Indiana University

This study is testing whether taking two oral drugs, zanzalintinib and etoposide, as long-term 'maintenance' therapy can help keep cancer from returning in patients with relapsed germ cell tumors (like testicular cancer). The goal is to see if this combination is safe and can ext…

This study is testing whether a dietary supplement called SAMe can improve liver function and reduce deaths in people with alcoholic cirrhosis. About 196 participants with mild to moderate liver scarring will be randomly assigned to receive either SAMe or a placebo pill. Research…

This study is testing if a lung medication called surfactant, given using a gentler method that doesn't require a breathing machine, can help more premature babies survive breathing problems in African hospitals. It will involve over 1,500 premature infants with breathing difficu…

This study is testing if a special heart scan can help personalize treatment to reduce heart disease risk in men with prostate cancer who are on hormone therapy. Researchers will compare patients who get the scan and tailored treatment to those who receive usual care. The goal is…

This small pilot study is testing whether a common acid reflux medication (proton pump inhibitor or PPI) can improve the flexibility of the esophagus in adults with eosinophilic esophagitis (EoE). Researchers will measure how stretchy the upper and lower parts of the esophagus ar…

This study aims to find the best way to involve parents or caregivers in helping teens (ages 12-17) with mild alcohol use problems. Researchers are comparing three approaches: a program for the teen only, the same program plus a single live session for a parent, or the teen progr…

This study is testing a new support program designed to help Black patients with early-stage liver cancer get faster access to potentially curative treatments like surgery or transplant. The program provides education, helps with social needs, and connects patients to cancer spec…

This study is testing a new inhaled nasal medication called Optate for people with early COVID-19 symptoms. Researchers want to see if this treatment can reduce the amount of virus in the nose and lungs and help people feel better faster. The study involves 40 participants who ha…

This study is testing if ondansetron, a drug commonly used to prevent nausea, can help control atrial fibrillation (Afib), a dangerous irregular heartbeat. Researchers will give 80 people scheduled for a heart procedure either ondansetron or a placebo pill for 28 days to see if i…

This study is testing whether a medication called guanfacine can help people with moderate to severe alcohol use disorder drink less. 200 participants will take either the medication or a placebo pill for 12 weeks, with all visits and monitoring done remotely via telehealth. Rese…

This study is testing whether an over-the-counter supplement called 5HTP can improve breathing and reduce anxiety in children with mild to moderate asthma. About 20 children ages 8-18 will take either 5HTP or a placebo for several weeks, then switch to see if there's a difference…

This study is testing a new support program called the Transitional Liver Clinic (TLC) for people with serious liver disease who are leaving the hospital. The goal is to see if this extra care helps patients avoid being readmitted to the hospital, improves their quality of life, …

This study is testing a new combination of two radiation treatments for men with higher-risk prostate cancer. The goal is to see if delivering a stronger dose of radiation using both an external beam and an internal implant is safe and well-tolerated. Researchers will closely mon…

This study is testing whether dietary nitrate, found in foods like beetroot juice, can help prevent muscle loss and weakness when a leg is immobilized. Researchers will have healthy young men wear a knee brace for two weeks while taking either nitrate supplements or a placebo. Th…

This study is testing a new support program to help people with epilepsy in Kenya stay on their medication and keep up with their doctor visits. Researchers will compare the new system, which uses task-sharing and electronic tracking, to usual care for 650 participants over 18 mo…

This study is testing a cream called tapinarof, which is already used for psoriasis, to see if it can help adults with palmoplantar keratoderma—a condition that causes thick, hard skin on the palms and soles. Researchers will apply the cream daily to see if it safely improves the…

This study aims to find out if adults with cystic fibrosis who are taking newer, highly effective modulator drugs can safely stop their daily nasal treatments like saline rinses, steroid sprays, and antibiotic drops. Researchers will follow 64 patients for 12 weeks, randomly assi…

This study is testing whether a new, non-invasive brain stimulation technique can help people who vape nicotine reduce their cravings and usage. The method, called temporal interference, uses mild electrical currents on the scalp to target deep brain areas linked to addiction. Re…

