New lung cancer cocktail aims to shrink tumors before surgery

NCT ID NCT06465329

Recruiting now Disease control Sponsor: Regeneron Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 09, 2026 · Updated 2 times

Summary

This study tests whether adding a third drug to standard immunotherapy (cemiplimab) plus chemotherapy works better for people with early-stage non-small cell lung cancer who can have surgery. About 120 adults will receive treatment before and after their operation. The main goal is to see if the extra drug helps eliminate more cancer cells in the removed tumor tissue.

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Conditions

The condition(s) this trial relates to.

lung neoplasm non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NON-SMALL CELL LUNG CANCER

Contacts and locations

Locations

BRCC/Oncology & Hematology Associates of SW Virginia
RECRUITING

Blacksburg, Virginia, 24060, United States
CHU Grenoble Alpes
RECRUITING

Grenoble, 38330, France
CHU Rennes
RECRUITING

Rennes, Brittany Region, 35033, France
Catalan Instituye of Oncology Badalona
RECRUITING

Badalona, Barcelona, 08916, Spain
Centre Hospitalier Intercommunal Toulon - CHITS
RECRUITING

Toulon, Var, 83055, France
Centre Hospitalier de la Cote Basque
RECRUITING

Bayonne, 64100, France
Clinica Universidad de Navarra
RECRUITING

Pamplona, Navarre, 31008, Spain
Clinique Belharra
RECRUITING

Bayonne, 64100, France
Consorci Hospital General Universitario de Valencia
RECRUITING

Valencia, 46014, Spain
Detroit Clinical Research Center
RECRUITING

Farmington Hills, Michigan, 48334, United States
Florya Medical Park Hospital
RECRUITING

Istanbul, 34295, Turkey (Türkiye)
Fundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto
RECRUITING

São José do Rio Preto, São Paulo, 15090-000, Brazil
Hospital Alemao Oswaldo Cruz
RECRUITING

São Paulo, 01323-903, Brazil
Hospital Clinico Lozano Blesa
RECRUITING

Zaragoza, 50009, Spain
Hospital Clinico Universitario Valencia
RECRUITING

Valencia, 46010, Spain
Hospital Mae de Deus Integrated Oncology Center
RECRUITING

Porto Alegre, Rio Grande do Sul, 90110-270, Brazil
Hospital Sao Lucas da PUCRS
RECRUITING

Porto Alegre, Rio Grande do Sul, 90610-000, Brazil
Hospital Universitario Clinico San Carlos
RECRUITING

Madrid, 28040, Spain
Hospital Universitario HM Sanchinarro
RECRUITING

Madrid, 28050, Spain
Hospital Universitario Insular de Gran Canaria
RECRUITING

Las Palmas de Gran Canaria, Las Palmas, 35016, Spain
Hospital Universitario La Paz
RECRUITING

Madrid, 28046, Spain
Hospital Valdecilla
RECRUITING

Santander, Cantabria, 39008, Spain
Hospital Virgen del Rocio
RECRUITING

Seville, 41013, Spain
Institut Curie
RECRUITING

Paris, Île-de-France Region, 75005, France
Instituto Mario Penna
RECRUITING

Belo Horizonte, Minas Gerais, 30380-472, Brazil
Instituto Sul Mineiro De Oncologia LTDA
RECRUITING

Pouso Alegre, Minas Gerais, 37554-238, Brazil
Instituto de Medicina Integral Professor Fernando Figueira
RECRUITING

Recife, Pernambuco, 50070-902, Brazil
Karmanos Cancer Institute
RECRUITING

Detroit, Michigan, 48201, United States
Klinikum Kassel GmbH, Hauttumorzentrum
RECRUITING

Kassel, Hesse, 34125, Germany
Lifespan Cancer Institute
RECRUITING

Providence, Rhode Island, 02903, United States
Liga Norte Riograndense Contra o Cancer
RECRUITING

Natal, Rio Grande do Norte, 59060-195, Brazil
MD Anderson Cancer Center
RECRUITING

Madrid, 28033, Spain
Montpellier Academic Hospital
RECRUITING

Montpellier, 34295, France
Morristown Medical Center
RECRUITING

Morristown, New Jersey, 07960, United States
Oncology Clinical Research Center
RECRUITING

Cachoeiro de Itapemirim, Espírito Santo, 29306014, Brazil
Oncology Hematology Care Clinical Trials LLC
RECRUITING

Cincinnati, Ohio, 45245, United States
Orchard Healthcare Research Inc.
RECRUITING

Skokie, Illinois, 60077, United States
Prairie Lakes Healthcare System
RECRUITING

Watertown, South Dakota, 57201, United States
Providence Portland Medical Center
RECRUITING

Portland, Oregon, 97213, United States
Rutgers Cancer Institute of New Jersey
RECRUITING

New Brunswick, New Jersey, 08901, United States
Sarah Cannon Research Institute (SCRI) Oncology Partners
RECRUITING

Nashville, Tennessee, 37203, United States
Tennessee Oncology
RECRUITING

Nashville, Tennessee, 37203, United States
Unimed Sorocaba
RECRUITING

Sorocaba, São Paulo, 18065-100, Brazil
University Hospital RWTH Aachen
RECRUITING

Aachen, 52074, Germany
University Medicine Gottingen
RECRUITING

Göttingen, Lower Saxony, 37083, Germany
University Of Nebraska Medical Center
RECRUITING

Portland, Oregon, 97213, United States
University of California Irvine
RECRUITING

Orange, California, 92868, United States
University of Leipzig
RECRUITING

Leipzig, Saxony, 04103, Germany
University of Tennessee Medical Center
RECRUITING

Knoxville, Tennessee, 37920, United States
Ynova Pesquisa Clinica
RECRUITING

Florianópolis, Santa Catarina, 88020-210, Brazil

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