CORONARY ARTERY DISEASE

This study compares two different drug-coated balloon catheters used to open small, narrowed heart arteries in Japanese patients with coronary artery disease. The research aims to see if one device is safer or more effective at keeping the artery open and preventing future heart …

This study is testing a new type of balloon catheter coated with two medications. Doctors will use it to open blocked heart arteries in patients experiencing chest pain or minor heart attacks. The goal is to see if this device is safe and works to keep arteries open longer after …

This study is observing how well a new type of heart stent works in everyday medical practice. The stent, called GENOSS DES, is coated with a medicine and a polymer that dissolves over time. Researchers are tracking 1,000 patients with blocked heart arteries to see if the stent s…

This study is testing if a medication called inclisiran, when added to standard cholesterol-lowering statin therapy, can slow or reduce the buildup of fatty plaque in the heart's arteries. It involves about 610 adults with early-stage coronary artery disease who have not yet had …

This study is testing whether performing a routine angiogram (a type of X-ray of the heart's arteries) 6 months after a stent is placed in the left main coronary artery can help reduce the risk of death, heart attack, or stroke over the next 3 years. It will involve 400 patients …

This study is testing which of two imaging methods is better for guiding the placement of stents (tiny mesh tubes) in complex blockages where a heart artery splits. Researchers want to see if using a more detailed ultrasound method inside the artery leads to fewer future heart pr…

This study follows 5,391 people with stable heart disease for up to 10 years to see which initial treatment approach helps people live longer. Participants were originally assigned to either receive heart procedures plus medications or medications alone. Researchers are now track…

This study compares two types of balloon angioplasty procedures for treating complex blockages where heart arteries split. Researchers want to see if using a drug-coated balloon works better than a standard balloon at preventing future heart attacks, cardiac deaths, or the need f…

This study aims to find a safer way to manage blood-thinning medication for people who have had a heart attack. Researchers are testing if using a simple blood test one month after treatment can identify patients who might be over-thinned and could safely switch to a milder drug.…

This study compares how well two different drug-coated stents heal inside heart arteries. Researchers are looking at 160 patients who need a stent for coronary artery disease, angina, or heart attack. They will use special imaging to check how the artery wall heals around the ste…

This study aims to see if a new type of heart stent (VIVO ISAR) heals faster inside arteries than a commonly used stent (XIENCE Skypoint). Researchers will compare how well each stent is covered by the body's own tissue one month after placement in 40 patients with coronary arter…

This study is testing whether a new type of drug-coated balloon works as well as the current standard treatment—a drug-coated metal stent—for opening up narrowed heart arteries. It will involve 1,820 patients with coronary artery disease to see if the balloon is just as effective…

This study is observing how well a new type of heart stent works for people with long blockages in their coronary arteries. The stent is designed to release medication without using a polymer coating. Researchers will follow 300 patients to check if the stent is safe and effectiv…

This large international study compares two common treatments for clogged heart arteries. Over 3,300 patients with coronary artery disease will receive either a drug-coated balloon (which delivers medication and is often removed) or a permanent drug-eluting stent. The main goal i…

This study follows 1,500 patients for 10 years to compare two common treatments for blocked heart arteries: modern stent placement guided by blood flow measurements versus traditional bypass surgery. Researchers want to see if the less invasive stent procedure provides similar lo…

This study is testing whether a more intensive combination of common heart medications (statins, blood pressure pills, and aspirin) can better protect women who have chest pain and signs of heart stress, but whose main heart arteries are not severely blocked. It compares this str…

This study compares two powerful combinations of cholesterol-lowering drugs for people who have had a heart stent placed. Researchers want to see which combination helps more patients keep their 'bad' cholesterol very low and which one causes fewer side effects, so patients are m…

This study tests whether a comprehensive program of lifestyle changes, medication, and special heart scans (PET imaging) works better than standard medical care alone for people with or at high risk for heart disease. Over 1,000 participants were randomly assigned to one of the t…

This study aims to find out if people with stable heart disease can safely stop taking beta-blocker pills, which are a common older medication. About 60 participants will be randomly assigned to either continue or stop their beta-blockers and followed for four years. Researchers …

This study compared two approaches for placing stents in blocked heart arteries that have important side branches. Researchers tested whether placing stents in both the main artery and side branch immediately was better than placing one stent first and only adding a second if nee…

