Ruijin Hospital

This early-stage study is testing the safety and initial effectiveness of a new treatment called RXIM002 for adults with severe autoimmune diseases that have returned or not improved with standard therapies. RXIM002 is an experimental RNA-based therapy designed to modify a patien…

This study is testing a two-part treatment for locally advanced pancreatic cancer that has worsened after standard first-line chemotherapy. It combines a procedure that freezes and destroys tumor cells (cryoablation) with an immunotherapy drug designed to help the immune system a…

This study is testing whether using PET scan results and a blood test for Epstein-Barr virus (EBV) to guide treatment decisions can improve outcomes for people with a rare type of nasal lymphoma. After initial chemotherapy, patients will receive different treatment combinations b…

This study is testing a two-part treatment for locally advanced pancreatic cancer that has worsened after standard chemotherapy. It combines a procedure that uses electrical pulses to destroy tumor cells (IRE) with an immunotherapy drug designed to help the immune system fight ca…

This study is testing if a low-dose colchicine pill, taken daily for a year, can help prevent the new blood vessel grafts from failing after coronary artery bypass graft (CABG) surgery. It will involve 100 adults who recently had successful bypass surgery. Researchers will use he…

This study is testing a freezing treatment called cryoablation for early lung cancer spots found on scans. It's for patients who cannot have or choose not to have standard surgery. Researchers will follow 90 patients for up to 5 years to see if the freezing treatment safely contr…

This study is testing a two-part treatment for patients with B-cell lymphoma that has come back or hasn't responded to standard treatments. First, patients receive a high-dose chemotherapy and their own stem cell transplant. Then, three days later, they receive an infusion of spe…

This early-phase study is testing a personalized mRNA vaccine designed to target a patient's specific cancer, combined with an immunotherapy drug (PD-1 inhibitor). It is for people who have had surgery for pancreatic cancer but cannot tolerate standard chemotherapy. The main goal…

This study is testing a two-drug combination (sintilimab and a bevacizumab biosimilar) given after surgery to see if it can prevent liver cancer from coming back. It focuses on a dangerous situation where the liver tumor has ruptured, which greatly increases the risk of the cance…

This study is testing a new combination of three targeted drugs (orelabrutinib, lisaftoclax, and rituximab) for people newly diagnosed with a high-risk form of mantle cell lymphoma, an aggressive blood cancer. The goal is to see if this combination can effectively control the dis…

This study is comparing two different chemotherapy combinations given after surgery for stage III stomach cancer. It aims to see if one treatment is as good as or better than the other at keeping the cancer from coming back. About 387 patients who have had their tumor surgically …

This early-stage study is testing a new treatment called PDR-001, delivered by injection directly into the brain. The goal is to clear a harmful protein believed to drive Parkinson's disease progression, rather than just treating symptoms. Researchers will enroll 12 people with e…

This study is testing a minimally invasive procedure to replace a leaky heart valve (aortic regurgitation) in patients aged 60 and older. It compares a specific new valve system (VitaFlow Liberty) against other approved devices to see which is safer and more effective at preventi…

This study is testing a personalized treatment approach for adults with early-stage NK/T-cell lymphoma, a rare cancer often linked to Epstein-Barr virus. It combines a type of immunotherapy (a PD-1 antibody) with radiation, aiming to improve survival rates while reducing treatmen…

This study is testing a combination of two drugs, orelabrutinib and rituximab, for people newly diagnosed with a type of blood cancer called mantle cell lymphoma (MCL). The main goal is to see how well this treatment can put the cancer into complete remission. Researchers will al…

This study tests whether adding personalized, gene-guided drugs to standard chemotherapy works better than standard therapy alone for people with untreated aggressive lymphoma. Researchers will compare two treatment groups in 152 Chinese patients to see which approach better cont…

This study is testing a combination of four medications for people with advanced stomach cancer that has spread to the lining of the abdomen. The treatment includes three drugs given through the bloodstream and one drug delivered directly into the abdomen. Researchers want to see…

This study is testing a less invasive stent procedure for patients with a dangerous tear in their main heart artery (aortic dissection) who are too high-risk for traditional open surgery. It will follow 149 patients aged 65 and older for one year to see if the stent is safe and e…

This study is testing if a non-invasive brain stimulation technique, called rTMS, can improve arm and hand movement when it's timed with physical exercises. Researchers are comparing this 'online' stimulation to standard 'offline' stimulation and a sham (fake) treatment in 60 str…

This study is testing a combination of targeted drugs and chemotherapy for lymphoma that has come back or not responded to treatment in the brain or spinal cord. It aims to see if this new approach is more effective and safe for patients who have few options. The study will enrol…

This study is testing a new combination of drugs (HRS-4642, gemcitabine, albumin-bound paclitaxel, and adebrelimab) for people with pancreatic cancer that doctors believe can be removed with surgery. The goal is to see if giving these drugs both before surgery (to shrink the tumo…

This early-stage study is testing a new mRNA-based therapy called ABO2203 in people with autoimmune diseases that haven't responded well to standard treatments. The main goal is to check if the treatment is safe and tolerable, while also looking for early signs that it might help…

This study is testing a two-step treatment for people with locally advanced colon cancer. First, patients receive standard chemotherapy. Then, they receive the same chemotherapy combined with an immunotherapy drug (Serplulimab) before having surgery. Researchers want to see if th…

This study is testing a new combination of treatments for people with locally advanced rectal cancer. The goal is to see if adding an immunotherapy drug to a standard mix of radiation, chemotherapy, and a targeted drug can better shrink tumors before surgery. Researchers will com…

This study is testing a new type of combined PET/MR scan to see if it can better identify which carotid artery plaques are unstable and likely to cause a stroke. It will enroll 100 people who have been diagnosed with carotid plaque. The goal is to see if this scan can provide cle…

This study is testing a new type of PET scan to see if it can better detect lung and kidney damage in people with ANCA-associated vasculitis, a rare autoimmune disease. Researchers will use a special tracer called 68Ga-FAPI during the scan to look for active disease throughout th…

This study is testing a new computer system (AI) designed to help doctors during nose and throat exams. It aims to automatically recognize different areas and flag suspicious spots that might be cancer or other diseases. Researchers will collect images from 500 patients to see if…

This study aims to see if analyzing how a person walks before surgery can help predict how well Deep Brain Stimulation (DBS) will work for their dystonia. Researchers will use wearable sensors to measure walking patterns in 50 patients scheduled for DBS surgery. They will then ch…

This is a first-in-human study to understand how a new inhaled drug, RJ026, moves through the body and how safe it is. It will enroll 84 people, including healthy volunteers and patients with interstitial lung disease (ILD), a condition that causes lung scarring. Researchers will…

This study aims to build a detailed picture of Parkinson's disease and a related condition called Multiple System Atrophy. Researchers will follow 700 patients in Shanghai over time, collecting health data, brain scans, and biological samples. The goal is to find better ways to s…