Can a PET scan reveal hidden heart harm from lung cancer treatment?

NCT ID NCT07761910

Recruiting now Diagnosis Sponsor: Indiana University Source: ClinicalTrials.gov ↗

First seen Aug 12, 2026 · Last updated Aug 13, 2026 · Updated 1 time

Summary

This trial is testing whether advanced PET-CT scans can spot early signs of heart damage caused by standard radiation therapy for locally advanced non-small cell lung cancer. Ten adults with stage III lung cancer will receive a special PET-CT scan before and three months after their radiation treatment. The goal is to see if changes in blood flow to the heart can be detected early, which could help prevent long-term heart problems.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: 18F-Flurpiridaz PET/CT and Coronary CT Angiography (CCTA)
What this could lead to: If this works, it could lead to better ways to detect and prevent heart damage in lung cancer patients receiving radiation therapy.
What could go wrong: This is a small, early-phase study, so results may not apply to all patients. The imaging techniques may not accurately predict long-term heart problems.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Cardiotoxicity non-small cell lung carcinoma radiation injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CARDIOTOXICITY LOCALLY ADVANCED NON-SMALL CELL LUNG CANCER NON-SMALL CELL LUNG CANCER RADIATION THERAPY

Contacts and locations

Locations

Indiana University Melvin and Bren Simon Comprehensive Cancer Center
RECRUITING

Indianapolis, Indiana, 46202, United States

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