BREAST CANCER

This early-stage trial is testing a vaccine designed to help the immune system recognize and attack HER2-positive breast cancer cells. The vaccine contains two small pieces of the HER2 protein, similar to existing drugs, to trigger an immune response. The study will enroll 36 adu…

This early-stage trial tests a new vaccine called ES2B-C001, with or without an immune booster (adjuvant), in 40 people with HER2-positive metastatic breast cancer who have already tried other treatments. The vaccine is designed to help the body's immune system recognize and atta…

This early-phase trial tests a personalized vaccine made from a patient's own immune cells (dendritic cells) trained to recognize unique proteins from their leftover breast tumor after standard chemotherapy and surgery. The goal is to see if the vaccine is safe and can boost the …

This study tests a new drug called BMS-986507, alone or with other cancer medicines, in adults with advanced lung or breast cancer that has spread. The goal is to check safety, side effects, and how well the drugs work. About 416 participants will receive different combinations t…

This study follows 650 women aged 18 to 65 who receive Eurosilicone LunaXT silicone breast implants for cosmetic augmentation or reconstruction after mastectomy. Researchers track how often the implants rupture or cause severe capsular contracture (hardening of scar tissue) over …

This phase 2 trial tests whether a patient's own white blood cells, genetically modified in a lab to recognize and attack their specific tumor mutations, can shrink metastatic cancers. Participants include people with several advanced solid tumors or multiple myeloma who have exh…

This study compares a one-week ultra-hypofractionated radiation regimen (26 Gy in 5 fractions) to the standard three-week moderate hypofractionated regimen (40 Gy in 15 fractions) for treating lymph nodes after breast cancer surgery. The goal is to see if the shorter course is ju…

This study tests a program called OPTIMISE that helps cancer patients manage other chronic conditions like diabetes or high blood pressure during treatment. It assigns a nurse navigator to improve communication between cancer doctors and primary care doctors. About 340 patients w…

This early-phase study tests a new drug called XMT-1660 in about 319 people with advanced solid tumors, including breast, ovarian, and endometrial cancers. The main goals are to find the safest dose and check for side effects. Researchers will also see if the drug shrinks tumors.…

This trial investigates whether sulforaphane, a nutrient found in broccoli, can reduce heart damage caused by the chemotherapy drug doxorubicin in breast cancer patients. About 70 participants will receive either sulforaphane or a placebo alongside their chemotherapy. The study m…

This phase 3 trial is testing whether premenopausal women with a common type of breast cancer (HR+/HER2-) can safely skip chemotherapy if their tumor responds well to hormone therapy before surgery. About 950 women will be randomly assigned to either standard surgery first or hor…

This study tests a new drug called rezatapopt (PC14586) in people with advanced solid tumors that have a specific TP53 Y220C mutation. The drug is designed to reactivate the p53 protein, which normally helps stop cancer growth. The trial will also test rezatapopt combined with th…

This phase 2 trial tests whether a new drug called culmerciclib, combined with fulvestrant, works better than standard CDK4/6 inhibitors plus fulvestrant for people with HR-positive, HER2-negative breast cancer that has worsened after first-line hormone therapy. About 98 women ag…

This phase 2 trial is testing whether giving a short course of targeted radiation (SBRT) followed by a reduced-dose chemotherapy (nab-paclitaxel) plus an immunotherapy drug (toripalimab) before surgery can improve outcomes for people with HR-positive, HER2-negative breast cancer.…

This early-stage trial is testing a new type of immune cell therapy called CAR-T cells that target a protein called B7-H3 on triple-negative breast cancer cells. The cells also have a safety switch to stop them if needed. Up to 42 adults whose cancer has returned or not responded…

This early-stage trial is testing a new type of radiation therapy that seeks out and attacks cancer cells while sparing healthy tissue. It's for people with advanced breast, lung, stomach, or bladder cancer who have run out of standard options. The study will check if the treatme…

This study looks at how well ribociclib, a targeted cancer drug, works when added to hormone therapy for people with HR+ HER2- stage II or III breast cancer. It will follow about 2,766 patients in Russia, comparing those who get ribociclib plus hormone therapy to those who got ho…

This study is for women whose breast cancer has come back after initial breast-conserving surgery and whole breast radiation. The standard treatment after repeat surgery is radiation twice a day for 30 sessions. This trial tests whether giving radiation once a day for 15 sessions…

This Phase 3 trial is testing whether a new drug called datopotamab deruxtecan (Dato-DXd), given alone or with another drug called durvalumab, works better than standard chemotherapy for people with a certain type of advanced triple-negative breast cancer (PD-L1 positive). About …

This study tests a new treatment using specially engineered immune cells (4SCAR-T cells) that target three different markers on breast cancer cells: GD2, Her2, and CD44v6. The goal is to see if this approach is safe and can shrink tumors in people with advanced or relapsed breast…

This study tests whether combining the drug inavolisib with other treatments can safely shrink or eliminate early-stage breast tumors that have a specific genetic change (PIK3CA mutation). About 60 people with untreated stage II-III breast cancer will receive the drug combination…

This study tests whether slowly increasing the dose of the drug abemaciclib over three weeks helps patients with early-stage HR+HER2- breast cancer stay on the full approved dose. About 50 participants will receive the drug alongside hormone therapy. The main goal is to see if mo…

This study tests a new treatment called 4SCAR-CD44v6 T cells for people with cancers that have a specific protein called CD44v6. The therapy uses a patient's own immune cells, modified to better recognize and attack cancer cells. The trial will enroll 100 participants to check sa…

This study is for people with breast cancer who need a mastectomy (breast removal) followed by immediate breast reconstruction using their own tissue. It compares two ways of giving radiation before surgery: the standard longer course versus a shorter course with fewer, higher do…

This phase 3 trial tests whether a shorter, higher-dose radiation schedule (3 weeks) is as safe and effective as the standard 5-week schedule for women with high-risk breast cancer who have had a mastectomy and immediate implant reconstruction. The study will enroll 506 women and…

This early-phase trial tests two radioactive drugs, [177Lu]Lu-A9-0631 and [225Ac]Ac-A9-0642, in people with advanced solid tumors that have a protein called GRPR on their surface. These cancers include certain breast, prostate, and colorectal cancers that have stopped responding …

This study tests whether adding AGuIX gadolinium-based nanoparticles to standard brain radiation can better control brain metastases that are at high risk of coming back. About 134 adults with certain cancers (like melanoma, lung, breast, or colorectal) that have spread to the br…

This study tracks the safety and effectiveness of Piqray (Alpelisib) in people with a specific type of advanced breast cancer (HR+, HER2-, with a PIK3CA mutation). It includes postmenopausal women and men whose cancer worsened after hormone therapy. Researchers observe patients i…

This trial tests a new approach to breast reconstruction after cancer surgery. Doctors take a patient's own fat and mix it with a substance made from their blood (platelet-rich fibrin) to create a 'lipobolus' that fills the gap left by tumor removal. The goal is to see how much o…

This study is testing whether women with early-stage breast cancer that has not spread to lymph nodes can safely skip radiation therapy after a lumpectomy, if their tumor completely disappeared with chemotherapy. The trial will enroll 352 women and follow them for cancer recurren…

This study tests a new drug called AZD8205, alone or with another drug (rilvegostomig), in people with advanced solid tumors like breast, ovarian, and lung cancers. The trial has two phases: first to find the safest dose, then to see if it shrinks tumors. About 460 adults whose c…

This Phase 2 trial is testing two experimental drugs (SSGJ-705 and SSGJ-612) with or without chemotherapy in 150 adults with advanced HER2-positive solid tumors, including colorectal, bladder, breast, bile duct, and stomach cancers. The goal is to see if the combination can shrin…

This study tests a new treatment for adults with certain cancers (pancreatic, kidney, breast, melanoma, or ovarian) that have a protein called CD70. Doctors take a sample of your blood, modify your white blood cells in a lab to recognize and attack CD70, and then give them back t…

This study tests a new drug called GDC-4198, alone or combined with another drug (giredestrant), against a standard treatment (abemaciclib plus giredestrant) in people with advanced ER+/HER2- breast cancer that has worsened after prior CDK4/6 inhibitor therapy. The trial has two …

This phase 3 trial is testing a new drug called palazestrant (OP-1250) combined with ribociclib against the standard letrozole plus ribociclib for people with ER+, HER2- advanced breast cancer who haven't had prior treatment. About 1,000 participants will be randomly assigned to …

This early-stage trial is testing a new drug called IM-1617 in people with advanced solid tumors (cancers that have spread or can't be removed by surgery). The study has two parts: first, finding a safe dose, then testing that dose in more people to see how well it works and how …

This phase 2 trial is testing a combination of two drugs—deruxtecan (a targeted chemotherapy) and ivonescimab (an immunotherapy)—in people with hormone receptor-positive, HER2-negative advanced breast cancer. The study aims to see how well the combination shrinks tumors and how s…

This study tests a new drug called IMP1734 in people with advanced solid tumors (breast, ovarian, or prostate cancer) that have not responded to prior treatments. The main goals are to check safety, find the right dose, and see if it shrinks tumors. About 156 participants will ta…

This phase 2 trial is testing whether adding a drug called inavolisib to two standard treatments (ribociclib and fulvestrant) can shrink tumors or slow cancer growth in people with advanced hormone-receptor-positive, HER2-negative breast cancer that has a specific genetic change …