This study is testing whether a ketone supplement drink can protect older adults from the negative health effects of eating too much salt. Researchers want to see if the supplement can prevent high salt from raising blood pressure, harming blood vessels, or causing kidney stress.…

This study is testing whether a virtual reality (VR) program can help people in early recovery from stimulant use disorders. The VR experience is designed to help participants feel more connected to their future self, think more about the future, and value long-term rewards over …

This study is testing whether vividly imagining positive personal future events can help people with alcohol use disorder make healthier long-term choices. Researchers will show participants different types of future-thinking images and measure if they prefer delayed rewards and …

This study is testing whether a special heat therapy device can improve blood flow in the lower legs and feet of veterans. Ten veterans with both poor leg circulation (peripheral artery disease) and nerve damage (neuropathy) will use the device twice daily for three months. Resea…

This study is testing whether a program that delivers healthy food kits and teaches cooking skills can help adults with high blood pressure and food insecurity. Researchers will compare this program to standard care to see which is better at lowering blood pressure and improving …

This study is collecting information on a procedure called G-POEM, which is used to treat gastroparesis—a condition where the stomach is slow to empty. Researchers will track 75 patients who get this endoscopic procedure to see how it affects their symptoms and quality of life. T…

This study is testing a low-temperature radiofrequency device to reshape nose and ear cartilage outside the body before putting it back in during nose surgery. The goal is to see if this new technique can improve breathing and cosmetic results compared to current methods. Researc…

This study is testing whether two tools can help doctors diagnose Alzheimer's and related dementias earlier during routine annual checkups. One tool is a computer program that scans a patient's health records for warning signs, and the other is a short questionnaire. Researchers …

This study is testing a new handheld device that helps doctors quickly diagnose brain and nerve problems at the patient's bedside. Researchers want to see if this portable scanner gives results as accurate as standard hospital equipment like MRI machines. The goal is to help pati…

This study is testing a new smartphone app called AWARE that uses your phone's microphone and speakers to listen to your breathing. The goal is to see if it can accurately help doctors diagnose lung diseases like asthma and COPD, and spot when symptoms are getting worse. Research…

This study is testing whether a new wearable sensor can detect high or low blood sugar events by analyzing chemicals in a person's breath. Researchers are recruiting 30 teens with type 1 diabetes in Indianapolis to wear the sensor for 3 days and compare its readings to standard f…

This study is testing whether a quick, non-invasive eye-tracking test can help identify autism risk in children ages 1 to 4 years. Researchers will measure where and how children look at things during a short session. They will compare these eye-tracking results to standard clini…

This study aims to find out how many older adults who break a hip from a simple fall might have an undiagnosed spinal cord condition called cervical myelopathy. Researchers will screen 75 hip fracture patients with a physical exam and questions. If signs of the condition are foun…

This study is testing whether a simple urine dipstick can quickly detect a serious complication called pancreatitis in patients who have just had part of their pancreas removed. Researchers will compare the new urine test results to the standard blood tests currently used for dia…

This study aims to find the best way to detect fluid overload, a common and serious problem for people on home dialysis. Researchers will compare three methods: a short symptom survey, a standard physical exam by a doctor, and a quick, non-invasive lung ultrasound. The goal is to…

This study is testing whether a ketone supplement drink can protect young adults from the negative health effects of eating too much salt. Researchers want to see if the supplement can prevent high salt from raising blood pressure, harming blood vessels, or causing kidney stress.…

This study is testing whether a combination of a brain-healthy diet and regular exercise can help prevent memory and thinking problems in Black adults who have high blood pressure. Researchers will compare two groups: one receives home-delivered meal kits, cooking classes, and ex…

This study aims to find the best way to manage pain after surgery to remove lymph nodes for testicular cancer. Researchers are comparing two standard pain control methods: a spinal injection of morphine versus an intravenous drip of methadone. They want to see which method provid…

This study investigates whether doing high-intensity walking training more frequently leads to better mobility outcomes for people who have had a stroke. Researchers will compare two groups: one receiving training three times per week for six weeks, and another receiving training…

