New imaging tool could make heart bypass safer during valve surgery

NCT ID NCT03977129

Ongoing Knowledge-focused Sponsor: Ruijin Hospital Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study compares two methods for deciding which blocked heart arteries need bypass during valve surgery. The standard method uses angiography (X-ray dye), while the new method uses a computer calculation called QFR. About 792 patients will be randomly assigned to one method, and researchers will track major complications like death, heart attack, or stroke within 30 days after surgery. The goal is to see if QFR leads to fewer problems by more accurately identifying which blockages truly need treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Quantitative Flow Ratio (QFR) imaging software
What this could lead to: If successful, this could show that using QFR to decide which blocked arteries need bypass during valve surgery reduces complications like heart attack or stroke within 30 days.
What could go wrong: This is a mid-stage study with 792 patients, but it only looks at short-term outcomes (30 days). The results may not apply to all patients or long-term benefits, and the new method might not be better than standard care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for CORONARY ARTERY DISEASE are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

coronary artery disorder heart valve disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PLANNED TO UNDERGO ELECTIVE ON-PUMP VALVE SURGERY DUE TO PRIMARY MITRAL AND/OR AORTIC VALVULAR HEART DISEASE PRIMARY VALVULAR HEART DISEASE WITH COMORBID CORONARY ARTERY DISEASE

Contacts and locations

Locations

Changhai Hospital of Shanghai

Shanghai, Shanghai Municipality, China
Fujian Medical University Union Hospital

Fuzhou, Fujian, China
Fuwai Central China Cardiovascular Hospital

Zhengzhou, Henan, China
Qilu Hospital of Shandong University

Jinan, Shandong, China
Ruijin Hospital Shanghai Jiao Tong University School of Medicine

Shanghai, Shanghai Municipality, 200025, China
Shanghai Chest Hospital

Shanghai, Shanghai Municipality, China
The Affiliated Hospital of Qingdao University

Qingdao, Shandong, China
The First Affiliated Hospital Zhejiang University School of Medicine

Hangzhou, Zhejiang, China
The First Affiliated Hospital of Anhui Medical University

Hefei, Anhui, China
The First Affiliated Hospital of Zhengzhou University

Zhengzhou, Henan, China
The Second XiangYa Hospital of Central South University

Changsha, Hunan, China
Tianjin Chest Hospital

Tianjin, Tianjin Municipality, China

More trials for these conditions

Other studies related to the condition(s) this trial covers.