CORONARY ARTERY DISEASE

This study is checking if a medical device called Essential Pro is safe and works well for people with narrowed heart arteries. About 100 people who already got the device as part of their normal care will be followed. Researchers will track serious heart problems like heart atta…

This study tests whether colchicine, a safe anti-inflammatory drug used for centuries, can reduce the risk of heart attack, stroke, or death in 700 heart disease patients undergoing major surgery. Participants take colchicine or a placebo before and after their operation. The goa…

This study compares an artificial intelligence (AI) method to the standard invasive method for guiding stenting in people with narrowed heart arteries. About 2100 adults with coronary artery disease will be randomly assigned to one of the two approaches. The goal is to see if the…

This study compares a new stomach acid reducer (tegoprazan) with a standard one (rabeprazole) in about 3,320 heart patients who take blood thinners and are at high risk for stomach bleeding or ulcers. The goal is to see if the new drug works just as well at preventing serious sto…

This study tests if a new pressure microcatheter is as good as the standard pressure wire for deciding when and how to place stents in heart arteries. About 2500 adults with stable heart disease or recent non-emergency heart attack will be randomly assigned to one device or the o…

This study tests whether a personalized blood-thinning plan (shorter dual therapy followed by one drug alone) is safer and just as effective as the standard approach for people with coronary artery disease who have received a stent guided by imaging. About 3,944 adults will be fo…

This study tests whether adding a PCSK9 inhibitor (a powerful cholesterol-lowering drug) to standard treatment can reduce major heart problems like heart attacks, strokes, or death in people with high-risk plaque in their coronary arteries. About 3,600 adults with specific plaque…

This study compares a new type of heart stent (XIENCE Skypoint) with other stents used to treat blocked arteries. About 2000 adults with coronary artery disease will receive the new stent and be followed for a year. Researchers will track rates of death, heart attack, and the nee…

This study tests whether a daily arm-cuff treatment (remote ischemic conditioning) plus mindfulness training can lower the risk of heart attacks, heart failure, and chest pain in 2,000 adults with coronary artery disease who still have blocked arteries after treatment. Participan…

This study compares two types of drug-coated stents (small mesh tubes placed in heart arteries) in 2,100 people who have had a heart attack or unstable chest pain. The goal is to see which stent causes fewer heart-related problems like death, another heart attack, or the need for…

This registry follows over 1,100 people with coronary artery disease who receive resorbable magnesium scaffolds to open blocked arteries. The goal is to see how well these temporary scaffolds work and how safe they are in everyday medical practice. Researchers will track heart-re…

This study looks for the safest and most effective dose of blood thinners (P2Y12 inhibitors) for people who have had a heart stent placed. About 355 participants will try different doses to find one that keeps blood clotting at a healthy level—not too high (which can cause clots)…

This study tests a new type of heart stent (a small mesh tube) in 500 people with heart disease who also take blood thinners. These patients have a high risk of bleeding. The new stent is designed to allow a shorter course of anti-clotting drugs, which may lower that risk. The go…

This study tests whether a drug-coated balloon is better than a drug-eluting stent for treating complex blockages in heart arteries. About 520 adults with coronary artery disease will be randomly assigned to one of the two treatments. The goal is to see which approach reduces the…

This study compares two imaging methods to guide stent placement in people with calcium buildup in their heart arteries. About 700 adults with signs of reduced blood flow to the heart will be randomly assigned to have their procedure guided by either a coronary CT angiogram or th…

This study looks at two common heart procedures in women with blocked arteries: stenting (a less invasive approach) and bypass surgery (open-heart surgery). The goal is to see which one helps women live longer and feel better. About 600 women will take part, and their survival an…

This study compares two diabetes medications, semaglutide and dapagliflozin, against standard treatment (metformin) to see if they can slow or reverse the buildup of plaque in the heart arteries. The trial involves 300 adults with pre-diabetes and confirmed coronary artery diseas…

This study compares two treatments for coronary artery disease in large blood vessels (≥3.5 mm): a drug-coated balloon and a drug-eluting stent. About 94 adults with heart artery blockages will be randomly assigned to one treatment. The main goal is to see which approach better p…

This study compares two strategies for deciding which narrowed heart arteries to treat with stents in high-risk patients. One strategy uses a special camera inside the artery to look at plaque buildup and vulnerability, while the other uses a pressure wire to measure blood flow. …

