Indiana University

This study tests whether a slow-release form of the hormone DHEA can improve asthma control in adults aged 18 to 50. Standard asthma steroids can lower the body's own DHEA, so supplementing it might help. The trial will compare DHEA capsules to a placebo in 30 participants, measu…

This study will test a new, non-invasive device that measures blood flow and oxygen levels in the brains of newborn babies. Researchers will compare babies who were exposed to opioids before birth with those who were not. The goal is to see if the device can detect signs of opioi…

This pilot study will test whether breathing controlled amounts of carbon dioxide (CO2) can help doctors see blood flow in the heart using MRI, without needing standard contrast dyes. Thirty adults with known or suspected coronary artery disease will take part. The goal is to che…

This pilot study tests whether a computer-controlled device that delivers precise gas mixtures can safely help identify coronary artery disease in people without known heart problems. Eighty healthy adults aged 45 and older will breathe different gas concentrations while their vi…

This early-phase study will test a new radioactive tracer called [18F]-AraG in just 5 people with advanced head and neck cancer. Participants will receive two PET/CT scans (before and during standard chemoradiotherapy) to see if the tracer's uptake matches immune cell activity an…

This study continues a community project in rural Kenya to prevent cervical cancer. It offers the 9-valent HPV vaccine to 2000 adolescent girls and tests self-collected swabs for high-risk HPV in adult women. Researchers will also study why some families do not participate and wh…

This study tests whether a more intensive diet and activity counseling program can help high-risk pregnant women keep their blood sugar in a healthy range and lower their chances of developing gestational diabetes. About 100 women early in pregnancy (16 weeks or less) who have ri…

This study tests whether a new, fully immersive virtual reality walking program can help people with traumatic brain injury (TBI) improve their mobility and quality of life. Thirty participants will try two types of VR therapy: one on a treadmill with screens, and another using a…

This study tests a special device that monitors sleep without any physical contact, designed for people with Alzheimer's or related dementias living in long-term care facilities. About 100 residents will use the device for four weeks. Researchers want to see if sharing sleep data…

This study explores whether a short virtual reality (VR) tour of Bali can reduce loneliness in adults aged 65 and older. Participants are randomly assigned to either a 13-minute VR travel experience or a puzzle activity, and their feelings of loneliness are measured before and af…

This study looks at whether high-intensity walking training can help people with cerebellar damage (a part of the brain that controls balance and coordination) improve their walking ability. Twenty participants will either do intense walking exercises or standard training. The go…

This study tests whether using the Replexa+ device twice daily for 3 months can improve blood flow in the lower legs and feet of veterans with peripheral artery disease (PAD) and peripheral neuropathy. Ten participants will have their blood flow measured before and after treatmen…

This study tests whether structured spiritual care from a chaplain can reduce anxiety and improve well-being for family members of ICU patients who cannot make decisions for themselves. The chaplain will meet with the family surrogate several times and stay in touch weekly. The t…

This study tests if a gentle electrical stimulation on the outer ear can activate the vagus nerve and reduce nausea, vomiting, and stomach discomfort in people with diabetes and gastroparesis. Sixty adults with both conditions will receive the treatment and report symptom changes…

This study tests a program that offers mental health screening, therapy, and follow-up to pregnant women who are in the hospital for medical complications. About 50 participants will receive brief counseling and symptom tracking during their stay and for three months after. The g…

This study tests whether a single dose of psilocybin (the active ingredient in magic mushrooms) combined with psychotherapy is safe and can reduce depression and substance use in veterans and first responders who haven't responded to standard treatments. Fifty participants will r…

This study tests a portable exercise bike that clamps to hospital beds, allowing patients to pedal their arms and legs while lying down. The goal is to see if using the bike for at least 15 minutes a day can help prevent muscle loss, weakness, and other problems like blood clots …

This study compares a new suction-based cervical stabilizer (Carevix) to the standard metal clamp (tenaculum) for IUD insertions. 100 women will be randomly assigned to one device, and they will rate their pain on a 0-10 scale. The goal is to see if the gentler suction tool cause…

This study tests two ways to deliver a group training program for caregivers of children with autism in low-resource areas. The program aims to reduce caregiver stress and improve the child's communication and behavior. About 320 caregivers of children aged 2 to 8 will take part.…

This study compares two ways of inviting people to screen for type 1 diabetes at home: a simple email or letter versus a personal phone call. Researchers want to see which method leads more people to complete and return a home screening kit. Participants are adults and children a…

This study looks at whether pregnancy complications like gestational diabetes or high blood pressure can accelerate ovarian aging. Researchers will follow 655 women over many years, tracking hormone levels and health outcomes. The goal is to understand if these complications lead…

This study looks at using simple, low-cost communication tools like picture boards and gestures for children with autism who have trouble speaking. It involves 500 children and their caregivers in rural Virginia and western Kenya. The goal is to find better ways to match each chi…

This study looks at whether using a set method for cervical ripening (preparing the cervix for labor) leads to more vaginal deliveries. About 1,158 pregnant women will be randomly assigned to receive either a balloon catheter alone or a balloon catheter plus the medication misopr…

This study will test 60 adults with bronchiectasis (a chronic lung condition) to see if they have an undiagnosed genetic disorder called primary ciliary dyskinesia (PCD). Researchers will measure nitric oxide in the nose and examine tiny hair-like cells from a nasal swab under a …

This study will test whether immunotherapy drugs (immune checkpoint inhibitors) change how the liver processes other medications. About 80 adults with various cancers who are starting immunotherapy will take a low-dose cocktail of 7 common drugs. Researchers will measure drug lev…

This study compares two approaches to help people with chronic traumatic brain injury (TBI) become more engaged and confident in managing their health. One approach focuses on what matters most to the patient, while the other provides general health education. The trial will invo…

This study looks at how being in hot or cold environments changes how hard it feels to breathe and how well you think when breathing is difficult. Fifteen healthy adults will do breathing tasks in different temperatures. The goal is to understand, not to treat or cure any conditi…

This study looks at whether changing the sound of a person's breathing can help them feel less breathless and think more clearly when breathing is hard. Researchers will have 15 healthy adults breathe through a mask that makes it harder to breathe, while playing back their breath…

This study looks at whether chemicals and other substances in a mother's body during pregnancy can help predict if her child will develop autism. Researchers will use stored urine and cord blood samples from 600 first-time mothers. The goal is to build a model that could estimate…

This study will collect blood samples from 100 adults with cancer who are starting immunotherapy. Researchers will analyze the samples to find patterns in immune cells and molecules that might predict how well the treatment works or if it causes side effects. The goal is to bette…

This study will enroll 150 pregnant individuals carrying twins to compare two ways of tracking fetal growth: the standard growth chart used for all pregnancies versus a chart designed specifically for twins. Participants will be randomly assigned to one of the two chart methods, …