Indiana University

This study looks at whether adding GLP-1 receptor agonists or SGLT inhibitors to insulin helps adults with type 1 diabetes manage their blood sugar better. Researchers will track 300 participants for one year, measuring changes in HbA1c and other health markers. The goal is to se…

This study tests a new virtual reality (VR) walking therapy for people who have had a stroke within the past 1 to 6 months. Participants will use either a fully immersive VR system that lets them walk over ground in realistic environments, or a semi-immersive VR system on a tread…

This study compares two blood sugar targets for overweight or obese women with gestational diabetes. One group aims for stricter goals (fasting under 90 mg/dL, after meals under 120 mg/dL), while the other follows standard targets (fasting under 95 mg/dL, after meals under 140 mg…

This study tests whether taking a ketone supplement can prevent the negative effects of eating too much salt, like high blood pressure and kidney strain. Researchers will give 35 healthy young adults either a high-salt diet with a ketone supplement or a placebo, then measure chan…

Most older Americans eat too much salt, which can raise blood pressure and harm the kidneys. This study tests whether a ketone supplement (a substance the body makes during fasting or exercise) can block those harmful effects. Thirty-five adults aged 60-85 will follow a high-salt…

This study tests a culturally tailored support program for Black patients with early-stage liver cancer. The program includes education, help with social needs, and easier access to cancer specialists. Forty participants will be randomly assigned to the program or usual care and …

This study tests whether an internet-based depression treatment called cognitive behavioral therapy (iCBT-D) can prevent insulin resistance from getting worse in adults with HIV who are on antiretroviral therapy and have depression. Researchers will compare the online therapy pro…

This study tests whether a new system that shares tasks among healthcare workers and uses an electronic medical records system can help people with epilepsy in Kenya take their medication regularly and stay in care. About 650 people aged 12 and older who have epilepsy but are not…

This study tests whether guanfacine extended release (Intuniv), a drug currently used for ADHD and high blood pressure, can help 200 adults with moderate to severe alcohol use disorder drink less. Participants take either guanfacine or a placebo daily for 12 weeks, and report the…

This study tests whether a virtual reality experience can help people in early recovery from alcohol use disorder drink less and stay abstinent longer. About 500 participants who have been sober for at least two weeks but less than a year will use a VR program designed to strengt…

This study tests whether a supplement called SAMe can improve liver function and reduce deaths in people with alcoholic cirrhosis. About 196 adults with mild to moderate cirrhosis will take SAMe or a placebo daily for 24 months. Researchers will measure liver health, gut function…

This study tests if giving surfactant (a natural substance that helps lungs stay open) through a less invasive method helps premature babies with breathing problems survive. About 1,500 babies weighing 1.5 to 4.4 pounds will receive this treatment in African hospitals that lack b…

This study looks at whether a special heart CT scan can find hidden artery plaque in prostate cancer patients who are on or about to start hormone therapy. About 100 participants will either get the scan or usual care. The goal is to see if the scan helps doctors prescribe better…

This study looks at whether giving people with high blood pressure and food insecurity free food and kitchen skills training can improve their health. About 200 adults aged 35-75 will either get the program or standard care. Researchers will measure blood pressure and blood sugar…

This study tests whether ondansetron, a drug usually used to prevent nausea from cancer treatment, can help people with atrial fibrillation (AFib). Researchers believe ondansetron may block a specific heart current that contributes to AFib. Eighty adults scheduled for AFib ablati…

This study tests whether adding a caregiver session to a brief alcohol counseling program helps teens aged 12-17 reduce their drinking. 615 teens with mild alcohol problems will be assigned to teen-only counseling, counseling with a live caregiver session, or counseling with an o…

This study tests whether taking two drugs (zanzalintinib and oral etoposide) after high-dose chemotherapy can help keep relapsed germ cell tumors from growing. About 38 adults whose cancer has not been cured by standard treatments will participate. The goal is to see if this comb…

This study is testing whether a new, shorter course of radiation therapy is safe and tolerable for men with unfavorable or higher-risk prostate cancer. It combines external beam radiation with a single internal radiation boost (brachytherapy). The trial will enroll 31 participant…