This study looks at whether giving a fast-acting blood thinner called cangrelor during a less invasive heart bypass surgery (MIDCAB) is safe and works well. About 30 adults with blocked heart arteries will get cangrelor through a vein during surgery, and their results will be com…

This study tests whether a remote monitoring program using text messages and a smartphone app can help people with coronary artery disease recover better after a stent procedure. About 200 participants will either get standard care or the digital program, which includes health co…

This study is testing a new, longer drug-coated stent (Orsiro Mission) to treat long blockages in the heart's arteries. About 150 people with coronary artery disease will receive the stent and be monitored for up to 5 years. The goal is to see if the stent is safe and effective a…

This study tests a drug called ziltivekimab in people who recently had a heart attack. The goal is to see if it can reduce dangerous fatty plaques in the arteries by lowering inflammation. About 332 participants will receive either the drug or a placebo, plus standard care, for 1…

This study tests a new type of heart stent that slowly dissolves over time. It is designed for people with long blockages in their coronary arteries. The goal is to see if the stent is safe and effective at keeping arteries open without needing a permanent metal implant.

This study looks at two ways to fix a common problem after heart stent placement: when the stent doesn't fully expand. The trial will compare a new technique called intravascular lithotripsy (using sound waves) with standard high-pressure balloons. About 80 adults with narrowed s…

This study looks at how well a drug-coated balloon works over time for people with coronary artery disease. Researchers will track 1,500 patients to see if the balloon helps prevent heart attacks, death, or the need for repeat procedures. The goal is to understand the treatment's…

This study tests a special balloon coated with medicine to open completely blocked heart arteries. 30 adults with chest pain or related symptoms will get this treatment. Doctors will use ultrasound and pressure measurements during the procedure and again after 6 months to see how…

This study tests a special balloon coated with medicine (Prevail DCB) to open blocked heart arteries in people with coronary artery disease. About 1,200 adults with narrowed arteries or re-blocked stents will receive this balloon treatment. The goal is to see if it works as well …

This study compares two strategies to reduce bleeding from standard blood thinners after a heart stent procedure: lowering the dose of one drug versus switching to a different drug. About 78 adults who have had a stent and are on dual antiplatelet therapy will be randomly assigne…

This study compares two ways to treat blocked heart arteries: a drug-coated balloon (DCB) and a drug-eluting stent (DES). About 256 adults with coronary artery disease will be enrolled. The goal is to see which method keeps arteries open longer by measuring changes inside the ves…

This study tests whether a lower dose of the blood thinner ticagrelor works better than the standard clopidogrel in stable heart disease patients who are at high risk of a heart attack during a stent procedure. Researchers will measure how well the drugs prevent blood clots using…

This study follows over 2,000 patients with coronary artery disease who received a device called Sequent Please Neo during routine care. Researchers want to confirm the device is safe and works well by tracking major heart problems like heart attacks or the need for repeat proced…

This study is testing a special drug-coated stent (Supraflex) in 10,000 people with coronary artery disease who need a stent to open blocked heart arteries. The goal is to see if the stent is safe and works well in everyday medical practice. Participants will be followed to track…

This early study tests a drug called meplazumab in 18 people with stable coronary artery disease. The drug targets a protein linked to inflammation that may worsen artery plaques. Researchers will use CT scans and blood tests to see if the drug reduces inflammation and plaque bui…

This study is testing a very long stent (a mesh tube) to treat long blockages in the heart's arteries. About 1,000 people with coronary artery disease will get one long stent instead of multiple shorter ones. The goal is to see if this approach is safe and works well at keeping t…

This study tests whether a comprehensive treatment can reduce heart attacks and other serious events in people with rapidly-progressive coronary artery disease caused by inflammation. About 39 adults who have already had heart procedures like stents or bypass surgery will receive…

This study compares two blood thinners, prasugrel and ticagrelor, when used alone after heart stent placement. About 48 adults with coronary artery disease who have been on dual therapy for at least 90 days will switch to just one of these medications. The goal is to see which on…

This study is testing a drug called regadenoson in children who need a heart stress test. The drug helps doctors see how well blood flows to the heart. The goal is to check the drug's safety and how the body processes it in different age groups, from infants to teenagers.