This study is testing two different radiation schedules for women with early breast cancer who have had a lumpectomy. One group gets radiation over one week, the other over two weeks with an extra boost to the tumor site. Researchers will compare side effects, breast appearance, …

This study tests whether adding a precise local treatment—like focused radiation or ablation—can help people whose cancer has a few new or growing spots while on standard therapy. Participants continue their usual medication while the resistant tumors are treated directly. The go…

This study tests whether tirzepatide, a drug used for diabetes and weight loss, is practical and acceptable for postmenopausal women who have had hormone receptor-positive breast cancer and are obese. Thirty participants will take the drug weekly for 24 weeks, with monthly check-…

This early-stage trial is testing a new type of immune cell therapy for people with advanced cancers that have a specific protein called KK-LC-1. The cancers being studied include stomach, breast, cervical, and lung cancer. Participants will receive chemotherapy followed by a sin…

This early-stage study tests a new treatment called NT-175 for people with advanced solid tumors (like lung, colon, or breast cancer) that have a specific mutation (TP53 R175H) and a certain immune marker (HLA-A*02:01). NT-175 is made from a patient's own immune cells, which are …

This study tests a new radiation approach for early breast cancer that uses real-time MRI guidance to deliver just three high-dose sessions over one week, instead of the usual several weeks. The goal is to see if this shorter treatment is safe, preserves the breast's appearance, …

This study tests a new treatment for people with metastatic breast or prostate cancer that has stopped responding to standard therapies. Participants receive infusions of their own immune cells that have been armed with a special antibody to help them find and attack cancer cells…

This early-stage trial tests a new drug called HRS-6209 combined with standard hormone therapies (fulvestrant or letrozole) in people with a certain type of advanced breast cancer (HR-positive/HER2-negative). The main goal is to check safety and find the right dose. About 15 part…

This study compares a combination of two drugs (elacestrant and capecitabine) to capecitabine alone in people with advanced estrogen receptor-positive breast cancer that no longer responds to CDK 4/6 inhibitors. About 297 participants will be randomly assigned to one of the two t…

This phase 3 trial is testing trastuzumab deruxtecan (T-DXd), a drug that delivers chemotherapy directly to cancer cells with a specific marker (HER2). It includes 250 people with advanced breast cancer that has low or even no HER2, which is often harder to treat. Participants re…

This study tests a combination of two drugs—elacestrant and trastuzumab deruxtecan—in people with a specific type of advanced breast cancer (HR-positive, HER2-low or ultralow) that has stopped responding to standard hormone therapy and CDK4/6 inhibitors. The goal is to find the s…

This study compares two drug combinations for people with a type of advanced breast cancer (HR+/HER2-) that has a specific genetic change (PIK3CA mutation) and has worsened after prior treatment. About 540 adults will receive either the experimental drug RLY-2608 plus fulvestrant…

This early-phase trial tests a new drug that delivers radiation directly to cancer cells carrying a specific protein called GRPR. The study includes 48 adults with advanced cancers like prostate, breast, lung, or colon cancer that have not responded to standard treatments. The ma…

This study tests a new drug called HRS-6209, taken as a capsule, combined with either letrozole or another drug HRS-2189 in 80 women with breast cancer. The goal is to find a safe dose and see if the combination can shrink tumors. It is an early-stage trial, so the main focus is …

This study tests two different doses of inavolisib combined with fulvestrant in people with a specific type of advanced breast cancer (PIK3CA-mutated, HR-positive, HER2-negative). About 80 participants whose cancer worsened after prior treatment will receive the drug combo. The g…

This early-phase trial is testing an experimental drug called CX-5461 (Pidnarulex) in people with advanced solid tumors (pancreatic, prostate, breast, or ovarian) that have specific BRCA2 or PALB2 gene mutations. The main goal is to find a safe and tolerable dose for future studi…

This phase 2 trial tests a drug called zanidatamab in about 200 adults with advanced HER2-positive cancers, including breast, lung, stomach, and others. Participants have already tried at least one standard treatment. The study measures how many tumors shrink or disappear. Zanida…

This early-phase trial is testing an experimental oral drug called RGT-490 in about 63 adults with advanced solid tumors (including certain breast, ovarian, and endometrial cancers) that have a PIK3CA gene mutation and have stopped responding to standard treatments. The main goal…

This study tests a new drug called STX-478 in people with advanced solid tumors that have a specific genetic change (PI3Kα mutation). The trial has two phases: first, it tests STX-478 alone to find safe doses; then, it combines STX-478 with other cancer drugs like fulvestrant or …

This phase 3 trial tests an immunotherapy called GLSI-100 in 750 people with HER2-positive breast cancer who are at high risk of their cancer returning after standard treatment. Participants receive a series of injections over a year to help their immune system target and destroy…

This study looks at whether giving hormone therapy before breast-conserving surgery helps reduce leftover cancer cells at the edges of removed tissue. It involves 176 postmenopausal women with stage 2-3 ER+/HER2- invasive lobular carcinoma. The goal is to see if this approach lea…

This study tests whether adding tivozanib (a drug that targets blood vessel growth) to atezolizumab (an immunotherapy) can help the immune system attack cancers that normally resist immunotherapy. The trial includes people with several cancer types like bile duct, pancreatic, pro…

This Phase 2 trial tests an oral drug called BAY 2927088 (sevabertinib) in about 111 adults with advanced solid tumors that have HER2 gene mutations. The drug aims to block the abnormal HER2 protein and stop cancer growth. Participants take a 20 mg tablet daily in 3-week cycles u…

This phase 2 trial is testing a drug called zanidatamab in 20 people with early-stage, low-risk HER2-positive breast cancer. The drug is given intravenously, along with hormone therapy pills (letrozole or tamoxifen). The main goal is to see if the cancer disappears completely by …

This study is for people with a high-risk type of breast cancer (ER+/HER2-) who have finished initial treatment but still face a chance of the cancer coming back. Researchers will use a simple blood test to look for tiny bits of tumor DNA. If found, participants will be randomly …

This early-phase study is testing an experimental drug called CLR 125 in 60 people with advanced triple-negative breast cancer that has not responded to prior treatments. The main goals are to find the safest and most effective dose and to understand what side effects occur. Part…

This early-phase study is testing a new oral drug called BG-75202, alone or with other medications, in people with advanced breast cancer or other solid tumors that have not responded to standard treatments. The main goals are to check the drug's safety, find the right dose, and …

This study looks at whether adding chemotherapy to standard hormone therapy (which suppresses ovarian function) can better prevent breast cancer from coming back in premenopausal women with early-stage, hormone-sensitive breast cancer. About 3,960 participants will be randomly as…

This study tests whether adding the drug inavolisib to standard hormone therapy and a CDK4/6 inhibitor can help people with a specific type of advanced breast cancer (PIK3CA-mutated, HR+, HER2-). About 450 adults whose cancer has not been treated yet in the advanced setting will …

This early-stage trial tests a new drug, GDC-0587, alone or with another drug (giredestrant), in people with advanced ER-positive, HER2-negative breast cancer whose cancer worsened after prior CDK4/6 inhibitor therapy. The study aims to find safe doses and check for side effects.…

This study tests a new drug called ifinatamab deruxtecan in people with advanced solid tumors that have not been cured by other treatments. The goal is to find the safest dose and see if the drug can shrink tumors. About 250 participants will take part, and those who benefit may …

This study tests two drugs, camizestrant and ribociclib, together in people with advanced hormone receptor-positive (HR+) breast cancer. The goal is to see if the combination can delay cancer growth better than current treatments. About 150 adults who have already received hormon…

This phase 3 trial compares an all-oral drug combination (pyrotinib, trastuzumab, and dalpiciclib) against standard chemotherapy plus targeted drugs for advanced HER2-positive breast cancer. About 502 patients who have had at most one prior treatment will be enrolled. The goal is…

This study tests whether a 1-week course of partial breast radiation is safe and effective for women who have had a breast cancer recurrence after prior whole-breast radiation. Participants will receive targeted radiation after breast-conserving surgery to remove the new tumor. T…

This early-stage trial tests the drug abemaciclib (a CDK4/6 inhibitor) given together with targeted radiation for people with metastatic HR+ HER2- breast cancer that has spread to bone. The main goal is to find the safest dose of abemaciclib when combined with radiation. About 28…

This Phase 2 trial at Fudan University tests several targeted drug combinations given before surgery for early-stage breast cancer. The goal is to see which combinations best eliminate all signs of cancer (pathological complete response) based on each tumor's specific subtype. Ab…

This study tests a new drug called elacestrant against standard hormone therapy in people with a certain type of early breast cancer (ER+/HER2-) that has spread to lymph nodes and has a high chance of returning. About 4,220 participants will be randomly assigned to receive either…

This study tests whether a drug called ribociclib can safely replace chemotherapy for women with a common type of early breast cancer (HR+ HER2-). About 3,900 women at intermediate risk of recurrence will receive either standard hormone therapy plus ribociclib or hormone therapy …

This study tests whether a negative pressure wound dressing (PICO) can reduce the risk of seroma—a common fluid buildup—after mastectomy for breast cancer. About 76 women will be randomly assigned to get either the standard dressing or the PICO device, which they wear for a week.…

