CORONARY ARTERY DISEASE

This study follows about 2,000 people with coronary artery disease who received a device called Sequent Please Neo to open blocked heart arteries. Researchers want to confirm the device is safe and works well by tracking major heart problems like heart attacks or the need for rep…

This study tests a special balloon coated with medicine to treat narrowed small arteries in the heart. About 960 adults with coronary artery disease will receive this balloon treatment or standard care. The goal is to see if the balloon safely opens the artery and reduces the ris…

This study tests whether ziltivekimab, an anti-inflammatory drug, can reduce dangerous plaque buildup in the arteries of people who recently had a heart attack. About 332 participants will receive either the drug or a placebo, plus standard care, for 15 months. Special imaging wi…

This study tests a special balloon coated with a drug (sirolimus) to open up small blocked arteries in the heart. It is for people with coronary artery disease who need a procedure to improve blood flow. The balloon delivers medicine directly to the vessel wall, aiming to keep th…

This study compares two ways to treat long or widespread blockages in heart arteries. One method uses a temporary magnesium scaffold plus drug-coated balloons, while the other uses standard permanent metal stents. The goal is to see if the newer approach works as well and leaves …

This study tests whether inhaling a drug called Aroxxen can reduce heart damage in people undergoing a stent procedure to open blocked heart arteries. About 180 adults with coronary artery disease will be randomly assigned to receive either Aroxxen inhalation or standard care. Re…

This study compares a new dissolvable scaffold (Firesorb) to a standard metal stent for treating blocked heart arteries. The scaffold is designed to support the artery temporarily and then dissolve, potentially avoiding long-term problems linked to permanent stents. About 2,000 p…

This study compares two methods for guiding stent placement in people with severe left main coronary artery disease: standard angiography (X-ray imaging) versus a more detailed pressure-wire measurement called fractional flow reserve (FFR). About 960 adults with angina or evidenc…

This study tests whether a new medicine, YN001, can help reduce plaque buildup in the heart arteries when added to standard cholesterol-lowering therapy. About 24 adults in Australia with coronary artery disease will receive YN001 through an IV. The main goal is to see if it safe…

This study tests whether a drug called indobufen works better than aspirin in older adults (over 65) who have had a heart attack or unstable angina and received a stent. About 2,800 participants will take either indobufen plus ticagrelor or aspirin plus ticagrelor for one year. T…

This study looks at whether using two or more artery grafts during heart bypass surgery is better than using just one. It involves over 4,300 adults with blocked heart arteries who need planned bypass surgery. The goal is to see if multiple grafts reduce the chance of death, stro…

This study tests two types of drug-coated balloons—one with sirolimus and one with paclitaxel—to see which works better for opening narrowed heart arteries in medium-small vessels. About 140 adults with stable angina or stabilized heart attack symptoms will be enrolled. The main …

This study tests a special balloon coated with medicine to open completely blocked heart arteries. 30 people with chest pain or other symptoms will get this treatment. Doctors will use ultrasound and pressure measurements to see how well the artery stays open after 6 months. The …

This study looks at whether a drug-coated balloon can effectively treat small coronary artery disease while allowing patients at high risk of bleeding to take blood thinners for only 7 days. About 501 participants will receive the balloon treatment during a standard heart procedu…

This study is following 100 people who have already been treated with the Essential Pro device for blocked heart arteries. Researchers want to confirm the device is safe and works as intended. They will track heart-related events like heart attacks or the need for repeat procedur…

This study tests a new, thinner stent coated with a drug that slowly releases to keep arteries open. It is for people with heart disease who also take blood thinners, which puts them at high risk for bleeding. The goal is to see if this stent allows for a shorter course of antipl…

This study compares two ways to open blocked heart arteries: a drug-coated balloon (DCB) and a drug-eluting stent (DES). Researchers will measure how much the artery narrows again over time using ultrasound. About 256 adults with coronary artery disease will take part to see whic…

This study compares a new pressure microcatheter to a standard pressure wire for guiding treatment of narrowed heart arteries. About 2500 adults with stable coronary artery disease or recent heart attack symptoms will be randomly assigned to one device. The goal is to see if the …