This study tests whether giving fluids tailored to each patient's needs, guided by a lung water monitor, can prevent acute kidney injury in elderly people with mild-to-moderate kidney disease who undergo a heart procedure called coronary angiography. About 320 participants aged 6…

This study looks at whether using two or more artery grafts during heart bypass surgery is better than using just one. About 4,300 people having planned, non-emergency bypass will be randomly assigned to one of the two methods. The goal is to see if multiple grafts lower the chan…

This study tests an inhaled medicine called Aroxxen in 180 people with coronary artery disease who are getting a stent to open blocked heart arteries. The goal is to see if breathing in the drug during and after the procedure can reduce heart muscle damage and find the best dose …

This study looks at two ways to treat chronic coronary syndrome (narrowed heart arteries). One group gets a procedure to open blocked arteries, guided by a special CT scan. The other group gets only medicines. The goal is to see which approach prevents heart attacks, death, or th…

This study tests a special balloon coated with a drug (sirolimus) to open up small arteries in the heart. About 1,600 adults with coronary artery disease will take part. The balloon is inflated to push plaque aside and release medicine to keep the artery open, aiming to improve b…

This study tests whether drug-coated balloons work as well as drug-eluting stents for people with blocked heart arteries at branch points. About 321 adults with stable or unstable heart disease will be randomly assigned to one of three treatments. The main goal is to check blood …

This study looks at people who recently had a major heart attack (STEMI) and have multiple blocked arteries. Doctors want to see if placing stents in unstable-looking plaques (that aren't severely blocking blood flow) plus medication is better than medication alone to prevent fut…

This study compares two common heart procedures—bypass surgery (CABG) and stenting (PCI)—in 754 people with severe coronary artery disease and a weak heart pump. The goal is to see which approach better prevents death, stroke, heart attack, or the need for repeat procedures over …

This study tests whether a drug called indobufen works better and causes fewer bleeding problems than aspirin in people over 65 who have had a heart attack or unstable angina and received a stent. About 2,800 participants will take either indobufen or aspirin along with another b…

This study tests whether a high-intensity statin, low-dose colchicine, or both can slow or change the buildup of fatty plaque in the heart arteries. It includes 200 adults aged 40-75 who have a high genetic risk for heart disease but no symptoms yet. Participants will get one of …

This study tests a drug-coated balloon (DCB) to treat small heart arteries in people with coronary artery disease who also have a high risk of bleeding. About 501 participants will receive the balloon treatment and then take only 7 days of blood thinners instead of the usual long…

This study looks at whether a 12-week cardiovascular rehabilitation program (exercise training three times a week) can improve artery health and reduce inflammation in adults aged 40-70 with coronary artery disease. Researchers will measure artery thickness, blood vessel function…

This study compares two techniques used during heart stent placement for left main coronary artery disease: one guided by standard angiography and another using a pressure wire (FFR). About 960 adults with significant left main artery blockage will be enrolled. The goal is to see…

This study tests whether a drug-coated balloon can make dangerous fatty plaques in heart arteries less risky than using standard medications alone. About 400 adults with acute coronary syndrome will be randomly assigned to receive either the balloon treatment or no extra treatmen…

This study compares two types of drug-coated balloons (Selution with sirolimus vs. SeQuent Please Neo with paclitaxel) to treat narrowed heart arteries in medium-small vessels. About 140 adults with stable angina or stabilized acute coronary syndrome will be enrolled. The main go…

This study looks at whether SGLT2 inhibitors (a type of diabetes drug) can prevent acute kidney injury caused by contrast dye used during heart procedures like angiography or stenting. Researchers will analyze data from 4,000 patients to compare kidney function before and after t…

This study looks at whether berberine, a natural compound, can help blood thinners work better in people who have had a heart stent placed. About 64 adults who are already taking aspirin and clopidogrel will receive different doses of berberine or no extra treatment. The goal is …

This study looks at whether using a high-tech camera called optical coherence tomography (OCT) during stent placement can help people with stable angina take blood thinners for a shorter time. Normally, patients take these drugs for 6 to 12 months to prevent clots, but that raise…

This study compares two common heart procedures—bypass surgery (CABG) and stents (PCI)—in 358 people with weak hearts (ejection fraction 40% or less) and multiple blocked arteries. The goal is to see which approach leads to better survival, fewer heart attacks or strokes, and imp…