This study is testing a coaching program designed to help Black patients who have both long-term pain and depression. The program uses four coaching sessions to help people learn about and stick with non-drug treatments, like physical therapy or mindfulness, and to talk more effe…

This study is testing if a simple, at-home heat therapy can help people with a specific type of heart failure feel better and be more active. Researchers will have 90 participants use special water-heated trousers on their legs daily to see if it improves their ability to exercis…

This study is testing whether a mobile app called Brain CareNotes can help reduce stress for people caring for loved ones with Alzheimer's disease. Researchers will compare the app against a basic education app over 12 months with 184 caregiver participants. The goal is to see if…

This study is testing whether an online therapy program can help older adults who have survived a serious hospital stay in the Intensive Care Unit (ICU). The goal is to see if treating depression with this accessible therapy can also slow down feelings of memory and thinking prob…

This small pilot study is testing whether a non-invasive brain stimulation technique can help reduce rumination—the cycle of repetitive negative thoughts—in adults with depression that hasn't responded to at least one medication. Researchers will use Transcranial Magnetic Stimula…

This study is testing whether acupuncture can help manage the chronic pain that often comes with sickle cell disease. Researchers will compare traditional needle acupuncture to a needle-free laser version in about 120 participants. They will also use brain scans and other tests t…

This study is testing whether a simple, at-home leg heat therapy can help people with peripheral artery disease (PAD) walk farther and feel better. About 106 participants will use special water-circulating trousers daily for three months, with half receiving warm therapy and half…

This study is testing whether different foot-strengthening methods can help middle-aged and older adults improve their balance, walking, and reduce their risk of falling. Researchers will compare using minimalist shoes, a foot exercise program, a foot-strengthening device called …

This small pilot study is testing whether a simple, daily 3-minute hand-held vibration therapy is safe and practical for reducing nerve pain in the hands caused by chemotherapy. Researchers want to see if this approach can ease symptoms and improve quality of life for cancer surv…

This study is testing whether a telephone counseling program can help patients with advanced gastrointestinal cancer better manage their fatigue and daily life. It also aims to see if the program reduces the stress and burden felt by their family caregivers. Researchers will comp…

This study is testing whether Kinesio tape can reduce muscle soreness that develops a day or two after hard exercise. Researchers will have 36 healthy young adults perform a tough arm workout to cause soreness, then apply either real tape, fake tape, or no tape. They will measure…

This study is testing whether a 16-week virtual exercise program can improve fitness, strength, and quality of life for people with stable metastatic breast cancer. Researchers will compare 100 participants who either follow the exercise plan or receive their usual care. The goal…

This study is testing whether a program of enjoyable outdoor activities, like gardening or walking a dog, is practical and liked by people with memory challenges and their care partners. Researchers want to see if this 'Green Activity Program' helps people stay active and improve…

This study is testing whether drinking beetroot juice can help women who have stopped having their periods. The lack of periods can reduce a key hormone (estrogen), which may weaken muscles and slow recovery after exercise. Researchers think the nitrate in beetroot juice might ac…

This study tests whether a virtual home exercise program can help reduce depression and anxiety in family caregivers of people with Alzheimer's disease. Participants are randomly assigned to either receive 24 weeks of guided virtual exercise sessions with provided equipment or jo…

This early-stage study is testing whether adding an existing epilepsy drug, lacosamide, to standard opioid painkillers is safe and tolerable for adults with chronic pancreatitis. The main goal is to see if the combination helps reduce severe abdominal pain and might allow patient…

This study is testing whether a support program called ADAPT can help people with heart failure feel better in their daily lives. The program involves weekly phone calls from nurses and social workers to help manage difficult symptoms and provide coping tools. Researchers want to…

This study is testing a version of Cognitive Behavioral Therapy (CBT) that has been specially adapted for teenagers with insomnia. Researchers will compare the adapted therapy, delivered in 4-6 virtual sessions, to a waitlist group that receives no initial treatment. The main goa…