This study is testing whether a blood test that looks for tumor DNA can find leftover cancer cells in people with germ cell tumors (a type of testicular or ovarian cancer). Researchers will enroll 130 patients with stage I, II, or III disease and check how well the test works aft…

This study looks at whether older adults who break a hip from a simple fall might have an undiagnosed spinal cord condition called cervical myelopathy. Researchers will check 75 patients with a physical exam and, if needed, an MRI before they leave the hospital. The goal is to fi…

This study is testing whether a simple, non-invasive eye-tracking test can help diagnose autism in young children (ages 24-72 months) born to mothers with HIV in Kenya. Researchers will compare eye-tracking results with standard clinical autism evaluations in 850 children. If the…

This study checks how accurate and repeatable a smartphone app called VisionApp is at measuring ghosting (a type of double vision). Twelve healthy adults will wear contact lenses and rate ghosting images while the app also measures it. The goal is to see if the app can reliably r…

This study tests whether a wearable breath sensor can detect high or low blood sugar in teens with type 1 diabetes. Participants wear the device for 72 hours and provide breath samples while checking blood sugar with a finger prick. The goal is to see if breath chemicals can repl…

Researchers at Indiana University are studying whether a short, non-invasive eye-tracking test can help detect autism risk in children aged 12 to 48 months. The test uses a camera to measure eye movements and pupil size while children watch pictures and videos. Results will be co…

This study looks at whether a bedside ultrasound (POCUS) can help doctors quickly diagnose acute chest syndrome in children and young adults with sickle cell disease. Researchers will enroll 30 hospitalized patients aged 0-25 to see if the ultrasound is practical and reliable com…

This study looks at whether a urine test can quickly detect pancreatitis after pancreas removal surgery. About 50 adults having elective pancreatectomy will provide urine samples before, during, and after surgery. The results will be compared with standard blood tests to see if t…

This study tests a new imaging system that uses light to monitor how breast cancer responds to chemotherapy before surgery. Researchers want to see if it can accurately predict when the cancer is completely gone. The study involves 15 women with specific types of breast cancer. I…

This study tests a portable, handheld device that can quickly check brain and nerve function at the patient's bedside. Researchers will compare its diagnostic accuracy to standard tests like MRI and EEG in 30 adults with neurological symptoms. The goal is to see if this device ca…

This study tests whether simple digital questionnaires can help primary care doctors identify new cases of Alzheimer's and related dementias during annual checkups. About 3,150 adults aged 65 and older without prior memory loss diagnosis will participate. The goal is to see if th…

This study tests whether a smartphone app (AWARE) can accurately detect and monitor lung diseases like asthma, COPD, and cystic fibrosis by analyzing sound waves from the phone's speaker and microphone. Researchers will enroll 800 people aged 8-70, including healthy volunteers an…

This study looks at whether combining the MIND diet (a mix of Mediterranean and DASH diets) with aerobic exercise can help prevent memory and thinking problems in Black adults aged 35-75 who have high blood pressure. Participants will be randomly assigned to either receive food d…

This study tests a short, virtual therapy for pregnant women and new mothers with PTSD. About 90 participants will either receive the therapy or standard care. The goal is to see if the therapy is practical and well-liked, and to measure its effect on PTSD and depression symptoms…

This study tests whether a coaching program combined with a decision aid can help Black patients with long-term muscle and joint pain and depression use non-drug treatments like physical therapy or counseling. 304 patients will be randomly assigned to either the coaching program …

This study tests a silk-based wound dressing against a standard adhesive dressing in 50 adults undergoing double-incision mastectomy for female-to-male gender affirmation. Each patient serves as their own control, with one side of the chest getting the silk dressing and the other…

This study is testing a version of Cognitive Behavioral Therapy for Insomnia (CBT-I) that has been adapted specifically for teenagers. The treatment includes healthy sleep habits, a consistent sleep schedule, and relaxation techniques. Researchers will compare teens who receive t…

This small pilot study tests whether using a hand-held vibration device for just 3 minutes each day can safely reduce nerve pain and numbness in the hands caused by chemotherapy. Sixteen adults who finished chemotherapy at least 60 days ago will try the therapy at home. The main …