This study tests a pharmacy-led program to help low-income patients with multiple chronic conditions take their medications correctly after leaving the hospital. The program provides free medications, bedside delivery, and health coaches to address common barriers like cost and t…

This study looks at how well two types of heart stents (Synergy XD and Synergy Megatron) work in everyday medical practice. About 2000 adults with coronary artery disease will receive these stents to open blocked arteries. Researchers will track deaths, heart attacks, and the nee…

This study tests a new medicine called YN001 in 24 adults with coronary atherosclerosis (plaque buildup in heart arteries). Participants receive YN001 by IV along with a standard cholesterol-lowering drug. The goal is to see if YN001 can reduce plaque volume and improve artery he…

This study tests a special balloon coated with medicine to treat narrowed small arteries in the heart. About 960 adults with coronary artery disease will receive this balloon treatment or standard care. The goal is to see if the balloon safely opens the artery and reduces the ris…

This study compares two ways to treat long or widespread blockages in heart arteries. One method uses a temporary magnesium scaffold plus drug-coated balloons, while the other uses standard permanent metal stents. The goal is to see if the newer approach works as well and leaves …

This study compares a new dissolvable scaffold (Firesorb) to a standard metal stent for treating blocked heart arteries. The scaffold is designed to support the artery temporarily and then dissolve, potentially avoiding long-term problems linked to permanent stents. About 2,000 p…

This study looks at whether using just one blood thinner (single antiplatelet therapy) is safer and as effective as using two (dual antiplatelet therapy) in older adults or those at high risk of bleeding who have had a heart procedure with a drug-coated balloon. About 576 partici…

This study compares two methods to treat hardened (calcified) blockages in heart arteries that branch. Half of the 200 participants will get standard balloon treatment before a stent, while the other half will get a special device called an orbital atherectomy to first remove som…

This study tests whether a personalized risk-score algorithm can better determine how long patients should take two blood thinners after getting a heart stent. About 2,788 adults receiving a drug-coated stent will be assigned to either algorithm-guided or standard treatment durat…

This study looks at two common ways to open blocked heart arteries in 600 minority patients: stenting (a small tube placed through a wrist or groin incision) and bypass surgery (using blood vessels from elsewhere in the body to create a detour). The goal is to see which procedure…

This study compares a new shockwave technique to standard balloon or cutting methods for treating severely calcified heart arteries. About 666 adults with coronary artery disease will be randomly assigned to one of the two approaches. The goal is to see which method is safer and …

This study compares two blood thinner combinations—aspirin plus prasugrel versus aspirin plus clopidogrel—in 3,500 adults with complex coronary artery disease who are receiving stents. The goal is to see which combo better prevents major heart events like death, heart attack, or …

This study tests whether a moderate-dose statin plus ezetimibe works as well as a high-dose statin alone to stabilize fatty plaques in heart arteries. About 408 adults with coronary artery disease will receive one of the two treatments for 52 weeks. Researchers will use special u…

This study compares two strategies to reduce bleeding in people with coronary artery disease who have had a stent placed and are on blood thinners. One approach switches to a milder antiplatelet drug while keeping aspirin, and the other stops aspirin while keeping a stronger drug…

This study tests whether the drug colchicine can prevent atrial fibrillation (a type of irregular heartbeat) after heart bypass surgery. Researchers will compare 70 patients who receive colchicine plus a special surgical technique with 70 patients who receive standard care. The g…

This study tests a new type of heart stent made from magnesium that slowly dissolves over time, compared to a permanent metal stent. The goal is to see if the dissolvable stent is safe and works as well for people with blocked heart arteries. About 1,859 adults with coronary arte…

This study tests a new balloon device that delivers the drug sirolimus to treat re-narrowed heart arteries (in-stent restenosis). It compares this balloon to an existing one that uses paclitaxel. About 740 adults with one re-narrowed artery will be randomly assigned to receive on…

This study looks at 2,000 people with chest pain and non-high risk blockages in their heart arteries. It compares whether doing an invasive procedure (like placing a stent) or using only medicines and monitoring leads to better outcomes. The goal is to see which approach prevents…

