BREAST CANCER

This study tests a personalized treatment plan for people with HER2+ breast cancer that has spread. Doctors use a special blood test (ctDNA) and scans to decide when to increase or decrease therapy, along with treatments to prevent spread to the brain. The goal is to see if this …

This study tests a personalized vaccine made from a patient's own tumor leftovers after chemotherapy and surgery. The vaccine uses dendritic cells to train the immune system to attack remaining cancer cells. The goal is to see if this approach is safe and can boost the body's def…

This early-phase trial tests an investigational vaccine designed to help the immune system recognize and attack HER2-positive breast cancer cells. About 36 adults with advanced HER2-positive breast cancer will receive the vaccine. The main goals are to check safety and measure th…

This study tests a drug called axelopran in people with advanced breast, lung, pancreas, or prostate cancer who are taking opioids for pain. The goal is to see if axelopran can slow tumor growth, improve bowel function, and reduce inflammation. About 34 adults will take the drug …

This study tests a new drug called YL202 combined with other anti-tumor treatments in people with advanced solid tumors, including breast and lung cancer. The goal is to see if the combination is safe and can shrink tumors. About 414 adults aged 18-75 who have already tried stand…

This early-phase study tests a new drug, OKI-219, designed to block a specific cancer-driving mutation (PI3KαH1047R) found in some advanced solid tumors and breast cancers. About 200 adults whose cancer has this mutation will receive OKI-219 alone or combined with other anti-canc…

This study tests a new drug, TER-2013, in people with advanced solid tumors that have certain genetic changes (AKT/PI3K/PTEN pathway). The goal is to see if the drug is safe and can shrink or control the cancer. About 205 participants with cancers like breast, endometrial, ovaria…

This early-stage study tests an experimental oral drug called BBI-940 in adults with advanced or metastatic breast cancer. The drug works by breaking down a protein that helps cancer cells grow. It is given alone or with another drug (fulvestrant). The main goals are to check saf…

This study tests a new way to choose pre-surgery treatment for postmenopausal women with stage II or III ER-positive, HER2-negative breast cancer. By using biomarkers, doctors hope to improve response and identify patients who may not need chemotherapy. The trial enrolls 81 parti…

This early-phase study tests a new drug called BL-B16D1 in people with advanced breast cancer or other solid tumors that have not responded to standard treatments. The main goals are to check the drug's safety, find the best dose, and see if it helps shrink tumors. About 21 adult…

This study looks at two ways to treat breast cancer that has spread to underarm lymph nodes after chemotherapy. One method is surgery to remove the nodes, and the other is radiation therapy. The goal is to see if radiation works just as well as surgery but causes less arm swellin…

This study tests whether a new drug called tinengotinib, given with or without fulvestrant, can shrink tumors in people with a certain type of advanced breast cancer (HR+/HER2-). About 94 participants will receive the treatment to find the best dose and see if the combination wor…

This study tests whether adding a low-dose chemotherapy pill (capecitabine) to a standard two-drug regimen (dalpiciclib plus hormone therapy) can help people with a common type of advanced breast cancer that has spread to organs like the liver or lungs. About 258 adults with HR+/…

This study tests a new hormone therapy pill (elacestrant) given alone or with a drug that temporarily stops ovarian function in premenopausal women with early-stage, hormone-sensitive breast cancer. The goal is to see if the pill alone can slow tumor growth as effectively as the …

This study looks at whether giving antibody-drug conjugates (ADCs) a second time is safe and effective for people with advanced breast cancer that has spread. About 160 adults who have already received ADCs will be enrolled. The goal is to see if the tumors shrink or stop growing…

This study compares a new targeted therapy (dalpiciclib plus an aromatase inhibitor) against standard chemotherapy for postmenopausal women with a specific type of early breast cancer (ER-positive, HER2-negative, low growth rate). The goal is to see if the new combo works just as…

This study tests a drug called talazoparib in people with metastatic breast cancer that has a BRCA1 or BRCA2 mutation. The goal is to see if the drug can stop or slow cancer growth. About 30 participants will take the pill and be monitored for tumor response and side effects.

This study is testing a drug called Disitamab vedotin (RC48-ADC) in 45 people with breast cancer. The goal is to see how long the drug can keep the cancer from growing and to check for side effects. Participants must have already used or be currently using this drug as part of th…

This study tests a new robotic technique for nipple-sparing mastectomy in people with breast cancer or high risk. It aims to see if the single-port robot is as safe and effective as standard surgery, while possibly improving nipple sensation and satisfaction. About 90 participant…

This study tests a new drug called HRS-6209 combined with other treatments for breast cancer. About 80 women aged 18-75 whose cancer has worsened after prior therapy will receive the combination. The goal is to find safe doses and see if the drugs can shrink tumors or slow diseas…

This study tests whether combining two drugs, trastuzumab deruxtecan and durvalumab, can eliminate or shrink a rare and aggressive type of breast cancer called inflammatory breast cancer before surgery. The trial enrolls 63 adults with stage III HER2-positive or HER2-low breast c…

This study tests a new daily pill, INX-315, in 150 people with advanced breast, ovarian, or other solid tumors that have stopped responding to standard treatments. The goal is to see if the drug is safe and can shrink or slow tumor growth. Participants will receive the drug alone…

This study is for women with early-stage breast cancer. It tests a single, focused dose of radiation using a special machine called GammaPod before the standard lumpectomy surgery. The goal is to find a safe and effective radiation dose that kills the tumor while reducing side ef…

This study tests a drug called elacestrant combined with other medicines in people with a common type of advanced breast cancer (ER+/HER2-). The goal is to find safe doses and see if the combinations can shrink tumors or slow the disease. About 435 adults will take part across mu…

This study is for people with operable, lymph node-positive triple negative breast cancer. It tests whether giving a low or high dose of radiation to the breast tumor along with immunotherapy (pembrolizumab) before standard chemotherapy can improve the chance of eliminating all c…

This study tests whether giving chemotherapy more frequently (dose-dense) works better for women with a specific type of breast cancer (HR+/HER2-) that is growing quickly. About 64 women with high-risk, early-stage breast cancer will receive this treatment before surgery. The goa…

This study tests a new way to treat early-stage ER+ breast cancer using a single, strong dose of radiation before surgery. It also explores using a special ultrasound to check lymph nodes without surgery. The goal is to see if this approach can destroy the tumor and reduce the ne…

This study tests whether a negative pressure wound therapy (a special vacuum dressing) can reduce complications like infection, wound opening, or slow healing after complex breast cancer surgery with immediate reconstruction. About 254 women at higher risk for scarring problems (…

This study tests whether customizing follow-up treatments—like radiation, surgery, or stronger drugs—based on how well the tumor shrinks after initial therapy can help people with advanced breast cancer live longer without the disease getting worse. About 157 women with cancer th…

This study tests two different drug combinations for people with early-stage HER2-positive breast cancer after their tumor has been removed. One group gets trastuzumab emtansine (T-DM1) followed by trastuzumab injections; the other gets paclitaxel plus trastuzumab. The goal is to…

This early-phase study tests a new drug called BL-M07D1 in people with advanced breast cancer or other solid tumors that have a specific marker (HER2). The main goals are to check the drug's safety, find the best dose, and see if it helps shrink tumors. About 26 adults who have n…

This early study tests if a mild electrical pulse to a nerve in the ear can help protect the heart in people receiving chemotherapy for breast cancer or lymphoma. Researchers will check heart function and inflammation markers in 104 adults who recently started chemo. The goal is …

This program gives people with certain solid tumors or blood cancers access to an experimental drug called AVM0703. It is for patients in the US whose doctor requests it. So far, 37 patients have received the drug, and side effects have been mostly mild, like itching during infus…

This study is for people with breast cancer who cannot undergo surgery due to health reasons or choose not to for cosmetic concerns. It uses a special device that first freezes and then heats the tumor to destroy it. The goal is to see how well this minimally invasive treatment c…

This early-phase study tests a new drug called XMT-1660 in people with advanced solid tumors, including triple-negative breast, ovarian, and endometrial cancers. The main goals are to find the safest dose and check for side effects. About 319 participants will receive the drug to…

This study tests whether combining the drug inavolisib with other treatments can safely shrink tumors in people with a specific genetic form of early breast cancer (PIK3CA-mutated, ER-positive, HER2-negative). About 60 participants will receive the drug combination before surgery…

This study is for women aged 51 or older who have a low-risk breast cancer recurrence or a new cancer in the same breast. Instead of removing the whole breast, doctors will give a short, focused course of radiation before surgery to shrink the tumor and then remove only the affec…

This study is for people with HR+ HER2- stage II or III breast cancer. It tests how well adding ribociclib to standard hormone therapy prevents the cancer from coming back. About 2,766 participants in Russia will be followed for up to 5 years. The goal is to see if the combinatio…

This study tests whether a shorter course of radiation before mastectomy and breast reconstruction works as well as the standard longer course. About 126 adults with invasive breast cancer will be randomly assigned to one of the two radiation schedules. The goal is to see if the …

This study compares a single, high-dose radiation treatment to the standard five-session approach for women with early-stage breast cancer. It aims to see if the one-time treatment is just as effective at preventing the cancer from coming back. Participants must be 40 or older wi…

This study is for people whose breast cancer has returned after previous breast-conserving surgery and whole-breast radiation. The standard treatment after repeat surgery is radiation twice a day for 30 sessions. This trial tests whether giving radiation once a day for 15 session…

This study tests a 5-session radiation treatment for early-stage breast cancer, including an extra boost to the tumor site during the same sessions. It aims to see if this shorter course is as safe and effective as longer treatments, with fewer side effects and less hassle. About…

This phase 3 study tests a new drug, PF-07248144, combined with fulvestrant for people with HR-positive, HER2-negative advanced or metastatic breast cancer that worsened after prior CDK4/6 inhibitor therapy. About 400 participants will be randomly assigned to receive either the n…

This study is testing an experimental drug called MGC026 in about 250 adults with advanced solid tumors that have not responded to other treatments. The main goals are to check the drug's safety and find the right dose. Participants receive the drug by IV and are closely monitore…

This early-phase study tests a new drug called AVA6000, a chemotherapy that is designed to activate only inside tumors, potentially reducing side effects. It is for people with advanced solid tumors (like breast, ovarian, or salivary gland cancer) that have not responded to stand…

This study tests whether taking three drugs (neratinib, an aromatase inhibitor, and trastuzumab) for 24 weeks before surgery can eliminate all signs of cancer in the breast for people with ER-positive, HER2-positive breast cancer. About 30 postmenopausal women will participate. A…

This early study tests a new way to treat small breast cancers using short electric pulses (IRE) instead of heat or cold. The goal is to see if it can safely destroy the tumor, which would then be removed by surgery to check. 24 women with early-stage breast cancer will take part…

This study tests a new drug called JSKN003 against standard chemotherapy in about 400 people with HER2-low breast cancer that has spread or come back. Participants are randomly assigned to receive either JSKN003 or a standard chemo drug chosen by their doctor. The main goal is to…

This study tests whether two pills—abemaciclib and hydroxychloroquine—can find and destroy leftover breast cancer cells hiding in the bone marrow. About 66 people with early-stage breast cancer who are at high risk of recurrence will take these drugs for six months. The goal is t…

This study tests whether tirzepatide, a weight-loss drug, can help clear tiny amounts of cancer DNA from the blood of overweight or obese patients with a high-risk type of early breast cancer. About 48 participants will receive tirzepatide along with standard hormone therapy. The…

This study tests a combination of two drugs, abemaciclib and bicalutamide, for people with a specific type of advanced breast cancer that has spread (metastatic). The cancer must test positive for androgen receptors and negative for HER2. The goal is to find the best dose and see…

This study tests a combination of two drugs, ribociclib and anastrozole, in people with a common type of advanced breast cancer (hormone receptor-positive, HER2-negative) that has spread or come back. The goal is to see if the combination works better and is safe. About 86 adults…

This study compares freezing breast tumors (cryoablation) to standard surgery (lumpectomy) in 120 women with low-risk, early-stage breast cancer. The goal is to see if freezing offers similar disease control with fewer complications and better quality of life. Participants must h…

This study tests a drug called Dato-DXd in people with a common type of advanced breast cancer (HR-positive, HER2-negative) that has stopped responding to hormone therapy. The goal is to see if the drug can slow cancer growth and to check its safety. About 100 adults whose cancer…

This early-phase study tests a radioactive drug called Lutetium-177 BL-ARC001 in people with advanced lung, breast, head and neck, or other solid tumors that have not responded to standard treatments. The main goals are to find a safe dose and check for side effects. About 22 par…

This study tests whether the drug sacituzumab govitecan (SG) can still shrink tumors in people with a certain type of advanced breast cancer (HR+/HER2 low) who have already received a similar drug called T-DXd. About 75 adults will receive SG at its standard dose. The goal is to …

This study tests a dose-escalation approach to help people with early-stage HR+HER2- breast cancer stay on the full FDA-approved dose of abemaciclib (150mg twice daily) for longer. About 50 participants will receive the drug alongside standard hormone therapy. The goal is to see …

This study is for Nigerian women with a specific type of breast cancer called HER2-positive. Doctors want to see if giving a combination of targeted drugs before and after surgery can destroy the cancer completely. About 74 women will receive the treatment, and researchers will c…

This study tests whether adding the drug inavolisib to a standard two-drug combination (ribociclib and fulvestrant) can shrink tumors or slow disease progression in people with a specific type of advanced breast cancer (HR+/HER2- with chromosome 8p loss). About 80 participants wh…

This study tests a new minimally invasive treatment that freezes and then heats breast tumors, comparing it to standard breast-conserving surgery. About 264 women aged 50 or older with early-stage, hormone-positive breast cancer will take part. The goal is to see if the new appro…

This early-phase study tests a new drug called BL-M17D1 in people with advanced breast cancer (HER2-positive or negative) or other solid tumors that have spread. The main goals are to check safety, find the best dose, and see if the drug can shrink tumors. About 20 adults aged 18…

This study tests whether combining three drugs (disitamab vedotin, pertuzumab, and toripalimab) before surgery can completely eliminate HER2-positive breast cancer in 40 adults with early-stage tumors larger than 2 cm. Participants receive the drug combination for several weeks, …

This study tests a personalized gene therapy for people with metastatic cancers that haven't responded to standard treatments. Doctors take a patient's own white blood cells, genetically engineer them in a lab to recognize and attack unique mutations in their tumor, and then infu…

This study looks at women with a low-risk type of breast cancer that has spread to nearby lymph nodes. It compares standard care, which includes radiation to the lymph nodes and chest wall, against skipping that extra radiation. The goal is to see if avoiding this treatment still…

This study tests whether adding the drugs entinostat and anlotinib to the standard hormone therapy fulvestrant can shrink tumors or slow cancer growth in people with a common type of advanced breast cancer (HR+/HER2-). About 118 adults whose cancer worsened after initial hormone …

This study tests a personalized cancer vaccine made from patients' own tumor cells grown in a lab. The cells are modified to trigger a stronger immune response, then killed and injected back into the patient. The goal is to help the immune system fight metastatic cancers like mel…

This study tests a drug called disitamab vedotin in people with advanced breast cancer that has spread and is hard to treat. Participants must have tumors with a protein called HER2 and have tried other treatments before. The drug is given as an IV every two weeks to see if it ca…

This study tests whether adding doxycycline, a cheap and safe antibiotic, to standard chemotherapy can better target cancer stem cells in early-stage ER+/HER2- breast cancer. About 50 participants will receive doxycycline alongside chemo before surgery. The goal is to see if this…

This early-stage study is testing whether giving radiation therapy along with two drugs (abemaciclib and letrozole) before surgery is safe for people with a common type of early breast cancer (HR+/HER2-). The study involves 15 participants and aims to see how well the body handle…

This study tests whether dapagliflozin, a drug used for diabetes, can prevent heart damage caused by the chemotherapy drug doxorubicin in breast cancer patients. About 46 adults with early-stage breast cancer will receive either dapagliflozin or a placebo during their chemotherap…

This study tests a new drug called MBRC-201 in people with advanced solid tumors (like prostate, breast, lung, colorectal, or pancreatic cancer) that have not responded to standard treatments. The goal is to find a safe dose and see if the drug can shrink tumors or slow their gro…

This study tests a technique called cryoablation, which uses liquid nitrogen to freeze and destroy small breast tumors in postmenopausal women with early-stage, hormone-sensitive breast cancer. The goal is to see if freezing the tumor is as effective as surgery, with fewer side e…

This study is testing whether women with certain aggressive breast cancers (triple negative or HER2-positive) can safely avoid breast surgery if their tumors completely disappear after a combination of chemotherapy and radiation before surgery. About 200 women will be enrolled to…

This early-phase trial tests an experimental drug called ALTA2618 in adults with advanced solid tumors (like breast or endometrial cancer) that have a specific AKT1 E17K gene mutation. The main goals are to check safety, find the right dose, and see if the drug can shrink tumors.…

This study tests a new drug called ETX-19477 in people with advanced solid tumors (like breast, ovarian, or prostate cancer) that have stopped responding to standard treatments. The drug works by blocking a protein (PARG) that cancer cells need to repair themselves. The main goal…

This study is testing the safety of a drug called trastuzumab deruxtecan in 100 Indian adults with advanced HER2-positive breast cancer that cannot be removed by surgery or has spread. Participants have already tried another anti-HER2 treatment. The main goal is to track side eff…

This early-phase study tests a new experimental drug (SYN818) combined with the approved cancer drug olaparib in adults with advanced solid tumors, including ovarian and breast cancers linked to BRCA gene changes. The main goals are to find the safest dose and check for side effe…

This early-phase study tests a new drug called OCT-598 in people with advanced solid tumors (breast, lung, prostate, head/neck, or stomach cancer). The main goals are to find a safe dose and check for side effects when given alone or with standard treatments. About 51 adults will…

This study tests a new drug, KESONOTIDE™, in people with advanced solid tumors like prostate, breast, lung, ovarian, pancreatic, skin cancer, or glioblastoma. The main goal is to check if the drug is safe and to find the right dose. About 80 adults will take part in two phases, s…

This study tests a new drug (PF-07220060) plus letrozole against standard treatments for people with HR-positive, HER2-negative advanced or metastatic breast cancer who haven't had prior therapy for advanced disease. About 1,020 adults will be randomly assigned to either the new …

This early-phase trial tests whether combining two drugs, neratinib and ruxolitinib, can safely shrink tumors in people with metastatic triple-negative breast cancer that has returned to the chest wall after chemotherapy. About 20 women whose cancer has spread and who have alread…

This study tests whether women who had breast cancer come back after a lumpectomy and radiation can safely have another breast-conserving treatment instead of a mastectomy. About 120 women with small, isolated recurrences will receive targeted radiation to the tumor area or the w…

This study tests a new way to rebuild breasts after cancer or for Poland syndrome. It uses a special expander to stretch the skin, then adds fat from the patient's own body, and finally places a permanent implant. The goal is to see if this method is safe and gives good results. …

This study tests a breast reconstruction method that combines fat grafting with a muscle flap from the back. It is for women who have had a mastectomy and want delayed reconstruction. The main goal is to see if this approach reduces wound infections or healing problems.