This study compares two blood thinners—low-dose ticagrelor and standard clopidogrel—in 50 stable heart disease patients getting a stent. It focuses on those with a high genetic risk score for poor response to clopidogrel. The goal is to see which drug better prevents blood clots …

This study tests a special balloon coated with medicine (Prevail DCB) to open blocked heart arteries in people with coronary artery disease. About 1,205 adults with narrowed arteries or previous stent blockages will receive this treatment. The goal is to see if the balloon safely…

This study tests a new stomach acid reducer (tegoprazan) against a standard one (rabeprazole) in about 3,320 heart patients who take blood thinners. The goal is to see if the new drug is as good at preventing serious stomach problems like bleeding and ulcers. Participants take on…

This study is testing a special long stent (a mesh tube) for people with long blockages in their heart arteries. The goal is to see if using one long stent instead of multiple stents is safe and works well. About 1,039 adults with coronary artery disease will take part, and resea…

This study tests whether a high-intensity statin, a low-dose anti-inflammatory drug (colchicine), or both can slow the buildup of artery plaque in people with a high genetic risk for heart disease. About 200 adults aged 40–75 with early, non-blocking plaque will take the medicati…

This study compares two types of drug-coated stents (small mesh tubes placed in heart arteries) in 2,100 people who have had a heart attack or unstable chest pain. The goal is to see which stent better prevents future heart problems, like heart attacks or the need for another pro…

This study looks at two common ways to open blocked heart arteries in 600 minority patients: stenting (a small tube placed through a wrist or groin incision) and bypass surgery (using blood vessels from elsewhere in the body to create a detour). The goal is to see which procedure…

This study is for people with chest pain (angina) but no major blockages in their heart arteries. It tests whether a special diagnostic procedure during a heart catheterization can help doctors choose the right medications to reduce pain and improve quality of life. About 1,500 p…

This study looks at whether using a tiny camera inside the heart's arteries during stent placement can lead to better outcomes for people with complex coronary artery disease. About 11,000 adults in the Netherlands who need a stent for severe blockages will be included. The goal …

This study tests if a new technique called intravascular lithotripsy (IVL) works better than standard high-pressure balloons to fix a narrowed heart stent. About 80 adults with a blocked stent due to incomplete expansion will be randomly assigned to one of the two treatments. The…

This study looks at 600 women with coronary artery disease to compare two ways to restore blood flow to the heart: stenting (a less invasive procedure) and bypass surgery (open-heart surgery). The goal is to see which approach leads to better survival and quality of life. Partici…

This study compares a new shockwave technique to standard balloon or cutting methods for treating severely calcified heart arteries. About 666 adults with coronary artery disease will be randomly assigned to one of the two approaches. The goal is to see which method is safer and …

This study compares two blood thinner combinations—aspirin plus prasugrel versus aspirin plus clopidogrel—in 3,500 adults with complex coronary artery disease who are receiving stents. The goal is to see which combo better prevents major heart events like death, heart attack, or …

This study looks at whether adding berberine, a natural compound, can help blood thinners work better in people who have had a heart stent placed. About 64 adults who are already taking aspirin and clopidogrel will receive different doses of berberine or no extra treatment for up…

This study compares two treatments for blocked heart arteries: drug-coated balloons and drug-eluting stents. About 321 adults with coronary artery disease will be randomly assigned to one of three groups. The goal is to see which method best improves blood flow and reduces future…

This study tests whether a moderate-dose statin plus ezetimibe works as well as a high-dose statin alone to stabilize fatty plaques in heart arteries. About 408 adults with coronary artery disease will receive one of the two treatments for 52 weeks. Researchers will use special u…

This study looks at whether a 12-week supervised exercise program can improve artery health and reduce inflammation in people with coronary artery disease (CAD). Researchers will measure artery thickness, blood vessel function, and inflammatory markers before and after the progra…

This study looks at how well a special balloon coated with medicine works to treat blocked heart arteries in everyday medical practice. Researchers will follow 1,500 adults for several years to see if the balloon helps prevent heart attacks, death, or the need for repeat procedur…