This study tests a temporary heart pump called iVAC 2L in 100 people with severe coronary artery disease who need high-risk angioplasty. The pump helps the heart keep pumping blood during the procedure. Researchers will track deaths, heart attacks, and strokes for one year to see…

This study is following 50,000 people with coronary artery disease who receive drug-eluting stents during routine care. The goal is to see how well these stents work and how safe they are in everyday practice. Researchers will track major heart problems like death, heart attack, …

This study looks at two ways to treat hardened calcium deposits (calcified nodules) in heart arteries after using sound waves to break them up. About 128 adults with coronary artery disease will be randomly assigned to get either a drug-coated balloon or a drug-coated stent. The …

This study tests whether adding a custom Chinese herbal medicine called Yiyang Huoluo Decoction to standard heart medications can improve symptoms and blood vessel health in older adults with coronary heart disease and atherosclerosis. Thirty participants aged 50-75 will be rando…

This study looks at how safe and effective scaffold implants are for people with coronary artery disease. Over 1,100 adults who need at least one scaffold will be followed for at least a year. The goal is to track heart-related events like heart attack or repeat procedures.

This study aims to find out if using multiple arteries for heart bypass surgery is better than using just one artery in women with coronary artery disease. About 2,300 women will be randomly assigned to one of the two surgical approaches. Researchers will track heart-related even…

This study compares two treatments for completely blocked heart arteries (chronic total occlusion). One uses a drug-coated balloon to open the blockage, the other uses a drug-coated stent to keep it open. The trial will enroll 200 adults and measure how well the artery stays open…

This study looks at two methods to treat hardened calcium deposits in heart arteries. It involves 120 adults who need a stent. One group gets a special balloon treatment alone, while the other gets the balloon plus a rotating device. The goal is to see which approach allows the s…

This study tests if a newer, less invasive heart-lung machine (MiECC) causes fewer serious problems after heart surgery than the standard machine. About 1300 adults having planned coronary bypass or aortic valve replacement will be randomly assigned to one of the two machines. Th…

This study is testing a medical device that uses gentle sound waves to break up hard calcium deposits inside heart arteries. The goal is to safely open severely hardened arteries so a stent can be placed more effectively. The study will enroll about 335 adults in the US with seve…

This study tests whether artificial intelligence can find early signs of coronary artery disease on regular, non-contrast chest CT scans—the kind people get for lung checks or health screenings. Researchers will enroll about 200 adults who have had both a standard chest CT and a …

This study tests a new 3D imaging tool (3DStent) to see if it can accurately detect when a heart stent is not fully expanded after placement. About 200 adults with coronary artery disease who need a stent will be enrolled. The 3DStent results will be compared to standard ultrasou…

This study compares two non-invasive heart tests—stress echocardiography (ultrasound) combined with a neck artery scan versus a standard CT scan—to see which better detects blocked arteries and prevents heart attacks or other serious events. About 2,000 people with suspected coro…

This study tests a new imaging method called µQFR to see if it can accurately detect leftover blockages in side branches of heart arteries after a single stent is placed. About 290 adults with coronary artery disease will have their results compared to the standard pressure-wire …

This study compares a new AI-powered CT scan that measures plaque in heart arteries against standard care for people with possible heart disease. About 1000 adults with symptoms like chest pain will be randomly assigned to either the AI-guided approach or usual care. The goal is …

This study tests whether artificial intelligence can automatically analyze ultrasound videos to detect coronary artery disease. Researchers will enroll 1,500 people with suspected heart disease who are already scheduled for a standard angiogram. The goal is to see if AI can provi…

This study tests a new imaging agent called [15-O]-H2O, given through an IV, to see if it can accurately detect coronary artery disease during a PET scan. About 215 adults with suspected heart disease will receive the agent at rest and during stress. The goal is to confirm how we…

This study looks at a new computer program that helps doctors diagnose blocked heart arteries from CT scans more accurately. It combines several checks into one step, which may reduce the need for invasive tests. Researchers will review past scans from 1,000 patients to see if th…

This study tests a new type of MRI that looks at heart metabolism to see which parts of the heart are still alive and working. The goal is to help doctors better select patients with coronary artery disease who will benefit from bypass surgery. About 30 people will participate, i…

This study is testing whether certain substances in the blood can tell doctors if a person has significant blockages in their heart arteries. About 1,000 adults with suspected coronary artery disease will have their blood tested and compared to results from a heart CT scan. The g…