This study tests two different doses of the drug inavolisib combined with fulvestrant in people with a specific type of advanced breast cancer (PIK3CA-mutated, HR-positive, HER2-negative). The goal is to see if a lower dose works just as well with fewer side effects. About 80 adu…

This study looks at whether a genetic test called RecurIndex can identify breast cancer patients with a low risk of recurrence who can safely skip additional radiation to the lymph nodes after surgery. About 540 participants with node-positive breast cancer will be randomly assig…

This study tests whether proton radiation, a precise type of radiation, can control early-stage breast cancer while causing fewer side effects than standard radiation. About 132 women aged 50 and older with early breast cancer will receive proton therapy only to the tumor area. R…

This early-phase study tests a combination of two drugs, alpelisib and pembrolizumab, in people with metastatic breast cancer or melanoma that has spread. The main goal is to find a safe dose and check for side effects. About 50 adults whose cancer has not responded to standard t…

This study tests whether combining two drugs, sacituzumab govitecan and atezolizumab, can clear leftover cancer cells in the breast or lymph nodes after standard chemotherapy. It includes 40 people with triple negative breast cancer who still have signs of cancer or tumor DNA in …

This study looks at how well a drug called Trop-2 ADC (sacituzumab govitecan) works for breast cancer patients whose cancer has spread to the brain. Researchers will track tumor shrinkage and side effects in 100 participants receiving the drug as part of their normal care. The go…

This early-phase study tests a new drug called BL-M07D1 in 280 adults with advanced solid tumors that have the HER2 protein. The goal is to see if the drug is safe, tolerable, and can shrink tumors. Participants must have tried at least two prior standard treatments.

This study tests whether combining two drugs, Sac-TMT and KL-A167, given before surgery can eliminate or shrink triple-negative breast cancer tumors. About 40 adults with early-stage, non-metastatic disease will receive the combination and then have surgery. The main goal is to s…

This study tests a new drug called NBQ72S in 10 people with breast cancer that has spread to the lining of the brain or spinal cord. The goal is to see if the drug can control the disease and help people live longer. Participants receive the drug every 28 days until it stops work…

This study tests a new drug (GDC-4198) alone or with another drug (giredestrant) for people with advanced ER+/HER2- breast cancer that has worsened after prior treatment. About 285 participants will be enrolled to see if the new combination is safer or works better than an existi…

This early-phase study tests a new drug called LNCB74 in people with advanced solid tumors (ovarian, breast, endometrial, bile duct, or lung cancer) that have not responded to standard treatments. LNCB74 is an antibody-drug conjugate designed to deliver a cancer-killing agent dir…

This study tests whether a combination of three drugs (anastrozole, fulvestrant, and abemaciclib) can shrink or control tumors in people with advanced hormone receptor-positive, HER2-negative breast cancer. About 20 participants will receive the treatment, and researchers will me…

This study tests whether women with breast cancer who have no signs of cancer in their armpit lymph nodes after chemotherapy can safely skip armpit surgery. Half the participants will have standard sentinel node surgery; the other half will have no armpit surgery at all. Research…

This early-stage study tests a new drug called GNC-077 in people with advanced breast cancer or other solid tumors that have spread. The main goals are to check the drug's safety, find the right dose, and see if it can shrink tumors. About 20 participants will receive the drug in…

This study tests a new approach for people with breast cancer that has spread to the brain. It combines focused radiation with two drugs: olaparib (which targets DNA repair) and durvalumab (an immunotherapy). The goal is to see if this combination is safe and can control the brai…

This study tests a new experimental drug, ACE-86225106, in adults with advanced solid tumors (like ovarian, breast, or prostate cancer) that have not responded to standard treatments. The goal is to see if the drug is safe and can shrink tumors. About 298 participants will receiv…

This study tests whether adding the experimental drug evexomostat (SDX-7320) to standard chemotherapy (eribulin) works better than chemotherapy alone for people with metastatic triple-negative breast cancer who also have metabolic dysfunction (like insulin resistance). About 55 a…

This study tests a new type of radiation therapy that adjusts the radiation beam in real time to match the patient's body changes. It involves 40 women who have had breast cancer surgery and need radiation. The goal is to see if this approach delivers the dose more accurately and…

This study is for women whose breast cancer has returned after previous radiation treatment. Instead of a mastectomy, they will have surgery to remove just the tumor followed by a 1-week course of targeted radiation. The goal is to see if this shorter treatment is safe and effect…

This study tests a personalized, lighter chemotherapy approach for women with early-stage triple-negative breast cancer. The treatment plan is adjusted based on immune system activity in the tumor and how the tumor shrinks on scans. The goal is to see if many patients can achieve…

This study aims to personalize breast radiotherapy by matching treatment intensity to each patient's risk of cancer returning and risk of side effects. Researchers will enroll 854 women with invasive breast cancer who have had surgery and need radiation. The goal is to reduce lon…

This study tests a new drug called BG-75202, alone or with other treatments, in people with advanced breast cancer or other solid tumors that have stopped responding to standard therapies. The main goals are to check the drug's safety, find the best dose, and see if it can shrink…

This study tests a new drug combination (BMS-986507) in about 416 adults with advanced solid tumors, specifically lung and breast cancers. The goal is to find safe doses and see if the treatment can shrink tumors. Participants must have measurable tumors and be in fairly good hea…

This study tests whether adding ribociclib to standard hormone therapy can lower the chance of breast cancer coming back in people with a high-risk type (HR+/HER2-) who still had cancer after initial chemo. About 446 participants will be randomly assigned to get either the drug c…

This early-phase trial tests an investigational drug called SYS6043 in adults with advanced or metastatic solid tumors that have spread or no longer respond to standard treatments. The main goals are to find a safe dose, understand side effects, and see if the drug can slow tumor…

This study tests a new drug called OP-1250 (palazestrant) against the usual treatments (fulvestrant or an aromatase inhibitor) in people with a common type of advanced breast cancer (ER+, HER2-). The goal is to see if OP-1250 can delay cancer growth better than current options. A…

This study looks at whether a handheld robotic tool called HandX can help surgeons perform a nipple-sparing mastectomy through a single small side incision, reducing scarring and improving recovery. About 15 women who already need a mastectomy for early breast cancer or genetic r…

This study is for people with breast cancer that has spread to only a few spots in the body (oligometastasis). It tests whether adding focused treatments like radiation or surgery to the cancer spots, on top of standard drug therapy, can help people live longer. About 340 partici…

This early-phase study tests a new treatment called CAR-T cells, which are immune cells engineered to target a protein called CEA found on certain cancer cells. The study includes up to 48 adults with advanced non-small cell lung cancer or breast cancer that has not responded to …

This study is for premenopausal women with a common type of breast cancer (HR+/HER2-). It tests a drug called elacestrant, given alone or with another drug (triptorelin) to block ovarian hormones, for 4 weeks before surgery. The goal is to see if the treatment slows tumor growth,…

This study tests a new treatment for people with cancers that have a specific marker called CD70, including pancreatic, kidney, breast, melanoma, and ovarian cancers. Researchers take a person's white blood cells, modify them in the lab to recognize and attack CD70, and then give…

This study tests whether adding a drug called entinostat to a standard two-drug combination (dalpiciclib and letrozole) works better at shrinking tumors before surgery in people with a common type of early breast cancer (HR-positive, HER2-negative). About 60 women will be randoml…

This study tests whether a new drug, datopotamab deruxtecan (Dato-DXd), given alone or with another drug (durvalumab), works better than standard chemotherapy for people with a certain type of advanced triple-negative breast cancer that has PD-L1 protein. About 625 participants w…

This early-stage study tests a new cancer treatment called FT836, a ready-made immune cell therapy, in people with advanced solid tumors like lung, colorectal, breast, ovarian, endometrial, or head and neck cancers. The treatment is given alone or with chemotherapy and/or antibod…

This study tests whether a blood test that finds tumor DNA can help doctors decide when to give extra treatment to people with a high-risk type of breast cancer (ER+/HER2-). About 70 participants who are on standard hormone therapy but still at high risk will be monitored. If the…

This study tests whether adding pembrolizumab to sacituzumab govitecan helps control advanced triple-negative breast cancer that has spread and is PD-L1-negative. About 110 adults will be randomly assigned to receive the combination or sacituzumab alone. The goal is to see if the…

This study tests whether adding the drug QL1706 to standard chemotherapy before surgery can eliminate more cancer cells in women with early HR+/HER2- breast cancer. About 238 participants will receive either the combination or chemo alone for 6 cycles, then undergo surgery. After…

This early-stage trial tests a new treatment called ES2B-C001, given alone or with an adjuvant, in 40 adults with HER2-positive metastatic breast cancer that has not responded to at least two prior therapies. The goal is to see if it is safe and can boost the immune system to fig…

This study tests whether a more aggressive approach to managing high blood pressure during breast cancer treatment is safer and more effective than standard care. Researchers want to see if it lowers blood pressure and reduces the risk of heart damage from chemotherapy. The trial…

This study tests a drug called trastuzumab deruxtecan (T-DXd) in people with advanced breast cancer that has low levels of a protein called HER2 or no HER2 at all. The goal is to see how long the drug can control the cancer before another treatment is needed. About 250 adults wit…

This study is testing a newer, less invasive surgery for breast cancer that uses a tiny camera (endoscope) to remove the breast and rebuild it right away. The goal is to see if this approach is as safe and effective as standard surgery. About 800 women with early to locally advan…

This study tests the drug atezolizumab in about 200 adults with different incurable solid tumors. Researchers use each person's tumor DNA and RNA to see if they might respond. The goal is to learn whether genetic markers can predict who benefits from this immunotherapy.

This study tests a new drug, STX-478, designed to attack cancer cells with a specific genetic change (PI3Kα mutation). It is for adults with advanced solid tumors, including breast cancer, that have not responded to other treatments. The study will test the drug alone or combined…

This study tests whether adding the antifungal drug posaconazole to standard immunotherapy and chemotherapy can help more women with triple-negative breast cancer achieve a complete response before surgery. About 72 women with early-stage, high-risk breast cancer will participate…

This study is for people with advanced breast cancer (T3 or T4) who have responded well to chemotherapy. Usually, after mastectomy, patients wait for radiation and then have delayed reconstruction. Here, doctors give radiation before surgery, so reconstruction can happen immediat…

This study is observing how well the drug trastuzumab deruxtecan works in real-world settings for Chinese patients with advanced breast cancer that is HER2-positive or HER2-low. About 800 adults whose cancer has spread or cannot be removed will be followed to see how long the tre…

This study looks at whether testing a blood sample for DNA changes (biomarkers) can help doctors pick the best treatment for people with a certain type of advanced breast cancer that has stopped responding to standard pills. About 484 participants will provide a blood or tumor sa…

This study tests a new drug called PC14586 (rezatapopt) in people with advanced or spreading solid tumors that have a specific TP53 Y220C mutation. The trial has two parts: first, finding the safest dose, and then seeing how well the drug works alone or with another drug (pembrol…

This study tests if dapagliflozin, a drug used for diabetes, can prevent heart damage caused by anthracycline chemotherapy in breast cancer patients. About 40 adults with breast cancer will take dapagliflozin or a placebo alongside their chemo. Researchers will measure heart func…

This study tests a new drug called AZD8205, alone or with other cancer treatments, for people with advanced solid tumors like breast, ovarian, or lung cancer that have spread. About 460 adults whose cancer has not responded to standard care will take part. The main goal is to che…

This study tests two different drug combinations given before surgery for HER2-positive breast cancer. About 100 adults with early-stage disease will receive either TCHP or THP to see which leads to a higher rate of complete tumor disappearance. The goal is to improve treatment a…

This study observes how a pertuzumab biosimilar is used in routine care for HER2-positive breast cancer, both before surgery (neoadjuvant) and for first-line metastatic disease. It will track 1,000 patients to see which treatment regimens are used, how long patients stay on thera…

This study tests an experimental drug called patritumab deruxtecan in people with advanced solid tumors that have spread or cannot be removed by surgery. The drug targets a protein called HER3 found on many cancer cells. About 740 adults with one of 12 cancer types (including lun…

This study is for people with breast cancer who have had surgery and are at higher risk of the cancer returning. It tests whether shorter courses of radiation to the lymph nodes are as safe and effective as standard longer courses. About 768 participants will be randomly assigned…

This study compares a newer drug, trastuzumab deruxtecan (T-DXd), to standard treatment for people with HER2-positive breast cancer that hasn't spread. About 370 participants will get either T-DXd or standard care before surgery, and then further treatment will be based on the tu…

This study looks at whether it is safe to give radiation therapy again to the breast after a second lumpectomy in women who have already had radiation before. The goal is to see what side effects occur and how well it controls cancer. The study includes 114 women with a specific …

This study is for people with stage 2 or 3 breast cancer. It tests whether giving a special type of radiation (SBRT) and an immunotherapy drug (pembrolizumab) directly into the tumor before standard chemotherapy can help shrink the cancer more effectively. The goal is to see if t…

This early-stage trial tests a new treatment for people with advanced melanoma and other solid tumors that have spread. Doctors take a patient's own immune cells, modify them in a lab to better recognize and attack cancer, and give them back after a short course of chemotherapy. …

This study looks at whether giving immunotherapy less often (extended dose intervals) works as well as the usual schedule for people with advanced triple-negative breast cancer. The goal is to keep the treatment effective while reducing side effects, improving quality of life, an…

This study looks at whether adding radiation therapy to standard medications can help shrink or slow the growth of advanced breast cancer in people who cannot or choose not to have surgery. About 30 adults with invasive breast cancer will receive radiation alongside their usual d…

This early-stage study tests a new treatment called NT-175 for people with advanced solid tumors (like lung, colon, or breast cancer) that have a specific genetic mutation (TP53 R175H) and a certain immune marker (HLA-A*02:01). NT-175 uses a patient's own immune cells, which are …

This early-phase study tests a new drug called BL-B01D1 in people with advanced lung cancer and other solid tumors that have spread or cannot be removed. The main goals are to check the drug's safety, find the best dose, and see if it helps shrink tumors. About 470 adults with se…

This study tests whether adding capivasertib to standard hormone therapy helps people with HR+/HER2- advanced breast cancer stay on treatment longer and maintain quality of life. About 250 adults whose cancer worsened after prior hormone therapy will take capivasertib plus standa…

This study tests a new treatment called TIL therapy for people with advanced breast cancer who have run out of standard options. Doctors take immune cells from a patient's own tumor, grow them in a lab, and put them back into the body to attack the cancer. The goal is to see if i…

This study tests whether artificial intelligence can help choose and dose the right combination of cancer drugs for each person. About 10 adults with solid tumors (like breast or gastrointestinal cancer) will have their tumor cells tested in a lab to find the best drug mix. Then,…

This early-phase study tests a new drug called AGX101 in people with advanced solid tumors that have not responded to standard treatments. The drug is given through an IV and aims to attack cancer cells. The main goals are to find the safest dose and understand side effects. Abou…

This study compares a new oral drug, D-0502, to a standard injected drug (fulvestrant) in 640 people with a common type of advanced breast cancer (ER-positive, HER2-negative). Participants must have already tried hormone therapy. The main goal is to see if D-0502 can delay cancer…

This study tests whether adding the drug zanidatamab to standard chemotherapy can completely eliminate cancer in the breast and armpit before surgery in people with early-stage HER2-positive breast cancer. About 125 adults with stage II or III disease will receive the combination…

This study tests a new drug that delivers radiation directly to cancer cells with a specific marker (GRPR). It is for adults with advanced cancers like prostate, breast, lung, or colon cancer that have come back or spread. The main goal is to find a safe dose and check for side e…

This study tests two drugs, tucatinib and Doxil, together in people with HER2+ breast cancer that has spread. The goal is to see if the combination shrinks tumors and to track any side effects. About 36 adults with advanced disease will take part.