This study is testing if adding special pelvic physical therapy before radiation treatment can help reduce pain and sexual problems that often occur after treatment. It involves 20 women with cervical, vaginal, vulvar, uterine, or anal cancer who are scheduled for curative pelvic…

This study is collecting information on a procedure that temporarily blocks nerves to manage severe pain from chronic pancreatitis. Researchers will track 35 patients for 24 weeks to see if the procedure reduces their pain and their need for opioid painkillers. The goal is to gat…

This study is testing a 30-minute smartphone app designed to help college students who have sleep problems and are at risk for developing serious mental health conditions like psychosis. The app teaches sleep improvement techniques and aims to reduce the stigma around seeking men…

This study is testing whether a brief online therapy program is practical and helpful for pregnant women and new mothers experiencing trauma-related stress. Researchers will compare the online therapy to usual care in 106 participants. The goal is to find the best way to deliver …

This small pilot study is testing whether regular visits with a trained chaplain can improve spiritual wellbeing and reduce anxiety and depression in people with advanced lung or gastrointestinal cancer. It will compare the chaplain's spiritual care program to informational suppo…

This study is testing whether a combination of computerized brain training exercises and gentle Tai Chi movement can help people with early-onset Alzheimer's disease. Researchers want to see if these activities can improve memory, thinking skills, daily functioning, and mood. The…

This study is testing if a gentle electrical stimulation behind the ear can affect insulin and blood sugar levels in healthy people. Researchers are studying 30 volunteers to see if stimulating a specific nerve (the vagus nerve) through the skin changes these levels. The goal is …

This study aims to see if brain scans can predict how well teens respond to a cannabis treatment program. Researchers will scan the brains of 80 teens (ages 14-17) who use cannabis, then have them join 10 weeks of virtual sessions where they report use and take drug tests. Teens …

This study aims to understand how a key HIV medication (efavirenz) interacts with two other drugs (methadone and tizanidine) and whether a person's genetics affects these interactions. Researchers will enroll 60 healthy volunteers, grouped by their genetic makeup, to measure drug…

This study aims to understand how older adults with and without vision problems walk over obstacles of different heights and colors. Researchers will measure how participants lift their feet, where they look, and how they time their steps. The goal is to gather information that c…

This study aims to understand if children with Primary Ciliary Dyskinesia (PCD) also have sensitive airways, a condition called bronchial hyperresponsiveness that's common in asthma. Researchers will test 40 children with PCD and healthy children using breathing tests and a medic…

This study is testing a prototype ankle brace with built-in sensors to see if it can accurately measure walking, running, and balance. Researchers will compare the brace's data to high-end lab equipment. The goal is to see if the device works well enough for future use in helping…

This study investigates whether a mild, painless form of brain stimulation can help people learn complex hand coordination tasks faster. Healthy adults will play the video game Guitar Hero while receiving either real or fake stimulation to their brain's movement control area. Res…

This study aims to understand how COVID-19 affects long-term health by measuring fitness, blood pressure, sleep, and stress. Researchers will enroll 100 adults for two lab visits involving questionnaires, fitness tests, and health monitoring. The goal is to learn how past COVID-1…

This study aims to understand how early-onset Alzheimer's disease changes over time in people aged 40-64. Researchers will follow about 850 participants with and without memory problems for 2-4 years, using brain scans, memory tests, and fluid samples. The goal is to gather detai…

This study is testing a new, non-invasive brain stimulation technique called Temporal Interference (TI) on healthy volunteers. Researchers want to see if TI can safely and precisely activate deep brain areas without affecting the surface of the brain, using an MRI scanner to meas…

This study aims to understand how common nerve damage is in the eyes of patients with graft-versus-host disease (GVHD), a complication of bone marrow transplants. Researchers will measure eye sensitivity and dryness in about 30 GVHD patients and compare them to healthy volunteers…

This study aims to better understand a condition where the vocal cords close during exercise, causing sudden breathing difficulty. Researchers will use a small, wearable neck device and other tests on 120 young, active adults to learn how and why this happens. The goal is to find…