This study tests whether taking fish oil for 12 weeks can help the body adapt to cold by activating brown fat, which burns energy to produce heat. Thirty healthy adults aged 18-40 will take either fish oil or a placebo and then undergo a cold chamber challenge. Researchers will m…

This study tests whether a virtual, home-based exercise program can reduce depression and anxiety in family caregivers of people with Alzheimer's disease. Twenty-five caregivers will be randomly assigned to either the exercise program or a wait-list group. The program includes we…

This study compares a Mediterranean diet to a Western diet to see which one better reduces fatigue in people with autoimmune hepatitis. About 48 adults will try both diets in a random order. Researchers will measure changes in fatigue and quality of life using a standard question…

This study is testing whether computerized brain training (BrainHQ) and Tai Chi-Qi Gong can improve memory, thinking, and mood in people with early-onset Alzheimer's disease. Sixty participants aged 40-64 will be assigned to either the training program or an active control group.…

This study tests a new kind of talk therapy called Smart Virtual Reminiscence (SVR) for older adults with mild cognitive impairment or early dementia. The therapy uses artificial intelligence to guide conversations about past memories, aiming to reduce troubling symptoms like agi…

This study compares two pain medicines, sufentanil and methadone, given during head and neck reconstruction surgery. About 128 adults will be randomly assigned to receive one of the drugs. Researchers will track pain levels and how much extra pain medicine is needed after surgery…

This study tests whether a 16-week virtual exercise program can improve fitness, muscle strength, and quality of life in people with indolent (slow-growing) metastatic breast cancer. Participants work with a trainer three times a week via video calls. The goal is to see if exerci…

This study tests whether virtual reality brain games can help older adults who survived a stay in the intensive care unit (ICU) and had delirium. About 100 people aged 50 and older will use a VR headset at home to play memory and attention games for 4 weeks. The goal is to see if…

This study tests a special hydrogel (PuraGel) placed inside the nose after skull base surgery to see if it helps the surgical site heal faster and reduces pain. Thirty adults having this surgery will be randomly assigned to get either the hydrogel or a standard silicone splint. D…

This study compares different types and intensities of walking therapy for people who had a stroke 1-6 months ago. 100 participants will receive up to 30 one-hour sessions of either high- or low-intensity walking or general physical therapy. The goal is to see which approach best…

This study compares two eye drops—SYSTANE PRO and MIEBO—to see if SYSTANE PRO works as well as MIEBO for treating dry eye disease. About 260 adults with moderate dry eye will use one of the two drops for one month. The main goal is to measure changes in dry eye symptoms using a s…

This study tests whether spiritual care sessions can improve spiritual wellbeing, reduce anxiety and depression, and increase satisfaction with care for people with stage IV lung or gastrointestinal cancer. About 36 adults will be randomly assigned to receive either spiritual car…

This study is testing whether a natural supplement called 5HTP can improve breathing and reduce anxiety in children aged 8-18 with mild to moderate asthma and allergies. About 20 participants will be randomly assigned to take either 5HTP or a placebo, then switch groups later. Th…

This study looks at whether adding pelvic floor physical therapy before standard radiation treatment can help reduce pain and sexual problems in women with cervical, vaginal, vulvar, uterine, or anal cancer. About 20 participants will receive education on using a vaginal dilator …

This study is tracking how well a procedure called G-POEM helps people with gastroparesis, a condition where the stomach empties too slowly. Researchers will follow 75 adults who are already scheduled for the procedure to see if their symptoms like nausea, bloating, and feeling f…

This study tracks how well a nerve block procedure called celiac plexus neurolysis (CPN) helps manage pain in people with chronic pancreatitis. Researchers will follow 35 patients for 24 weeks, recording their pain scores and pain medication use. The goal is to see if the procedu…

This study compares two standard pain relief methods—spinal morphine versus IV methadone—for men undergoing testicular cancer surgery. The goal is to see which approach provides better pain control and reduces the need for additional opioids. About 142 participants will be enroll…

This study tests a new, non-invasive brain stimulation method called temporal interference (TI) to reduce nicotine cravings and vaping. 120 adults who vape heavily will receive either real TI stimulation to deep brain areas linked to addiction or a sham (fake) treatment during a …