This study is for women aged 65 and older with low-risk breast cancer who have had a lumpectomy. It compares two follow-up treatments: a short course of targeted radiation (5 sessions) versus 5 years of hormone pills. The main goal is to see which approach gives a better quality …

This phase II trial tests whether two oral drugs, abemaciclib (a targeted cancer therapy) and hydroxychloroquine (an older malaria drug), can eliminate leftover cancer cells hiding in the bone marrow of breast cancer patients. About 44 people with a history of breast cancer and d…

This study tests whether a single-port robotic system can safely harvest tissue from the abdomen for breast reconstruction. Four women who need DIEP flap reconstruction will undergo the procedure. The goal is to see if the robotic approach is feasible and leads to fewer complicat…

This study tests a new drug, TER-2013, in people with advanced solid tumors (like breast, ovarian, or lung cancer) that have specific genetic changes in the AKT/PI3K/PTEN pathway. The goal is to see if the drug is safe and can shrink tumors. About 205 participants will receive th…

This study tests a drug called patritumab deruxtecan in people with HER2-positive breast cancer that has spread or cannot be removed by surgery. The goal is to see if the drug can shrink tumors and how safe it is. About 81 adults will take part. This is not a cure, but aims to co…

This study tests two new drug combinations (DB-1311 with BNT327 or DB-1305) in 450 adults with advanced or metastatic solid tumors that have not responded to other treatments. The main goals are to check safety and see if tumors shrink. Participants must be in fairly good health …

This phase 2 trial tests a personalized approach for people with HER2+ metastatic breast cancer. Doctors use ctDNA blood tests and imaging to decide when to step up or down treatments, including targeted drugs and local therapies, to achieve long-term remission. The goal is to se…

This Phase 3 trial compares a new drug, HRS-8080, against standard hormone therapies (like letrozole or tamoxifen) in 5,500 women with intermediate or high risk early breast cancer who have already completed at least 2 years of standard hormone treatment. The goal is to see if HR…

This early-phase trial tests whether freezing a tumor (cryoablation) can boost the immune response to the drug pembrolizumab in people with metastatic or locally advanced triple negative breast cancer. About 30 participants will be randomly assigned to receive either the combinat…

This study tests a new combination of drugs (L-Ornithine L-Aspartate, N-Acetylcysteine, CDK4/6 inhibitors, and Fulvestrant) in 40 women with HR-positive/HER2-negative advanced breast cancer whose disease got worse after standard therapy. The goal is to see if the combo can shrink…

This phase 2 trial is testing whether adding a targeted drug called patritumab deruxtecan to standard immunotherapy and chemotherapy can improve outcomes for people with high-risk early-stage triple-negative or hormone receptor-low positive breast cancer. About 372 participants w…

This early-phase trial is testing a new combination of three drugs—cyclophosphamide, axatilimab, and retifanlimab—in people with metastatic triple negative breast cancer that has stopped responding to standard treatments. The main goal is to find the safest dose of the new combin…

This study is a safety check required by Korean health authorities after capivasertib was approved for breast cancer. Researchers will watch for side effects and see how well the drug works in everyday medical practice. About 130 patients in Korea who are already prescribed the d…

This study is testing whether shorter courses of radiation therapy can work as well as standard treatment for people with breast cancer that has spread to lymph nodes. About 768 participants who have had surgery will receive either a very short (ultrahypofractionated) or moderate…

This Phase 3 study tests whether adding the experimental drug gedatolisib to standard hormone therapy and palbociclib can delay cancer growth better than the current standard treatment (hormone therapy plus ribociclib) in people with HR-positive, HER2-negative advanced breast can…

This study tests whether hyperbaric oxygen therapy (HBOT) can help transplanted fat survive longer in breast reconstruction after radiation treatment. Sixteen women who had radiation for breast cancer will each receive two fat grafting sessions—one with HBOT and one without—in a …

This phase 2 trial is testing an experimental drug called patritumab deruxtecan (HER3-DXd) in 740 people with advanced solid tumors, including melanoma, lung, breast, and other cancers. The drug is given by IV every three weeks. The main goal is to see if the drug shrinks tumors.…

This early-phase trial tests AVA6000, a chemotherapy drug that is designed to activate only in tumors, potentially reducing side effects. About 158 adults with advanced solid tumors (like breast, ovarian, or salivary gland cancer) will receive the drug intravenously. The main goa…

This study is for adults with certain cancers (like breast, lung, or ovarian) that are in complete remission but have persistently low platelet counts from past chemotherapy. It tests whether adding a vitamin A derivative (ATRA) to a standard platelet-boosting drug works better t…

This study is testing whether a more aggressive approach to managing high blood pressure during breast cancer treatment can safely reduce the risk of heart damage. About 130 women with breast cancer who are receiving anthracycline chemotherapy will be randomly assigned to either …

This phase 2 trial is testing whether combining two hormone-blocking drugs, elacestrant and exemestane, can help people with a certain type of advanced breast cancer (HR+/HER2-) that has stopped responding to initial treatments. The study uses a special PET scan to select partici…

This study follows about 300 women with HER2-positive breast cancer that has spread. They are getting a three-drug combination (tucatinib, capecitabine, trastuzumab) as part of their normal care. The goal is to see how well the treatment works and how safe it is in everyday medic…

This study is for women with early-stage breast cancer that has spread to 1-2 lymph nodes. It tests whether skipping radiation to the lymph nodes can reduce side effects and improve quality of life without increasing the risk of cancer coming back. About 1,350 participants will b…

This study compares two treatments—Shengbai Oral Liquid (a herbal remedy) and Leucogen tablets (a standard drug)—for moderate neutropenia (low white blood cells) caused by anti-tumor drugs in breast cancer patients. Sixty participants will be randomly assigned to receive one trea…

This phase 2 trial is testing whether a less extensive lymph node surgery, called targeted axillary dissection (TAD), can safely control cancer in women aged 45 and older with early-stage ER+ breast cancer that has spread to lymph nodes detected by ultrasound. Participants will h…

This study is testing a drug called Dato-DXd in 100 people with a type of advanced breast cancer (HR-positive, HER2 IHC 0) that has stopped responding to hormone therapy. Participants receive the drug by IV every 3 weeks. The goal is to see if it can slow cancer growth and to che…

This study tests whether eating one avocado daily for 4 months can slow biological aging in 120 female breast cancer survivors. The researchers will measure changes in telomere length (a marker of cellular aging) and other health indicators like inflammation and heart disease ris…

This study tests a precise, high-dose radiation technique called SBRT as an alternative to surgery for breast cancer in patients over 70 who are too frail for an operation. The goal is to find the safest highest dose that can be given in one to five sessions. If it works, it coul…

This phase 2 trial is testing whether a liquid biopsy (a simple blood test) can help choose the right treatment for people with ER+/HER2- metastatic breast cancer that has stopped responding to standard therapies. About 484 participants will be assigned to one of several drug arm…

This study is testing a procedure called cryoablation, which uses extreme cold to freeze and destroy breast cancer tumors. It is for people who cannot have surgery due to medical reasons or personal choice. Researchers will follow 100 participants to see how safe the freezing tre…

This study tests a combination of two drugs (Sac-TMT and Tagitanlimab) in 35 people with a specific type of advanced breast cancer that is hormone receptor-positive, HER2-negative, and PD-L1-positive. Participants must have already been treated with a CDK4/6 inhibitor. The goal i…

This study tests IKS014, a drug designed to seek out and destroy HER2-positive cancer cells, in people with advanced solid tumors like breast, stomach, and gastroesophageal cancers. The main goals are to find the safest dose and check for early signs of tumor shrinkage. About 165…

This Phase 3 trial tests whether the drug elacestrant can help prevent breast cancer from coming back in people with high-risk HR+/HER2- early breast cancer. About 1,520 participants will receive either elacestrant or standard hormone therapy for up to 7.5 years. The study compar…

This study looks at whether using a mobile app helps people with HR+ HER2- stage II or III breast cancer stick to their prescribed ribociclib and aromatase inhibitor therapy for a full year. The app provides reminders and information about side effects and relapse risks. About 24…

This Phase 3 trial is testing whether a new drug called PF-07248144, taken with fulvestrant, can help people with a common type of advanced breast cancer (HR-positive, HER2-negative) that has worsened after previous treatment. About 400 participants will either receive the new co…

This study tests whether combining two drugs, sacituzumab govitecan and atezolizumab, can clear leftover cancer cells in the breast or lymph nodes of people with triple negative breast cancer. About 40 participants who still have cancer after standard chemotherapy will receive th…

This study tests if axelopran, a drug used for opioid-induced constipation, can slow tumor growth in people with advanced breast, lung, pancreas, or prostate cancer. About 34 adults whose cancer has worsened after standard treatment will take axelopran daily for up to a year. Res…

This study tests a new drug called MDX2001 in people with advanced solid tumors that have spread. The main goals are to check the drug's safety and see if it can shrink tumors. About 285 adults with various cancers like lung, breast, or colon cancer will take part. This is an ear…

This phase 2 trial is testing the drug talazoparib (Talzenna) in 30 people with metastatic breast cancer that has spread beyond the breast. The cancer must have a specific BRCA gene mutation found only in the tumor (not inherited). Talazoparib works by blocking proteins that help…