This study tests whether a new type of CT scanner, called Photon Counting Detector CT (PCD-CT), can provide clearer images of heart artery disease when used with a drug that makes the heart work harder. About 450 adults with suspected coronary artery disease will get both a stand…

This study tests whether the blood thinner clopidogrel can prevent major heart problems like heart attacks and strokes in people who have early signs of artery disease on scans but don't yet need surgery. About 11,000 adults aged 40 and older with non-critical blockages will take…

This study looks at whether a tailored prevention plan can stop coronary artery disease in people who had cancer treatment (chemotherapy or radiation) more than 5 years ago. About 748 survivors aged 40-70 will get heart risk checks, including CT scans, and those at higher risk wi…

This study tests whether taking CoQ10 and glutathione before and after heart surgery can prevent acute kidney injury. About 242 adults having elective bypass surgery will receive either the supplements or a placebo. The goal is to see if these mitochondrial-supporting nutrients r…

This study tests whether an AI tool can help doctors find hidden calcium buildup in heart arteries from routine chest CT scans. The goal is to start or strengthen cholesterol-lowering medications early to prevent heart disease. About 1,500 adults aged 40-75 who have had a chest C…

This study looks at whether opening blocked heart arteries with stents can improve quality of life for people with heart failure with preserved ejection fraction (HFpEF), a condition where the heart muscle is stiff. About 350 adults with both HFpEF and coronary artery disease wil…

This study looks at whether watching a short educational video can reduce anxiety in patients waiting for a common heart procedure called PCI (angioplasty). About 144 adults will take part, with some watching the video and others getting standard care. Researchers will measure an…

This study looks at 570 people with chronic coronary syndrome (ongoing chest pain or discomfort due to narrowed heart arteries). Participants get a special PET scan to check blood flow. Those with abnormal results are randomly assigned to either immediate heart catheterization or…

This study tests if giving a numbing medicine (ropivacaine) through chest tubes after heart surgery helps patients recover better and feel less pain. About 116 adults having planned heart surgery will take part. Half will get the medicine, half a placebo, and researchers will mea…

This study tests if a device called Bioboosti, which uses pulsed electromagnetic waves, can improve blood flow to the heart in people with coronary artery disease. Researchers will measure blood flow and exercise ability in 120 adults who cannot have standard heart procedures. Th…

This study tests an online decision aid for adults with both chronic kidney disease and heart disease. The tool helps patients and doctors understand the risks and benefits of heart procedures like angiograms or surgery, which can be riskier for people with kidney problems. About…

This study looks at people who have chest pain but no major blockages in their heart arteries. Doctors will use an extra test during a routine heart procedure to see if it helps choose the right medicine. The goal is to find out if this approach improves symptoms, daily function,…

This study looks at why some ICU patients bleed longer after a tube is removed from an artery in the groin following heart procedures. Researchers will track 157 adults to find factors that affect how long it takes to stop bleeding and how long patients must lie flat. The goal is…

This study asks 600 heart patients and their doctors which treatment they prefer for blocked arteries: a permanent metal stent or a drug-coated balloon that dissolves over time. The goal is to understand how much extra risk people are willing to accept to avoid having a metal imp…

This study looks at 350 adults with coronary artery disease to understand why some plaques in heart arteries become dangerous. Researchers will use special imaging and blood tests to study the immune system's role. The goal is to better predict heart attacks and improve treatment…

This study compares two ways to open completely blocked heart arteries (chronic total occlusions) in 74 patients. One method works from the front of the blockage, the other from behind. Researchers will measure which is faster, safer, and less stressful for doctors.