This study compares two strategies to reduce bleeding in people with coronary artery disease who have had a stent placed and are on blood thinners. One approach switches to a milder antiplatelet drug while keeping aspirin, and the other stops aspirin while keeping a stronger drug…

This study compares two strategies for deciding which narrowed heart arteries to treat with stents in 1944 high-risk patients. One strategy uses a pressure wire to find blockages that limit blood flow, while the other uses a tiny ultrasound camera to see dangerous plaque buildup.…

This study compares two common heart procedures—bypass surgery (CABG) and stenting (PCI)—in 754 people with heart failure and severe blockages in multiple heart arteries. The goal is to see which approach better prevents death, stroke, heart attacks, and repeat procedures over ab…

This study tests whether the drug colchicine can prevent atrial fibrillation (a type of irregular heartbeat) after heart bypass surgery. Researchers will compare 70 patients who receive colchicine plus a special surgical technique with 70 patients who receive standard care. The g…

This study tests a new type of heart stent made from magnesium that slowly dissolves over time, compared to a permanent metal stent. The goal is to see if the dissolvable stent is safe and works as well for people with blocked heart arteries. About 1,859 adults with coronary arte…

This study tests whether clopidogrel, a blood thinner, can prevent major heart problems like heart attacks and strokes in people who have early, non-blocking plaque in their heart arteries. About 11,000 adults aged 40 and older with plaque found on scans but no symptoms will take…

This study tests a new balloon device that delivers the drug sirolimus to treat re-narrowed heart arteries (in-stent restenosis). It compares this balloon to an existing one that uses paclitaxel. About 740 adults with one re-narrowed artery will be randomly assigned to receive on…

This study tests whether colchicine, a safe anti-inflammatory drug used for gout, can prevent heart attacks, strokes, and death in 700 veterans with heart disease who are undergoing major surgery. The goal is to see if calming inflammation around the time of surgery reduces compl…

This study tests whether adding a PCSK9 inhibitor (a powerful cholesterol-lowering drug) to standard treatment can prevent major heart problems like heart attacks and strokes in people with high-risk coronary plaques seen on CT scans. About 3,600 adults with at least one high-ris…

This study looks at whether a class of diabetes drugs called SGLT2 inhibitors can prevent acute kidney injury caused by contrast dye used during heart catheterization. Researchers will analyze data from 4000 patients who had these procedures. The goal is to see if those taking SG…

This study looks at 2,000 people with chest pain and non-high risk blockages in their heart arteries. It compares whether doing an invasive procedure (like placing a stent) or using only medicines and monitoring leads to better outcomes. The goal is to see which approach prevents…

This study tests a temporary heart pump called iVAC 2L in 100 people with severe coronary artery disease who need high-risk angioplasty. The pump helps the heart keep pumping blood during the procedure. Researchers will track deaths, heart attacks, and strokes for one year to see…

This study tests whether using a special CT scan (coronary CT angiography) to guide treatment of calcium buildup in heart arteries leads to better stent placement than the current standard method (IVUS). About 700 adults with evidence of reduced blood flow to the heart will be ra…

This study looks at whether giving a fast-acting blood thinner called cangrelor during a minimally invasive heart bypass procedure is safe and effective. About 30 adults with coronary artery disease will receive cangrelor through a vein during surgery, and their results will be c…

This study is following 50,000 people with coronary artery disease who receive drug-eluting stents during routine care. The goal is to see how well these stents work and how safe they are in everyday practice. Researchers will track major heart problems like death, heart attack, …

This study looks at two ways to treat people with chronic coronary syndrome, a condition where the heart's arteries are narrowed. One group will get a special CT scan to guide procedures like stents, while the other group will receive only medications. The goal is to see which ap…

This study looks at two ways to treat hardened calcium deposits (calcified nodules) in heart arteries after using sound waves to break them up. About 128 adults with coronary artery disease will be randomly assigned to get either a drug-coated balloon or a drug-coated stent. The …

This study tests whether a personalized blood-thinner plan can reduce bleeding risk in people with coronary artery disease who have received a stent. About 3,944 adults will be assigned to either a tailored plan (shorter dual therapy followed by one drug alone) or standard care. …