This early-phase trial tests two immune-boosting drugs—Mitazalimab and Nivolumab—injected directly into breast tumors before surgery. The goal is to see if this approach is safe and can activate the immune system to fight the cancer. About 32 adults with resectable breast cancer …

This study tests a program to help people with early-stage breast cancer take their hormone therapy and heart medications as prescribed. Participants receive a pharmacist review, training on using a patient portal, and a reminder app. The goal is to see if this support improves m…

This phase 2 trial is testing two standard chemotherapy combinations given before surgery for people with HER2-positive early breast cancer. One group gets docetaxel, carboplatin, trastuzumab, and pertuzumab (TCHP); the other gets the same without carboplatin (THP). The main goal…

This study will compare two surgical approaches for breast cancer patients who need a mastectomy (breast removal) and immediate reconstruction. One group will have standard surgery, while the other will use a newer, endoscopic-assisted technique that may involve smaller incisions…

This study is for people with a type of advanced breast cancer called HR+/HER2-negative. It tests a new drug, VS-6766, combined with two standard drugs (abemaciclib and fulvestrant). The goal is to find the safest dose and see if the combination can shrink tumors or stop them fro…

This phase II trial tests whether taking leucogen alongside standard ribociclib therapy can prevent severe neutropenia (dangerously low white blood cell counts) in women with early-stage hormone-positive breast cancer. About 94 participants will receive the combination and be mon…

This study tests whether dapagliflozin, a diabetes drug, can prevent heart damage caused by anthracycline chemotherapy in breast cancer patients. About 70 women aged 18-70 with low to medium heart risk will take either dapagliflozin or standard care during their chemo. The goal i…

This phase 2 trial is testing whether adding low or high dose radiation to standard chemotherapy and the immunotherapy drug pembrolizumab can improve treatment for people with node-positive triple negative breast cancer. Thirty-two participants will be randomly assigned to receiv…

This phase III trial tests whether adding ribociclib to standard hormone therapy (aromatase inhibitor) can prevent breast cancer from coming back in women with hormone receptor-positive, HER2-negative early breast cancer who still have cancer after initial chemotherapy. About 446…

This study looks at a new material called SC DERM® Recon, used in breast reconstruction surgery after mastectomy for breast cancer. Researchers want to see if it causes fewer short-term problems than similar materials. About 120 women will take part, and the study will track comp…

This phase 2 trial tests whether adding the experimental drug evexomostat (SDX-7320) to standard chemotherapy (eribulin) works better than chemotherapy alone for people with metastatic triple-negative breast cancer who also have metabolic dysfunction (like insulin resistance). Th…

This study tests whether adding zanidatamab to standard chemotherapy can completely eliminate cancer in people with early-stage HER2-positive breast cancer before they have surgery. About 125 participants with stage II or III disease will receive the combination, and doctors will…

This study tests whether adding pembrolizumab to sacituzumab govitecan helps control metastatic triple-negative breast cancer that is PD-L1-negative. About 110 adults with advanced TNBC will be randomly assigned to receive either the combination or sacituzumab alone. The goal is …

This phase 2 trial is testing two different drug combinations for people with stage I HER2-positive breast cancer after surgery. One group gets trastuzumab emtansine (T-DM1) followed by trastuzumab injections, while the other gets paclitaxel plus trastuzumab. The goal is to see w…

This phase 2 trial is testing whether the drug elacestrant, given alone or with triptorelin (which temporarily stops ovary hormone production), can slow or shrink hormone-sensitive breast tumors in premenopausal women. About 96 women will take the pills daily for 30 days before t…

This phase 2 trial is testing whether a fasting-mimicking diet (a low-calorie, plant-based diet) can improve the effectiveness of standard chemoimmunotherapy for early or locally advanced triple-negative breast cancer. About 80 women aged 18 to 70 will follow the diet for five da…

This study tests a drug called disitamab vedotin in 100 adults with advanced breast cancer that has spread and is hard to treat. Participants must have tumors with HER2 protein and have had prior treatment. They receive the drug into a vein every two weeks. Researchers will check…

This study is for people with a high-risk type of breast cancer (triple-negative) who still have cancer cells left after standard treatment and surgery. Researchers will use a special blood test (ctDNA) to look for tiny traces of cancer DNA that scans might miss. If the test find…

This early-phase trial tests an experimental drug called GTB-5550 in adults with advanced solid tumors that have stopped responding to standard treatments. The drug is a nanobody designed to bridge natural killer cells to cancer cells, helping the immune system attack the tumor. …

This study tests a drug called 177Lu-FAP-2286, which delivers radiation directly to cancer cells. It is for people with advanced solid tumors (like pancreatic, lung, or breast cancer) that have a specific protein called FAP. The trial has two parts: Phase 1 finds the safest dose,…

This study tests whether adding a drug that blocks a certain immune cell (CSF-1R inhibitor) and radiation to standard immunotherapy (pembrolizumab) can help the body fight high-risk triple-negative breast cancer more effectively. About 35 women with this aggressive cancer will re…

This phase 2 trial tests whether dapagliflozin, a drug used for diabetes, can prevent heart damage caused by the chemotherapy drug doxorubicin in breast cancer patients. Researchers will enroll 46 women with early-stage breast cancer who are about to start chemotherapy. Participa…

This study tests whether giving a precise, high-dose radiation treatment called SBRT to one growing tumor can help people with metastatic breast cancer keep their disease under control. Participants continue their usual drug therapy while receiving SBRT to a single site where can…

This early-phase study is testing two drugs together — alpelisib and pembrolizumab — in people with metastatic breast cancer or melanoma that has spread to the brain or other organs. The main goal is to find a safe dose and see what side effects occur. Up to 50 adults whose cance…

This program provides access to the drug alpelisib (BYL719) for patients with PIK3CA-related overgrowth spectrum or breast cancer who have no other treatment options and cannot join a clinical trial. It is not a study but a way for doctors to request the drug for individual patie…

This early-stage trial is testing a new drug called TGW101 in people with advanced solid tumors that have not responded to other treatments. TGW101 is given in two parts: an antibody-drug conjugate and a chemical trigger that activates it. The main goal is to check safety and fin…

This study tests whether freezing early-stage breast cancer tumors (cryoablation) can safely and effectively destroy them in postmenopausal women. Participants will have the frozen tumor removed afterward to check for any remaining cancer cells. The goal is to see if this less in…

This early-stage trial tests a new drug called KIVU-107 in 76 adults with advanced solid tumors that have not responded to standard treatments. KIVU-107 is an antibody-drug conjugate designed to target and kill cancer cells. The main goal is to find a safe dose and check for side…

This early-stage study tests a new oral drug, BBI-940, in people with advanced or metastatic breast cancer that has not responded to standard treatments. The drug works by breaking down a protein that helps cancer cells grow. The study aims to find the safest dose and check for s…

This study tests a combination of two drugs, ribociclib and anastrozole, in people with a common type of advanced breast cancer (HR-positive, HER2-negative) that has spread or come back. The goal is to see if the combo can shrink tumors and how safe it is. About 86 adults in Japa…

This study tests a new drug called NBQ72S in 10 people with breast cancer that has spread to the lining of the brain or spinal cord (leptomeningeal metastases). Participants receive the drug every 28 days. The goal is to see if the drug can control the cancer and improve survival…

This study tests two drugs, abemaciclib and bicalutamide, together in people with a type of metastatic breast cancer that has spread and is positive for androgen receptors but negative for HER2. The goal is to find the safest dose and see if the combination can control the diseas…

This study looks at the long-term safety of the drug enzalutamide in people with prostate cancer who have already been taking it in a previous study and are still benefiting. About 900 participants will continue their current treatment and be monitored for side effects. The goal …

This study looks at whether proton therapy can safely treat cancers that return after standard radiation. Proton beams are more targeted than traditional X-rays, so they may deliver stronger doses to the tumor while sparing healthy tissue. Researchers will track side effects and …

This program offers ribociclib, a targeted cancer drug, to patients with serious or life-threatening breast cancer who have no other treatment options and cannot join a clinical trial. Doctors must request the drug for their patients. The goal is to provide potential benefit when…

This early-stage trial tests a new drug called QXL138AM in about 100 people with advanced solid tumors (like ovarian, pancreatic, or lung cancer) or multiple myeloma. The drug is designed to help the immune system attack cancer cells. The main goal is to check safety and find the…

This phase II trial is testing whether using specific genetic tests (Ki67 and Oncotype DX) can help doctors choose the best treatment before surgery for women with a common type of breast cancer (ER-positive, HER2-negative). The study includes 81 postmenopausal women with stage I…

This study tests a program to help Black women with breast cancer stick to their prescribed treatments, like chemotherapy or hormone therapy. Researchers will compare the program to standard care in 250 women recently diagnosed with early-stage breast cancer. The goal is to see i…

This study tests whether an artificial intelligence model can identify patients with advanced HR+ HER2- breast cancer whose tumors might still respond to a second CDK4/6 inhibitor after the first stopped working. About 105 participants will either receive the AI-recommended drug …

This study compares two surgical approaches for breast cancer: one that removes extra tissue around the tumor (routine cavity shave margins) and one that uses a special device (Savi Scout®) to guide removal of only suspicious margins. About 204 women with early-stage breast cance…