This study looks at whether different foot-strengthening methods—like wearing minimalist shoes, doing foot exercises, or using a device called ToePro—can make feet stronger and improve balance and walking in adults aged 45 to 85. Over 8 weeks, participants will try one of these a…

This study looks at whether doing high-intensity walking training more often helps people who had a stroke more than six months ago improve their walking ability. Forty adults will be assigned to either frequent or less frequent training sessions, plus a home walking program. The…

This study tests whether a telephone-based counseling program can help patients with advanced gastrointestinal cancer and their family caregivers feel better. The program teaches strategies to manage stress and symptoms, and is compared to a standard education and support program…

This study tests whether daily leg heat therapy can improve walking ability and quality of life in people with peripheral artery disease (PAD). About 106 adults over 50 with PAD will use special heated trousers for 90 minutes a day at home for 12 weeks. Researchers will measure c…

This study tests whether showing people in early recovery from alcohol use disorder personalized, high-intensity images of future events can help them prefer delayed rewards and increase their interest in treatment. Twenty-one participants will be split into two groups: one recei…

This study tests whether internet-based cognitive behavioral therapy (CBT) can reduce depression and slow cognitive decline in older adults who survived an ICU stay. About 300 participants aged 50+ with depressive symptoms will receive either online CBT or standard depression edu…

This study tests whether a low-temperature radiofrequency device can reshape nose or ear cartilage during surgery to improve breathing and appearance. Twenty adults having septorhinoplasty will have their cartilage reshaped with the device before reimplantation. Researchers will …

This study tests whether a mobile app called Brain CareNotes can reduce stress for unpaid caregivers of people with Alzheimer's or related dementias. The app offers coaching and tips for managing difficult behaviors like agitation or wandering. Over 12 months, 184 caregivers will…

This study tests whether daily leg heat therapy can help people with heart failure with preserved ejection fraction (HFpEF) exercise longer and feel better. Participants wear water-circulating trousers heated to 42°C for 90 minutes each day at home. The goal is to see if this imp…

This study tests a 30-minute smartphone app designed to improve sleep and reduce stigma in college students who may be at risk for psychosis. About 115 students with poor sleep and certain experiences (like hearing voices or feeling paranoid) will use the app or wait to receive i…

This study tests whether Kinesio tape, a special stretchy tape placed on the skin, can reduce muscle soreness after hard exercise. Thirty-six healthy adults aged 18 to 30 will have the tape applied to their upper arm for up to 72 hours. Researchers will measure pain, range of mot…

This study looks at whether acupuncture can reduce pain in people with sickle cell disease. Researchers will also use brain scans and other tests to understand how acupuncture works. The study involves 120 participants aged 14 to 80 who have chronic pain or recent pain crises.

This study tests a program called the Green Activity Program, designed for people aged 45+ with mild memory problems. The program encourages enjoyable nature activities like walking, gardening, or outdoor yoga, with a partner. Researchers want to see if the program is easy to do …

This pilot study tests whether a non-invasive brain stimulation technique called TMS can reduce rumination—repetitive negative thinking—in adults with treatment-resistant depression. Twenty participants will receive 20 TMS sessions targeting a specific brain region and undergo br…

This study tests whether training your breathing muscles for 8 weeks can improve your thinking skills when you have to breathe against resistance. Researchers will measure diaphragm thickness and cognitive performance in 32 healthy adults aged 18-40. The goal is to see if stronge…

This study follows 250 people who had ankle fractures to see how many develop nerve-related chronic pain after the bone heals. Participants answer pain questionnaires and undergo simple sensory tests. The goal is to better understand this type of pain, not to test any new treatme…

This study tests an online portal called SCP-PHR designed to help colon and rectal cancer survivors manage their survivorship care. Researchers will enroll 250 adults who have completed initial treatment within the past year. The goal is to see if the portal improves how often su…

This study aims to uncover the genetic causes of cardiomyopathy in children by analyzing DNA from affected individuals and their families. Researchers hope to identify mutations that lead to different types of cardiomyopathy, which could improve genetic counseling and deepen unde…

This study looks at whether brain activity related to learning can predict how well teens respond to a program aimed at reducing cannabis use. Teens aged 14-17 get a brain scan, then attend 10 weekly virtual sessions where they report use and take drug tests. They can earn prizes…