This study observes 10,000 people with a severe blockage in the left main coronary artery, a key heart vessel. It compares the long-term results of three approaches: medication alone, stenting with drug-coated stents, and bypass surgery. The goal is to see which works best in rea…

This study looks at whether a special CT scan (FFR CT) can accurately measure blood flow in heart arteries without needing a catheter procedure. Researchers will compare results from the CT scan with the standard invasive test in 500 adults with suspected coronary artery disease.…

This study looks back at 5,000 adults who had heart or blood vessel surgery at UC Davis Medical Center. Researchers want to find out what factors affect survival and recovery, both in the hospital and up to a year later. The goal is to learn how to improve care and reduce risks f…

This study follows 120 adults with coronary artery disease and signs of chronic inflammation to understand their symptoms, current treatments, and health outcomes over time. Researchers will track major heart events like heart attacks, need for procedures, or death. The goal is t…

This study looks at whether problems with mitochondria—the energy factories inside heart cells—are linked to how heart failure progresses. Researchers will take small heart tissue samples and blood from 45 to 60 people with heart failure and blocked arteries who are having bypass…

This study is re-examining 1,400 adults in Stockholm who were part of a larger national health study. Researchers are using advanced imaging, blood tests, and questionnaires to find risk factors for heart, lung, and liver diseases. The goal is to better understand what causes the…

This study is for 1200 people with coronary artery disease who are starting a cardiac rehab program. Researchers will collect detailed information—like fitness, activity, and health data—to understand what helps people stick with a healthy lifestyle and avoid future heart problem…

This study is testing a new type of MRI scan that looks at how the heart uses energy, to see if it can help doctors understand heart muscle health better than current methods. Researchers will compare this new scan with standard PET and SPECT scans in 15 people—6 healthy voluntee…

This study looks at how well different treadmill tests measure oxygen use during exercise in people with coronary artery disease. Researchers will test 54 adults (18+) to see if one test works better for women and another for men. The goal is to improve how doctors assess heart h…

This study looks at whether using a tiny camera inside the heart's arteries during stent placement can prevent future heart attacks, repeat procedures, or death. Over 11,000 adults with complex coronary artery disease will be tracked to see if this imaging approach works better t…

This study looks at whether telling people they have a high genetic risk for heart disease helps them improve their heart health over one year. About 200 adults aged 40 to 75 who have a high genetic risk but no current heart disease will take part. Half will learn their genetic r…

This study watches how drug-coated balloons change blood flow and plaque in heart arteries. About 165 adults with coronary artery disease will get CT scans before and after the procedure. The goal is to see how these changes relate to patient outcomes.

This study looks at why heart disease affects women differently than men, especially after menopause. Researchers will measure inflammation and hormone levels in 6,000 women with chest pain. The goal is to understand how these factors influence heart attack risk and recovery, lea…

This study looks at whether tiny plastic particles (microplastics and nanoplastics) are present in the blood of people with chronic heart disease. Researchers will collect blood samples from 120 patients during a routine heart catheter procedure and analyze the samples for plasti…

This study looks at how calcium buildup in artery walls affects the healing of a heart stent after one month. Researchers will use a special camera to compare stent struts over calcium deposits to those without calcium. The goal is to understand if calcium slows down the covering…

This study looks at why some people with heart disease get worse much faster due to inflammation. Researchers will compare 20 patients with inflammation-related rapid coronary artery disease to 10 patients with typical disease. The goal is to find patterns in their health history…

This study looks at why some people tolerate ventricular tachycardia (a fast, abnormal heart rhythm) better than others. Researchers will measure blood pressure and blood flow in the heart's arteries during a controlled fast pacing in 70 adults already scheduled for a heart cathe…

This study is testing new MRI techniques to see how the heart works during physical stress, like exercise or fluid changes. Researchers will compare healthy volunteers and people with heart conditions to better understand heart function. The goal is to improve diagnosis and care …

This study looks at whether group or solo singing is a practical activity for older adults with coronary artery disease. Researchers want to see if people will stick with it and if it could lower heart disease risk. The study involves 32 participants and focuses on attendance and…

This study looks at whether telling people their genetic risk for heart disease helps them lower their cholesterol and improve heart health. About 500 adults aged 30-75 who are not on cholesterol medication will take part. Half will get their genetic risk score right away, the ot…

This study looks at whether a simple blood test called the triglyceride-glucose (TyG) index can help predict the severity of heart artery disease in people who do not have diabetes but develop heart disease early. Researchers will study 180 adults aged 18 and older who have confi…

This study follows about 20,000 people with coronary artery disease who had a heart procedure guided by a special measurement called FFR. The goal is to see how well the treated arteries hold up over 2 years by tracking heart-related events like heart attacks or repeat procedures…

This study looks at how aging cells in the body may lead to heart artery problems. Researchers will measure markers of cell aging in 300 people with different types of chest pain or heart attacks. The goal is to understand the link between cell aging and artery plaque instability…

