CORONARY ARTERY DISEASE

This study looks at whether stents that slowly dissolve in the body are safe and effective for treating blocked heart arteries. About 120 adults with stable chest pain or mild heart attacks will receive these bioresorbable stents. The goal is to see if they help the artery heal b…

This study compares two types of drug-coated balloons used to open blocked small arteries in the heart. About 180 adults with coronary artery disease will be randomly assigned to receive one of the two balloons. The goal is to see which balloon better prevents future heart proble…

This study tests a special stent (a small mesh tube) coated with a drug that helps keep heart arteries open. It involves 591 people in China with narrowed arteries who need a procedure to restore blood flow. The goal is to see if the stent is safe and effective at treating blocka…

This study tests a new laser device that breaks up calcium buildup in heart arteries, making it easier to place stents. It involves 426 adults with coronary artery disease who need a stent. The goal is to see if the laser treatment is safe and helps stents work better.

This study looks at whether taking blood thinners for just 1 month after getting a heart stent is as safe and effective as the usual 12 months. It involves over 3,700 people with acute coronary syndrome. Doctors also compare using ultrasound guidance during stent placement versus…

This study tests whether inclisiran, an injectable medication, can reduce the amount of plaque buildup in the heart's arteries compared to a placebo. It includes 610 adults with non-obstructive coronary artery disease (blockages less than 50%) who are already taking statins. Part…

This study tests if a special balloon coated with sirolimus works as well as a standard drug-coated stent for opening blocked heart arteries. About 1,820 adults with coronary artery disease will be randomly assigned to one of the two treatments. The goal is to see which approach …

This study tests a temporary heart pump placed in the main pumping chamber during high-risk coronary stenting. It includes 300 patients with severe coronary artery disease and weak heart muscle. The goal is to see if the pump reduces serious complications like heart failure, stro…

This study looks at how well a special heart stent called Onyx works in everyday medical practice. About 4,500 adults with narrowed heart arteries who receive an Onyx stent will be followed to check for safety and effectiveness, such as whether the stent stays open and prevents h…

This study looks at whether using a blood test to measure certain proteins (biomarkers) can help doctors create a more personalized treatment plan for people with coronary artery disease. About 276 adults with stable heart disease will be split into two groups: one gets treatment…

This study compares two treatments for people with a leaky heart valve (ischemic mitral regurgitation) and blocked heart arteries. One group gets open-heart surgery to fix the valve and bypass the blockages. The other group gets a less invasive valve repair first, followed by byp…

This study tests if using a drug-coated balloon (DCB) instead of a regular balloon for the side branch after main artery stenting can reduce major heart problems like heart attack or death within one year. About 784 adults with coronary artery disease and complex blockages at bra…

This study tests a daily combination pill (obicetrapib and ezetimibe) to see if it can reduce fatty plaque buildup in the arteries of 300 adults with heart disease. Participants must already be on cholesterol-lowering therapy but still have high LDL cholesterol and measurable pla…

This study looks at whether a drug-coated heart stent can be expanded more than its normal size to treat tricky blockages in arteries. 30 adults with coronary artery disease will have the stent placed and then checked with a special camera to see if it stays safe and effective. T…

This study tests a new type of heart stent (Angiolite) and a shorter course of blood thinners after stent placement. About 2,300 people with narrowed heart arteries will be randomly assigned to get either the new stent or a standard one, and also to take blood thinners for a shor…

This study tests whether a comprehensive lifestyle program can improve chest pain and quality of life in people with coronary microvascular dysfunction, a condition where small heart vessels don't work properly despite clear major arteries. About 120 adults with confirmed microva…

This study was designed to see if a new type of heart stent that slowly dissolves (MeRes100) works as well as standard permanent stents in people with narrowed heart arteries. The trial planned to enroll adults with coronary artery disease who needed a stent. However, the study w…

This study is a registry that follows 400 people with coronary artery disease who received the ihtDEStiny drug-eluting stent during a routine procedure to open blocked heart arteries. Researchers are tracking how well the stent works over time, including rates of death, heart att…

This study tests a new stenting method called double kissing Nano-Culotte for people with complex blockages in heart arteries. The goal is to see if this technique lowers the risk of major heart problems like heart attack or need for repeat procedures. The study included 12 adult…

