Can donor immune cells boost lung cancer remission?
NCT ID NCT07759856
First seen Aug 12, 2026 · Last updated Aug 13, 2026 · Updated 1 time
Summary
This trial is for people with extensive-stage small cell lung cancer who have completed initial chemotherapy plus immunotherapy and have stable or improved disease. Participants are randomly assigned to receive either standard immunotherapy alone or immunotherapy combined with infusions of natural killer (NK) cells from healthy donors. The goal is to see if adding NK cells can help keep the cancer from growing longer and improve overall survival.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Allogeneic natural killer (NK) cells from healthy donors, given as intravenous infusions alongside standard immunotherapy (immune checkpoint inhibitors).
- What this could lead to
- If adding donor NK cells to standard immunotherapy works, it could extend the time before extensive-stage small cell lung cancer progresses, potentially improving survival.
- What could go wrong
- This is an early-phase exploratory trial with a small number of participants, so results may not be conclusive. NK cell infusions can cause side effects, and the added benefit over immunotherapy alone is uncertain.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Tianjin First Central Hospital
RECRUITINGTianjin, Tianjin Municipality, 300192, China
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