This study aims to find the safest order for two common heart procedures. It compares performing a procedure to open blocked heart arteries either before or after a minimally invasive valve replacement in patients who need both. The goal is to see which timing leads to fewer comp…

This study compares two imaging methods for planning stent placement in clogged heart arteries. It tests whether using a CT scan before the procedure works as well as using ultrasound during the procedure to guide the stent placement. Researchers will follow 1090 patients for up …

This study is testing if a small injection of nitroglycerin into the wrist can make it easier for doctors to access the radial artery for heart procedures like angiograms. The goal is to reduce the number of needle sticks, lower the chance of artery spasms, and prevent the need t…

This study is testing the safety of a new type of lab-grown blood vessel for heart bypass surgery. The research involves 20 patients with severe coronary artery disease who need multiple bypasses. Doctors will implant one engineered vessel alongside traditional grafts to see if i…

This early study is testing a new device that freezes dangerous, non-blocking plaque in heart arteries to try to stabilize it and prevent it from rupturing and causing a major heart attack. It involves up to 30 patients who recently had a heart attack or unstable chest pain and h…

This study follows 102 patients who received large-sized heart stents to treat blocked coronary arteries. Researchers are observing how well these stents perform in everyday medical practice, tracking whether patients experience heart-related complications. The goal is to confirm…

This study aims to see how well the Xience Sierra stent works and how safe it is for patients in real-world, everyday medical practice. It will follow 2,000 adults who have received this specific stent to treat blocked heart arteries. The main goal is to compare its performance t…

This small pilot study is testing if a special exercise program combining high-intensity interval training with Nordic walking (using poles) is a good alternative for people with coronary artery disease. The goal is to see if this whole-body workout is feasible and can improve ph…

This study is observing a specific medical procedure used to treat women with hardened, narrowed heart arteries. It aims to gather real-world information on how safe and effective the procedure is for this group. About 400 women who are already scheduled to get this standard trea…

This study is testing a new type of heart stent—a tiny mesh tube—that is made of iron and designed to dissolve over time. It is coated with a medication to help keep a blocked artery open after it's placed. The goal is to see if this new stent is safe and effective for treating p…

This study is a registry that tracks how well a specific drug-coated heart stent (ihtDEStiny) works in everyday medical practice. It will follow 400 patients with blocked heart arteries who receive this stent to see how they fare over time. The main goal is to monitor safety and …

This study compares two similar drug-coated stents used to prop open blocked heart arteries. It will enroll 550 patients in China who need this procedure to see if the newer Resolute Onyx stent performs as well as the established Resolute Integrity stent. Researchers will track p…

This study is testing a new type of heart stent that is made of iron and designed to dissolve in the body over time. It is being compared to a standard, permanent metal stent in 518 patients with coronary artery disease. The main goal is to see if the new dissolving stent is as s…

This study is testing whether using a temporary heart pump during high-risk stent procedures helps prevent serious complications like heart failure or death. It involves 300 patients with severe coronary artery disease and weakened heart muscle who face higher risks during these …

This study is testing whether customizing treatment based on specific blood protein levels can help people with coronary artery disease. Researchers are comparing personalized medication adjustments and lifestyle changes against standard care to see which approach better lowers r…

This study is testing if a simple 'talk test' is a safe and effective way to guide exercise for people recovering from heart surgery or stents at home. Researchers are comparing this easy method—where you exercise at a pace that still allows comfortable conversation—to the standa…

This early study is testing a new type of drug-coated stent called IoNIR to see if it is safe and effective at keeping heart arteries open after a procedure to clear blockages. It will involve about 30 patients with coronary artery disease who need a stent. Researchers will track…

This study compares two procedures for opening clogged heart arteries in patients who are at high risk of serious bleeding. It tests whether a drug-coated balloon, which leaves no permanent implant, works as well as the standard drug-coated metal stent. The goal is to see if the …

This study is comparing two different types of biodegradable heart stents (SUPRAFLEX Cruz vs. SYNERGY) in patients with severe blockages in all three major heart arteries. About 1,550 participants will have the stents placed and be followed for at least a year to see which stent …

This study is testing if using a small heart pump device during a high-risk artery-opening procedure is better than the standard approach for patients with weak heart function. It aims to see if the pump helps reduce serious heart problems like heart attacks, strokes, or death ov…