This early study tests the safety of a new artificial blood vessel (called Vascudyne) used in heart bypass surgery. Only 5 people with blocked heart arteries will receive the vessel during their bypass. The goal is to see if the vessel stays open and does not cause serious heart …

This study looks at the best way to place stents in heart arteries that have blockages near side branches. It compares placing stents in both the main artery and the side branch versus stenting only the main artery and treating the side branch if needed. The goal is to see which …

This study looks at nearly 1,000 people with severe aortic stenosis (a narrowed heart valve) and blocked heart arteries. It compares two approaches: opening the blocked arteries before or after replacing the heart valve. The goal is to see which timing leads to fewer deaths, hear…

This study looks at whether collecting and re-infusing blood lost during off-pump coronary artery bypass surgery is safe and effective. About 50 adults having this surgery will be included. The goal is to see if this method reduces the need for donor blood transfusions and lowers…

This early study tests a new freezing treatment for people who recently had a heart attack or unstable angina. The treatment uses a balloon to freeze high-risk plaque in heart arteries, aiming to make it stable and less likely to cause a future heart attack. About 30 participants…

This study tests whether a web-based program can help people who have had a heart attack better manage their health and avoid future heart problems. About 864 participants are randomly assigned to either the web program or usual care. The program includes tracking things like blo…

This study tests a special laser (ELCA) to treat severely blocked heart arteries that standard balloons cannot cross or expand. About 230 adults with coronary artery disease will receive the laser procedure and be followed for one year. The goal is to see if the laser can safely …

This study tests two different stents (tiny mesh tubes) used to open blocked heart arteries. It compares a newer drug-coated stent without a permanent polymer to a standard one, to see which allows the artery lining to heal faster after placement. About 40 adults with coronary ar…

This study compares two drug-coated stents (SUPRAFLEX Cruz and SYNERGY) in about 1,550 people with severe blockages in three heart arteries. Participants receive modern heart care including imaging and medications. The goal is to see which stent is safer and more effective at pre…

This study tests whether a drug-coated balloon is as good as a drug-eluting stent for opening blocked heart arteries in people who have a high risk of bleeding. About 1,359 adults with coronary artery disease will be randomly assigned to one of the two treatments. The goal is to …

This study tests a new device called an iron bioresorbable scaffold, which is placed in a blocked heart artery to keep it open and then slowly dissolves over time. It releases a drug to prevent re-blockage. The trial compares it to a standard permanent stent in about 518 adults w…

This early study tests a special balloon coated with two drugs to open blocked heart arteries in 28 people with chest pain or minor heart attacks. The balloon is inflated inside the artery to deliver medication directly to the blockage, aiming to keep the artery open without leav…

This study tests a newer heart stent (Resolute Onyx) against an older one (Resolute Integrity) in 550 people in China with narrowed arteries. Both stents are drug-coated tubes that prop open arteries and release medicine to prevent re-blockage. The main goal is to see which stent…

This study tests whether a blood test can help doctors safely lower the dose of strong blood thinners (P2Y12 inhibitors) in people who have had a heart attack or unstable chest pain and received a stent. The goal is to reduce bleeding complications without increasing the risk of …

This study looks at 556 people with complex coronary artery blockages to see if using intravascular ultrasound (IVUS) to guide a special stenting technique (DK crush) works better than using standard angiography (X-ray). The goal is to lower the chance of heart-related death, hea…

This study is testing a new type of stent (a small mesh tube) coated with a drug that slowly releases to keep heart arteries open. The stent's coating dissolves over time, which may reduce long-term risks. About 1000 adults with coronary artery disease who need a stent will take …

This study compares two ways to treat coronary artery disease: a drug-coated balloon (Selution DEB) and a drug-eluting stent (DES). About 3,300 adults with blocked heart arteries will be randomly assigned to one of the two treatments. The goal is to see which approach better prev…

This study compares two high-dose cholesterol-lowering drug combinations (rosuvastatin/ezetimibe vs. atorvastatin/ezetimibe) in 200 adults with coronary artery disease who have received a drug-eluting stent. The goal is to see which combo is better at keeping LDL cholesterol belo…

This study looks at whether a combination of three common heart medications (a statin, an ACE inhibitor or ARB, and aspirin) can reduce the risk of major heart problems in women who have chest pain or shortness of breath but no blocked arteries. About 2,500 women are taking eithe…

This study is testing a special drug-coated stent (Cre8) in 300 people with long blockages in their heart arteries. The goal is to see if the stent is safe and effective at keeping arteries open. Participants must be 19 or older and have a blockage at least 30 mm long.