This study is testing a new 3D-printed biodegradable mesh used during breast reconstruction after mastectomy for breast cancer. The mesh is designed to support the implant and help tissue heal, then safely dissolve over time. Researchers are enrolling 25 women to see if the mesh …

This study tests whether a new drug called HRS-8080 works better than standard hormone therapy for people with high-risk early breast cancer. Participants must have already received at least 2 years of standard hormone therapy after surgery. The goal is to see if HRS-8080 can hel…

This early-phase study tests a new drug combination for people with a specific type of advanced breast cancer (ER+/HER2-) that has stopped responding to standard hormone therapy. The treatment adds a radioactive molecule ([177Lu]Lu-NeoB) to two existing hormone-blocking drugs (ri…

This study tests whether adding the immunotherapy drug pembrolizumab, with or without the targeted drug olaparib, to standard radiation therapy is safe and works better than radiation alone for people with metastatic breast cancer. About 34 adults with triple-negative or hormone-…

This early-phase study tests an experimental oral drug, RGT-490, in adults with advanced solid tumors (including breast, ovarian, and endometrial cancers) that have a specific genetic change called PIK3CA. The main goals are to check the drug's safety, find the right dose, and se…

This study tests whether adding the experimental drug JS105 to two standard therapies (dalpiciclib and fulvestrant) helps people with a certain genetic mutation (PIK3CA) and advanced, hormone-receptor-positive, HER2-negative breast cancer live longer without their cancer growing.…

This study tests two experimental drugs, SI-B003 alone or combined with BL-B01D1, in people with advanced HER2-negative breast cancer that has stopped responding to standard treatments. The goal is to see if these drugs can shrink tumors or slow the disease. About 58 adults aged …

This early-stage trial tests a new treatment called IDOV-Immune, a virus designed to infect and destroy cancer cells while also boosting the immune system. It is for adults with advanced solid tumors (like colorectal, lung, or breast cancer) that have not responded to standard tr…

This study tests whether a new treatment called Bria-IMT, given with an immunotherapy drug, helps people with advanced metastatic breast cancer live longer compared to standard chemotherapy. It is for patients whose cancer has not responded to available treatments. About 404 adul…

This study is for women with early-stage breast cancer who had chemotherapy before surgery. If the chemotherapy completely destroyed the tumor, doctors want to see if it's safe to skip radiation after lumpectomy. The goal is to reduce side effects while keeping the cancer from co…

This study tests whether a web application can help breast cancer patients better follow their hormone therapy and improve quality of life. About 438 adults starting hormone therapy after breast cancer treatment will either use the app or receive standard care. The main goal is t…

This study looks at whether adding CDK4/6 inhibitors after surgery can help prevent breast cancer from returning in people with hormone receptor-positive, HER2-negative breast cancer. About 229 adults will receive these drugs as part of their standard follow-up care. The main goa…

This early-phase study tests a new drug called BL-B01D1 in people with advanced breast cancer or other solid tumors that have not responded to standard treatments. The main goals are to find the safest dose and see if the drug can shrink tumors. About 36 adults aged 18 to 75 will…

This study tests whether a new drug combo (RLY-2608 plus fulvestrant) works better than another combo (capivasertib plus fulvestrant) for people with advanced breast cancer that has a specific genetic mutation (PIK3CA). About 540 adults whose cancer worsened after prior treatment…

This early-stage study tests a new drug called KIVU-107 in people with advanced solid tumors that have not responded to standard treatments. The drug is designed to deliver a toxin directly to cancer cells. The main goals are to find a safe dose and check for side effects. About …

This study tests a drug called patritumab deruxtecan in people with HER2-positive breast cancer that has spread or cannot be removed by surgery. The main goals are to check safety and see if the drug shrinks tumors. About 81 adults will take part in this early-phase trial.

This study tests whether the drug ribociclib can safely replace chemotherapy for women with a common type of early breast cancer (HR+ HER2-) that has an intermediate risk of coming back. About 3,900 participants will receive either standard chemotherapy followed by hormone therap…

This study tests a new treatment using donor immune cells (CAR-NK cells) designed to attack cancer. The specific target on the cancer cells is chosen by analyzing a tumor sample or a blood test. The study includes adults aged 18-75 with advanced solid tumors that have not respond…

This study tests whether a drug called leucogen can prevent severe neutropenia (dangerously low white blood cell counts) in women with early-stage hormone receptor-positive, HER2-negative breast cancer who are taking ribociclib and hormone therapy. About 94 participants will rece…

This study tests a new device that uses focused ultrasound waves guided by MRI to partially destroy breast tumors. About 34 women with breast cancer will have half of one tumor treated with this method, then undergo standard surgery. The goal is to see if the procedure is safe an…

This study is for people with a high-risk type of breast cancer (triple-negative) who still have cancer cells left after standard chemotherapy and surgery. Researchers will use a sensitive blood test (ctDNA) to look for tiny traces of cancer that scans might miss. If the blood te…

This study tests whether adding targeted radiation and immunotherapy to standard hormone therapy can turn a woman's own breast tumor into a personalized vaccine. It involves 100 post-menopausal women with HR+ HER2- breast cancer who have not yet had surgery. The goal is to see if…

This study looks at people with advanced HER2-positive breast cancer whose first treatment stops working. It compares two different targeted therapy combinations to see which works better when switched. About 600 participants will be followed to track how long the cancer stays co…

This study compares high-intensity interval training (HIIT) to moderate-intensity continuous exercise for improving heart health in 158 women who completed chemotherapy for breast cancer. Participants will be assigned to one of two exercise programs to see which better reduces ca…

This study tests a treatment called cryoablation, which uses extreme cold to freeze and destroy small, low-risk breast tumors. It aims to see if freezing the tumor works as well as surgery, while offering a better quality of life with less pain, no general anesthesia, and better …

This study tests a chemotherapy regimen made of three pills (cyclophosphamide, methotrexate, and capecitabine) for people with early-stage breast cancer who have had surgery. The goal is to see if this all-oral approach is as effective and safer than standard IV chemo. About 25 a…

This early-stage study tests a new drug, QXL138AM, for safety in about 100 people with advanced solid tumors (like ovarian, pancreatic, lung, or breast cancer) or multiple myeloma. Participants must have tried other treatments without success. The study will find the right dose a…

This large phase 3 trial is for premenopausal women with early-stage, hormone-sensitive breast cancer that hasn't spread to many lymph nodes. It compares two treatments: hormone therapy alone versus hormone therapy plus chemotherapy. The goal is to see if adding chemo helps preve…

This Phase 3 study tests whether adding the experimental drug gedatolisib to standard hormone therapy and CDK4/6 inhibitors can delay cancer growth in people with advanced HR+/HER2- breast cancer. About 674 adults with locally advanced or metastatic disease will be randomly assig…

This study aims to help Latina women who have a higher chance of getting breast cancer due to genetics or life challenges. Researchers will provide phone-based support to help them get recommended screenings and genetic tests. The goal is to see if this support helps more women g…

This study looks at how well the drug dalpiciclib works and how safe it is for people with advanced hormone receptor-positive (HR+) breast cancer. Researchers will follow 420 patients who are already taking or about to start dalpiciclib as part of their normal care. The goal is t…

This study tests a 12-week video program called WeCan-Rural for breast cancer survivors living in rural areas. The program helps with healthy eating, physical activity, and weight management to lower heart disease risk. Researchers will check if the program is easy to follow and …

This study looks at whether women with early breast cancer that has spread to lymph nodes can avoid additional lymph node surgery or radiation after chemotherapy, if the cancer in the nodes has disappeared. The goal is to see if skipping this extra treatment is just as effective …

This early-phase study tests a new three-drug combination for people with metastatic triple-negative breast cancer that has spread or come back. The goal is to find the safest and most effective doses of two drugs (cyclophosphamide and axatilimab) when added to a standard dose of…

This study is for people with early-stage breast cancer who still have leftover cancer cells in their bone marrow after standard treatment. Researchers are testing whether adding avelumab or hydroxychloroquine, with or without palbociclib, can clear these hidden cells and lower t…

This study looks at whether using a mobile app helps people with HR+ HER2- stage II or III breast cancer stick to their prescribed ribociclib and aromatase inhibitor therapy for a full year. The app provides reminders and information about side effects and relapse risks. About 24…

This study tests whether adding the drug abemaciclib to standard hormone therapy can help prevent breast cancer from coming back or spreading in people with a specific type of breast cancer (HR-positive, HER2-negative) that has returned in the same area. About 290 participants wi…

This study tests whether proton therapy can safely treat tumors that have come back after previous radiation. Unlike standard X-ray radiation, proton beams target the tumor more precisely, sparing nearby healthy tissue. Researchers will enroll 1,800 adults with various cancers to…

This study tests whether adding a CDK4/6 inhibitor to standard hormone therapy can help prevent breast cancer from returning in women with a high-risk type called HR+/HER2+ early breast cancer. About 1,900 women who have already completed anti-HER2 treatment will be randomly assi…

This study tests whether adding a drug called axatilimab (which targets immune cells) and radiation to standard immunotherapy (pembrolizumab) can completely eliminate triple-negative breast cancer before surgery. About 35 women with high-risk, early-stage disease will receive thi…

This study is for women aged 45 and older with early-stage ER-positive, HER2-negative breast cancer that has spread to lymph nodes found on ultrasound. The goal is to see if doing a targeted lymph node removal (TAD) at the same time as breast surgery helps keep the cancer from co…

This study tests whether giving a precise, high-dose radiation treatment (SBRT) to a single cancer spot that has started growing can help keep the rest of the cancer under control. Participants continue their usual drug therapy while receiving SBRT. The goal is to prevent the can…

This study tests whether injecting a very dilute hydrogen peroxide solution into breast tumors can make standard radiotherapy work better. About 184 adults with advanced or recurrent breast cancer will receive either radiotherapy alone or radiotherapy plus the injections. Early r…

This early-phase study tests an experimental oral drug, RGT-419B, in people with advanced or metastatic HR+/HER2- breast cancer whose disease worsened after standard treatments. The drug is given alone or with hormone therapy. The main goals are to check safety and find the right…

This study tests a new drug, HMBD-501, in people with advanced cancers (melanoma, lung, or breast) that have stopped responding to standard treatments. The goal is to find a safe dose and see if it can shrink tumors. About 180 adults will take part in two phases: first to check s…

This early-stage study tests a new drug, RLY-2608, designed to block a faulty protein in cancer cells with a specific gene change (PIK3CA mutation). It is for adults with advanced solid tumors or certain breast cancers that have not responded to other treatments. The study will t…

This study tests whether adding a probiotic supplement called Biolosion to standard chemotherapy before surgery can help more people with early-stage triple-negative breast cancer achieve a complete remission. About 192 women will be randomly assigned to receive either standard t…

This study is for women and men with a certain type of advanced breast cancer (HR+ HER2-). It tests whether adding targeted radiation to each tumor site, along with standard hormone therapy and a CDK4/6 inhibitor, can delay cancer growth. About 102 participants will be randomly a…

This study tests a combination of two drugs, neratinib and capecitabine, in people with a type of breast cancer that has spread to the brain. The cancer is HER2-negative by standard tests but shows abnormal HER2 activity on a special test. The goal is to see if this treatment can…

This early-stage study tests an experimental drug called VSV-02 in 6 adults with advanced solid tumors (like melanoma, breast, or lung cancer) who have run out of standard options. The drug is given both into a vein and directly into the tumor to see if it can shrink or control t…

This study tests an experimental drug called YL202 in about 200 adults with advanced solid tumors, including lung, breast, and head/neck cancers. The goal is to see if the drug can shrink tumors and control the disease. Participants must have tried other treatments first. This is…

This study tests a new way to care for cancer patients who also have other chronic conditions like diabetes or high blood pressure. It brings together cancer doctors and primary care providers to improve communication and support. The goal is to help patients better manage their …

This study tests a drug called zanidatamab in people with advanced solid tumors that have high levels of HER2 protein. Participants must have already tried at least one other cancer treatment. The goal is to see if the drug can shrink tumors or stop them from growing. This is not…

This study tests whether a special low-calorie diet that mimics fasting can make standard chemotherapy and immunotherapy work better for people with early or locally advanced triple-negative breast cancer. About 80 participants will receive the diet alongside their usual treatmen…

This study is testing whether giving radiation treatment for breast cancer in just 3 sessions over 1.5 days is safe and effective. It includes women aged 45-79 with early-stage breast cancer who have had a lumpectomy. The goal is to see if this shorter treatment causes fewer side…

This early-stage study tests a new treatment for triple-negative breast cancer that has come back or stopped responding to other therapies. The treatment uses a patient's own immune cells, modified in a lab to recognize and attack cancer cells. The main goal is to check the safet…

This study is tracking how well a single dose of radiation given during breast cancer surgery works to keep the cancer from coming back. It includes 500 women aged 45 and older with early-stage breast cancer who are good candidates for partial breast radiation. The goal is to see…

This study looks at whether holding your breath deeply during breast cancer radiation can keep the heart safe from radiation damage. About 400 women with early-stage breast cancer will either use a special breathing device or breathe normally during treatment. The goal is to meas…

This study tests an immunotherapy called GLSI-100 (GP2 + GM-CSF) in 750 people with HER2-positive breast cancer who are at high risk of their cancer returning after standard treatment. Participants receive a series of injections over a year to see if the treatment can help keep c…

This study compares two treatments for advanced estrogen receptor-positive (ER+) breast cancer that has stopped responding to CDK 4/6 inhibitors. About 297 participants will receive either a combination of capecitabine (chemo) and elacestrant (a hormone-blocking drug) or capecita…

This study looks at women with early-stage breast cancer that has spread to 1 or 2 lymph nodes. It compares two types of radiation after surgery: one that treats a larger area of lymph nodes and one that treats only the nearby armpit area. The goal is to see if the smaller radiat…

This study tests a program to help Black women with breast cancer stick to their prescribed treatments, like chemotherapy or hormone therapy. The goal is to see if the program helps them start treatment on time and complete it as planned. About 250 participants will be involved, …

This study looks at combining breast-conserving surgery with a single dose of radiation given during the operation for people with early-stage, HER2-negative breast cancer. The goal is to see if this approach lowers the chance of cancer coming back in the same breast, reduces wou…

This early-phase study tests a new drug called OP-1250 combined with other targeted therapies (ribociclib, alpelisib, everolimus, or atirmociclib) in adults with advanced or metastatic ER-positive, HER2-negative breast cancer. The main goals are to find safe doses and check for s…

This program provides access to the drug alpelisib (BYL719) for patients with serious or life-threatening conditions like PIK3CA-related overgrowth spectrum (PROS) or breast cancer. It is for people who cannot join a clinical trial and have no other satisfactory treatment availab…

This study tests two different drug combinations given before surgery for early or locally advanced HER2-positive breast cancer. About 60 participants will receive either pyrotinib plus trastuzumab and docetaxel or the standard pertuzumab plus trastuzumab and docetaxel. The goal …

This early-phase study tests a new drug called BG-68501 in people with advanced solid tumors (like breast, ovarian, or lung cancer) that haven't responded to standard treatments. The main goals are to find a safe dose and see if the drug can shrink tumors, either alone or combine…

This early-phase study tests a new drug, CLSP-1025, designed to attack cancer cells that have a specific change in the p53 gene (called R175H). The trial enrolls adults with advanced solid tumors (like lung, colon, or pancreatic cancer) that have this mutation and have not respon…

This study tests a new radioactive drug (177Lu-NeoB) combined with chemotherapy (capecitabine) in adults with a specific type of advanced breast cancer (ER+, HER2-) that has spread and stopped responding to hormone therapy. The goal is to find the best dose and see if the combina…