This study aims to collect DNA samples and medical information from 2,000 people with heterotaxy (a condition where organs are arranged abnormally) and related heart defects, along with their family members. Researchers hope to identify the genetic causes of these conditions, whi…

This study aims to find a blood marker that can tell how healthy the blood vessels in the eye are for people with diabetic retinopathy. Researchers will collect blood samples from 192 participants with type 2 diabetes and analyze special cells in the blood. The goal is to discove…

This observational study tracks over 10,000 people with advanced or metastatic cancer to understand why outcomes vary by race and background. Researchers collect social, genetic, and treatment data from patients at four cancer centers. The goal is to identify factors—like social …

This study collects small tissue samples from the stomach and upper intestine of people with severe gastroparesis (delayed stomach emptying). Researchers look for specific cell abnormalities that might predict whether a patient will benefit from a gastric electrical stimulation d…

This study compares two techniques—esophageal manometry and EndoFLIP balloon measurements—to evaluate how well they assess swallowing difficulties (dysphagia). Researchers will enroll up to 1,000 patients with known esophageal conditions to see how these measurements relate to sy…

This study looks at whether a program called ADAPT, where nurses and social workers call people with heart failure weekly to help manage symptoms and improve well-being, can work outside of a research setting. The program aims to reduce hospital visits and improve quality of life…

This study is creating a registry of up to 5,000 patients with various gut movement disorders, such as GERD, gastroparesis, and IBS. Doctors will use standard criteria to make accurate diagnoses and collect patient-reported outcomes. The goal is to improve understanding of these …

This study looks at whether bacterial biofilms (sticky layers of bacteria) on breast implants can lead to complications like chronic inflammation or Breast Implant Illness. Researchers will collect blood and discarded tissue from 1000 women—some with implants and symptoms, some w…

This study uses special cameras to take detailed pictures of the eye's drainage system in people with glaucoma or high eye pressure. Half of the 50 participants will use Rhopressa eye drops daily for two weeks, while the other half will use artificial tears. The goal is to see if…

This study looks at people with gastroparesis (slow stomach emptying) who have a gastric electrical stimulator (GES) implanted. Researchers will turn off the device for up to four hours to see how it changes insulin and other hormone levels. The goal is to understand the device's…

This study looks at whether replacing red meat with plant-based protein can lower levels of certain gut toxins in people with stage 3 chronic kidney disease. Fifteen participants will try both a vegetarian diet and a diet with red meat, with a break in between. Researchers will m…

This study looks at how a pregnant woman's body handles caffeine and how much of it reaches her unborn baby. Researchers will give a small dose of caffeine to 30 women at risk of preterm delivery before a planned C-section. Blood samples from the mother, placenta, and newborn wil…

This study explores whether a gentle electrical current applied to the scalp (tDCS) can help healthy adults learn a virtual reality game called Beat Saber more quickly. Researchers will compare game performance before and after stimulation in 52 participants aged 18-45. This is a…

This study looks at how a brain area called the primary motor cortex helps us learn and remember new motor skills. Researchers will use a non-invasive technique called rTMS to temporarily lower activity in this area while 32 healthy adults learn to play a song on Guitar Hero. The…

This study looks at how a person's genetic makeup and the HIV drug efavirenz change the way the body processes methadone and tizanidine. Sixty healthy volunteers will be grouped by their CYP2B6 gene type and take these drugs with and without efavirenz. The goal is to understand w…

This study looks at whether making changes at hospitals and dialysis centers can help more people with kidney failure start the process to get a transplant. About 14,000 patients at five large transplant centers will be included. The goal is to see if these changes lead to more p…

This study tests a non-invasive brain stimulation method called temporal interference (TI) in 30 healthy adults. Using scalp electrodes, TI aims to safely reach deep brain areas like the dorsal anterior cingulate cortex without affecting the surface. Researchers will measure brai…

This study looks at how men and women react differently to two weeks of not drinking alcohol. Researchers will measure alcohol intake, brain responses, and personal feelings after the break. The goal is to use this information to create better ways to prevent and treat alcohol us…

This study will enroll 50 people with dry eye disease to compare three different devices that measure the thickness of the tear film's lipid layer. Researchers want to see which device gives the most consistent readings and which one best matches other signs of dry eye. The goal …