This study tests whether giving a different antibody-drug conjugate (ADC) to people with advanced breast cancer who have already tried an ADC can still shrink tumors or slow the disease. About 160 participants will receive one of several ADCs or a targeted pill. The goal is to se…

This phase 2 trial is testing whether giving a combination of three drugs—neratinib, an aromatase inhibitor (letrozole or anastrozole), and trastuzumab—before surgery can completely eliminate invasive breast cancer in postmenopausal women with ER-positive, HER2-positive breast ca…

This study is for people with early-stage ER+ breast cancer who still have hidden cancer cells in their bone marrow after surgery and standard therapy. It tests whether adding drugs like hydroxychloroquine or avelumab, with or without palbociclib, can clear those leftover cells a…

This study tests whether a new treatment called Bria-IMT, given with an immunotherapy drug, helps people with advanced metastatic breast cancer live longer compared to standard chemotherapy. About 404 adults whose cancer has not responded to other treatments will participate. The…

This early-phase study tests an experimental therapy called FT836, a ready-made CAR T-cell treatment, in people with advanced solid tumors like lung, colorectal, breast, ovarian, endometrial, or head and neck cancers that have not responded to prior treatments. The main goals are…

This early-phase trial is testing an investigational drug called SYS6043 in adults with advanced or metastatic solid tumors that have spread or no longer respond to standard treatments. The study aims to find a safe dose and watch for side effects, while also looking for early si…

This Phase 2 trial tests whether adding entinostat to a two-drug regimen (dalpiciclib and letrozole) before surgery can better shrink tumors in women with HR-positive, HER2-negative early breast cancer. Sixty participants will receive either the three-drug combo or the standard t…

This Phase 2 trial is testing whether a combination of three drugs—tucatinib, eribulin, and trastuzumab—is safe and effective for people with advanced HER2+ breast cancer that has not responded to prior treatments. The study will enroll 30 participants and measure tumor shrinkage…

This early-stage trial tests a new oral drug called RGT-419B, given alone or with hormone therapy, in 64 adults with a specific type of advanced breast cancer (HR+/HER2-) that has worsened after prior treatment. The main goal is to check safety and find the right dose, while also…

This study tests a new, ultra-short radiation schedule for early-stage breast cancer. Instead of the usual 3 weeks, patients receive 5 radiation sessions over one week, with an extra boost to the tumor site given at the same time. The goal is to see if this approach is safe, redu…

This study tests a new oral drug called INX-315 in 150 people with advanced breast cancer, ovarian cancer, or other solid tumors that have not responded to standard treatments. The drug is given alone or combined with other cancer drugs (fulvestrant or abemaciclib). The goal is t…

This phase 3 trial compares a new oral drug, D-0502, against the standard injection fulvestrant for people with ER-positive, HER2-negative advanced or metastatic breast cancer. The study aims to see if D-0502 can delay cancer growth better than fulvestrant. About 640 participants…

This study looks at women and men with early-stage breast cancer that had spread to lymph nodes. After chemotherapy, if a sentinel node biopsy shows no cancer left, the trial compares doing nothing further versus standard axillary lymph node removal or radiation. The goal is to s…

This study tests whether adding an oral probiotic (Biolosion) to standard chemotherapy before surgery can help eliminate more cancer cells in women with early-stage triple-negative breast cancer. About 192 participants will receive either standard treatment alone or standard trea…

This study tests a more personalized chemotherapy plan for women with early-stage triple-negative breast cancer. The treatment is adjusted based on immune system activity in the tumor and imaging results. The goal is to see if a lighter chemo can still be effective, reducing side…

This study tests whether adding tinengotinib to fulvestrant can shrink tumors in people with a common type of advanced breast cancer (HR+/HER2-). About 94 adults whose cancer has returned or spread despite prior treatments will take part. The goal is to find the best dose and see…

This early-stage trial is testing a new daily oral medication called ETX-19477 in about 120 adults with advanced solid tumors, including breast, ovarian, prostate, and other cancers. The drug blocks a protein called PARG to interfere with cancer cells' ability to repair themselve…

This study tests whether injecting a very dilute hydrogen peroxide solution directly into breast tumors can make standard radiotherapy more effective. Researchers are enrolling 184 adults with locally advanced or recurrent breast cancer. Participants will receive injections twice…

This study tests whether a new drug combination (pyrotinib + trastuzumab + docetaxel) works better than the standard combo (pertuzumab + trastuzumab + docetaxel) for shrinking early-stage HER2-positive breast tumors before surgery. Researchers will use a blood test to measure tum…

This Phase 1 trial tests a new drug called BL-M07D1 in 280 adults with advanced HER2-positive cancers, including breast, lung, and stomach cancers. The study aims to find safe doses and check for early signs of tumor shrinkage. Participants must have tried at least two prior trea…

This study tests a new type of radiation therapy that adjusts the beam in real time to match the patient's body shape each day. It includes 40 women who have had breast cancer surgery and need radiation. The goal is to see if this approach delivers the dose more accurately and ca…

This early-stage trial tests whether a stool transplant (FMT) can help cancer patients who develop severe diarrhea or colon inflammation from immune-checkpoint inhibitor drugs. About 40 patients with various cancers will receive the transplant via colonoscopy. The main goal is to…

This study is testing a new robotic method for nipple-sparing mastectomy in people with breast cancer or a high risk of developing it. The goal is to see if the robotic approach is as safe and effective as standard surgery, while possibly improving nipple sensation and patient sa…

This study is for people with HER2-positive breast cancer that has spread or cannot be removed by surgery. It tests two drugs together: tucatinib and Doxil. The goal is to see how well the combination shrinks tumors and to track any side effects. About 36 adults will take part.

This early-phase trial tests CPO301, a drug designed to seek out and attack cancer cells that have a protein called EGFR on their surface. About 132 adults with advanced solid tumors (including lung, breast, and head & neck cancers) will receive the drug by IV every three weeks. …

This early-phase trial tests a new treatment for people with advanced melanoma or other solid tumors that have spread. Doctors take a patient's own immune cells, modify them in a lab to better recognize and attack cancer, and give them back after a short course of chemotherapy. T…

This early study tests a device called Muse MRgFUS that uses focused ultrasound waves to heat and destroy a portion of a breast tumor without any cuts. Thirty-four women with breast cancer will have part of their tumor ablated before their standard surgery. The goal is to see if …

This study tests a new minimally invasive treatment that freezes and then heats breast tumors, comparing it to standard breast-conserving surgery in 264 women with early-stage, hormone-positive breast cancer. The goal is to see if the ablation method can control the cancer just a…

This study tests a new drug, KESONOTIDE™, in people with advanced solid tumors like prostate, breast, lung, ovarian, brain, pancreas, or skin cancer. The trial has two phases: first, finding the safest dose, then testing that dose in a larger group. About 80 participants will be …

This study tests whether an augmented reality (AR) system called SKIA-Breast can help surgeons locate and remove breast tumors as well as the standard ultrasound method. About 94 women with breast cancer will be randomly assigned to have surgery guided by either AR or ultrasound.…

This Phase 3 trial tests whether adding a chemotherapy drug (capecitabine) to a standard two-drug regimen (dalpiciclib plus hormone therapy) can slow cancer growth longer in people with HR+/HER2- breast cancer that has spread to internal organs. About 258 participants will be ran…

This study tests a new drug called OP-1250 (palazestrant) against the usual treatments (fulvestrant or an aromatase inhibitor) in people with a certain type of advanced breast cancer (ER+, HER2-). The goal is to see if OP-1250 can slow cancer growth better than standard care. The…

This study tests two treatments for people whose cancer has spread to the brain and is growing despite prior therapy. One group receives palbociclib alone; the other gets palbociclib plus pembrolizumab. The goal is to see if these drugs can shrink or stabilize brain tumors. About…

This study tests whether a combination of three drugs (anastrozole, fulvestrant, and abemaciclib) can shrink or control tumors in people with a common type of advanced breast cancer (hormone receptor positive, HER2-negative). About 20 participants whose cancer has spread or retur…

This study is testing whether personalizing the dose and schedule of radiation therapy after breast cancer surgery can reduce long-term side effects like scarring (fibrosis) and radiation-induced cancers, while still preventing the cancer from coming back. The trial will enroll 8…

This phase 3 trial is testing whether giving radiation only to the lower armpit lymph nodes works as well as giving radiation to a larger area of lymph nodes in breast cancer patients who have 1-2 positive sentinel nodes. The study plans to enroll 1608 women with early-stage brea…

This study is testing whether a generic version of the chemotherapy drug paclitaxel albumin-bound works the same as the brand-name version in people with breast cancer. The trial involves 24 participants who will receive both versions at different times to compare how the drug be…

This study looks at what happens when people with HER2-positive advanced breast cancer switch between two different targeted therapy combinations after their first treatment stops working. About 600 women will be split into two groups: one switches from HP+chemo to HPy+chemo, the…

This study tests whether a blood test that looks for cancer DNA (ctDNA) can find breast cancer returning earlier than usual scans or exams. About 976 people with HR-positive/HER2-negative early breast cancer who had surgery will give blood samples over time. If the test shows sig…

This study tests an experimental drug called HMBD-501 in 180 adults with advanced solid tumors (melanoma, lung, or breast cancer) that have a protein called HER3 on their cells and have stopped responding to standard treatments. The trial has two phases: first, finding the safest…