This is a very early safety study to see if a new, lab-made blood vessel graft is safe and works for heart bypass surgery. It will be tested in 5 patients with severe coronary artery disease who need multiple bypasses. The main goal is to check if the graft stays open and if pati…

This study aims to see how three different methods for treating severely hardened heart arteries affect tiny blood vessel flow. It will enroll 30 patients with coronary artery disease who need a stent. Researchers will compare lithotripsy (shockwaves), super-high pressure balloon…

This study compares two types of dissolving stents (Absorb and Desolve) used to treat blockages where heart arteries branch. It aims to see which stent is safer and allows the artery to heal better. Researchers will follow 120 patients for up to 10 years, using special imaging sc…

This study is comparing the safety and effectiveness of Onyx brand heart stents against other drug-coated stents in real-world medical practice. It will follow 4,500 adults with blocked heart arteries who receive an Onyx stent. Researchers will track complications like blood clot…

This study is testing whether a medication called nicorandil can help prevent serious heart problems in people who have both severe heart disease and kidney failure requiring dialysis. It will involve about 268 patients to see if taking the drug lowers their risk of heart attacks…

This study is testing a laser-based device designed to break up hard calcium deposits inside clogged heart arteries. The goal is to see if using this tool before placing a stent makes the procedure safer and more successful for patients. The study will enroll about 420 adults wit…

This study aimed to test whether using heart scans to guide treatment could reduce heart attacks and deaths in veterans with severe leg artery disease who recently had leg surgery. It planned to compare heart scans plus medication against medication alone. The trial was withdrawn…

This study is testing a laser tool for patients with severely hardened or blocked heart arteries that cannot be opened with standard balloon procedures. It will observe 230 patients who receive this laser treatment to see how well it works and how safe it is. The main goal is to …

This study is observing patients who have had a heart stent procedure to see if using a genetic test to choose their blood thinner medication leads to better outcomes. Researchers are tracking about 1,600 patients for a year to see if this personalized approach helps prevent futu…

This study is testing the safety and effectiveness of a specific drug-coated heart stent (the Medtronic Resolute Onyx) in Chinese patients with blocked coronary arteries. About 591 participants who are eligible for a standard artery-opening procedure (angioplasty) will receive th…

This study is testing whether new risk assessment tools can help doctors decide which patients with new chest pain actually need advanced heart scans. Researchers want to see if using these tools can safely reduce unnecessary testing while maintaining good outcomes and quality of…

This study aims to see if a special heart scan can find hidden heart disease in people who went to the hospital with chest pain but were sent home after tests ruled out a heart attack. Researchers will use a CT scan to look for problems in patients who have low levels of a heart …

This study aims to compare two simpler methods for measuring blood flow in narrowed heart arteries against the current gold standard test. Researchers want to see if using a simple saline solution works as well as a medication (nitroglycerin) to predict when a blockage is severe …

This study is testing a new AI tool designed to help doctors choose the right diagnostic test for patients with suspected heart artery disease. For low-risk patients, the AI may recommend a safer, non-invasive CT scan instead of a more invasive procedure. The goal is to reduce pa…

This study is testing whether a new, faster process can assess a person's risk for serious heart problems after they report new chest pain. About 500 people referred by their doctor for possible angina will use digital questionnaires and simple home tests. The goal is to see if a…

This study aimed to test a new imaging catheter that takes two types of pictures inside heart arteries at the same time. The goal was to see if these combined images could help doctors better identify dangerous plaque and guide treatment during a procedure. The trial was withdraw…

This study aims to prevent a common and serious complication called delirium, or sudden severe confusion, in older adults after major heart surgery. Researchers are testing if giving regular, scheduled doses of intravenous acetaminophen (the medicine in Tylenol) after surgery can…

This study is testing a web-based program designed to help people who have just had a heart attack prevent another one. 864 participants are randomly assigned to either use this special program or receive their usual care. The program includes tracking health data, educational le…

This study aimed to test a new support program for adults hospitalized with heart disease. The program would automatically screen patients for social needs like food or housing insecurity and connect them electronically to local community resources. The goal was to see if address…

This study is testing a culturally-appropriate education program designed to help Native American men reduce their consumption of sugary drinks like soda and juice. The program involves group classes and text message support over six months. The goal is to see if this approach ca…