This early-phase trial tests a new drug called IKS014 in people with advanced HER2-positive solid tumors, including breast, stomach, and gastroesophageal cancers. The drug is designed to deliver a cancer-killing agent directly to HER2-positive tumor cells. The main goals are to f…

This study is testing whether giving radiation therapy before surgery is safe and effective for people with early-stage breast cancer. The goal is to find the best dose that causes the fewest side effects, like skin irritation. About 21 women aged 50 and older with a specific typ…

This early-phase study tests a new drug called IDE161, alone or with another drug (pembrolizumab), in people with advanced solid tumors (like breast, ovarian, prostate, or lung cancer). The main goals are to check safety, find the best dose, and see if the drug shrinks tumors. Ab…

This study tests whether adding an antivascular drug to standard chemotherapy helps prevent breast cancer from returning in people with a specific, high-risk type of triple-negative breast cancer. About 764 women with stage II to III cancer will receive either the combination or …

This study tests if a shorter, 3-week course of proton radiation is as safe and effective as the standard 5-week course for women with breast cancer who also need radiation to nearby lymph nodes. About 276 participants will receive either the shorter or longer treatment. The goal…

This program provides ribociclib (Kisqali) to people with serious or life-threatening breast cancer who have no other treatment options and cannot join a clinical trial. A doctor must request the drug on behalf of the patient. The goal is to offer potential benefit when standard …

This study tests whether adding a new drug (patritumab deruxtecan) to standard chemotherapy and immunotherapy before surgery can eliminate more cancer cells in people with high-risk early-stage triple-negative or hormone-receptor-low breast cancer. About 372 participants will be …

This early-phase trial tests whether a drug called bortezomib can make metastatic triple-negative breast cancer more sensitive to two other drugs (pembrolizumab and cisplatin). About 20 women who have already had standard chemotherapy will receive bortezomib first, then the combi…

This study tests a combination of three drugs (tucatinib, eribulin, and trastuzumab) in 30 people with advanced HER2+ breast cancer that has not responded to prior treatments. The goal is to see if the combination is safe and can shrink tumors or slow cancer growth. Participants …

This study aims to see if a generic version of the chemotherapy drug paclitaxel works as well as the standard brand in people with breast cancer. About 24 participants will receive both versions at different times to compare how the drug behaves in the body. The goal is to confir…

This study is for women aged 45 and older with early-stage breast cancer or DCIS who have had a lumpectomy. It tests whether a very short course of radiation (over a few days) is safe and works as well as longer schedules. The goal is to reduce side effects while still controllin…

This study tests a new triple-drug combination (CDK4/6 inhibitors, Fulvestrant, and L-Ornithine L-Aspartate) in 20 women with HR-positive/HER2-negative advanced breast cancer that has worsened after standard treatments. The goal is to see if the combination can shrink tumors or s…

This study tests a device that uses heat to destroy any remaining cancer cells in the tissue around a removed breast tumor. Ten women aged 50 and older with a specific type of breast cancer will receive this treatment right after their lumpectomy. The goal is to see if the device…

This study looks at whether giving hormone therapy before surgery helps women with a certain type of breast cancer (invasive lobular carcinoma) have cleaner surgical results. The goal is to see if this approach lowers the chance of cancer cells being found at the edges of removed…

This study tests whether adding a type of radiation (stereotactic radiosurgery) and an immunotherapy drug (zimberelimab) to a standard chemotherapy (sacituzumab govitecan) is safe and works better than the chemotherapy alone for people with triple negative breast cancer that has …

This study tests two different chemotherapy combinations given before surgery for a type of breast cancer called triple-negative breast cancer. The goal is to shrink tumors enough to make surgery easier and possibly allow breast-conserving surgery. About 520 women will take part,…

This study tests whether giving two different antibody drug conjugates (Dato-DXd and T-DXd) one after the other can shrink tumors in people with HER2-negative metastatic breast cancer whose cancer has already progressed after prior antibody drug conjugate therapy. About 357 parti…

This early-phase trial tests a new treatment called GC203 TIL, which uses a patient's own immune cells that are engineered in a lab to better attack cancer. It is for people with advanced solid tumors (like lung, breast, or gastrointestinal cancers) who have not responded to stan…

This study tests a drug called zanidatamab in 20 people with early-stage HER2-positive breast cancer. The goal is to see if the drug can make the cancer disappear completely before surgery. Participants will receive the drug and then have surgery to check if any cancer remains.

This study tests whether combining two drugs—elacestrant and trastuzumab deruxtecan—can safely shrink tumors in people with a common type of advanced breast cancer (HR+/HER2-low) that has stopped responding to standard hormone therapy. About 65 adults with metastatic disease will…

This early-phase study tests the safety and best dose of a new drug called BL0175 in postmenopausal women with advanced hormone receptor-positive breast, ovarian, or endometrial cancer that has spread or cannot be removed by surgery. About 9 participants will receive multiple dos…

This study tests whether elacestrant, a new hormone therapy pill, works better than standard hormone therapy at preventing breast cancer from returning in people with high-risk, ER+/HER2- early breast cancer that has spread to lymph nodes. About 4,220 women and men who have alrea…

This study is for people with stage II or III breast cancer who will receive chemotherapy before surgery. It compares standard treatment with several experimental drug combinations to see which works better at eliminating all signs of cancer. About 100 participants will be enroll…

This large Phase 3 trial is comparing a new drug combination (palazestrant + ribociclib) against the current standard treatment (letrozole + ribociclib) for people with advanced ER-positive, HER2-negative breast cancer. The study aims to see if the new combination can better cont…

This early-stage study is testing whether adding the drug abemaciclib to standard radiation therapy is safe for people with advanced breast cancer that has spread to the bones. Researchers want to find the highest dose of abemaciclib that can be given safely alongside radiation. …

This early-stage study is testing three different dose levels of an experimental drug called CLR 125 in people with advanced triple-negative breast cancer that has returned or stopped responding to other treatments. The main goals are to find the safest and most effective dose fo…

This study is testing whether an artificial intelligence (AI) model can help doctors choose the next treatment for people with advanced breast cancer. It focuses on patients whose cancer has started growing again after their first round of a specific type of targeted drug. The AI…

This study is testing the safety and effectiveness of a new drug, VS-6766, when combined with two existing breast cancer drugs (abemaciclib and fulvestrant). It is for people with advanced HR+/HER2- breast cancer that has worsened despite prior standard treatments. The goal is to…

This early-stage trial is testing the safety of a new two-part treatment for people with advanced HER2-positive solid tumors, such as breast, lung, or gastric cancer. First, a specially designed virus is injected directly into one tumor to help alert the immune system. A few days…

This study aims to see if a special breast MRI scan before surgery can identify patients with early, low-risk breast cancer who can safely skip radiotherapy after their tumor is removed. It will enroll 1,400 women aged 50 and older who have had surgery. The goal is to confirm if …

This study is testing whether a 12-week Pilates exercise program can help improve bone strength in breast cancer survivors who are taking hormone-blocking medications. These medications can weaken bones, increasing the risk of osteoporosis. Researchers will measure changes in bon…

This is an early-stage study testing a new drug called GDC-0587 for people with advanced breast cancer that has stopped responding to a common type of treatment. The main goals are to find a safe dose and see how the body processes the drug, both alone and when combined with anot…

This study is testing whether adding a new drug called inavolisib to two standard breast cancer medications works better than the standard two-drug combination alone. It involves 450 people with advanced breast cancer that has a specific genetic mutation and responds to hormone t…

This is an early-stage study testing a new drug called MT-4561 in people with various advanced solid tumors who have run out of standard treatment options. The main goals are to find a safe dose, see how the body processes the drug, and check for any early signs that it might hel…

This study tests a new dye called pHLIP ICG that makes breast cancer cells glow during surgery, helping surgeons see and remove all cancer. About 55 adults with early-stage breast cancer will get the dye before surgery. The goal is to see if this method is safe and improves cance…

This study tests a new radioactive dye for PET scans that targets a protein called LRRC15, found on many aggressive tumors. Researchers will scan 26 healthy volunteers and cancer patients (with pancreatic, breast, lung, sarcoma, head and neck, brain, colorectal, or skin cancer) t…

This study compares two imaging methods—MBI and MRI—to see which is better at finding breast cancer in women at high risk. About 300 women will get both scans, and researchers will check how well each test spots tumors. The goal is to find a more comfortable and equally accurate …

This study is testing a new 3D automated breast ultrasound system (ATUSA) to see if it can accurately detect breast cancer. About 800 women with suspicious breast findings (BI-RADS 4 or 5) will get the new scan along with standard imaging and a biopsy. The goal is to create a reg…

This study tests whether contrast-enhanced mammography (CEM) can safely reduce the number of breast biopsies for women with breast findings that are suspicious but not highly suspicious (BI-RADS 4A or 4B). About 2,100 women scheduled for a biopsy will first get a CEM. The goal is…

This study compares a special contrast-enhanced mammogram (CEDM+CEDBT) with standard breast MRI to see if it can accurately predict whether chemotherapy has eliminated all cancer before surgery. About 30 women with locally advanced breast cancer will get 1-2 of these mammograms d…

This study tests whether a newer PET tracer, 68Ga-FAPI-46, can find more cancer spots than the standard tracer in people with ER-positive breast cancer. About 20 women with advanced or recurrent breast cancer will get both types of scans. If the new tracer works better, it could …

This study looks at whether adding a special type of mammogram (contrast-enhanced mammography, or CEM) every two years to the standard yearly 3D mammogram can find breast cancer earlier in women who have already had breast cancer. About 1,500 women aged 30-79 who are at least one…

This study is testing a new blood test that looks at tiny particles from breast cancer cells to determine the cancer's subtype. The goal is to see if this test can accurately identify cancer types without needing a tissue biopsy. Researchers will compare the blood test results to…

This study compares a special type of mammogram (contrast-enhanced) to standard 3D mammography in women with dense breasts. The goal is to see if the contrast method finds more cancers and leads to fewer false alarms. About 2,000 women with dense breasts but no symptoms will be s…

This study tests whether a special PET/CT scan (68Ga-FAPI) can accurately see if breast cancer has spread to lymph nodes after chemotherapy. 150 women who have finished chemotherapy and are scheduled for surgery will get this scan. If it works well, it might help doctors decide i…

This study tests if a safe green dye (indocyanine green) can find sentinel lymph nodes—the first nodes cancer spreads to—during mastectomy. Currently, doctors use a radioactive tracer and often need a separate cut in the armpit. The dye is injected after anesthesia and viewed wit…

This study compares a newer X-ray-based breast imaging method (contrast-enhanced digital breast tomosynthesis, or CE-DBT) with standard contrast-enhanced MRI in women with known breast lesions. The goal is to see if CE-DBT gives radiologists similar confidence in identifying and …

This study tests whether a special PET scan (FES PET/CT) can improve detection and treatment planning for brain metastases in people with estrogen-receptor positive breast cancer. About 20 participants will receive the scan before standard radiation therapy and be followed for 12…

This study in Indonesia will use a portable ultrasound machine to quickly check breast lumps found during a physical exam. The goal is to tell which lumps are likely harmless and which might be cancer, so that only women with suspicious findings need further tests like mammograms…

This study tests if a dye called indocyanine green (ICG) can accurately find cancer that has spread to lymph nodes in people with breast cancer who have already had chemotherapy. About 100 adults will receive both the new dye and the standard two-dye method during surgery to see …

This study is testing whether using artificial intelligence (AI) together with one or two breast radiologists can find breast cancers in mammograms just as well as the current standard of two radiologists reading independently. About 150,000 women in Norway's BreastScreen program…

This study is testing a new ultrasound imaging technique called Contrast Enhanced Super-Resolution (CESR) to see if it can better find cancer in the breast, liver, and kidney. It will involve 30 patients with known lesions and 10 healthy volunteers. The goal is to compare CESR im…

This study is testing a new device that uses engineered bacteria and laser technology to find and study rare tumor cells in the blood of breast cancer patients. The goal is to improve early detection and help doctors choose personalized treatments. The study will include 80 women…

This study is testing a new device called ARTIDIS that measures how stiff breast tissue is to help doctors tell if a lump is cancerous or not. About 2,700 women with suspicious breast lumps will have their biopsy samples tested with ARTIDIS. The goal is to see if this method can …

This study compares robotic ultrasound to traditional sonographer-led screening for breast cancer in 70,000 women aged 35-64. Participants will receive a breast ultrasound by either a robot or a human, then follow standard care based on results. The goal is to see if robotic scre…

This study is testing whether a special imaging scan called PYLARIFY PET-CT can better detect when cancer has spread in people with pancreatic cancer, liver cancer, or breast cancer. About 36 adults will get the scan, and doctors will compare the results to standard methods to se…

This study tests a new device called SPCTRone that helps surgeons check if all cancer has been removed during breast-conserving surgery. About 100 women with breast cancer will have their removed tissue scanned by the device, and the results will be compared to standard lab tests…

This study tests whether non-expert examiners using AI-supported ultrasound can accurately detect breast cancer in community settings. It involves 4,800 women, both with and without symptoms, in limited-resource areas. The goal is to see if this approach is safe and effective for…

This study is testing a new blood test that looks for tiny molecules called MicroRNA in people with breast cancer. The goal is to see if this test can accurately detect the disease. About 100 healthy volunteers will take part to help measure how sensitive and specific the new met…

This study tests a fluorescent dye called indocyanine green (ICG) to help surgeons find sentinel lymph nodes in breast cancer patients. The dye glows under special light, making it easier to locate the first lymph nodes where cancer might spread. The goal is to see if this method…

This study tests a new way to find the first lymph node where breast cancer might spread. Instead of using a radioactive tracer, doctors use a green dye and a special camera during surgery. The goal is to make the procedure safer, cheaper, and more convenient for patients. About …

This study tests a new imaging method that combines MRI with near-infrared light to get clearer pictures of breast cancer tumors. Twenty women recently diagnosed with breast cancer will receive this extra scan before surgery. The goal is to see if this tool can help doctors bette…

This study tests a new imaging device that combines a special PET scan with 3D mammography to better see estrogen receptor positive breast cancer. About 20 adults with newly diagnosed ER+ breast cancer will get an injection of a radioactive tracer and then be scanned. The results…

This study is testing two experimental methods—a blood test called Liquid Biopsy and a special camera called Positron Emission Mammography (PEM)—to see if they can help doctors find breast cancer more accurately in women at high risk. About 100 women who already need an MRI-guide…

This study is testing whether a simple breath test can help detect breast cancer. Researchers will collect and analyze breath samples from 5,175 women aged 40 to 74 who are already scheduled for a breast biopsy or MRI. By comparing the breath profiles of women with and without br…

This study is testing a new blood test that uses laser technology and artificial intelligence to find early signs of breast, colon, pancreatic, ovarian, and lung cancers. Researchers will collect blood samples from 1,400 people aged 45 and older who are suspected of having one of…

This study trains Nigerian radiologists to use a tablet-based ultrasound system to perform breast biopsies. The goal is to make breast cancer diagnosis more accessible and reliable in Nigeria. About 900 women with suspicious breast lumps will take part.