This study aims to understand how well a person's own kidneys recover function after receiving a combined liver and kidney transplant. Researchers will follow 15 patients with reduced kidney function who are scheduled for this dual transplant, using special scans before and after…

This study aims to understand how healthy brains learn to coordinate vision and the sense of body position (proprioception) to make accurate hand movements. Researchers will use safe, non-invasive brain stimulation on 300 healthy, right-handed adults while they perform simple tou…

This study aims to understand how chronic inflammatory diseases like type 2 diabetes, irritable bowel disease, and kidney failure might change how the body processes medications. Researchers will collect blood samples and health records from 150 patients with these conditions to …

This study aims to understand how eating dried plums (prunes) might help protect bone health in women after menopause. Researchers will enroll 30 healthy women aged 60-75 to see if adding prunes to their diet changes their immune cell function and gut bacteria, and if their vitam…

This study is testing whether a new optical scanning device called NearWave can monitor how breast cancer responds to chemotherapy before surgery. Researchers will use the device on 15 patients receiving chemotherapy to see if it collects good enough data to predict treatment suc…

This study is testing a new, non-invasive brain stimulation technique called temporal interference (TI) on healthy volunteers. The goal is to see if TI can safely and precisely target deep brain areas without affecting the surface, using brain scans (fMRI) to measure its effects.…

This study is creating a large collection of health information and biological samples from people with plasma cell disorders like multiple myeloma. The goal is to build a detailed research database to help scientists ask better questions and design future studies. Participants w…

This study aims to understand if making breathing physically easier improves a person's focus and reaction time, especially under stressful conditions relevant to military personnel. Researchers will have 15 healthy, fit adults breathe through a device that makes breathing harder…

This study is testing a non-invasive tool called Body Surface Gastric Mapping (BSGM) to see if it can help doctors predict which patients with severe gastroparesis will benefit most from a specific endoscopic surgery called G-POEM. Researchers will enroll 20 patients and use the …

This study aims to learn if advanced brain scans (MRI and PET) can predict genetic mutations in brain tumors called gliomas. Researchers will enroll 20 adults with a glioma who are scheduled for a tumor biopsy. They will compare detailed scan images with genetic data from the act…

This study is testing if a common B-vitamin called niacin can get into the brain and spinal fluid of people with Alzheimer's disease. Researchers will give 30 participants either a 500mg niacin pill or a placebo (sugar pill) for 60 days. The main goal is to measure how much niaci…

This study is testing a tool that uses lab results and other health information to predict how long patients with advanced cancer might live after starting palliative radiation therapy. Researchers will give patients a score and then track their survival and quality of life over …

This study aims to understand the non-medical challenges, like financial strain or housing issues, that people with chronic liver disease face. Researchers will survey 400 patients and their doctors at Indiana University to see how common these problems are and whether patients w…

This study aims to find genes linked to Alzheimer's disease by collecting genetic samples from families with multiple affected members. It is enrolling up to 10,000 participants from families with at least two living relatives diagnosed with Alzheimer's or dementia. The collected…

This study aims to see if a new, faster blood clotting test works properly for children. Researchers will collect a small blood sample from 125 children having planned surgery to find out what normal results look like for them. The goal is to gather information that could help do…

This study aims to understand why Black Americans often report higher levels of paranoia than White Americans. Researchers will test if exposure to stressful experiences related to race directly increases feelings of paranoia in 480 Black American participants. The goal is to imp…

This study aims to understand how men and women respond differently when they take a break from drinking alcohol. Researchers will observe 160 moderate social drinkers to see how their drinking patterns, brain responses, and feelings about alcohol change after two weeks of abstin…

This study aims to understand how people recover walking ability after a stroke and what new movement patterns they develop. Researchers will track 150 stroke survivors from early recovery through later stages to see how different rehabilitation approaches affect walking speed, d…

This study is testing a decision support tool designed to help parents facing the threat of an extremely premature birth (between 22 and 25 weeks). The tool provides information and helps clarify values about difficult care choices for the newborn. Researchers are comparing paren…