This study tests a new lab-made blood vessel (ATEV) for coronary bypass surgery in 20 people with multi-vessel heart disease. The goal is to see if it's safe and can be used when patients don't have enough healthy veins. Success is measured by how well the vessel works and if the…

This study looks at whether using the Impella heart pump during a high-risk procedure to open blocked arteries can help people with weak hearts feel better and live longer compared to standard care. About 1,250 adults with reduced heart function and complex coronary artery diseas…

This study compares two ways to do heart bypass surgery for people with blocked arteries. One method uses a small cut on the left side of the chest (minimally invasive), while the other opens the breastbone (traditional open-chest surgery). The goal is to see which approach helps…

This study looks at a larger version of a heart stent (a tiny mesh tube) used to open blocked arteries in people with coronary artery disease. Researchers want to see if it stays safe and works well when used in everyday medical practice. About 100 people took part, and the main …

This study tests a new device called the Sirolimus-Eluting Iron Bioresorbable Coronary Scaffold System (IBS) in 1059 people with coronary artery disease. The scaffold props open blocked heart arteries and slowly dissolves over time, releasing a drug to prevent re-blockage. The go…

This study looks at whether a drug called nicorandil can lower the risk of heart problems like heart attacks, strokes, and heart-related death in people who have both coronary artery disease and end-stage kidney disease and are on dialysis. About 268 adults are taking part. The g…

This study tests a new stent (a small mesh tube) coated with a drug called ridaforolimus to keep blocked heart arteries open. About 30 adults with coronary artery disease will receive the stent during a standard procedure. The goal is to see if the stent is safe and effective at …

This study looks at whether people with stable heart disease (but without heart failure or irregular heartbeat) can safely stop taking beta-blockers. Researchers will compare those who continue the drug versus those who stop, tracking heart attacks, hospitalizations, and death ov…

This study looks at a treatment called IVL (intravascular lithotripsy) for women with hardened calcium deposits in their heart arteries. About 400 women will receive the treatment during a standard heart procedure. The goal is to see if IVL helps place stents more safely and effe…

This study compares a comprehensive program of lifestyle changes, cholesterol-lowering drugs, and PET heart scans against standard medical care for people with stable coronary artery disease. About 1,085 adults aged 40 and older with suspected or known heart disease are participa…

This study will test a new AI tool that automatically finds and measures dangerous fatty plaques in heart arteries using CT scans. Researchers will check if the AI can spot high-risk plaques as well as special ultrasound probes do, and whether it helps predict future heart proble…

This study aims to improve how doctors diagnose coronary artery disease using stress echocardiograms. Researchers will collect blood samples and analyze echocardiogram images from up to 23,000 patients in the UK to find new biomarkers that make interpretation more objective and a…

This study looks at new ways to tell whether heart artery blockages are in large or small vessels. Researchers will test two new measurements that combine blood flow and pressure readings. About 68 adults with known or suspected coronary artery disease will take part. The goal is…

This study tests whether using personalized risk models can safely reduce the number of diagnostic tests needed for people with new, stable chest pain. Researchers will compare this approach to standard care in 2000 adults aged 30-75. They will also test a new laser method to mea…

This study looks at whether showing people their own coronary CT scan images can motivate them to lower their LDL (bad) cholesterol, reduce reported side effects from cholesterol-lowering medications, and slow the progression of non-obstructive coronary artery disease. About 273 …

This study tests a culturally-appropriate education program called Indigenous SIPin for Native American men who are part of athletic communities. The goal is to help them drink fewer sugary beverages like soda and juice, which can lead to obesity, diabetes, heart disease, and som…

This study tests whether a small shot of nitroglycerin under the skin can widen the wrist artery, making it easier for doctors to insert a tube for heart procedures. It involves 1,400 adults with coronary artery disease who need a heart catheterization. The goal is to reduce the …