This study is testing a new way to detect cancer by looking at specific enzymes in the blood. Researchers will compare enzyme levels in people with breast, lung, or pancreatic cancer to those without cancer. The goal is to develop a simple, non-invasive blood test that could help…

This study tests a new imaging system that uses light to monitor how breast cancer responds to chemotherapy before surgery. The goal is to see if the device can accurately predict when the cancer is completely gone. About 15 women with specific breast cancer types will be enrolle…

This early-phase study tests whether a PET scan using a radioactive tracer (89Zr-trastuzumab) can show which HER2-positive breast cancer patients are likely to benefit from targeted therapy. Ten newly diagnosed adults will receive the tracer and undergo PET/MRI imaging. The goal …

This study is testing whether a special PET/MRI scan can predict how breast cancer will respond to hormone therapy given before surgery. About 53 postmenopausal women with newly diagnosed, hormone-sensitive breast cancer will receive the scan before and after starting therapy. Th…

This study is testing two new imaging agents that light up specific markers (Trop2 and HER2) on breast cancer cells during a PET/CT scan. The goal is to see if these probes can find tumors and their spread more accurately than current methods. About 200 women with breast cancer o…

This study tests whether a special PET scan using FES (a tracer that binds to estrogen receptors) is better than the standard FDG PET scan at finding and tracking metastatic lobular breast cancer. About 30 adults with ER-positive, HER2-negative metastatic lobular breast cancer wi…

This study is testing a blood test that looks for DNA signals from 20 different cancers, including lung, breast, and colon cancer. Researchers will check if the test can find cancer early, tell which type it is, and detect any remaining cancer after treatment or a relapse before …

This study tests whether contrast-enhanced mammography (CEM) can find breast cancers that standard mammography might miss in women with dense breasts. About 1,000 women aged 30-75 with dense breasts will get both types of mammograms. The goal is to see if CEM improves early detec…

This study tests a new device that uses light and AI to check for cancer cells on the surface of removed breast tissue during surgery. About 1 in 5 women need a second operation because some cancer is left behind. The device scans the tissue in real time, helping surgeons remove …

This study tests whether a special ultrasound using a contrast agent (Sonazoid) can accurately locate the sentinel lymph node—the first node cancer spreads to—in people with melanoma, breast cancer, or head & neck cancer. Currently, doctors use a radioactive tracer and a gamma pr…

This study tests a special PET/CT scan that uses a modified form of tryptophan to make tumors stand out more clearly from healthy tissue. Researchers hope this will help doctors better assess treatment response and plan future care. The study involves 24 adults with brain tumors,…

This study tests if a local antibiotic called Stimulan Rapid Cure can lower the risk of infections in women who get tissue expanders placed during mastectomy. About 392 women will take part. The goal is to see if this treatment works better than standard care at preventing infect…

This study tests whether a gel containing diclofenac (a common anti-inflammatory drug) can prevent skin rashes caused by radiation therapy. About 156 adults with head/neck or breast cancer will apply the gel daily during their radiation treatment. The goal is to see if the gel re…

This study follows women with genetic mutations (like BRCA1/2) that raise their risk for ovarian cancer. Participants choose either preventive surgery (removing fallopian tubes now, ovaries later, or both) or close monitoring. Researchers track cancer rates, ovarian function, and…

This study tests two low-dose hormone drugs, exemestane and tamoxifen, in 140 postmenopausal women at high risk for breast cancer. The goal is to see which one better maintains quality of life over 12 months while reducing cancer risk. Participants take a daily pill, and research…

This study tests whether a comprehensive prevention program can reduce the risk of lymphedema (arm swelling) in women with breast cancer who have lymph nodes removed. About 285 participants will be followed for at least a year. The program focuses on helping lymph fluid drain pro…

This study tests whether drinking tart cherry juice can prevent nerve pain caused by the chemotherapy drug paclitaxel in people with breast or ovarian cancer. About 86 participants will be randomly assigned to take either a high or low dose of the juice during their 12-week chemo…

This study tests whether acupuncture, compression therapy, or both can prevent nerve damage (peripheral neuropathy) caused by taxane chemotherapy in breast cancer patients. About 384 adults with early or intermediate-stage breast cancer will be enrolled. The goal is to find a saf…

This study looks at how exercise might reduce breast cancer risk in women with dense breast tissue. Researchers will measure changes in blood and breast tissue in 46 women who are inactive. Half will start an exercise program, and the other half will wait. The goal is to see if e…

This study tests whether dapagliflozin, a drug used for diabetes, can prevent heart damage in women receiving anthracycline chemotherapy for breast cancer. About 100 participants will take either the drug or a placebo daily during chemo. Researchers will monitor heart function, b…

This study compares the usual annual mammogram approach to a personalized screening schedule based on each woman's personal risk of breast cancer. Up to 100,000 women aged 30-74 in the U.S. can join and choose their preferred screening method. The goal is to see if personalized s…

This study is testing an online program designed to help women at high risk for breast cancer lower their risk through lifestyle changes. The program provides personalized education and motivation about diet, exercise, and other modifiable factors. It is being offered to over 1,5…

This large international study is testing if giving an intravenous lidocaine (a numbing medicine) drip during and right after breast cancer surgery can prevent patients from developing long-lasting pain months later. About 1,600 patients will be randomly assigned to receive eithe…

This study is testing a program designed to help more Native American women get mammograms to screen for breast cancer. It will compare two approaches: one using a tablet-based education tool and another that adds monthly one-on-one support from a community peer navigator. The go…

This study aims to improve early breast cancer detection for women at high genetic risk. Researchers are testing whether shorter, faster MRI scans work as well as standard MRIs for regular monitoring. The study will create a registry of 400 high-risk women who will receive scans …

This study is testing a community outreach program to help more people get screened for breast, lung, and prostate cancer. It focuses on adults in underserved areas who are eligible for these screenings. The program aims to connect people with screening, help them navigate the he…

This study tests a 6-week online program designed to help breast cancer survivors feel better emotionally and reduce worry about cancer coming back. The program includes weekly video sessions with coping strategies and support. Researchers will compare the well-being, quality of …

This study tests a special pain management program for breast cancer survivors who have joint and muscle pain caused by their hormone therapy (aromatase inhibitors). The program uses cognitive behavioral therapy (CBT) and other techniques to help reduce pain, improve thinking and…

This study looks at whether a new version of the chemotherapy drug docetaxel, which does not contain ethanol (alcohol), causes fewer alcohol-like side effects in breast cancer patients. About 1,052 participants will be observed before and after surgery to track symptoms like flus…

This study looks at whether coloring mandala patterns for 30 minutes during chemotherapy can help breast cancer patients feel less distressed and anxious, and more comfortable. About 60 women will be randomly assigned to either color mandalas or receive usual care. Researchers wi…

This study looks at two ways to manage side effects from aromatase inhibitors, a hormone therapy for early-stage breast cancer. About half of women stop taking these drugs early due to side effects, raising the risk of cancer returning. The study will compare switching to a diffe…

This study compares a new care pathway called AMADeuS, which includes awake surgery and same-day discharge with telemedicine follow-up, to standard hospital care for women having mastectomy with immediate breast reconstruction. The goal is to see if the AMADeuS pathway controls p…

This study tests whether combining the drug memantine with a structured exercise program can improve memory and thinking problems (often called 'chemo brain') in women undergoing chemotherapy for early-stage breast cancer. About 90 participants will be split into three groups: on…

This study tests whether the MIND diet, a diet rich in brain-healthy foods, can improve memory and thinking in breast cancer survivors who have ongoing mental fogginess after treatment. About 200 survivors will follow the diet for 12 weeks, then a maintenance phase. The goal is t…

This study tests whether an online group program called Project SOAR Awakenings can help Black American women with breast cancer feel less depressed and tired, and improve their overall well-being. About 90 women will be randomly assigned to either join four small-group video dis…

This study tests a smartphone app that connects young adults (ages 18-40) who have finished treatment for lymphoma, breast cancer, testicular cancer, or sarcoma. The app pairs them with trained peer navigators to help with challenges like symptom burden, career gaps, and emotiona…

This study tests a technique called systematic shaving, where surgeons remove a thin layer of extra tissue around the tumor during breast-conserving surgery. The goal is to see if this lowers the chance that cancer cells are left behind, reducing the need for a second surgery. Ab…

This study tests a new type of radiation therapy (adaptive radiotherapy) for breast cancer patients who are at high risk of developing fibrosis (scar tissue) after standard treatment. The goal is to see if this approach reduces side effects like skin burns and swelling. About 500…

This study tests whether a non-surgical radiofrequency treatment, combined with pelvic floor exercises, can reduce vaginal dryness and other menopause-related symptoms in women who have survived breast cancer. Fifty participants will receive either active or sham radiofrequency o…

This study looks at whether a telehealth exercise program with extra protein can help women aged 65 and older with breast cancer stick to their full chemotherapy schedule. Participants will either do resistance exercises and take protein supplements or receive health education an…

This study looks at whether a short, focused upper body massage after each radiation treatment can help breast cancer patients feel less pain and stiffness in their muscles and joints. Researchers will also check if massage improves quality of life and how well patients like it. …

This study compares two standard numbing methods for people having a mastectomy (breast removal) due to breast cancer or high risk. One method uses a nerve block before surgery, the other uses numbing medicine during surgery. The goal is to see which approach leads to less pain a…

This study is testing a mobile app called TEAMWork that gives breast cancer patients advice on talking to their employers and doctors about work. The goal is to help patients keep their jobs during and after treatment. Researchers are asking about 546 patients to try the app and …

This study looks at whether a 16-week high-intensity interval training (HIIT) program can help women with breast cancer maintain their thinking and memory skills while undergoing chemotherapy. About 30 women will be enrolled and will have their brain function, heart fitness, and …

This study tests whether a special nutrient supplement (APPORTAL®) can help reduce severe tiredness in women with breast cancer who are on chemotherapy. About 92 participants will take either the supplement or a placebo for 8 weeks, along with recommended exercise. Researchers wi…

This study tests whether Revaree Plus, a vaginal moisturizer, can help relieve vaginal dryness in women being treated for hormone-receptor-positive breast cancer. About 60 participants will use the product for 8 weeks. Researchers will measure changes in vaginal health using a st…

This study tests whether a single 60-minute counseling session can reduce anxiety and depression in breast cancer patients who are waiting for ongoing therapy. Twenty participants will try the session and report how helpful it was. The goal is to see if this quick support can imp…

This study tests whether a gentle heat treatment (radiofrequency) applied inside the vagina can reduce dryness and pain during sex in women being treated for breast cancer. Participants will either receive standard moisturizing therapy alone or combined with three radiofrequency …

This study looks at whether a simple strength-training program can help breast cancer survivors manage fatigue. Researchers will work with 60 women from different backgrounds to see if factors like income or support affect how well they stick with the program. The goal is to find…

This study tests whether a nutritional supplement called Epidiferphane can reduce common side effects like anemia and nerve pain caused by taxane chemotherapy in breast cancer patients. About 74 adults starting taxane treatment will take Epidiferphane alongside their chemo. Resea…

This study tests whether numbing specific shoulder nerves can reduce pain in people who have shoulder pain after breast cancer surgery and radiation. Sixty adults aged 18-65 will be randomly assigned to receive the nerve block or standard care. The main goal is to see if pain sco…

This early-phase study tests whether fecal microbiota transplantation (FMT) can safely reduce diarrhea and colon inflammation caused by immune-checkpoint inhibitors in people with genitourinary and other cancers. About 40 participants will receive FMT and be monitored for side ef…

This study is testing whether a gentle energy therapy called Medical Reiki, given before breast cancer surgery, can improve mood, reduce stress, and help with recovery. About 32 women with early-stage breast cancer will take part. The goal is to see if this approach is practical …

This study looks at whether a community-based exercise program called Get Real and Heel can help people with metastatic breast cancer become more active. Researchers want to see if it improves quality of life, physical function, and social support while reducing isolation. About …

This study tests a new method of arm massage guided by a special dye (ICG) to prevent swelling after breast cancer surgery. About 30 women having lymph node removal will be assigned to either standard massage or dye-guided massage. The goal is to see if the new method helps patie…

This study tests whether a remotely supervised online cognitive stimulation program can reduce memory and thinking complaints in 300 breast cancer patients who finished chemotherapy. Participants will either get supervised brain exercises with a neuropsychologist or do the same e…

This study is testing whether a special exercise program using both arms and legs can help protect the heart in women with breast cancer who are receiving chemotherapy. The researchers will measure heart function and blood vessel health before and after the exercise program. The …

This study tests whether a new type of exercise prescription, based on how you feel during activity, helps breast cancer survivors become more active. About 85 survivors who finished treatment within the last 5 years will either get this affect-based plan or a standard effort-bas…

This study looks at whether a 12-week virtual dance program can improve quality of life, reduce pain, and ease fatigue in breast cancer survivors who have ongoing pain after surgery. About 30 adults who had a lumpectomy or mastectomy and still have moderate to severe pain will ta…

This study tests whether offering personalized sexual health support early on (proactive) is better than waiting for patients to ask for it (on-request). About 264 breast cancer patients who finished standard treatment will be randomly assigned to one of two groups. The goal is t…

This study tests two digital mindfulness programs—one live on Zoom and one self-paced app—to see if they can reduce depression in younger breast cancer survivors. About 402 women diagnosed at or before age 50, who finished cancer treatment at least 6 months ago and have high depr…

This study tests whether a headband with special semiconductors can help with memory and thinking problems (often called 'chemo brain') after cancer treatment. About 50 breast or gynecological cancer patients who finished chemotherapy within the last 90 days will wear the headban…

This study looks at two different exercise programs to help women increase muscle mass after finishing breast cancer treatment. Researchers will track changes in muscle and fat, as well as how well participants stick with the program. The goal is to find the best way to help surv…

This study tests whether a single dose of psilocybin (the active ingredient in magic mushrooms) combined with talk therapy can reduce the intense fear of cancer returning in women who have finished treatment for early-stage breast or ovarian cancer. Twenty women in remission will…

This study tests whether regular phone or video calls from a nurse can help breast cancer patients on CDK inhibitor drugs catch and manage side effects early. About 124 women will be split into two groups: one gets standard care, the other adds structured telenursing check-ins. T…

This study tests whether a special spa therapy program can improve skin-related quality of life for people who have skin hardening or scarring (fibrosis) after radiation for breast or head/neck cancer. About 110 adults who finished radiation at least 6 months ago will be randomly…

This study looks at whether taking creatine supplements can help breast cancer survivors get stronger and have more energy from exercise. Researchers will compare results from 60 women who recently finished chemotherapy. The goal is to see if creatine helps them build muscle and …

This study tracks 184 breast cancer patients getting a lumpectomy with a special dye called Magtrace to find lymph nodes. The main goal is to see how often the dye causes skin discoloration and how that affects patients' feelings about their appearance. Researchers will follow pa…

This study tests a program called MyCarePulse and ASCENT to help cancer patients overcome barriers to healthy eating. About 100 adults recently diagnosed with cancers like breast, lung, or colorectal cancer will either get the program or standard care. Researchers will check if t…

This study tests a community-based, peer-led course called BBCSI designed to improve quality of life for Black breast cancer survivors. Researchers will enroll 46 Black women who had stage 0-III breast cancer and have no signs of spread. The course focuses on social and environme…

This study looks at whether combining resistance and aerobic arm exercises can improve arm strength, function, and quality of life in breast cancer patients. About 40 women who are at least 15 months past surgery will take part. The goal is to find simple, safe ways to reduce com…

This study tests a digital health program called AYA STEPS for adolescent and young adult cancer survivors. The program helps manage common symptoms like pain, fatigue, and emotional distress, and encourages engagement with recommended follow-up care. About 260 participants who h…

This study tests whether a genetic test can help doctors choose the best anti-nausea medicines for Chinese women with early breast cancer undergoing their first round of chemotherapy. About 200 participants will either get standard care or a personalized anti-nausea plan based on…

This study tests whether progressive resistance exercise (strength training) can improve arm swelling, function, and quality of life in people who developed lymphedema after breast cancer treatment. Researchers will enroll 50 adults aged 18-60 who are at least 3 months past surge…

This study tests whether walking exercise can help reduce fatigue in older breast cancer survivors. About 24 women aged 60 and older who finished cancer treatment within the past year will take part. They will either walk at a center or at home for 12 weeks. The goal is to see if…

This study tests two different walking programs for women with breast cancer who are getting chemotherapy. One program has a fixed amount of walking each week, while the other adjusts the walking amount based on how the person responds. The goal is to see which approach better im…

This study tests whether a shorter 5-day course of whole breast radiation works as well as the usual 9-day course for women with early-stage breast cancer. About 144 participants will be randomly assigned to one of the two schedules. The main goal is to see if women are equally s…

This study compares a standard physiotherapy program to one that adds visual biofeedback—a system that shows real-time movement on a screen—for women recovering from breast cancer surgery. The goal is to see if the visual feedback helps improve shoulder strength, range of motion,…

This study tests whether radiofrequency therapy, pelvic floor exercises, or both can reduce symptoms like vaginal dryness and pain in breast cancer survivors. About 117 women who have finished breast cancer treatment and have pelvic floor issues will take part. The goal is to fin…

This study looks at whether simple mindfulness-based breathing exercises can help breast cancer patients feel better during chemotherapy. Researchers will measure symptoms like pain and fatigue, as well as stress levels, in 72 women. Half will learn the breathing exercises, and t…

This study looks at whether a special retreat program called 'Via Shalva' is helpful and practical for people who have finished treatment for breast or gynecologic cancer. About 30 survivors will take part, and researchers will measure changes in quality of life, stress, and othe…

This study tests whether using opioid-free anesthesia during mastectomy can lower the chance of chronic pain one year after surgery. 230 breast cancer patients will be randomly assigned to receive either opioid-free or standard opioid-based anesthesia. Researchers will also look …

This study tests if a newer, less invasive mastectomy (endoscopic skin-sparing) leads to fewer wound complications and higher patient satisfaction compared to standard mastectomy. About 258 women with breast cancer will be randomly assigned to one of the two surgeries. The goal i…

This study looks at whether a program of exercise and personalized nutrition, started right after diagnosis and before treatment begins, can help women with breast cancer feel better and recover faster. 66 women with stage 0-III breast cancer will be enrolled. The goal is to see …

This study tests whether adding acupuncture to standard nausea medicine works better than medicine alone for cancer patients who still feel sick during chemotherapy. About 90 adults with breast, prostate, lung, or other cancers will be randomly assigned to one of two groups. Rese…