This study compares two blood thinners, prasugrel and ticagrelor, when used alone after stopping aspirin in people with coronary artery disease who had a stent placed at least 90 days ago. The goal is to see if one is better at preventing blood clots. About 48 adults aged 18-75 w…

This study tests whether a home monitoring program using text messages and a smartphone app can help people with heart disease recover better after a stent procedure. About 200 patients will either get standard care or extra digital support, including remote blood pressure checks…

This study compares two ways to deliver cardiac rehabilitation—in-person sessions and telehealth—for people with heart conditions like heart attack, heart failure, or after heart surgery. The goal is to see if both methods are equally effective at improving exercise ability and q…

This study compares two treatments for coronary artery disease in large heart arteries: a drug-coated balloon and a drug-eluting stent. About 94 participants will be randomly assigned to one treatment, and after 8 months, doctors will check how well the treated artery can relax a…

This study tests a program to help low-income people with multiple chronic conditions (like diabetes, heart disease, and lung disease) take their medications correctly after leaving the hospital. The program provides free medications, delivers them to the bedside and then home, a…

This study tests whether adding a custom Chinese herbal medicine called Yiyang Huoluo Decoction to standard heart medications can improve symptoms and blood vessel health in older adults with coronary heart disease and atherosclerosis. Thirty participants aged 50-75 will be rando…

This study looks at how safe and effective scaffold implants are for people with coronary artery disease. Over 1,100 adults who need at least one scaffold will be followed for at least a year. The goal is to track heart-related events like heart attack or repeat procedures.

This study looks at two types of stents (Synergy XD and Synergy Megatron) used to open blocked heart arteries in everyday medical practice. About 2,000 adults with coronary artery disease will be followed to see how well the stents work and if they cause any problems, compared to…

This study compares a new stent called XIENCE Skypoint to other drug-coated stents in 2000 adults with coronary artery disease. Researchers will track deaths, heart attacks, and the need for repeat procedures over one year to see which stent works better. Participants must be 19 …

This study tests whether a personalized risk score can help doctors decide how long patients should take two blood thinners after getting a heart stent. About 2,788 adults who have had a stent placed will be assigned to either standard care or a tailored plan based on the algorit…

This study aims to find out if using multiple arteries for heart bypass surgery is better than using just one artery in women with coronary artery disease. About 2,300 women will be randomly assigned to one of the two surgical approaches. Researchers will track heart-related even…

This study looks at whether using just one blood thinner (single antiplatelet therapy) is safer and as effective as two blood thinners (dual antiplatelet therapy) in older adults or people with high bleeding risk who have had a heart procedure using a drug-coated balloon. About 5…

This study is testing a special drug-coated stent (Supraflex) in 10,000 people with coronary artery disease who need a stent. The goal is to see if it is safe and works well in everyday medical practice. Participants will be followed to check for heart-related problems like heart…

This study compares two treatments for completely blocked heart arteries (chronic total occlusion). One uses a drug-coated balloon to open the blockage, the other uses a drug-coated stent to keep it open. The trial will enroll 200 adults and measure how well the artery stays open…

This study tests whether a daily, non-invasive blood-flow training (remote ischemic conditioning) combined with mindfulness therapy can reduce serious heart events like heart attacks and hospitalizations. It involves 2,000 adults with coronary artery disease who have not had comp…

This study is testing a new, longer drug-coated stent (Orsiro Mission) to treat long blockages in the heart's arteries. About 150 people with coronary artery disease will receive the stent and be followed for up to 5 years. The goal is to see if the stent is safe and effective at…

This study tests whether giving elderly patients with kidney disease a personalized amount of fluids, guided by a lung water monitor, can prevent acute kidney injury after a heart procedure called coronary angiography. The trial involves 320 participants aged 60 and older with ch…

This study is tracking how well resorbable magnesium scaffolds work for people with coronary artery disease in everyday medical practice. About 1,100 participants will be followed for 12 months to see if the scaffolds safely keep arteries open. The goal is to confirm the device's…

