Could a simple gas challenge detect clogged arteries?

NCT ID NCT06000540

Not yet recruiting Diagnosis Sponsor: Indiana University Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This pilot study tests whether a computer-controlled device that delivers precise gas mixtures can safely help identify coronary artery disease in people without known heart problems. Eighty healthy adults aged 45 and older will breathe different gas concentrations while their vital signs and symptoms are monitored. The goal is to see if the gas challenge is tolerable and can reveal early signs of heart disease.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this could lead to a new, non-invasive way to screen for coronary artery disease using controlled breathing of different gas mixtures.
What could go wrong: This is a very early pilot study with only 80 healthy participants, so it may not work in people with actual heart disease. The gas challenge may cause temporary discomfort like headache or dizziness.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

coronary artery disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CORONARY ARTERY DISEASE

Contacts and locations

Locations

IU Health Methodist Hospital

Indianapolis, Indiana, 46202, United States

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