This study tests if limiting when you eat (time-restricted eating) can reduce side effects from cancer treatment, improve mood, and even affect tumor biology. Researchers will enroll 175 adults with rectal or breast cancer who are receiving treatment. Participants will follow a s…

This study tests whether brief guided meditation during daily radiation therapy can help reduce anxiety in people with breast or gynecologic cancers. About 34 adults will either receive the meditation or standard care. The goal is to see if meditation makes treatment less stressf…

This study tests if a mobile app can improve quality of life for people with early-stage breast cancer who are taking hormone therapy. About 180 participants will either use the app plus standard care or standard care alone for 12 weeks. The app provides education and self-care t…

This study tests a free, personalized exercise program for women with breast cancer. Participants can choose supervised or at-home workouts tailored to their treatment stage. The goal is to see if regular exercise improves quality of life, fitness, and well-being. The program is …

This study tests two types of ultrasound-guided nerve blocks to see which one controls pain better after breast cancer surgery. Fifty women having a mastectomy will receive either a newer SPSIP block or a standard ESPB block. The goal is to reduce morphine use and improve recover…

This study tests whether using no opioids during breast reconstruction surgery can reduce the need for morphine afterward. About 158 women having free flap breast reconstruction will be randomly assigned to opioid-free or standard opioid anesthesia. The goal is to see if the opio…

This early-stage study tests whether breast cancer patients can use a topical azelaic acid cream twice daily during radiation treatment. The goal is to see if it's practical and well-tolerated, with the hope of reducing skin irritation. About 33 adults with darker or sun-sensitiv…

This study looks at whether a supervised exercise program with moderate aerobic and resistance training can safely reduce pain in breast cancer survivors who have ongoing pain. Ten women who finished treatment at least six months ago will take part. The goal is to see if the prog…

This study looks at whether a mobile app called Mighty Pro can help young women (ages 18-45) with breast cancer feel less distressed. About 120 participants will use the app for 26 weeks to track their feelings and communicate with their care team. The goal is to see if using the…

This study tests whether giving only radiation after lumpectomy is safe and effective for women aged 60 and older with early-stage, low-risk breast cancer. The goal is to see if skipping long-term hormone therapy can improve quality of life while still controlling the cancer. Abo…

This study is testing whether a 12-week physical activity program can improve quality of life for women with early-stage hormone receptor positive breast cancer who are on hormone therapy. About 44 participants will join an exercise program and fill out questionnaires about their…

This study follows 104 breast cancer patients whose cancer has spread to the chest wall and who are having surgery to remove the affected area. Researchers want to see how the surgery impacts quality of life, pain, and survival. The goal is to provide better information to help p…

This study tests if a supervised exercise program (high-intensity interval and resistance training) during chemotherapy can help breast cancer tumors disappear completely. About 712 patients will be randomly assigned to exercise or usual care and followed for two years. The goal …

This study tests whether using artificial intelligence (AI) to guide side effect management can improve quality of life for people with breast or colorectal cancer undergoing chemotherapy. About 174 adults will be randomly assigned to receive either standard care or care where do…

This study looks at whether time-restricted eating (eating all food within an 8-hour window each day) is practical and helpful for people starting chemotherapy for breast cancer. Researchers will test three different eating windows compared to a control group over 24 weeks. The g…

This study tests a nasal spray medication (dexmedetomidine) to help women relax and stay comfortable while awake during breast-conserving surgery for breast cancer. About 394 women aged 20–70 will receive either the active spray or a placebo before surgery. Researchers will measu…

This study is testing a smartphone app called iCareBreast+ designed to help women with breast cancer manage their care during chemotherapy. About 40 women will use the app to track symptoms, learn about their treatment, and get support. The goal is to see if the app is easy to us…

This study looks at whether changing the order of mammogram pictures can make the exam less painful and more satisfying for women who have had breast cancer. About 400 women who had breast-conserving surgery in the last five years will be randomly assigned to one of four differen…

This study looks at women who have had breast surgery and radiation before and need another breast surgery. Because radiation makes healing harder, researchers want to find the best way to prevent wound problems. They will compare three options: a week of antibiotics, a wound vac…

This study looks at whether patient navigators—people who guide and support patients through their care—can help more African American, Native American, and Hispanic patients complete their radiation therapy for breast or prostate cancer. The study will enroll 420 adults and use …

This study tests whether combining electroacupuncture with self-acupressure can improve quality of life for early-stage breast cancer patients undergoing chemotherapy. About 192 adults aged 18-75 who are starting chemotherapy will be randomly assigned to receive the acupuncture/a…

This study looks at whether upper body aerobic exercise can reduce artery stiffness caused by cancer treatments in women with breast cancer. Researchers will measure blood vessel health before and after exercise sessions. The goal is to find a safe, drug-free way to improve heart…

This study is testing a program called Mindful After Cancer (MAC) to help breast and gynecologic cancer survivors who have sexual health or body image concerns. The program includes mindfulness training, education, and support delivered online over 8 weeks. Researchers want to fi…

This study looks at whether a 16-week virtual exercise program (aerobic and strength training) can improve fitness, muscle strength, and quality of life in people with indolent (slow-growing) metastatic breast cancer. Researchers will enroll 100 adults whose cancer has not worsen…

This study looks at whether a 12-week exercise program can improve heart and muscle function in women over 60 who have had breast cancer treatment. Chemotherapy can sometimes weaken the heart, and this research compares structured exercise to a stretching-yoga program. The goal i…

This study tests a 5-session radiation treatment for people with early-stage breast cancer who have had a lumpectomy. The goal is to see if this shorter approach is safe and causes fewer side effects. About 40 participants aged 50 and older with small, hormone-positive tumors wil…

This study compares two drugs, solifenacin and clonidine, to see which better reduces hot flashes in breast cancer patients taking hormone therapy. About 110 women who have at least 14 hot flashes per week will take one of the drugs for three weeks. The goal is to find a more eff…

This study tests whether 12 weeks of supervised dragon boat racing improves body composition, physical function, and quality of life more than unsupervised home exercises in women who had breast cancer surgery. 72 participants will be randomly assigned to either group. The goal i…

This study compares two treatments for breast cancer that has spread to lymph nodes: radiotherapy (using radiation) and surgery to remove the lymph nodes. The goal is to see which approach better preserves arm function and quality of life, and reduces the risk of arm swelling (ly…

This study tests whether a program of resistance training (weight lifting) combined with a high-protein drink after workouts can help women with breast cancer maintain muscle and reduce fat while undergoing chemotherapy before surgery. Researchers will enroll 30 women aged 20-89 …

This study tests whether a program combining physical therapy, yoga, and patient education can reduce joint and muscle pain caused by hormone therapy in breast cancer patients. About 108 adults with non-metastatic breast cancer and moderate-to-severe pain will be randomly assigne…

This study looks at whether adding gabapentin to standard pain management can reduce the need for stronger opioids after mastectomy. About 1,896 adults aged 18 to 65 having same-day mastectomy at a single center will take part. The goal is to see if gabapentin helps control pain …

This study tests whether a special low-calorie diet that mimics fasting can safely lower high cholesterol and reduce side effects from hormone therapy in post-menopausal women with early-stage breast cancer. About 60 participants will follow the diet in cycles while continuing th…

This study looks at whether a 15-week cycling program can help breast cancer patients keep up their physical fitness during chemotherapy. Researchers will compare patients who cycle once a week to those who receive standard care. The goal is to see if the cycling group can mainta…

This study tests a new, less invasive way to remove breast cancer through a single small cut in the armpit, avoiding a large scar on the breast. It involves 10 women with early-stage breast cancer who are eligible for nipple-sparing mastectomy and immediate implant reconstruction…

This study looks at 250 women who have had early-stage breast cancer and are now overweight and have trouble sleeping. Researchers want to see if a short program to improve sleep (called CBT-I) before starting a weight loss program helps them lose more weight than just learning a…

This study tests a new care plan that uses technology to help doctors better manage the health of older adults (70+) who have cancer and other medical conditions. The goal is to see if this approach improves their quality of life after 6 months. About 720 people from 8 hospitals …

This study tests a decision aid for women aged 70 and older with early-stage, low-risk breast cancer. The tool helps them and their doctors discuss treatment options, aiming to reduce aggressive treatments like mastectomy or radiation when they may not be needed. About 402 partic…

This study looks at whether a 16-week cardiac rehabilitation exercise program can improve heart health and fitness in women who have had early-stage breast cancer. About 100 participants will take part in the program, which includes exercise and lifestyle support. Researchers wil…

This large study tests whether giving lidocaine (a common numbing medicine) through an IV during breast cancer surgery can prevent moderate to severe pain that lasts for a year or more. About 4,300 women having mastectomy or lumpectomy will be randomly assigned to receive lidocai…

This study looks at how a light-based treatment called photobiomodulation affects sexual quality of life in women with breast cancer who have menopause-like symptoms from their treatment. About 25 women will complete a questionnaire about their sexual health before and after the …

This study looks at how different supervised group exercise programs affect fitness and body composition in women who have completed breast cancer treatment. About 15 women aged 20-89 will try one of four resistance training regimens to see which best improves heart-lung fitness …

This study tests whether nurse-delivered hypnosis before and during breast cancer surgery can lower the amount of opioid painkillers patients need after surgery. About 225 adults having breast surgery will be randomly assigned to receive hypnosis plus standard anesthesia, standar…

This study tests whether a 6-week online mindfulness-based stress reduction (MBSR) program can lower stress, anxiety, depression, and other side effects in women with breast cancer who are starting chemotherapy. About 200 participants will be randomly assigned to either the onlin…

This study tests a pre-surgery program (prehabilitation) for adults 65+ with breast cancer. The program includes exercise, nutrition advice, and a full health check. Researchers want to see if it improves physical function and reduces complications after surgery. 90 participants …

This study looks at two types of breast-conserving surgery for breast cancer: one using a robot and the other using an endoscope. Researchers want to see which approach leads to fewer complications and better cosmetic results. The study involves 200 women aged 18 to 80 with early…

This study tests whether taking tart cherry concentrate and fish oil together can reduce joint pain and stiffness caused by aromatase inhibitors, a common breast cancer treatment. About 30 women with breast cancer who have joint pain will take these supplements for 12 weeks. The …

This study compares two ultrasound-guided nerve block techniques (RISS block vs. erector spinae plane block) for pain relief after mastectomy in 40 breast cancer patients. The goal is to see which method reduces the need for morphine and other opioids after surgery, helping patie…

This study is for women with a high-risk type of breast cancer (HR+/HER2-). It tests whether adding the drug ribociclib to standard radiation therapy after surgery is safe and tolerable. About 30 participants will take ribociclib daily for up to 6 weeks while receiving radiation.…

This study tests whether a diet called MIND (a mix of Mediterranean and DASH diets) can help protect memory and thinking in women with breast cancer who are receiving chemotherapy or other systemic treatments. About 43 women with stage II-IV breast cancer will be randomly assigne…

This study tests short, easy-to-use digital tools (called micro-interventions) designed to help breast cancer survivors manage stress and improve their mood. Researchers will enroll 120 women who were diagnosed with early-stage breast cancer in the past 5 years and have some symp…

This study tests whether computer-based brain exercises can improve memory and thinking problems that some breast cancer survivors experience after treatment. About 386 women who had early-stage breast cancer and report mental fogginess will be randomly assigned to either a brain…

This study tests whether a telehealth exercise program can reduce cancer-related fatigue in rural breast and prostate cancer survivors. About 134 participants will receive a personalized exercise plan with virtual coaching, or join a wait-list control group. The program aims to i…

This study is testing a program of exercise and psychological support for people with solid tumors (like breast cancer) before they receive surgery or radiation. The goal is to see if this "prehabilitation" helps patients have better physical fitness and emotional well-being afte…

This study looks at whether a group exercise program called Strength After Breast Cancer can help women who finished breast cancer treatment improve their physical function. About 40 women will take part in the program at a hospital clinic. Researchers want to see if the program …

This study is testing whether a special breathing muscle training program can help obese breast cancer survivors exercise for longer periods and feel less tired. It will involve 78 survivors who have finished their main cancer treatment within the last 6 months to 5 years and who…

This study is testing whether taking a daily probiotic powder for six months can help reduce the unpleasant side effects of chemotherapy in people with breast cancer. It will involve 100 participants who are receiving common chemotherapy drugs. Researchers will track side effects…

This study is testing whether the drug riluzole can prevent or reduce thinking and memory problems (often called 'chemo brain') in cancer patients receiving chemotherapy. It will enroll 24 adults with various cancers who are scheduled to receive specific types of chemotherapy. Pa…

This study is testing whether a digital support program can help people sit less during cancer treatment. It involves 172 patients with breast, prostate, or colorectal cancer who are receiving chemotherapy, radiation, or other therapies. Participants use a digital tool and get gu…

This study is testing a stress management program designed to help women in Vietnam who have breast or gynecologic cancer. The program, called Self-Help Plus, aims to reduce feelings of depression and anxiety and improve quality of life. Researchers will compare the program to st…

This study is testing if giving high-dose steroids can prevent or reduce severe skin reactions on the hands and feet caused by a specific chemotherapy drug (liposomal doxorubicin) used for breast cancer. Researchers will compare high-dose steroids, standard-dose steroids, and no …

This study tests whether short, frequent bursts of physical activity ('exercise snacks') are as effective as standard 30-minute workouts at controlling blood sugar levels. It involves 24 sedentary breast cancer survivors on hormone therapy and similar women without cancer. Resear…

This study looks at how BRCA gene changes and cancer treatments affect the ovaries in premenopausal women with early-stage breast cancer. Researchers will measure hormone levels in the blood before, during, and after treatment to understand the risk of early menopause and fertili…

This study looks at how near-complete estrogen deprivation (NCED) therapy, used to treat breast cancer, affects heart function. Researchers will use heart scans to measure blood flow in 90 women aged 55 or younger who are premenopausal at diagnosis. The goal is to understand if t…

This study looks at how a 13-week physical activity program (called KHEOPS) affects motivation and cancer-related psychological symptoms in 80 women undergoing treatment for non-metastatic breast cancer. Researchers will track changes in participants' attitudes, confidence, and m…

This study is for women aged 60 and older with newly diagnosed breast cancer who are scheduled for chemotherapy. Researchers want to understand how chemotherapy affects thinking skills and the brain over time. Participants will complete thinking tests and some may have brain scan…

This study aims to collect blood samples (liquid biopsies) from 2,500 people with cancer or at high risk for cancer, along with their medical information. The samples will be stored and used by researchers to develop better ways to detect, monitor, and understand cancer over time…

This study follows 100 adults with high-risk, hormone-sensitive early breast cancer to see which treatments doctors choose in real life. Participants take their prescribed medications and fill out questionnaires about their quality of life. The goal is to understand current treat…

This study looks at whether the phase of a woman's menstrual cycle when she starts chemotherapy affects how well the treatment works. Researchers will collect blood samples from 100 women with triple-negative breast cancer before they begin neoadjuvant treatment. The goal is to s…

This study looks at whether a wearable activity tracker can be used to collect heart rate data from people with pancreatic or breast cancer who are undergoing treatment. The goal is to see if patients find the device easy to use and if they will wear it consistently for 14 days. …

This study aims to find out if younger women (45 and under) with non-metastatic breast cancer experience more pain from pegfilgrastim (a drug that helps white blood cell recovery during chemotherapy) compared to older women. About 115 women will report their pain levels and have …

This study is for women with suspicious breast findings or newly diagnosed breast cancer. Researchers will collect tissue and blood samples and have participants fill out questionnaires to learn how genetics and other factors affect breast cancer risks and outcomes. The study doe…

This study looks at two ways to remove breast cancer while keeping as much healthy tissue as possible. About 204 women with early-stage breast cancer will be assigned to one of two surgical methods. The goal is to see which method leads to fewer cancer cells left at the edge of t…

This study tests whether a 14-day mobile diary is a practical way to measure daily stress and thinking skills in breast cancer survivors from diverse racial backgrounds. Researchers will enroll 30 women aged 40+ who are at least five years past diagnosis. Participants complete sh…

This study tests whether watching a short educational video about safe opioid use can help people use fewer opioids after breast reconstruction surgery. About 68 women who have had a mastectomy for breast cancer will be randomly assigned to either watch the video or receive stand…

This study is looking at a specific type of breast cancer that has spread (metastatic) and is HER2-negative but has androgen receptors (AR-positive). Researchers want to see if a special PET/CT scan that detects a protein called PSMA can help predict which cancers will not respon…

This study is testing a mobile decision aid for breast cancer patients who have had surgery. Twenty participants will use the tool on their phones and share their thoughts out loud. Researchers will measure how much the tool improves knowledge about reconstruction options. The go…

This study tests whether educational tools can help breast cancer patients and their doctors better recognize and manage side effects from certain targeted drugs (antibody drug conjugates). About 30 patients and their clinicians will receive training and complete surveys to measu…