This Phase 1 trial tests IDOV-Immune, a genetically engineered virus designed to infect and destroy cancer cells while boosting the immune system. It is for adults with advanced solid tumors (like colorectal, pancreatic, or lung cancer) that have not responded to standard treatme…

This phase 3 study tests whether adding capivasertib to standard hormone therapy helps people with HR+/HER2- advanced breast cancer stay on treatment longer and maintain quality of life. About 250 adults whose cancer worsened after prior hormone therapy will take capivasertib plu…

This study compares a freezing technique called cryoablation to standard lumpectomy surgery in people with low-risk, early-stage breast cancer. The goal is to see if freezing the tumor offers similar disease control with fewer complications and better quality of life. About 120 p…

This study tests whether adding an antifungal drug (posaconazole) to standard immunotherapy and chemotherapy can help more women with triple-negative breast cancer achieve a complete response before surgery. About 72 women with early-stage, high-risk disease will be randomly assi…

This study is testing a single, focused dose of radiation delivered by the GammaPod machine before lumpectomy surgery for early-stage breast cancer. The goal is to find a safe and effective dose that minimizes side effects and improves cosmetic outcomes. About 50 women with invas…

This study tests a new approach using immune cells from healthy donors, engineered to recognize and attack cancer cells. The target is chosen based on each participant's tumor profile. The trial includes 85 adults with advanced solid tumors that have not responded to standard tre…

This study tests a new drug called MBRC-201 in people with advanced solid tumors (prostate, breast, colorectal, lung, or pancreatic cancer) that have not responded to standard treatments. The drug is an antibody-drug conjugate, designed to deliver a cancer-killing agent directly …

This phase 2 trial is testing a combination of anti-HER2 drugs (trastuzumab emtansine, pertuzumab, and docetaxel) plus hormone therapy (tamoxifen or letrozole) given before and after surgery in 74 Nigerian women with HER2-positive breast cancer. The main goal is to see if the can…

This study tests whether adding the immunotherapy drug pembrolizumab, with or without the targeted drug olaparib, to standard radiation therapy is safe and effective for people with metastatic triple-negative or hormone-receptor-positive/HER2-negative breast cancer. About 34 adul…

This early-stage trial tests whether giving the drug bortezomib first can make metastatic triple-negative breast cancer more sensitive to two other drugs (pembrolizumab and cisplatin). About 20 women with advanced breast cancer that has already been treated with standard chemothe…

This study tests whether tirzepatide, a weight-loss medication, combined with standard hormone therapy can help clear tiny amounts of cancer DNA from the blood of people with obesity or overweight who have had hormone-positive, HER2-negative, node-positive early breast cancer. Th…

This study tests a device called SIRA-1000 that uses heat to destroy any cancer cells left behind after a lumpectomy for breast cancer. About 10 women aged 50 and older with a specific type of breast cancer will take part. The goal is to see if the device is safe and works well a…

This phase 2 trial is testing whether giving a short course of radiation (SBRT) and two injections of the immunotherapy drug pembrolizumab (Keytruda) before standard chemotherapy can improve outcomes for people with stage 2 or 3 breast cancer. The study aims to see if this combin…

This early-phase trial is testing a new drug called CLSP-1025 in about 90 adults with advanced solid tumors (like lung, colon, or breast cancer) that have a specific p53 mutation (R175H). The drug works by directing the body's immune cells to attack cancer cells carrying this mut…

This study is for people with advanced breast cancer (T3 or T4) who have responded well to chemotherapy. Usually, radiation is given after mastectomy, which delays reconstruction. Here, radiation is given before surgery, so reconstruction can happen immediately using the patient'…

This early-stage trial tests AGX101, a drug that delivers chemotherapy directly to cancer cells by targeting a protein called TM4SF1. About 80 adults with advanced solid tumors (like breast, prostate, or pancreatic cancer) who have run out of standard options will receive the dru…

This study is for people with breast cancer that has spread to only a few spots in the body (oligometastasis). It tests whether adding focused treatments like radiation or surgery to the cancer spots, along with standard drug therapy, can help people live longer. About 340 partic…

This study is for women with advanced breast cancer that has spread to nearby lymph nodes. After initial chemotherapy, doctors will adjust the next steps—surgery and radiation—based on how much cancer remains. The goal is to see if this personalized approach can help people live …

This study is testing a precise, high-dose radiation treatment called SABR as an alternative to surgery for women aged 65 and older with early-stage breast cancer. The goal is to control the cancer while avoiding surgery and maintaining quality of life. Participants will receive …

This study tests whether a new type of radiation machine that uses MRI to guide treatment is safe and practical for people with gastric, breast, or other cancers. About 70 adults will receive radiation guided by real-time MRI, sometimes with chemotherapy. The goal is to see if th…

This study tests whether giving immunotherapy every 6 weeks instead of every 3 weeks works as well for advanced triple-negative breast cancer. The goal is to keep the cancer under control while reducing side effects and improving quality of life. About 416 participants whose canc…

This early-phase trial tests MGC026, a biologic drug given by IV, in 250 adults with advanced solid tumors that have not responded to standard treatments. The study has two parts: first, finding a safe dose, then expanding to see if the drug shrinks tumors. Participants receive u…

This early-stage trial tests a new combination treatment for people with advanced HER2-positive solid tumors (like breast, lung, or stomach cancer). Participants receive an injection of a special virus directly into one tumor to help the immune system attack cancer, followed by a…

This study tests whether a special vacuum dressing (negative pressure therapy) can reduce wound complications like infection, reopening, or slow healing after complex breast cancer surgery with reconstruction. About 254 women with risk factors like obesity or smoking will be rand…

This early-stage trial is testing whether combining valemetostat tosylate with two different antibody-drug conjugates (T-DXd or Dato-DXd) is safe and effective for people with advanced solid tumors. About 210 adults with at least one measurable tumor will receive the drugs orally…

This study looks at how different group exercise programs affect fitness and body composition in women who have finished breast cancer treatment. About 15 women will try one of four supervised resistance training regimens. The goal is to see which approach best improves heart-lun…

This study tests whether women with breast cancer who have no signs of cancer in their armpit lymph nodes after chemotherapy can safely skip armpit surgery. About 464 participants will be randomly assigned to either have or skip the surgery. The goal is to see if skipping surgery…

This early-phase study is testing whether the drug ribociclib (Kisqali) can be safely given alongside standard radiation therapy after surgery for women with a high-risk type of breast cancer (HR+/HER2-). About 30 participants will take ribociclib daily for up to 6 weeks while re…

This study looks at whether women who had breast cancer come back after earlier lumpectomy and radiation can avoid a mastectomy by getting a second round of targeted radiation. About 120 women with small, isolated recurrences will receive partial or whole breast radiation dependi…

This phase II trial is testing a combination of two drugs—Sac-TMT (a targeted chemotherapy) and KL-A167 (an immunotherapy)—given before surgery to 40 people with triple-negative breast cancer. The goal is to see if the combo can eliminate or shrink tumors enough to improve long-t…

This phase 2 trial is testing a new approach for post-menopausal women with HR+HER2- breast cancer. Participants receive standard hormone therapy plus focal radiation, and some also get the immunotherapy drug pembrolizumab and an immune booster (CDX-301). The goal is to see if th…

This early-phase study tests a new drug called BL-B01D1 in people with advanced lung cancer or other solid tumors that have spread or cannot be removed. The main goals are to check the drug's safety, find the best dose, and see if it helps shrink tumors. About 470 adults will tak…

This early-stage trial is testing a new drug, BM230, in people with advanced solid tumors, especially those linked to HER2. The study has two parts: first, finding the safest dose, then expanding to see how well it works. About 123 participants will be enrolled worldwide.

This early study tests if a mild electrical pulse to a nerve in the ear (vagus nerve) can help protect the heart in people receiving strong chemotherapy for breast cancer or lymphoma. About 104 adults who recently started chemo and have extra heart risks will be randomly assigned…

This study tests a new 3D-printed biodegradable mesh used with a silicone implant for immediate breast reconstruction after mastectomy in women with breast cancer. The goal is to see if the mesh improves cosmetic results, patient satisfaction, and safety. The trial will enroll 25…

This study is testing an anti-PD-1 antibody (a type of immunotherapy) alone or combined with low-dose decitabine and/or standard chemotherapy in people whose cancers have come back or not responded to treatment. The trial includes patients with several cancer types, such as lymph…

This early-phase trial is testing an experimental oral drug called OCT-598 in 51 adults with advanced solid tumors, including breast, lung, and prostate cancers. The study aims to find the safest dose and see if the drug works alone or with standard chemotherapy. It is too early …

This study tests whether adding a CDK4/6 inhibitor to standard hormone therapy can help prevent breast cancer from coming back in high-risk patients with HR+/HER2+ early breast cancer. About 1,900 women aged 18-70 who have already completed anti-HER2 therapy will be randomly assi…

This phase 3 trial tests whether adding an anti-vascular drug to standard chemotherapy can help prevent cancer from returning in people with a specific, aggressive type of triple-negative breast cancer. About 764 women with stage II to III cancer will receive either the combinati…