This study tests whether a comprehensive treatment approach can reduce heart attacks and other serious events in people with rapidly-progressive coronary artery disease driven by inflammation. It involves 39 adults who have already had heart procedures like stents or bypass surge…

This study looks at two methods to treat hardened calcium deposits in heart arteries. It involves 120 adults who need a stent. One group gets a special balloon treatment alone, while the other gets the balloon plus a rotating device. The goal is to see which approach allows the s…

This study compares a new AI-driven method that analyzes angiogram images to a standard invasive test that uses a pressure wire inside the heart artery. Both tests help doctors decide if a stent is needed. About 2,100 adults with coronary artery disease will be randomly assigned …

This study looks at 600 people who had a major heart attack and have multiple blocked arteries. It compares two approaches for treating non-blocking but unstable plaques: adding a preventive stent plus medication versus medication alone. The goal is to see which strategy better r…

This study tests if a newer, less invasive heart-lung machine (MiECC) causes fewer serious problems after heart surgery than the standard machine. About 1300 adults having planned coronary bypass or aortic valve replacement will be randomly assigned to one of the two machines. Th…

This study compares two ways to treat hardened (calcified) heart arteries before placing a stent. About 200 adults with severe calcium buildup in a branching artery will be randomly assigned to either standard balloon treatment or a special device (orbital atherectomy) that grind…

This study compares two diabetes medications, semaglutide and dapagliflozin, against standard treatment (metformin) to see if they can slow or reverse artery plaque buildup in people with pre-diabetes and heart disease. About 300 adults aged 18-80 will take one of the drugs for 2…

This study is testing whether using a special drug-coated balloon during a heart procedure can make dangerous, fat-filled artery plaques safer. It compares this balloon treatment to standard heart medications alone. Researchers will enroll 400 adults who have recently had a heart…

This study is testing whether a drug called meplazumab, an antibody that targets inflammation, can help reduce plaque buildup in the arteries of people with coronary artery disease. It will involve 18 patients who will receive either the drug or a placebo to compare effects. Rese…

This study is testing a medical device that uses gentle sound waves to break up hard calcium deposits inside heart arteries. The goal is to safely open severely hardened arteries so a stent can be placed more effectively. The study will enroll about 335 adults in the US with seve…

This study is testing a new type of heart stent called Freesolve, which is made of magnesium and dissolves over time. It aims to see if this stent is safe and effective for treating longer blockages in the heart's arteries. The study will follow 100 participants for up to five ye…

This study is testing a new way to place stents (tiny mesh tubes) in complex, branching heart arteries. Researchers want to see if this new technique, which aims to minimize how much the stent sticks out into the main artery, leads to fewer heart problems like heart attacks or th…

This study compares two different procedures for treating complex blockages where heart arteries split. One approach uses two permanent stents, while the other uses a special drug-coated balloon plus one stent. Researchers want to see which method leads to fewer heart problems an…

This study looks at a new computer program that helps doctors diagnose blocked heart arteries from CT scans more accurately. It combines several checks into one step, which may reduce the need for invasive tests. Researchers will review past scans from 1,000 patients to see if th…

This study tests a new PET scan that uses a special form of water to see if it can accurately detect coronary artery disease. About 215 adults with suspected heart disease will receive the scan at rest and during stress. The goal is to confirm the scan's ability to diagnose block…

This study tests whether artificial intelligence can automatically detect blocked heart arteries from ultrasound videos. Researchers will enroll 1500 people who are already scheduled for a standard heart catheterization. The goal is to see if AI can provide a fast, non-invasive w…

This study tests whether doing several heart scans (blood flow, ultrasound, and CT) all in one day can give faster results and lower costs compared to the usual step-by-step approach. About 500 people with possible coronary artery disease will take part. Researchers will also che…

This study is testing a new type of MRI that looks at how the heart uses energy. The goal is to see if this scan can better identify which people with heart disease will benefit from bypass surgery. About 30 adults with coronary artery disease and healthy volunteers will take par…

This study tests a new 3D imaging technology called 3DStent to see if it can detect when a heart stent is not fully expanded after a procedure to open blocked arteries. About 200 adults with coronary artery disease who need a stent will be enrolled. The goal is to compare 3DStent…