This study looks at people who have a gene variant (called a secondary finding) that was found during genetic testing for another reason. Researchers want to understand how these variants affect health and how people understand and share their results. Up to 5,000 participants wi…

This study aims to develop artificial intelligence (AI) that can help doctors make better, personalized decisions for patients with heart disease, breast cancer, or sepsis. The researchers are creating new AI methods that are not only accurate but also explainable and safe, so do…

This study aims to identify women at risk for hereditary breast, ovarian, and colorectal cancers who may not have easy access to genetic testing. Using mobile mammography units, researchers will offer genetic screening and counseling to 1,000 underserved women in Texas during the…

This study tests a new device that prepares blood samples to look for cancer cells and DNA. It includes 45 people: 20 healthy volunteers and 25 with advanced breast cancer. The goal is to see if the tool works well for liquid biopsy, which may help doctors find and monitor cancer…

This study looks at whether women who finished breast cancer treatment can safely switch to a simpler follow-up plan after two years. Instead of regular in-person visits, they would only need an annual mammogram. The goal is to see if this approach is safe and improves quality of…

This study looks at how many breast and lung cancer patients have a strong, ongoing fear that their cancer will return. Researchers will survey 200 patients and interview 40 of them to understand their feelings, thoughts, and whether they feel they get enough support. The goal is…

This study is for 500 adults with breast cancer who are about to start treatment like chemotherapy or immunotherapy before surgery. Researchers will collect tumor tissue, blood, and sometimes MRI scans and stool samples during treatment. The goal is to learn why some cancers shri…

This study tests a new AI program called Mirai that analyzes mammograms to predict breast cancer risk more accurately than current methods. Researchers will invite 200 women identified as high-risk by Mirai to receive an additional MRI scan. The goal is to see if using AI leads t…

This study collects mammogram images and survey responses from 20,000 adults to train artificial intelligence (AI) models. The goal is to improve how mammograms are read for different groups and types of breast cancer. Participants donate their images and may also get access to v…

This study collects blood and leftover tissue from 9,600 people with various solid tumors, such as breast, lung, and pancreatic cancer. The samples help researchers develop better tests to detect cancer recurrence and monitor treatment response. Participants provide samples and m…

This study looks at whether chemotherapy for early-stage breast cancer speeds up aging in different organs. Researchers will measure specific proteins and cell changes in blood samples from 80 women before and after treatment. The goal is to identify patients at higher risk for l…

This study aims to collect information from 25 adults with breast, lung, ovarian, multiple myeloma, or acute myelogenous leukemia. Participants will use a phone, tablet, or computer to complete weekly surveys about their symptoms for at least 12 weeks. The goal is to build a data…

This study is building a registry of 1000 breast cancer survivors aged 50 or younger who have dense breast tissue. Researchers will collect information from their regular MRI scans to better understand how well MRI works for finding cancer in dense breasts. The goal is to gather …

This study aims to create an artificial intelligence system that can predict if and where breast cancer will spread to other parts of the body, such as the bones, lungs, liver, or brain. Researchers will analyze tumor samples and health data from 2,000 women with breast cancer to…

This study looks at whether a special decision-making toolkit can help women aged 80 and older who have had breast cancer decide if they should continue getting yearly mammograms. The goal is to see if the toolkit helps them make more informed choices that match their personal he…

This study is testing a digital chatbot that provides educational information about mammograms to women who recently had one. Researchers want to see if using the chatbot helps women, especially those from underserved communities, follow screening recommendations and get needed f…

This observational study is testing whether advanced MRI scans can predict breast cancer response to chemotherapy earlier and more accurately than standard tumor size measurements. About 135 participants receiving standard chemotherapy will have MRI scans that also measure tumor …

This study follows 126 people with early-stage HER2-negative breast cancer who are prescribed olaparib by their doctor. Researchers will track how many complete the full 12-month treatment and look at genetic factors like BRCA mutations. The goal is to understand real-world use a…

This study is a registry that collects information from 200 people with stage III or IV inflammatory breast cancer (IBC) who have had a blood test called Signatera to look for leftover cancer cells (MRD). Researchers want to see how these test results relate to quality of life an…

This study is creating a Spanish version of a decision aid called BREASTChoice to help Spanish-speaking Latina breast cancer survivors learn about breast reconstruction options. Only 13.5% of Spanish-speaking Latinas get reconstruction after mastectomy, compared to 41% of others,…

This study looks at how hormone receptor-positive/HER2-negative breast cancer cells use energy (sugar). About 16 people with early-stage breast cancer will receive a special glucose infusion before surgery. Researchers will then analyze the tumor tissue to understand its metaboli…

This study aims to understand why some breast cancers with BRCA mutations become resistant to PARP inhibitor drugs. Researchers will analyze tumor and blood samples from 120 patients with advanced breast cancer to see if certain proteins (POLQ, Shieldin complex, 53BP1) can predic…

This study looks at 300 people with HER2-positive breast cancer that hasn't spread. Researchers want to see if those with very high HER2 levels respond differently to a combination of two targeted drugs (trastuzumab and pertuzumab). The goal is to understand if HER2 levels can pr…

This study collects blood or cheek swab samples from people with cancer who are being treated at the National Cancer Institute. Researchers want to analyze genetic differences that may affect how the body processes cancer treatments and influence side effects. The goal is to bett…

This study looks at whether artificial intelligence can help analyze tiny particles in the blood (called liquid biopsies) from people with triple negative breast cancer. The goal is to develop a test that tells doctors early on if the cancer has spread and how much tumor remains …

This study compares three types of remote medical interpreting (simultaneous, consecutive, and video) to see which one leads to fewer errors when Spanish- or Mandarin-speaking breast cancer patients talk with their English-speaking doctors. About 700 patients with stage II or III…

This study is for women with a certain type of breast cancer that is hormone-sensitive, HER2-negative, and has spread to 1-3 lymph nodes. Researchers want to see if it is safe to skip radiation therapy to the lymph nodes in patients whose tumors show a low risk of coming back on …

This study looks at how the cost of cancer treatment affects the finances of people with early-stage breast cancer. Researchers will follow 864 patients for one year, using a questionnaire to measure changes in financial distress. The goal is to understand what causes financial p…

This study looks at genetic changes (called HRD/HRR) in people with HER2-low breast cancer. Researchers will collect tumor and blood samples from 255 participants to see how common these changes are and whether they affect survival. No new treatments are tested—the goal is to lea…

This study is testing a new artificial intelligence (AI) tool called Ataraxis that analyzes images from breast cancer biopsies to predict how well a patient will respond to chemotherapy before surgery. The goal is to see if the tool can be easily used by doctors in everyday pract…

This study collects fluid from around the lungs (pleural fluid) from people with lung cancer, breast cancer, or lung infections. The goal is to build a registry of samples and health information for future research. No new treatments are tested—this is purely for learning and dis…

This study is a large registry that will follow 8,000 cancer patients treated with a new type of radiation machine called an MR-Linac, which combines an MRI scanner with a radiation beam. The goal is to see if this technology improves survival, tumor control, and quality of life …

This study tests whether a weekly electronic questionnaire can help catch cancer treatment delays early, especially among different racial groups. About 240 people with newly diagnosed breast or colorectal cancer will use the tool before starting treatment. The goal is to see if …

This study looks at whether certain fats from food are linked to breast cancer and body weight in postmenopausal women. Researchers will measure these fats in the blood and track weight, diet, and quality of life. 60 women will join, some with breast cancer and some without, and …

This study aims to measure how often and how severely breast cancer survivors experience menopause-related symptoms like vaginal dryness and pain. Researchers will compare women receiving hormone therapy or chemotherapy with healthy women. The goal is to better understand the bur…

This study looks at whether a probiotic supplement called BIOHM can change the bacteria and fungi living in the breast tumors and guts of 100 women with breast cancer. Researchers want to understand how these tiny organisms might affect cancer development. Participants will take …

This study looks at whether a new telehealth option can safely reduce the number of in-person doctor visits for people with breast or prostate cancer. About 1,750 participants from Memorial Sloan Kettering will be split into groups to compare standard care versus enhanced telehea…

This study looks at a new method to mark the area where breast cancer was removed during surgery. The goal is to help radiation doctors see the exact spot on scans so they can aim radiation more precisely. It also aims to reduce the need for repeat surgeries when cancer cells are…

This study is testing a new PET-CT scanner that takes detailed pictures of cancer tissue right after it is removed during surgery. Researchers want to see if these images match the standard lab analysis and if they help doctors make better decisions. About 850 people with prostat…

This study is building a platform to better understand who is at risk for developing or having a cancer recurrence. Researchers will collect blood and tissue samples from 850 people with breast, colon, ovarian, melanoma, or lung cancer to look for genetic markers and other biolog…

This study looks at whether using surgical mesh during breast reconstruction after mastectomy is helpful or not. About 120 women will be randomly assigned to get reconstruction with or without mesh. The goal is to see if mesh reduces complications and improves how satisfied women…

This study looks at tiny particles in the blood, called extracellular vesicles, to see if they can predict nerve damage caused by chemotherapy. About 120 adults with certain cancers will give blood samples and answer questions before, during, and after treatment. The goal is to f…

This study looks at how genes influence breast cancer risk. Anyone 18 or older living in the US can join, even if you don't have cancer. You fill out online surveys and mail in a saliva sample. Participants may get free genetic ancestry information.

This study is testing a new type of MRI, called TMEM-MRI, to see if it can measure how likely breast cancer is to spread. About 95 people with operable breast cancer will get this special scan before surgery. The goal is to see if the scan works well, not to treat the cancer dire…

This study is testing whether an artificial intelligence tool can help connect cancer patients with the right clinical trials. Researchers will enroll up to 50,000 people with various cancers to see if the AI improves trial enrollment rates and patient outcomes. The goal is to ma…

This study explores whether age-related differences in blood components can predict how well breast cancer patients respond to treatment. Researchers will compare blood samples from younger and older women with HR+HER2- breast cancer before and during therapy. The goal is to iden…

This study aims to collect and analyze genetic information from 25,000 adults who either have cancer or are at risk of developing it. Researchers will look at tumor DNA and other health records to better understand what drives different cancers. The goal is to find new ways to de…

This study compares two ways to mark non-palpable breast tumors before surgery: a magnetic clip versus a thin wire. Researchers will see which method costs less and works better, looking at how often the tumor is fully removed and patient satisfaction. About 772 women having brea…

This study looks at how a protein called Ki67 changes in breast cancer cells after 2 weeks of hormone therapy. Researchers want to see if women with a BRCA2 gene mutation have a different response compared to those without the mutation. About 42 postmenopausal women with ER+/HER2…

This study follows 2000 people with early-stage, hormone-positive breast cancer to see how doctors decide on treatments and how patients fare over 10 years. It compares those who get a special gene test (EndoPredict) with those who don't. The goal is to learn which treatments wor…

This study looks at whether brain MRI scans can find breast cancer that has spread to the brain in people with certain types of advanced breast cancer. About 214 participants will get regular brain scans to see if this helps catch problems early. The goal is to learn if screening…

This study looks at how antibiotics change the bacteria in the gut and breast after mastectomy with implant reconstruction. Researchers want to see if certain bacteria make infections more likely. About 200 women with breast cancer or a genetic risk will provide tissue and fluid …

This study analyzes the DNA of breast cancer tumors from 1,600 people to find genetic changes that could help doctors choose more targeted treatments. It uses a special test that looks at over 500 cancer-related genes. The goal is to see if this detailed genetic information leads…

This study looks at how well CDK4/6 inhibitors work for people with HR+/HER2- advanced breast cancer in everyday medical practice. It also explores which treatments doctors choose when the cancer stops responding to these drugs. The goal is to gather real-world data to help guide…

This study reviews 250 women who had breast-conserving surgery with a special flap technique that leaves no visible scar on the breast. The goal is to see how often cancer comes back at the edge of the removed tissue and how well the breast looks and feels afterward. Researchers …

This study aims to understand how well pre-operative therapy works for breast cancer and how it impacts long-term survival. Researchers will compare different treatment plans and patient characteristics in about 488 women with early or advanced breast cancer. The goal is to find …

This study tests a device called OneMark that helps doctors see breast cancer during surgery and follow-up scans. About 60 people with breast cancer will take part. The goal is to see if OneMark is easier to see than the current standard device, especially in women with dense or …

This study aims to understand why different people have different risks and outcomes for breast cancer. Researchers will collect blood, tissue samples, and survey data from 800 adults in South Florida. The goal is to find genetic and non-genetic factors that may explain these dif…

This study tests a magnetic tracer and clip to help surgeons locate lymph nodes in breast cancer patients before chemotherapy. About 459 adults will receive the injection before surgery to see how well it works. The goal is to improve detection and reduce the need for more invasi…

This study looks at whether body composition (like total body fat and BMI) changes how the chemotherapy drug docetaxel is processed in women with early breast cancer. Researchers will compare drug levels in obese, overweight, and lean patients using CT scans and blood tests. The …

This study collects tumor tissue from 10,000 women having breast cancer surgery. The samples are stored and used in future research to help doctors learn more about the disease. No treatment is given; the goal is to gather information for science.

This study is looking at small molecules called microRNAs in the blood of 80 women with breast cancer. Researchers want to see if changes in these molecules can predict how well chemotherapy works before surgery. The goal is to find a simple blood test that helps doctors choose t…

This study is building a large, diverse registry of people who have had breast cancer. Participants share their health information and samples to help researchers better understand the disease and improve care for everyone. The goal is to include up to 200,000 people from all bac…

This study explores whether using alternative and complementary therapies, like turmeric supplements, influences how well patients with early-stage breast cancer take their prescribed tamoxifen. Researchers will follow 200 participants for one day to measure adherence and tamoxif…

This study aims to find genetic markers that make some women more likely to experience early menopause after chemotherapy for breast cancer or Hodgkin lymphoma. Researchers will analyze stored ovarian tissue from 50 women who had fertility preservation before treatment. The goal …

This study is testing a virtual patient navigation program for 260 underserved adults who speak English, Chinese, or Spanish and have breast cancer or heart disease. The program uses a phone-based portal to connect patients with navigators who can help them manage their care. The…

This study looks at how often breast cancer that has spread to lymph nodes also spreads to other parts of the body after chemotherapy and surgery. About 120 people will get CT scans at the start and again after 6 months to check for distant spread. The goal is to better understan…

This study is a registry for people with triple negative breast cancer or those with inherited gene mutations linked to breast and ovarian cancer. It aims to learn how common these mutations are and how they affect treatment response and long-term survival. Participants must be w…

This study looks at how a woman's immune system reacts to breast cancer, especially if she has been pregnant before. Researchers will follow 800 young women with breast cancer to understand these interactions. The goal is to learn more, not to test a new treatment.

This study tests whether adding new experimental drugs to standard chemotherapy before surgery can improve outcomes for people with breast cancer. It enrolls 5,000 participants with early-stage or locally advanced breast cancer. The goal is to learn which drug works best for whic…

This study is testing a web-based app that lets cancer patients report side effects from radiation therapy in real time. The goal is to catch problems early and improve care. About 30 adults with gynecologic, urologic, or breast cancer will use the app to answer simple questionna…

This study collects tumor samples from 400 breast cancer patients at key moments—diagnosis, surgery, and if the cancer returns or spreads. Researchers will grow mini-tumors in the lab and study genes and immune cells to better understand the disease. No treatment is given; the go…

This study is looking back at medical records of 300 adults with breast cancer that has spread to only a few other parts of the body (oligometastatic). Researchers want to see if a precise type of radiation called stereotactic body radiotherapy (SBRT) can help control the cancer …

This study looks at whether measuring body fat before and after breast reconstruction surgery can help predict outcomes. About 40 women having a mastectomy followed by immediate reconstruction will take part. The goal is to see if these measurements are easy to collect and if the…

This study is testing whether women with early-stage breast cancer can stick to a special diet (ketogenic or low-protein) for about 9 days before their surgery. The goal is to see if this diet change is practical and to learn how it might affect cancer cells and the body's immune…

This study aims to help Black individuals and their families in Houston learn about their risk for hereditary cancers like breast and colorectal cancer. Participants will fill out a simple genetic risk screening questionnaire and can receive genetic counseling and testing through…

This study is for people with invasive breast cancer who had chemotherapy before surgery but still had some cancer left after surgery. Researchers will take blood samples over time to look for tiny pieces of tumor DNA. The goal is to see if these DNA fragments can help predict wh…

This study enrolls 3,300 women with invasive breast cancer in North Carolina to see how a program that teaches communication and self-advocacy skills can improve their care and outcomes. Researchers will also look at tumor biology and social factors to understand why some groups,…

This study looks at how well older women (70+) with breast cancer tolerate CDK4/6 inhibitor drugs compared to younger women. Researchers will track side effects and whether treatment needs to be changed. The goal is to fill a gap in knowledge since most drug studies focus on youn…

This study follows 500 breast cancer patients whose cancer has returned in the same area. They will receive radiation again, with or without heat therapy (hyperthermia). The goal is to compare side effects, quality of life, and survival over five years to help doctors and patient…

This study looks at how a common breast cancer drug called an aromatase inhibitor changes the bacteria in your gut. Researchers want to see if these changes affect estrogen levels in the body. About 25 women starting this drug will provide stool and blood samples over 12 weeks.