This study tests an iPad app called Periviable GOALS that helps parents facing a very early preterm birth (22-25 weeks) understand their options and clarify their values. The app includes videos and outcome information designed for people with varying literacy levels. Researchers…

This study is testing a simple scoring system to predict whether people with metastatic cancer will survive at least 30 days after starting palliative radiation therapy. The score uses lab results, emergency room visits, and cancer type. About 214 adults will join to see if the t…

This study tests a digital tool called CGM ASSIST that combines a continuous glucose monitor with easy-to-read displays. The goal is to help people with Alzheimer's or dementia and diabetes, along with their caregivers, better understand blood sugar levels and make informed decis…

This study looks at whether taking longer breaks between repeated head impacts (like heading a soccer ball) can reduce brain injury. Researchers will measure blood markers and brain scans in 102 soccer players. The goal is to find safer ways to play sports and serve in the milita…

This study looks at how the brain's sensory and motor areas work together to keep hand movements precise. Researchers will test 300 healthy right-handed adults aged 18-45 using touchscreen tasks. The goal is to understand sensorimotor learning, which may one day help improve reha…

This study looks at tooth wear and tooth sensitivity in 2,500 adults across five U.S. locations. Researchers will use dental scans and questionnaires to find out how common these problems are and what factors—like diet or brushing habits—might cause them. Participants must be 18 …

This study tests whether taking fish oil supplements (DHA and EPA) before soccer heading can reduce brain injury markers. 208 soccer players aged 18-30 will take either fish oil or placebo capsules daily, then undergo controlled heading sessions. Researchers will measure blood bi…

This study looks at how often doctors use a portable ultrasound device (POCUS) during checkups at free clinics and street medicine sites in Indianapolis. Researchers will track what they find and whether the ultrasound changes the patient's treatment plan. About 50 adults will ta…

This study aims to understand why Black Americans often report higher levels of paranoia than White Americans, even without a mental health diagnosis. Researchers will use an online guided imagery task to see if race-related stress triggers paranoia in 480 Black American particip…

This study looks at how short walks affect pain in older adults who have muscle or joint pain. Researchers will measure pain during movement and how the body adapts to pain. 40 adults who have had pain in the past month can join. The goal is to better understand the link between …

This study looks at whether breathing a lighter gas mixture (heliox) can make it easier to breathe and think clearly when breathing is hard. Fifteen healthy adults will breathe normal air or heliox while doing thinking tests. The goal is to see if reducing the work of breathing i…

This study tracks 15 people getting a simultaneous liver-kidney transplant to see how much their own kidneys recover. Researchers use a special nuclear scan and blood tests to measure kidney function before and after transplant. The goal is to create a way to predict who might no…

This study follows 150 people who recently had a stroke to see how their walking ability recovers over time. Researchers will measure walking speed and distance, and test if specific therapies can improve recovery. The goal is to create better rules for predicting and enhancing r…

This study tests whether a mild electrical stimulation behind the ear (taVNS) can temporarily change insulin, C-peptide, and blood sugar levels in 30 healthy adults. Half will get real stimulation, half a sham. Researchers want to see if this nerve trick could one day lead to new…

This study looks at whether a common vitamin, niacin (nicotinic acid), can get into the brain fluid of people with Alzheimer's disease. Researchers will give 30 adults aged 60-85 with mild-to-moderate Alzheimer's a single 500 mg dose of extended-release niacin or a placebo. The m…

This study looks at why some active young adults have trouble breathing during exercise due to their vocal cords closing when they shouldn't. Researchers will use a small wearable device on the neck, treadmill tests, and MRI scans to measure breathing patterns and vocal cord move…

This study compares three ways to check for fluid overload (too much fluid in the body) in people doing dialysis at home. Researchers will ask about symptoms, do a physical exam, and use a safe ultrasound of the lungs. The goal is to find which method works best to help prevent h…

This study tests whether taking dietary nitrate (found in beets) can help prevent muscle loss and weakness when a leg is immobilized in a brace for 14 days. Researchers will measure muscle function and energy use in 24 healthy young men. The goal is to find a simple, drug-free wa…