This study explores whether a new exercise program that combines high-intensity interval training with Nordic walking (using poles) can improve physical and mental health in people with coronary artery disease. Researchers will test if this whole-body workout is a safe and enjoya…

This study tested whether training family members to help care for patients before heart bypass surgery (CABG) improves emotional and physical outcomes. 54 adults having their first bypass surgery were randomly assigned to either standard care or a program where family received s…

This study tracks over 1600 heart patients who had a stent placed and received genetic testing to help choose their blood thinner medication. The goal is to learn which patients benefit most from genotype-guided therapy and how to reduce risks like heart attack or bleeding. Resea…

This study planned to find better ways to manage heart disease in veterans with severe peripheral artery disease (poor leg blood flow) after they had leg surgery. It aimed to reduce heart attacks and heart-related deaths in this high-risk group. However, the study was withdrawn b…

This study examines whether a simple score based on blood tests (albumin and lymphocyte counts) can predict serious complications after coronary artery bypass surgery. Researchers reviewed records of 117 patients to see if the score, called the Prognostic Nutritional Index, helps…

This study is a large registry that collects medical information, lab results, and tissue samples from 30,000 people with heart disease and healthy volunteers. The goal is to analyze risk factors, treatments, and outcomes to better understand cardiovascular disease. Participants …

This study looks at 40 people who recently had a heart attack and had one blocked artery treated. Researchers want to check other partially blocked arteries using two special tests: one measures blood pressure inside the artery, and the other takes detailed pictures of the artery…

This study follows over 5,700 people with coronary artery disease to find blood or ECG markers that can predict sudden cardiac death. The goal is to identify those at highest risk so they can get life-saving treatments like defibrillators. Participants have mild to moderate heart…

This study looks at 50 people with partially blocked heart arteries to see if a new measurement method (NTG-Pd/Pa) works better than the standard saline method for diagnosing blockages. Participants will have both tests along with the usual FFR test. The goal is to find which met…

This study compares two drug-coated stents (SYNERGY and BioMatrix NeoFlex) used to open blocked heart arteries. Researchers will use a special camera to look at how the artery heals around the stent at one and three months after placement. The goal is to see which stent leads to …

This study aimed to see if notifying patients and their primary care doctors about calcium buildup in heart arteries (found on a prior chest CT) would increase the number of people prescribed statins. It was designed for adults aged 18-84 without known heart disease and not alrea…

This study looks at whether combining stress echocardiogram results with routine health information (like blood pressure and diabetes) can better predict major heart problems, such as heart attacks or strokes, in adults with chest pain. Researchers will use artificial intelligenc…

This study follows over 1,000 people with suspected coronary artery disease to see if special blood flow measurements in the heart's tiny vessels can predict future heart attacks, need for repeat procedures, or hospital stays. Participants undergo standard heart catheterization w…

This study looks back at medical records from about 1,000 people who had special tests to check blood flow in their heart arteries. The goal is to see if these test results can help predict future heart attacks or the need for more procedures. Researchers hope this information wi…

This study follows 1,500 people with coronary artery disease for 10 years to see which treatment—bypass surgery or stenting—leads to better survival and quality of life. Participants were already treated and are now being monitored long-term. The goal is to understand which appro…

This study looks at data from 100,000 people around the world to make heart disease risk prediction tools more accurate, especially for Asian populations. Current tools were mostly developed using Western data, but Asians may have different risk factors. The goal is to improve ho…

This study aimed to see if using wearable devices and game-like features could encourage hospital patients with heart conditions to walk more. It was designed for adults aged 50 and older admitted to medicine or cardiology floors. However, the study was withdrawn before any parti…

This study looks at people who go to the hospital with chest pain but are told they did not have a heart attack. Even so, some may have hidden heart disease that raises their risk of a future heart attack. Researchers want to see if a special heart scan (CTCA) can find this hidde…

This study looks at whether the bacteria living in your gut (the microbiome) can help predict your risk of heart disease. Researchers will collect blood and stool samples from 700 adults who are already having a heart catheterization. They will analyze the blood for signs of infl…

This study tests a new imaging method called OCT-NIRAF to see if it can predict how plaque builds up in heart arteries. About 40 adults with heart disease will get this special scan during a standard heart procedure, then a CT scan a year later. The goal is to learn if the new sc…