This study is testing a special blood test that catches cancer cells floating in the bloodstream of breast cancer patients who have already completed chemotherapy and surgery. Researchers want to see if the number of these cells can help predict whether the cancer will come back.…

This study looks at whether women having breast reconstruction after mastectomy are comfortable being randomly assigned to receive either a biological or synthetic mesh. Sixty women will take part and be followed for six months. The goal is to see if a larger future study compari…

This study looks at whether watching an animated video before DIEP flap breast reconstruction surgery helps patients understand the procedure better and feel less anxious. About 300 adults scheduled for this surgery will fill out surveys before and after watching the video, and a…

This study looks at whether it's possible and acceptable to take multiple small tissue samples (biopsies) from different tumor spots in people with advanced breast cancer, at different times during their treatment. The goal is to learn how the cancer changes and becomes resistant…

This study collects leftover tumor tissue and a one-time blood sample from people with breast cancer or precancerous breast conditions during their scheduled medical procedures. Researchers will analyze these samples to identify cancer-related markers and gene patterns. The goal …

This study is for people with a certain type of advanced breast cancer (lobular) that is hormone receptor-positive. Researchers want to see if special PET scans and blood tests can detect early signs that the cancer is not responding to hormone therapy. The goal is to find better…

This study is creating and improving educational materials about genetic testing for people with breast, ovarian, prostate, pancreatic, or colorectal cancer. Researchers will interview 445 patients from diverse cultural and language backgrounds to get their feedback. The goal is …

This study is testing whether a blood test that looks for tumor DNA (ctDNA) can find cancer returning sooner than standard scans. Researchers will follow 100 people with various solid tumors to see if early detection leads to better treatment options. The goal is to improve how w…

This study aims to map the genetic makeup of breast and prostate cancers in patients treated through Brazil's public health system. Researchers will analyze tumor and normal DNA from 882 participants to identify mutations linked to prognosis and treatment response. The goal is to…

This study aims to understand how certain proteins called selenoproteins relate to triple-negative breast cancer (TNBC), an aggressive type. Researchers will look at tissue samples from past patients and blood samples from up to 300 current patients and 100 healthy volunteers. Th…

This study looks at how the chemotherapy drug paclitaxel is processed in cancer patients with low muscle mass. Researchers want to see if giving the drug over a longer time (2-3 hours instead of 1 hour) helps these patients reach the same drug levels as patients with normal muscl…

This study is for people with metastatic breast cancer (cancer that has spread). It will test whether using specific biomarkers (biological clues from tumors or blood) can help doctors pick the best standard treatment for each person. About 700 participants will receive therapy b…

This study looks at whether a family history screening program can help more women in rural public health clinics get tested for genetic risks linked to breast and ovarian cancer. About 3,200 women will take part to see if the program increases screening and follow-up care. The g…

This study tests whether daily CT scans can help doctors see and protect the ovaries during pelvic radiation in women under 50 with various cancers. The goal is to keep radiation doses to the ovaries low enough to avoid early menopause and infertility. Ten participants will recei…

This study follows 475 women with breast cancer or lymphoma to understand how their treatments impact sexual function, fertility, and family-building decisions. Participants complete questionnaires and may optionally provide blood samples to measure ovarian health. The goal is to…

This study looks at whether regular brain MRIs can find cancer spread to the brain early in people with HER2-positive metastatic breast cancer. About 69 participants will either get routine brain scans or only have scans if symptoms appear. The goal is to see if this approach is …

This study is testing a new, highly sensitive blood test to detect tiny particles called extracellular vesicles released by breast cancer cells. Researchers will compare levels of these particles in 105 women with early or metastatic breast cancer and healthy volunteers. The goal…

This study collects small samples of breast tumor tissue from people with known or suspected breast cancer. The samples are stored in a tissue bank and used by researchers to study the biology of breast cancer, including how it grows and responds to treatments. The goal is to imp…

This study looks at how certain immune cells, called MDSCs, may stop the body's natural killer cells from fighting breast cancer. Researchers will collect blood or tumor samples from 99 adults with early-stage breast cancer. The goal is to understand how these cells work, not to …

This study looks at whether a special breathing technique during radiation therapy for breast cancer keeps the radiation dose on target and away from healthy organs. About 25 women who have had breast cancer surgery will be observed. The goal is to see if the treatment plans are …

This study surveys 2000 breast cancer patients and their doctors to understand current care and communication. The goal is to identify gaps and develop better, patient-focused care models. Participants complete questionnaires about their experiences and needs.

This study looks for tiny bits of tumor DNA left in the blood after surgery in 100 women with early-stage breast cancer that spread to 1-3 lymph nodes. The goal is to see if this test can find women at higher risk of the cancer coming back. The study specially includes African Am…

This study looks at a method called target axillary dissection (TAD) to see if it can accurately tell whether breast cancer has spread to lymph nodes after chemotherapy. Researchers will compare TAD results with standard surgery in 162 people with locally advanced breast cancer. …

This study looks at the best times to send messages that encourage physical activity to older adults (65+) who have survived certain cancers and still have chronic pain. Researchers will track activity with a wearable device and ask participants to rate their pain four times a da…

This study aims to understand the genetic and molecular causes of breast and prostate cancer in people of African ancestry. Researchers will collect blood and tumor samples from 1,500 participants across nine countries and the US, along with information about lifestyle and social…

This study looks at whether a simple blood test can find signs of breast cancer returning before it shows up on scans. About 976 people who had surgery for a common type of early breast cancer will give blood samples over time. If the test detects cancer DNA, participants may rec…

This study looks at whether giving doctors extra genetic information about a patient's metastatic breast cancer tumor helps them choose better treatments. Currently, doctors use standard hormone receptor tests to guide therapy. This trial will test if a more detailed genetic prof…

This study takes tumor samples from people with breast, colorectal, or ovarian cancer and grows them in mice. Researchers then test different drugs on these mouse-grown tumors to see which ones work best. The goal is to match each patient with a treatment that is most likely to s…

This study looks at how doctors currently diagnose lung and breast cancer using tissue samples, and tests whether artificial intelligence (AI) can help make the process faster and more accurate. Researchers will review medical records from 600 adults to measure how long diagnosis…

This study looks at whether changes in a blood marker called ctDNA can help doctors know early on if immunotherapy is working for people with advanced cancers like lung, breast, or colorectal cancer. About 50 adults with stage IV cancer who are starting immunotherapy will give bl…

This observational study will use artificial intelligence to analyze stored tumor tissue samples from 400 women with breast cancer. The goal is to see if the AI can accurately predict which patients are at risk of the cancer spreading (metastasis) within 5 years after surgery. No…

This study looks at whether giving breast, prostate, and colorectal cancer survivors a personal referral to a tailored nutrition and exercise program helps them eat better and move more. Researchers will track how many survivors agree to join, complete the sessions, and feel sati…

This study looks at whether sharing a patient's genetic information with their cancer doctor can help personalize chemotherapy doses and reduce serious side effects. About 860 adults with certain cancers (like breast or gastrointestinal) will be randomly assigned to either have t…

This study tests whether a large language model (a type of AI) can help junior doctors write more accurate and efficient cancer treatment reports. 60 junior doctors will be split into two groups: one uses AI assistance, the other uses traditional methods. Their reports will be sc…

This study looks at whether special imaging (lymphoscintigraphy) can help doctors find the sentinel lymph nodes in people with inflammatory breast cancer. About 50 women with stage III inflammatory breast cancer will take part. The goal is to improve surgical accuracy and underst…

This study follows 100 people with stage III triple-negative breast cancer who are receiving standard treatment. Researchers will track quality of life through questionnaires and monitor tumor DNA in the blood over time. The goal is to understand how treatment affects well-being …

This study follows up with people who previously received a type of gene therapy (using poxviral vectors) for cancers like prostate, liver, breast, colon, or lung cancer. The goal is to monitor their health annually for 15 years to check for any long-term side effects, since gene…

This study looks at breast cancer risk and screening in people aged 30-75 who are on hormone therapy. Researchers will collect imaging data and interview participants to understand their experiences and identify barriers to screening. The goal is to improve early detection and ca…

This study is monitoring the safety and effectiveness of the drug capivasertib when used in routine care for breast cancer patients in Korea. About 130 people who are already prescribed the drug by their doctor will take part. The goal is to find any side effects and see how well…

This study collects and stores tissue, blood, and urine samples from up to 4,000 women with or without breast cancer. The goal is to create a repository of DNA, RNA, and proteins linked to pathology specimens. This resource will help researchers better understand breast cancer an…

This study compares a new 3D imaging method (digital breast tomosynthesis) with standard 2D imaging during breast-conserving surgery for early-stage breast cancer. The goal is to see if the 3D method helps surgeons remove all cancer cells in one operation, reducing the need for a…

This study is looking at whether clusters of tumor cells found in the blood can help predict how well treatment works in people with high-risk early breast cancer. Researchers will follow 130 participants before and after chemotherapy to see if those with these cell clusters have…

This study looks at why some hormone receptor-positive breast cancers become resistant to standard hormone therapy. About 100 women with early-stage breast cancer will receive anti-estrogen treatment for 4-12 weeks before surgery. Researchers will analyze tumor samples to see how…

This study aims to improve a tool that helps women aged 39-49 in rural areas decide whether to get a mammogram. Researchers will test the tool with and without a summary for their doctor, compared to usual care. About 39 women and their doctors will participate to see what works …

This study looks at what breast cancer survivors and their family members know about chemicals in everyday products like lotions and makeup that might affect hormones. Researchers also want to see if there is a link between being overweight and these chemicals. About 30 people fr…

This study looks at whether a decision aid tool called RECONJOINT can help women with breast cancer or a genetic risk make informed choices about breast reconstruction after mastectomy. Researchers want to see if it's practical to run a larger study on this tool. About 131 partic…

This study looks at whether a simple blood test can find tiny bits of cancer DNA left in the body after breast cancer treatment. Finding these leftover cells, called minimal residual disease, may help predict if the cancer will come back. The study will follow 900 breast cancer p…

This study is collecting information from 200 breast cancer patients whose cancer has spread to a few lymph nodes under the arm. Doctors want to see if a newer, less invasive biopsy method (targeted sentinel node biopsy) works as well as standard approaches. The goal is to reduce…

This study tests whether a new radioactive tracer can safely highlight tumors on PET/CT scans in people with solid cancers like colon, lung, or breast cancer. About 32 adults will receive a single injection of the tracer, which targets a sugar found on many cancer cells but not o…

This study looks at how well the drug ribociclib works for people with early-stage (stage II or III) hormone receptor-positive, HER2-negative breast cancer when used in routine medical care. Researchers will track 3,000 participants to see how long they stay cancer-free, how they…

This study enrolls 3,000 women with at least twice the normal risk of developing breast cancer. Researchers collect breast tissue samples and blood to build a better risk-prediction tool and find markers that could one day help prevent the disease. Participants are followed over …

This study collects and analyzes information from 30,000 breast cancer patients treated at the Bergonie Institute since the 1990s. Researchers aim to understand survival rates, treatment patterns, and factors that affect outcomes. No new treatments are tested—this is purely an ob…

This study looks at spinal fluid from 69 people with breast cancer that has spread to the brain or its lining. By analyzing genetic material shed by cancer cells into the fluid, researchers hope to understand why some breast cancers spread to the brain and find better treatments.…

This study is for people with a certain type of advanced breast cancer (ER+/HER2-). It aims to see how three common drugs (abemaciclib, ribociclib, or palbociclib) change body composition—like fat and muscle—over 24 weeks. Researchers will use CT scans and DEXA scans to measure t…

This study is testing a new type of CT scan called HyperSight, which may produce clearer images than current scans used during radiation therapy. About 50 adults with various cancers (head and neck, breast, lung, liver, or others) will receive the new scan in addition to their st…

This study looks at whether a blood test called DiviTum, which measures a protein linked to cancer growth, can help doctors monitor women with advanced breast cancer. About 55 participants will be followed to see if the test results lead to fewer routine scans and blood tests. Th…

This study tests a training program called 'Just ASK™' that helps doctors and nurses talk to breast cancer patients about joining clinical trials. Researchers will compare how often these discussions happen before and after the training. The goal is to see if the program works an…

This study follows 800 adults with advanced HER2-positive, HER2-low, or HER2-ultralow breast cancer who are receiving the drug trastuzumab deruxtecan as part of their normal care in Germany. Researchers will track how long patients stay on treatment, their quality of life, and an…

This study looks at how willing and able women with non-metastatic breast cancer are to make healthier food choices. About 200 women who have finished their main cancer treatment will fill out online surveys and review an educational flyer about diet and cancer. The goal is to un…

This study is testing a new way to remove a breast (mastectomy) for cancer using a small cut in the armpit, leaving no visible scar on the breast. It is for women with small to medium-sized breasts who need a mastectomy but want to keep their nipple. The goal is to see if this te…

This study is for people with triple-negative breast cancer who still have signs of cancer after standard chemotherapy. Researchers will use a simple blood test (liquid biopsy) to look for tumor DNA and see if it can tell who will benefit from the drug capecitabine. The goal is t…

This study looks at how hormone treatments for prostate and breast cancer affect sleep quality. Researchers will monitor 60 patients using sleep tests, questionnaires, and activity trackers before treatment starts and again at 6 and 12 months. The goal is to understand if these t…

This study looks at whether the quality of sleep before breast cancer surgery affects pain and inflammation after the operation. Researchers will track 150 women, measuring their sleep quality, blood markers of inflammation, and pain levels. The goal is to see if poor sleepers ha…

This study collects blood, tissue, urine, saliva, and surgical drainage samples from 7,000 people with various cancers who have had or will have treatment aimed at curing their cancer. Researchers will analyze these samples for tiny traces of cancer DNA (called molecular residual…

This study aims to find out if certain changes in the CTNNA1 gene increase the risk for stomach and breast cancers. Researchers will collect family health history from 100 adults who carry this gene change or are close relatives of a carrier. The goal is to better understand whic…

This study aims to understand why some breast cancers become resistant to treatment. Researchers will analyze tumor and blood samples from 320 people with different types of breast cancer. The goal is to find changes in the cancer that allow it to keep growing despite therapy. Th…

This study looks at women who have had a mastectomy (breast removal) for breast cancer and also need radiotherapy. It compares different types of breast reconstruction—using implants or the patient's own tissue—and different timing (before or after radiation). The goal is to find…

This study collects blood, tissue, urine, saliva, and stool samples from adults with cancer (and healthy volunteers) to learn how certain immune cells change before and after chemotherapy. Researchers will also analyze genetics and link results to patient outcomes. No treatment i…

This study tests a program called CARES that provides support, education, and resources to rural cancer patients. The goal is to see if it helps them start treatment sooner and finish it on time. About 320 adults with cancers like lung, breast, or colon cancer will take part. The…

This study looks at how sleep issues impact memory, thinking, and quality of life in women treated for breast cancer. Researchers will track sleep patterns and mental function in 75 patients aged 39 to 69. The goal is to understand the link between sleep and cognition to develop …

This study aims to create a computer algorithm that can predict whether a breast cancer tumor will completely disappear after chemotherapy given before surgery. Researchers will collect medical images, lab tests, and genetic data from 300 early-stage breast cancer patients. The g…

This study looks at how social factors like stress and support might be linked to inflammation in women newly diagnosed with breast cancer. About 200 participants will fill out questionnaires and give one blood sample. The goal is to understand these connections, not to test a tr…

This study looks at whether a simple blood test can predict serious side effects from radiation therapy in women who have had a mastectomy (breast removal) followed by immediate breast reconstruction with an implant. The test, called NovaGray RILA Breast®, measures how sensitive …

This study is creating a large database of medical information and biological samples from adults with or at risk for many types of cancer, as well as healthy volunteers. The goal is to help researchers better understand what causes cancer, how it progresses, and how to improve p…

This study takes leftover breast cancer tissue from patients who still have cancer after initial treatment and uses it to create personalized tumor models in mice and lab dishes. The goal is to learn why some cancers resist treatment and to test new drug combinations. Adults with…

This study is looking at how often breast cancer that has spread to the brain can be found early with an MRI in people with certain high-risk types (triple negative or HER2+ stage IIb or III). About 100 participants will get a brain MRI, give a blood sample, and answer a question…

This study explores whether an algorithm called ENLIGHT can identify approved drugs that might work better for people with advanced breast cancer that has stopped responding to standard treatments. About 175 adults with triple-negative or hormone-resistant breast cancer will have…