This study looks at whether a special heart scan (coronary CT angiography) is better than standard follow-up care for high-risk patients who have had a stent placed to open blocked arteries. About 3,500 adults aged 19 and older with complex heart conditions will be enrolled. The …

This registry is a long-term study that collects information on the safety and effectiveness of Medtronic medical devices already on the market. It will include up to 100,000 people who have or will receive a Medtronic device for conditions like heart, nerve, or digestive problem…

This study looks at how a short course of high-dose statins affects fatty buildup (plaque) in the heart's arteries. About 140 adults with mild heart disease will get either a statin or a placebo, and advanced CT scans will track changes over 3 months. The goal is to understand wh…

This study follows 30,000 people diagnosed with coronary artery disease to see how different risk factors affect long-term survival. Researchers will track deaths from any cause and from heart problems. The goal is to better understand what influences outcomes in real-world patie…

This study looks at whether a special score that combines genetics and patient information can identify people with stable coronary artery disease who are at higher risk for a heart attack or heart injury during a planned stent procedure. About 500 adults will be enrolled and fol…

This study tests whether doing several heart scans (blood flow, ultrasound, and CT) all in one day is faster and cheaper than the usual step-by-step approach for people with possible coronary artery disease. About 500 patients from primary care centers in Sweden will take part, a…

This study looks at 1300 heart patients who had a stent placed (PCI) and are at high risk for bleeding. Researchers will use artificial intelligence to find which blood thinner medicines work best and for how long to prevent heart attacks and strokes while avoiding dangerous blee…

This study observes whether giving back leftover blood from the heart-lung machine during heart surgery lowers the need for blood transfusions afterward. About 130 adults having planned coronary bypass surgery will take part. Researchers will compare patients who get the blood ba…

This study will test a new, high-speed CT scanner to see if it can better detect dangerous plaques in heart arteries and measure blood flow, all without invasive procedures. Researchers will enroll 500 adults with known or suspected coronary artery disease. The goal is to see if …

This study follows 80 adults who had coronary artery bypass surgery to see how developing pneumonia in the hospital affects their heart and lung health over the next year. Researchers will compare medical tests and scans between those who get pneumonia and those who don't. The go…

This study compares two ways of delivering cardiac rehabilitation: in-person sessions at a clinic and telehealth sessions done from home. Researchers want to see if both methods produce similar improvements in walking ability and quality of life for people with heart conditions. …

This study looks at four simple physical tests—like timed walking and standing up from a chair—to see which one best measures how well patients recover after coronary artery bypass graft (CABG) surgery. Researchers will test 150 adults aged 30-50 on the third and fifth day after …

This study tests whether customizing medications based on a person's specific type of heart microcirculation problem can improve quality of life better than standard care. About 180 people with chest pain but no major artery blockages will be randomly assigned to either personali…

This study tests a new device that collects blood samples directly from the coronary arteries of people with established heart disease. The goal is to measure specific molecules related to artery blockages, which could help doctors develop more personalized treatments. About 300 …

This study follows 4,000 people with coronary artery disease who have had special imaging of their heart arteries. Researchers want to see if the images can predict serious heart events like heart attack or death. No new treatment is given; the goal is to learn how well imaging c…

This study looks at how taking multiple medications affects the health of elderly people with chronic diseases like heart disease, diabetes, and high blood pressure. Researchers will survey 2000 patients aged 65 and older in Shaanxi Province, China, over two years. The goal is to…

This study compares how heart disease patients and healthcare providers weigh the importance of different health events, like heart attack or stroke, compared to death. Researchers want to see if patients and doctors value these events differently, which could help design better …

This study is a large registry that will follow 25,000 people with multivessel coronary artery disease (blockages in multiple heart arteries) to see how they fare over the long term with different treatments: medication, bypass surgery, or stents. The goal is to understand which …

This pilot study is testing whether wearable devices like smartwatches can be useful for tracking the health of people recovering from a serious illness that required intensive care. Researchers want to see if patients find these devices easy to use and helpful over a 6-month per…

This study aims to determine how accurately a CT scan can measure plaque buildup in heart arteries compared to ultrasound. Researchers will enroll 250 people with stable coronary artery disease who need standard heart imaging. The study focuses on improving measurement techniques…