This study tests a new imaging tool called µQFR to see how well it can detect leftover blockages in side branches of heart arteries after a single stent is placed. About 290 adults with complex coronary artery disease will be enrolled. The goal is to see if µQFR can accurately me…

This study is testing whether certain substances in the blood can tell doctors if a person has significant blockages in their heart arteries. About 1,000 adults with suspected coronary artery disease will have their blood tested and compared to results from a heart CT scan. The g…

This study tests whether artificial intelligence can find early signs of coronary artery disease on standard chest CT scans that don't use dye. Researchers will analyze scans from about 1,600 adults to see if the AI can accurately detect dangerous plaque and blockages. If success…

This study tests whether a new type of CT scanner, called Photon Counting Detector CT (PCD-CT), can provide clearer images of heart artery disease when used with a drug that makes the heart work harder. About 450 adults with suspected coronary artery disease will get both a stand…

This study tests whether using an AI-powered CT scan to look at plaque buildup in heart arteries helps doctors diagnose coronary artery disease more accurately and make better treatment decisions. About 1000 people with symptoms of heart disease will be randomly assigned to eithe…

This study compares two common heart scan methods to see which better detects clogged arteries and prevents heart attacks. 2,000 patients with suspected heart disease will receive either a CT scan or an ultrasound stress test with a neck artery check. Researchers will follow part…

This study tests whether taking CoQ10 and glutathione before and after heart surgery can prevent acute kidney injury. About 242 adults having elective bypass surgery will receive either the supplements or a placebo. The goal is to see if these mitochondrial-supporting nutrients r…

This study tests whether an AI tool can help doctors find hidden calcium buildup in heart arteries from routine chest CT scans. The goal is to start or strengthen cholesterol-lowering medications early to prevent heart disease. About 1,500 adults aged 40-75 who have had a chest C…

This study looks at whether a risk-based plan can prevent coronary artery disease in people who survived cancer. It includes 748 cancer survivors aged 40-70 who had chemotherapy or radiation more than 5 years ago. Participants get heart scans and risk assessments to guide prevent…

This study looks at whether using a detailed camera inside the heart arteries (called OCT) can help doctors place stents more precisely. If the stent is perfect, patients with stable angina might only need blood thinners for a short time, lowering their risk of bleeding. About 13…

This study tests if giving a numbing medicine (ropivacaine) through chest tubes after heart surgery helps patients recover better and feel less pain. About 116 adults having planned heart surgery will take part. Half will get the medicine, half a placebo, and researchers will mea…

This study tests if a device called Bioboosti, which uses pulsed electromagnetic waves, can improve blood flow to the heart in people with coronary artery disease. Researchers will measure blood flow and exercise ability in 120 adults who cannot have standard heart procedures. Th…

This study looks at 570 people with chronic coronary syndrome who have chest pain. They will have a special PET scan to check blood flow. Those with abnormal results will be randomly assigned to either immediate heart catheterization or medication optimization. The goal is to see…

This study tests whether watching a short educational video before a planned heart procedure (called PCI) can help lower anxiety. About 144 adults will take part, with some watching the video and others getting usual care. Researchers will measure anxiety levels before and after …

This study is for people with heart failure with preserved ejection fraction (HFpEF) and blocked heart arteries. It aims to find out if placing stents to open blocked arteries improves quality of life. 350 participants will be randomly assigned to receive either a real stent proc…

This study is testing new MRI techniques to see how the heart handles stress, like exercise or extra fluid. Researchers will compare healthy volunteers and people with heart conditions to better understand heart function. The goal is to improve how doctors assess heart disease wi…

This study looks at what patients and healthcare providers prefer when treating blocked heart arteries: permanent metal stents or drug-coated balloons that dissolve over time. Researchers want to understand how much risk people are willing to accept to avoid having a stent left i…

This study tests whether customizing medications based on a person's specific type of heart microcirculation problem can improve quality of life better than standard care. About 180 people with chest pain but no major artery blockages will be randomly assigned to either personali…

