to their first treatment. The main goal is to see if this new drug works better and is as safe …

This study is testing an experimental drug called linvoseltamab for people whose multiple myeloma has returned after prior treatments. It will compare linvoseltamab to a standard combination of three other cancer drugs. The goal is to see which treatment is more effective at cont…

This study is testing a new drug called ubamatamab, given alone or with another drug (cemiplimab), for people with recurrent ovarian, fallopian tube, peritoneal, or endometrial cancers. The main goals are to find a safe and effective dose and to see if the treatment can shrink tu…

This study is testing an experimental drug called linvoseltamab for people newly diagnosed with multiple myeloma, a type of blood cancer. The trial aims to find the right dose, check for side effects, and see how well the drug shrinks tumors in 149 participants. It includes both …

This early-stage study is testing a new, experimental immunotherapy drug called REGN10597, both by itself and combined with an existing drug (cemiplimab), in people with advanced solid tumors like melanoma and kidney cancer. The main goals are to find a safe dose and see if the t…

This study is testing a new combination of two drugs, pozelimab and cemdisiran, for people with paroxysmal nocturnal hemoglobinuria (PNH), a rare blood disease. The main goal is to see if this new combination is more effective and safe than two existing standard treatments, ravul…

This study is testing an experimental drug called dupilumab in very young children (6 months and up) who have active eosinophilic esophagitis (EoE), a condition that causes painful inflammation in the food pipe and makes eating difficult. The main goal is to see if the drug is sa…

This study is testing an experimental drug, REGN7508, to see if it can safely prevent blood clots in people with advanced solid tumors who are receiving cancer treatment. About 860 participants will be randomly assigned to receive either the study drug or a placebo (inactive subs…

This study is testing an experimental drug, REGN7508, to see if it can safely prevent dangerous blood clots in adults having elective total knee replacement surgery. It will compare the new drug against two standard blood clot prevention medications. The goal is to find a more ef…

This study is testing an investigational drug called linvoseltamab in people who have early, precancerous blood conditions that put them at moderate risk of developing multiple myeloma. The main goal is to see if the drug can eliminate the abnormal cells and signs of these condit…

This study is testing if an experimental drug called REGN7508 works better than aspirin to prevent dangerous blood clots in the legs or lungs after a planned knee replacement surgery. It will involve 2,000 adults who are having this elective surgery. The main goal is to see which…

This study is testing two new antibody drugs, alone and in combination, to see if they can safely reduce the itchy, red eyes caused by birch pollen allergies. Researchers will compare the treatments against a placebo in 350 people with confirmed birch pollen eye allergies. The ma…

This early-stage study is testing a new imaging agent, 89Zr-DFO-REGN5054, in patients with advanced solid tumors who are receiving the immunotherapy drug cemiplimab. The main goal is to see if the imaging agent is safe and to understand how it moves through the body. Researchers …

This study is observing 350 patients in the US who have eosinophilic esophagitis (EoE) and have been prescribed Dupixent as part of their normal medical care. Researchers will collect information about patients' symptoms, quality of life, and treatment experience through question…

This study aims to monitor the long-term safety and health of people who received an experimental gene therapy in a previous trial. It will follow up to 50 participants for many years to check for any delayed side effects and see if the treatment's effects last. The goal is to ga…