This study follows 850 people aged 40-64 with early-onset cognitive impairment to understand how Alzheimer's disease progresses. Participants undergo cognitive tests, brain scans, and genetic analysis, but no experimental treatment is given. The goal is to gather data that could …

This study tests whether a non-invasive device called Body Surface Gastric Mapping can predict which patients with gastroparesis will benefit from G-POEM surgery. Researchers will monitor 20 patients before and after the procedure using a sticky electrode patch on the stomach are…

This study tests a new method called temporal interference (TI) that uses electrical currents to stimulate deep brain areas without surgery. Thirty healthy adults aged 18-50 will receive TI stimulation while their brain activity is measured with fMRI. The goal is to understand ho…

This study tests a new, non-invasive brain stimulation technique called temporal interference (TI) that uses scalp electrodes to safely reach deep brain regions without affecting the surface. Researchers will measure brain activity changes in 30 healthy volunteers using fMRI. The…

This study looks at how inflammation from type 2 diabetes, end-stage kidney disease, or irritable bowel syndrome affects the way the body processes drugs. Researchers will collect blood samples from 150 adults and children to measure inflammation markers and estimate how they mig…

This study aims to find out if children with primary ciliary dyskinesia (PCD) also have a condition called bronchial hyperresponsiveness, which makes airways overly sensitive. Researchers will compare 40 participants (those with PCD and healthy volunteers) using breathing tests. …

This study looks at whether people with cystic fibrosis who are on highly effective modulator therapy can safely stop using nasal saline rinses and steroid sprays. Researchers will monitor sinus health, lung function, and quality of life in 64 adults. The goal is to see if these …

This pilot study at Indiana University will test whether a 2-month course of high-dose proton pump inhibitors (PPIs) can improve the flexibility (distensibility) of the esophagus in 10 people with eosinophilic esophagitis (EoE). Researchers will measure flexibility in both the up…

This study looks at how older adults with and without vision problems step over obstacles of different heights and colors. Researchers want to understand how vision and eye movements affect walking to help prevent falls. About 200 adults who can walk on their own will take part.

This study is creating a large collection of blood samples, tissue, and health information from 2,500 people with plasma cell disorders like multiple myeloma. Researchers will use this repository to better understand how the disease develops and changes over time. No new treatmen…

This study looks at how well a rapid blood test called TEG 6s measures clotting in healthy children. About 125 kids having planned surgery will give a small blood sample for the test. The goal is to find normal values for children and compare them to existing ranges. No treatment…

This study from Indiana University looks at how the COVID-19 pandemic may have changed people's physical activity, sleep, diet, blood pressure, and mental stress. Researchers will track 100 adults aged 18-75 using wearable devices, fitness tests, blood samples, and blood pressure…

This study looks at how eating dried plums (prunes) might help reduce bone loss in women after menopause. Researchers want to know if prunes change immune cell function and gut bacteria. Thirty women aged 60-75 will eat prunes or their normal diet for four weeks at a time, and pr…

This study tests a special follow-up program called the Transitional Liver Clinic (TLC) for people with advanced liver disease after they leave the hospital. The program includes extra phone calls or video visits and more attention from liver specialists. The goal is to see if th…

This study explores whether nerve damage in the cornea causes stubborn dry eye in people with ocular graft-versus-host disease (GVHD), a complication of stem cell transplants. Researchers will measure corneal sensation in 30 GVHD patients and compare it to healthy controls. The g…

This study is testing a new ankle brace with built-in motion sensors to see if it can accurately measure how people walk, run, jump, and balance. Researchers will compare the brace's readings to standard lab equipment. The goal is to see if the brace is reliable enough for future…

This study collects blood or brain tissue from families with two or more members diagnosed with Alzheimer's or dementia. The goal is to build a large DNA bank that researchers can use to find genes linked to the disease. No individual results are returned, but the data may lead t…

This study looks at the social and economic challenges faced by people with chronic liver disease, like trouble paying for food or housing. Researchers will survey 400 patients and their doctors at Indiana University Health to find out what needs are most common and how patients …

This study looks at how brain tumors (gliomas) change over time and whether advanced MRI and PET scans can predict those changes. Twenty adults with suspected glioma will have special scans before surgery, and their tumor tissue will be analyzed. The goal is to see if imaging can…