This study is for women aged 51 or older whose breast cancer has returned or who have a new cancer in the same breast. The goal is to see if giving a focused, short course of radiation before surgery is safe and effective enough to allow breast-conserving treatment instead of mas…

This early-phase study tests a new drug called FORX-428 in about 40 adults with advanced solid tumors that have certain gene changes (like BRCA1/2 mutations). The main goals are to check the drug's safety, find the best dose, and see if it can shrink tumors or slow their growth. …

This early-phase study tests a new drug called GNC-077 in 20 adults with advanced breast cancer or other solid tumors that have spread. The main goals are to check safety, find the best dose, and see if the drug can shrink tumors. Participants receive the drug by injection, and r…

This Phase I trial is testing a new drug called BL-M17D1 in 20 people with advanced breast cancer (HER2-positive or negative) or other solid tumors that have spread. The main goals are to check the drug's safety, find the right dose, and see early signs of whether it shrinks tumo…

This study is testing whether a special MRI scan before surgery can identify women with early breast cancer who have a very low risk of the cancer coming back. If so, they may be able to skip radiotherapy after surgery, avoiding its side effects. The trial will follow 1,400 women…

This study tests whether doing Pilates exercises three times a week for 12 weeks can improve bone density in breast cancer survivors aged 40-60 who are taking hormone therapy (aromatase inhibitors). These women are at higher risk for bone loss and osteoporosis. The trial will mea…

This study is testing whether combining fat grafting with a muscle flap from the back can improve delayed breast reconstruction after mastectomy. Twenty women who had a nipple-sparing mastectomy will receive the procedure. The main goal is to see if it reduces wound infections or…

This early-stage trial is testing an experimental drug called BL0175, a nano-medicine designed to deliver treatment directly into tumors. It is for postmenopausal women with advanced or metastatic hormone-receptor-positive breast, ovarian, or endometrial cancer that has progresse…

This study is tracking 800 Chinese patients with advanced HER2-positive or HER2-low breast cancer who are receiving trastuzumab deruxtecan (T-DXd) in real-world clinics. Researchers want to see how long patients stay on treatment and how well it works outside of clinical trials. …

This study tests whether adding two drugs (entinostat and anlotinib) to a standard hormone therapy (fulvestrant) can shrink tumors or slow cancer growth in people with a common type of advanced breast cancer (HR+/HER2-). About 118 adults whose cancer returned or worsened after pr…

This study tests whether adding the drug QL1706 to standard chemotherapy before surgery can eliminate more cancer in people with early HR+/HER2- breast cancer. About 238 participants will receive either the combination or chemo alone for 6 cycles, then have surgery. After surgery…

This study tests whether freezing small, low-risk breast tumors (cryoablation) is as effective as surgery. About 234 women with early-stage, hormone-sensitive breast cancer will receive cryoablation plus standard treatments like radiation. The goal is to see if this less invasive…

This early-phase study tests a new drug called SIBP-A13 in 144 adults with advanced solid tumors that no longer respond to standard treatments. The main goals are to check safety, find the best dose, and see if the drug can shrink tumors or slow their growth. Participants will re…

This early-phase study tests a radioactive drug called lutetium BL-ARC001 in 22 people with advanced lung, breast, head and neck, or other solid tumors that have stopped responding to standard therapies. The drug is given by IV infusion over a 6-week cycle. The main goals are to …

This study is testing whether giving chemotherapy on a faster schedule (called dose-dense) works better for women with a common type of breast cancer (HR+/HER2-) that grows quickly (high Ki67). About 64 women will receive the faster chemo before surgery to see if it reduces the a…

This phase 3 trial is testing whether adding a new oral drug called JS105 to two standard drugs (dalpiciclib and fulvestrant) can better control advanced breast cancer in people with a PIK3CA gene mutation. The study will enroll 312 adults with HR-positive, HER2-negative breast c…

This study is for people with early-stage ER+/HER2- breast cancer. It tests whether adding doxycycline, a safe and inexpensive antibiotic, to standard chemotherapy can better target cancer stem cells—cells that may cause the cancer to come back. About 50 participants will receive…

This study is testing an experimental drug called ACE-86225106 in adults with advanced solid tumors that are difficult to treat or have stopped responding to standard therapies. The drug works by blocking a protein that helps cancer cells repair themselves, potentially slowing or…

This Phase 2 trial is testing whether the drug sacituzumab govitecan (Trodelvy) can shrink tumors in people with a specific type of advanced breast cancer (HR+/HER2 low or ultra low) who have already received another targeted drug called T-DXd. The study will enroll 75 participan…

This study is testing a new way to treat early-stage breast cancer without traditional surgery. It uses a device that sends electric pulses to destroy the tumor. The goal is to see if this approach is safe and can kill all cancer cells. About 24 women with small, early-stage brea…

This study tests a three-part approach for people with breast cancer that has spread to the brain. First, they receive focused radiation (stereotactic radiosurgery) along with a drug called olaparib, which may make cancer cells more sensitive to radiation. After that, they get an…

This study tests a completely oral (pill-based) chemotherapy combination called CMC for people with early-stage breast cancer who have had surgery. The goal is to see if this all-oral regimen is as effective and safer than standard IV chemo. About 25 adults will take three differ…

This study is testing a handheld robotic tool called HandX to help surgeons perform a nipple-sparing mastectomy through a single small incision. The goal is to remove breast tissue while keeping the skin and nipple, leading to less scarring and better cosmetic results. About 15 w…

This phase 2 trial is testing whether women with certain aggressive breast cancers (triple negative or HER2-positive) can safely avoid breast surgery if their tumors disappear completely after a combination of chemotherapy and radiation. The study will enroll 200 women and follow…

This Phase 2 trial tests whether adding targeted radiation (SBRT) to standard hormone therapy and a CDK4/6 inhibitor can help women with metastatic HR+ HER2- breast cancer live longer without their disease worsening. About 102 participants will be randomly assigned to receive eit…

This phase 2 trial is testing whether a combination of two drugs, neratinib and capecitabine, can help people with HER2-negative breast cancer that has spread to the brain. The study enrolls 22 adults whose tumors show abnormal HER2 activity on a special test. Researchers will me…

This early-phase study tests a new drug, LNCB74, in people with advanced solid tumors (ovarian, breast, endometrial, bile duct, or lung cancer) that have not responded to standard treatments. The drug is designed to deliver a cancer-killing agent directly to tumor cells. The main…

This study is for people with advanced breast cancer who cannot or choose not to have surgery. Researchers want to see if adding radiation therapy to standard medications can shrink the cancer and keep it from getting worse. About 30 participants will receive radiation and be mon…

This early-phase trial tests a new drug called MT-4561 in about 27 people with advanced solid tumors (like lung, breast, or pancreatic cancer) who have no standard options left. The main goals are to find a safe dose and see if the drug can shrink tumors. It is a first-in-human s…

This study tests a treatment called TIL therapy for people with advanced breast cancer who have run out of standard options. Doctors take immune cells from a patient's own tumor, grow them in a lab, and put them back into the body to attack the cancer. The goal is to see if it is…

This phase II trial compares a daily pill (dalpiciclib) plus hormone therapy against standard chemotherapy for postmenopausal women with a specific type of breast cancer (ER+ HER2-). The goal is to see if the pill combination works as well as chemo but with fewer side effects. Ab…

This early-phase study tests a new treatment called GC203 TIL for people with advanced solid tumors (cancers in organs like the breast, lung, or gut) that have not responded to standard therapies. The treatment uses a patient's own immune cells, which are modified in a lab to bet…

This study tests whether adding two drugs (sacituzumab govitecan and zimberelimab) to precise brain radiation can help people with metastatic triple negative breast cancer that has spread to the brain. The trial will enroll 31 adults and compare the combination against sacituzuma…

This phase 2 trial is testing a drug called Hetrombopag to raise platelet counts in 56 breast cancer patients who developed low platelets (thrombocytopenia) after T-DM1 therapy. The goal is to see if the drug can safely keep platelets at a safe level so patients can continue thei…

This study compares a single, high-dose radiation treatment to the standard five-session approach for women with early-stage breast cancer. The goal is to see if the one-time treatment controls cancer just as well while reducing side effects and visits. Participants must be 40 or…

This early-stage trial is testing a new drug called VSV-02 in 6 people with advanced solid tumors (like melanoma, breast, or lung cancer) who have no good treatment options left. VSV-02 is a modified virus that is injected into a vein and directly into the tumor, aiming to kill c…

This phase 2 trial is testing whether the drug elacestrant alone works as well as elacestrant combined with a drug that suppresses ovarian function (leuprorelin) in premenopausal women with early-stage, hormone-receptor-positive breast cancer. The study involves 140 women who wil…

This study tests whether adding vitamin K, α-lactalbumin, and D-chiro-inositol to standard calcium and vitamin D supplements can improve bone health in women with breast cancer who are on hormone therapy. These women are at higher risk for bone loss and fractures. The trial will …

This study tests a new breast reconstruction method for women who have had breast cancer or have Poland syndrome. The approach uses a special tissue expander to stretch the skin, followed by fat grafting from the patient's own body, and finally a permanent breast implant. The goa…

This early-stage study is testing a new treatment called CEA-targeted CAR-T cells in people with advanced non-small cell lung cancer or breast cancer that has not responded to standard therapies. The treatment uses a patient's own immune cells, modified to recognize and attack ca…

