Could adding chest radiation extend life in advanced lung cancer?
NCT ID NCT05552846
First seen Aug 12, 2026 · Last updated Aug 13, 2026 · Updated 1 time
Summary
This trial is testing whether adding radiation to the chest can help people with extensive-stage small-cell lung cancer, a type of lung cancer that has spread widely. Participants first receive standard chemotherapy plus an immunotherapy drug, and if their cancer does not worsen, they then receive chest radiation alongside continued immunotherapy maintenance. The study aims to see if this combination can delay cancer progression and improve overall survival, while also monitoring side effects.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- thoracic radiotherapy (radiation to the chest)
- What this could lead to
- If it works, adding chest radiation could help control extensive-stage small-cell lung cancer longer, potentially improving survival when combined with standard chemo-immunotherapy and maintenance treatment.
- What could go wrong
- This is a single-arm, early-phase trial without a comparison group, so results may not be definitive. Radiation to the chest can cause side effects like fatigue, lung irritation, or difficulty swallowing.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Ruijin Hospital, Shanghai jiaotong univestigy school of medicine
RECRUITINGShanghai, Shanghai Municipality, 200025, China
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