This study looks at how mitochondria—the energy factories inside cells—might influence the course of heart failure. Researchers will take small heart tissue samples from 45-60 patients during bypass surgery and compare the mitochondria's structure with blood tests and patient out…

This study aims to learn more about people who have coronary artery disease (narrowing of heart arteries) that is linked to ongoing inflammation. Researchers will track 120 adults to see what treatments they receive and how their health changes over time, including serious heart …

This study tests a new way to take pictures of the heart to see how well the heart muscle is working. It involves 15 people: 6 healthy volunteers and 9 patients with severe heart disease who are scheduled for bypass surgery. Participants will get special MRI and PET scans before …

This study aims to better understand how fatty plaques in heart arteries grow and change over time. Researchers will use a special camera inside the arteries and analyze blood cells at a detailed level. About 350 adults with coronary artery disease will participate, but no new tr…

This study looks at whether a measure called the triglyceride-glucose (TyG) index can help predict the severity and pattern of coronary artery disease in people who do not have diabetes but develop heart disease early. Researchers will review the angiograms of 180 non-diabetic ad…

This study is a registry that collects information on the safety and effectiveness of Medtronic medical devices already on the market. It will include up to 100,000 people who have received or will receive one of these devices for conditions like heart, nerve, or digestive proble…

This study looks at how calcium deposits in artery walls affect the healing of a heart stent after one month. Researchers will use a special camera to compare stent struts over calcium with those in calcium-free areas. The goal is to understand if calcium slows down the covering …

This study looks at four simple physical tests—like timed walking and standing up from a chair—to see which one best measures how well patients recover after coronary artery bypass graft (CABG) surgery. Researchers will test 150 adults aged 30-50 on the third and fifth day after …

This study looks at whether telling people their genetic risk for heart disease (called a polygenic risk score) helps them lower their cholesterol and improve their heart health over one year. About 500 adults aged 30-75 who are not on cholesterol medication will be randomly assi…

This study looks at whether a special score, called ABCD-GENE, can identify people with stable coronary artery disease who are at higher risk for a heart attack or heart injury during a routine stent procedure. Researchers will enroll 500 patients and use genetic and clinical inf…

This study re-examines 1,400 adults in Stockholm who previously took part in a large national health survey. Researchers will use advanced imaging, blood tests, and questionnaires to find new risk factors for conditions like coronary artery disease, COPD, and fatty liver disease.…

This study tests a new device that collects blood samples directly from the coronary arteries of people with established heart disease. The goal is to measure specific molecules related to artery blockages, which could help doctors develop more personalized treatments. About 300 …

This study looks at how aging at the cellular level might make heart artery plaques more dangerous. Researchers will measure DNA damage and aging markers in blood samples from 300 people with different types of chest pain or heart attacks. The goal is to find better ways to predi…

This study reviews medical records from 5,000 adults who had heart or blood vessel surgery at UC Davis Medical Center. Researchers want to find out which factors affect recovery and survival after surgery. The goal is to improve future care and reduce risks.

This study follows 4,000 people with coronary artery disease who have had special imaging of their heart arteries. Researchers want to see if the images can predict serious heart events like heart attack or death. No new treatment is given; the goal is to learn how well imaging c…

This study looks at why some people with coronary artery disease get worse quickly due to inflammation. Researchers will compare 20 patients with inflammation-linked rapid disease to 10 patients with standard disease. The goal is to find patterns in lab results, imaging, and trea…

This study watches how a special balloon, coated with medicine, affects blood vessels in people with heart disease. Researchers will use CT scans to see changes in blood flow and plaque buildup before and after the procedure. The goal is to learn how these changes relate to patie…

This study looks at how taking multiple medications affects the health of elderly people with chronic diseases like heart disease, diabetes, and high blood pressure. Researchers will survey 2000 patients aged 65 and older in Shaanxi Province, China, over two years. The goal is to…

This study compares how heart disease patients and healthcare providers weigh the importance of different health events, like heart attack or stroke, compared to death. Researchers want to see if patients and doctors value these events differently, which could help design better …

This study aims to measure the amount of tiny plastic particles (microplastics and nanoplastics) in the blood of the heart arteries of 120 people with chronic coronary syndrome (a type of heart disease). Researchers will also look at heart scans to see if there is a link between …