This study tested whether training family members to help care for patients before and after heart bypass surgery improves recovery. In the trial, 54 patients were randomly assigned to receive either this family support training or standard hospital care alone. The results showed…

This study is testing whether a comprehensive lifestyle program can reduce chest pain and improve quality of life for people with coronary microvascular dysfunction—a condition where the heart's smallest blood vessels don't work properly, causing pain despite clear arteries. Abou…

This study aimed to see if adding game-like challenges to a patient's daily step goals could help them be more active while in the hospital. It planned to use wearable devices and text messages with older adults who had heart or metabolic conditions. The goal was to see if more w…

This study aims to find simple, inexpensive markers—like those from blood tests or heart tracings (ECGs)—that can specifically predict which heart disease patients are at highest risk for sudden cardiac death. It is following over 5,700 people with a history of heart attack or mi…

This study aims to improve how doctors predict a person's risk of coronary artery disease (heart disease). Researchers will analyze existing medical data from 100,000 people across different global populations to see if current risk calculation tools work equally well for everyon…

This study is testing whether a new genetic risk score helps doctors and patients manage heart disease risk better. It will follow 1,000 adults without known heart disease for 5 years to see if getting this score changes how doctors prescribe medications or order tests, and if it…

This study is testing whether a new imaging technique called OCT-NIRAF can help doctors better understand plaque buildup in heart arteries. Researchers will use this special imaging during heart procedures on 40 participants with heart disease, then check for plaque changes one y…

This study aims to understand if test results taken one month after a heart stent procedure can predict who might have future heart problems. Researchers will follow 500 adults with heart disease for up to 3 years, using blood tests and artificial intelligence analysis of heart s…

This study looked back at medical records of 117 patients who had coronary artery bypass surgery. Researchers wanted to see if a simple score based on two common blood tests (albumin and lymphocyte count) could predict who might develop serious complications after surgery. The go…

This study is testing whether a special type of heart scan, called T1 mapping, can accurately detect heart disease and predict patient outcomes like survival and hospitalization. It will enroll 8,000 adults who are already scheduled for a heart scan for medical reasons. The goal …

This study is collecting information from about 1,000 patients who had a heart artery test in Verona, Italy, between 2010 and 2024. Researchers will track these patients for up to 10 years to see if the results from a special artery measurement taken during their initial test can…

This study aims to see if an artificial intelligence (AI) model can better predict serious heart problems in people with chest pain. It will analyze past stress echocardiogram results and patient health records from about 3,000 people to see if the AI, using both the scan and cli…

This study is a large registry tracking 1,003 adults with suspected heart disease. Its main goal is to understand how problems with the heart's smallest blood vessels affect a patient's long-term health after doctors decide on a treatment plan. It also aims to see if using specia…

This is a long-term observational study that aims to understand how heart and blood vessel diseases develop in people before they show symptoms. It follows over 6,400 healthy men and women from four different ethnic backgrounds, aged 45-84, using regular scans and tests over many…

This Mayo Clinic study aims to find out if the types of bacteria living in a person's gut are linked to their risk of heart disease. Researchers will collect blood and stool samples from 700 adults who are already scheduled for a heart catheterization test. By comparing the gut b…

This study is looking at whether a special heart imaging scan (coronary CT angiography) can help doctors better predict which patients with coronary artery disease are at highest risk for future heart problems. Researchers will follow 300 patients who have already had this scan a…

This large registry study aims to understand how a new AI tool that analyzes plaque in heart scans changes the medical management of patients with coronary artery disease. It will follow 20,000 clinically stable patients for up to 5 years, collecting data on their treatments, tes…

This study aimed to see if telling patients and their primary care doctors about previously unnoticed calcium buildup in heart arteries (found on old chest CT scans) would lead more people to start taking cholesterol-lowering statin medication. It focused on adults without known …

This study aims to find out why people of South Asian descent have higher rates of heart disease and stroke, even when typical risk factors are accounted for. Researchers are following over 2,300 South Asian adults in the US for several years to identify new causes. The goal is t…

This study aims to understand how receiving information about heart disease risk influences people's lifestyle habits. It follows 400 participants already enrolled in a larger heart attack prevention trial. Researchers will track changes in diet, smoking, and activity over 6 mont…