Can a gene test spare breast cancer patients from extra radiation?
NCT ID NCT04517266
First seen Aug 11, 2026 · Last updated Aug 12, 2026 · Updated 1 time
Summary
This trial is testing whether a genomic test can identify early-stage breast cancer patients who might safely skip radiation to the internal mammary lymph nodes. Participants have 1-3 positive lymph nodes and are considered at intermediate risk. Half will receive standard radiation to the chest and supraclavicular area, while the other half will also receive internal mammary irradiation. The goal is to see if skipping this extra radiation does not increase the risk of cancer returning within two years.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Radiation therapy (internal mammary irradiation vs. omission)
- What this could lead to
- If successful, this could personalize breast cancer treatment, sparing some women from unnecessary radiation and its side effects.
- What could go wrong
- The trial is relatively small and early, and the long-term benefits of skipping this radiation are uncertain. There is a risk of increased cancer recurrence.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Ruijin Hospital, Shanghai jiaotong univestigy school of medicine
RECRUITINGShanghai, Shanghai Municipality, 200025, China
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