This study follows 400 people already enrolled in the larger SCOT-HEART 2 trial to see how being in the trial influences their diet, exercise, smoking, and weight. Researchers will measure these habits at the start and again after 6 months. For those who get a CT scan of their he…

This study is looking at whether a special blood test that measures different types of cholesterol and fats can help predict if a heart stent will narrow again after it is placed. Researchers will study 3,600 adults who have had a stent placed in their heart arteries. The goal is…

This long-term study followed over 6,400 adults from different racial and ethnic backgrounds to learn how early signs of heart disease develop and lead to serious events like heart attacks or strokes. Participants were healthy at the start and were monitored for years through exa…

This study looks at how a special heart scan (coronary CT angiography) can help predict future heart problems in people with coronary artery disease. Researchers will follow about 300 adults for at least a year to see which types of fatty plaques are most dangerous and whether st…

This study looks at whether the Talk Test—a method where patients exercise just enough to still speak comfortably—can safely replace standard lab tests for prescribing exercise in home-based cardiac rehab. Forty adults who recently had heart surgery or a stent procedure will be m…

This study follows over 5,000 people with stable heart disease for up to 10 years to compare two treatment approaches: an early invasive strategy (procedures like stents or bypass) plus medications, versus medications alone. Researchers want to see if one strategy leads to fewer …

This study tests a new hybrid catheter that takes two types of pictures (sound and light) inside heart arteries at the same time. Researchers want to see if it is safer and more accurate at finding dangerous fatty plaques than the standard single-picture method. The study was pla…

This study follows 2,314 South Asian adults (ages 40-84) in the US to uncover why they have high rates of heart disease and stroke, even without typical risk factors. Researchers measure artery calcium, diabetes, and other markers over time. The goal is to identify unique causes …

This study looks at whether people with possible angina can get a full risk assessment within one working day. About 500 adults will fill out a health questionnaire at home, have an ECG, and get a blood test. The goal is to see if this fast approach is possible and can help sort …

This study watches 2,000 people with coronary artery disease who received the Xience Sierra stent during routine care. Researchers track deaths, heart attacks, and repeat procedures to see how safe and effective the stent is compared to other stents. The goal is to learn how the …

This study planned to help adults with heart disease who also face social challenges (like trouble finding food or housing) avoid going back to the hospital. It would have used a screening tool to identify these patients and connect them with community resources. However, the stu…

This study tests whether giving doctors a special risk score—one that combines a person's genes with things like cholesterol and age—helps them make better decisions to prevent heart disease. About 1,000 people at moderate risk for heart disease but who have never had a heart att…

This study collects data from 20,000 people with coronary artery disease to see if an AI tool (HeartFlow AI-QCPA) helps doctors make better treatment decisions compared to standard CT scans alone. Participants are stable adults who have had a heart CT or stress test. The study do…

This study looks at three different techniques (lithotripsy, super-high pressure balloon, and orbital atherectomy) used to break up hardened calcium deposits in heart arteries before placing stents. The goal is to see how these methods affect the tiny blood vessels that feed the …

This study looks at whether getting an angiogram (a special X-ray of the heart arteries) 6 months after a stent procedure in the left main coronary artery can lower the risk of death, heart attack, or stroke over the next 3 years. About 400 adults aged 18-85 who received a specif…

This study tests whether using a CT scan before and during a heart stent procedure works as well as using an ultrasound probe inside the artery. About 1,090 adults with narrowed heart arteries will be randomly assigned to one of the two imaging methods. The main goal is to see if…

This study follows 500 people who had heart bypass surgery and were part of an earlier trial comparing different blood thinner treatments. Researchers want to see if taking two blood thinners (ticagrelor plus aspirin) for one year after surgery reduces the risk of heart attacks, …

This study follows 500 adults who had a heart stent and were doing well one month later. Researchers want to see if blood tests and special X-rays taken at that one-month mark can predict heart attacks, strokes, or other serious events over the next three years. Participants get …

This study uses a special MRI technique called T1 mapping to measure changes in heart muscle tissue. Researchers will follow 8,000 adults who are already having a heart MRI to see if these measurements can help predict future health problems like heart failure or death. The goal …