This study looks at whether telling people they have a high genetic risk for heart disease helps them improve their heart health over one year. Researchers will compare a group that learns their genetic risk to a group that gets standard care. The study involves 200 adults aged 4…

This study looks at whether using a special heart scan (coronary CT angiography) to monitor high-risk patients after they receive a stent is better than usual care. About 3,500 adults who had a stent placed will be followed to see which approach reduces the chance of serious hear…

This study will test a new, faster CT scanner to see if it can better detect risky plaques and measure blood flow in the heart arteries of 500 adults with known or suspected coronary artery disease. Researchers will compare the CT results with standard tests like angiography and …

This study follows 80 adults who had heart bypass surgery to see how developing pneumonia in the hospital affects their heart and lung health over the next year. Researchers will compare those who get pneumonia with those who don't, using blood tests, heart and lung function test…

This study looks at why some people tolerate a fast heart rhythm called ventricular tachycardia (VT) better than others. Researchers will measure blood flow and blood pressure in 70 people undergoing heart artery procedures. The goal is to see if blocked arteries or their treatme…

This study looks at how a short course of high-dose statins affects plaque buildup in the heart arteries of people with mild coronary artery disease. About 140 adults who have never taken statins will receive either the drug or a placebo for 3 months, and advanced CT scans will m…

This study follows 30,000 adults diagnosed with various forms of coronary artery disease to see how different risk factors affect their long-term health. Researchers will track who dies and from what cause, aiming to better understand what influences survival. The goal is to impr…

This study compares two methods (antegrade dissection and re-entry vs. retrograde) for opening completely blocked heart arteries in people with coronary artery disease. About 74 participants will be randomly assigned to one technique to see which is faster, safer, and less stress…

This study follows 10,000 people with a severe blockage in the left main coronary artery to see how different treatments—medication, stents, or bypass surgery—work over the long term in everyday medical practice. Participants are observed for years to track rates of death, heart …

This study follows 1,200 people with coronary artery disease through cardiac rehabilitation to understand what helps them succeed long-term. Researchers collect data from activity trackers, blood pressure monitors, and heart tests, then use artificial intelligence to find pattern…

This study looks at why some ICU patients bleed longer than others after a tube in their leg artery is removed following a heart procedure. Researchers will track 157 adults to find factors that affect how long it takes for bleeding to stop and how long patients must lie flat. Th…

This study watches 130 adults having heart bypass surgery to see if giving back leftover blood from the heart-lung machine (using a saltwater "chase") lowers the need for donated blood transfusions. The researchers compare patients who get this blood back to those who don't, with…

This study looks at why heart disease affects women differently than men, especially after menopause. Researchers will measure inflammation and hormone levels in 6,000 women with chest pain. The goal is to understand how hormones like estrogen influence heart disease risk and out…

This study is a large registry that will follow 25,000 people with multivessel coronary artery disease (blockages in multiple heart arteries) to see how they fare over the long term with different treatments: medication, bypass surgery, or stents. The goal is to understand which …

This study follows about 20,000 people with coronary artery disease who had a procedure to open blocked heart arteries using a special measurement called FFR. The goal is to track their health over two years to see how well the treatment works and what problems may arise. Partici…

This study looks at 1,300 adults who had a heart stent placed and are at high risk for bleeding. Researchers will use artificial intelligence to find the best blood-thinning medicines and treatment lengths to prevent heart attacks, strokes, and dangerous bleeding. The goal is to …

This pilot study is testing whether wearable devices like smartwatches can be useful for tracking the health of people recovering from a serious illness that required intensive care. Researchers want to see if patients find these devices easy to use and helpful over a 6-month per…

This study aims to determine how accurately a CT scan can measure plaque buildup in heart arteries compared to ultrasound. Researchers will enroll 250 people with stable coronary artery disease who need standard heart imaging. The study focuses on improving measurement techniques…

This study aims to find out which type of treadmill exercise test gives the most accurate fitness results for women and men with coronary artery disease. Researchers will compare four different testing methods with 54 participants to see if men and women achieve their best result…