This study tests a new drug called YL202 in people with advanced solid tumors, including lung, breast, and head/neck cancers. The goal is to see if the drug can shrink tumors and control the disease. About 200 participants will receive the drug, and researchers will monitor safet…

This study is testing a drug called sacituzumab govitecan (Trop-2 ADC) in 100 breast cancer patients whose cancer has spread to the brain. Researchers want to see if the drug can shrink brain tumors and delay disease progression, while also monitoring side effects. The study coll…

This phase 4 study is testing the safety of trastuzumab deruxtecan, a targeted antibody-drug combination, in 100 Indian adults with advanced HER2-positive breast cancer that cannot be removed by surgery or has spread. Participants have already received at least one prior anti-HER…

This study looks at how safe and effective a human tissue graft called AlloMend® is for women having breast reconstruction after mastectomy. Researchers will review medical records of 200 patients who received the graft and follow them for up to 6 months after surgery. The goal i…

This study tests whether adding new drugs to standard chemotherapy before surgery can eliminate early-stage breast cancer (stage II-III) more effectively. About 100 participants will receive either standard treatment or an experimental combination. The main goal is to see if the …

This study tests whether giving radiation in 3 treatments over 1.5 days is safe and effective for women with early-stage breast cancer after lumpectomy. About 170 women aged 45-79 will participate. The goal is to see if this shorter course causes fewer side effects and maintains …

This study looks at whether high-intensity interval training (HIIT) is better than moderate exercise for improving heart health in women who finished chemotherapy for breast cancer. About 158 participants will be assigned to either HIIT or moderate exercise to see which approach …

This study is testing a new device that first freezes and then heats breast tumors to destroy them. It is for patients who cannot have surgery due to health reasons or who choose not to. The goal is to see if this approach can control the cancer and prevent it from coming back, w…

This study is looking at whether taking a CDK4/6 inhibitor (either abemaciclib or ribociclib) after surgery can help prevent breast cancer from coming back in people with HR+/HER2- breast cancer. The researchers will follow 229 participants to see how long they stay cancer-free a…

This early-phase study is testing whether giving radiation therapy together with two drugs (abemaciclib and letrozole) before surgery is safe and doable for people with a common type of early-stage breast cancer (HR+/HER2-). About 15 participants will receive this combination to …

This study tests whether giving radiation again after a second lumpectomy is safe for women with a common type of breast cancer (ER+HER2-). About 114 women who had radiation before and whose cancer came back at least 18 months later will receive targeted radiation over 3 weeks. T…

This early-phase trial tests whether combining two oral drugs, neratinib and ruxolitinib, is safe and can shrink tumors in people with metastatic triple-negative breast cancer that has come back on the chest wall after chemotherapy. About 20 women will take the drugs daily, and d…

This study tests a new drug called SOA101, a special antibody that can attach to both cancer cells and immune cells to help the immune system attack tumors. It is for people with advanced solid tumors (like lung, ovarian, or breast cancer) who have no other standard treatment opt…

This study tests a new way to treat early-stage ER+ breast cancer using a single, strong dose of radiation before surgery. It also explores using a special ultrasound with microbubbles to check lymph nodes without a surgical biopsy. The goal is to see if this approach can elimina…

This study is testing a 5-session radiation treatment (stereotactic body radiotherapy) for people with early-stage breast cancer who have already had a lumpectomy. The goal is to see if this shorter course is safe and has fewer side effects than standard longer radiation. About 4…

This phase 2 trial is testing two antibody-drug conjugates—trastuzumab deruxtecan (Enhertu) and datopotamab deruxtecan (Dato-DXd)—in people with HER2-negative metastatic breast cancer whose disease has worsened after prior antibody-drug conjugate therapy. Participants will receiv…

This early-phase study tests a new drug called OP-1250 (palazestrant) combined with other targeted therapies in people with advanced or metastatic ER-positive, HER2-negative breast cancer. The main goals are to find safe doses and check for side effects. About 190 adults will joi…

This study tests a new medical device designed to reinforce breast reconstruction surgery after mastectomy. About 180 women having their first breast reconstruction will be enrolled, with some receiving the device and others having standard surgery without it. The goal is to see …

This study tests whether following exercise and healthy eating guidelines can improve heart health and reduce metabolic problems in breast cancer survivors. Forty-five postmenopausal women who had breast cancer will be split into three groups: exercise only, exercise plus dietary…

This program provides early access to an experimental drug called AVM0703 for people with various solid tumors and blood cancers, including hard-to-treat types like glioblastoma and metastatic breast cancer. It is available to patients in the US whose doctor requests it. So far, …

This study is testing whether a 16-week cardiac rehabilitation exercise program can improve heart health in women who have had early-stage breast cancer. One hundred participants will take part in the program, and researchers will measure changes in fitness, heart function, and q…

This study tests whether a combination of three drugs—disitamab vedotin, pertuzumab, and toripalimab—can shrink or eliminate HER2-positive breast tumors before surgery. About 40 adults with early-stage breast cancer will receive the drugs intravenously for 18 weeks, then have sur…

This early-phase trial tests a personalized vaccine made from a patient's own tumor cells or donor cells. The cells are modified and killed in the lab, then injected under the skin to train the immune system to attack the cancer. The study includes 50 adults with metastatic melan…

This phase 3 trial tests whether adding the drug abemaciclib to standard hormone therapy can prevent breast cancer from coming back or spreading in people whose cancer has returned in the same breast, chest wall, or nearby lymph nodes. About 290 participants will receive either h…

This early-phase study tests a new drug called BL-B01D1 in 36 adults with advanced breast cancer or other solid tumors that have not responded to standard treatments. The main goals are to find a safe dose and check for early signs of tumor shrinkage. Participants will be closely…

This phase II trial tests two experimental drugs, SI-B003 and BL-B01D1, in people with advanced HER2-negative breast cancer that has not responded to standard treatments. The study will see if the drugs can shrink tumors and determine the best dose. About 58 participants will rec…

This early-phase trial is testing a new drug called BL-M07D1 in people with advanced HER2-positive or low-expression breast cancer and other solid tumors that have not responded to standard treatments. The study has two parts: first, finding the safest dose, and then testing that…

This registry study is following 500 women with early-stage breast cancer who receive a single dose of radiation directly to the tumor site during surgery (IORT). The goal is to see how well this approach controls cancer locally and what side effects occur. Participants are women…

This study tests the immunotherapy drug atezolizumab in 200 people with advanced solid tumors (breast, lung, GI, and others). Researchers use each person's tumor DNA to see if it predicts a response. Participants get the same dose every 3 weeks. The goal is to see if DNA analysis…

This trial tests whether supervised exercise during chemotherapy can help eliminate breast cancer more effectively. 712 participants will be randomly assigned to either a structured exercise program or usual care. The main goal is to see if exercise increases the rate of complete…

This study tests whether dapagliflozin, a drug used for diabetes, can prevent heart damage caused by anthracycline chemotherapy in breast cancer patients. Forty women with breast cancer will take dapagliflozin daily alongside their chemo. Researchers will measure heart function a…

This study tests two AI platforms to personalize cancer treatment for people with solid tumors like gastrointestinal or breast cancer. First, a platform called QPOP analyzes a patient's tumor sample to find the best drug combination. Then, another AI called CURATE.AI adjusts the …

This early-stage study is testing a new drug called RLY-2608, which is designed to block a specific mutant protein (PIK3CA) that helps some cancers grow. The trial includes people with advanced solid tumors or breast cancer that has not responded to other treatments. Participants…

This study is testing whether a genetic test called RecurIndex can identify breast cancer patients with cancer in their lymph nodes who can safely skip radiation to the lymph nodes. The goal is to reduce side effects like arm swelling and pain without increasing the risk of cance…

This phase II trial is testing whether combining two drugs—trastuzumab deruxtecan (Enhertu) and durvalumab—given before surgery can eliminate cancer in people with stage III inflammatory breast cancer that has HER2 protein. The study will enroll 63 participants and measure how ma…

This study tests whether temporarily stopping blood flow in the arm with a blood pressure cuff can protect the hearts of lymphoma patients receiving chemotherapy. The procedure, called remote ischemic preconditioning, is done before each chemo session. Researchers will compare he…

This study is looking at how well a drug called Disitamab vedotin (RC48-ADC) works for breast cancer patients in real-world settings, outside of strict clinical trials. Researchers will track 45 patients to see how long they live without their cancer getting worse and what side e…

This early-stage trial is testing a new drug called BL-B16D1 in 21 people with advanced breast cancer or other solid tumors that have not responded to standard treatments. The drug is given by IV every three weeks. The main goals are to check safety, find the right dose, and get …

This study is testing whether a shorter, higher-dose radiation treatment (APBI) given over just three days is safe and effective for women with early-stage breast cancer or DCIS who have had a lumpectomy. The goal is to see if this approach causes fewer or milder side effects com…

This study tests a technique called systematic margin shaving during breast-conserving surgery for breast cancer. The idea is to remove a thin extra layer of tissue around the tumor right after the main lump is taken out, based on a pathologist's check. Researchers want to see if…

This study tests whether giving a single dose of radiation during breast-conserving surgery works as well as standard weeks-long radiation for early-stage, HER2-negative breast cancer. About 620 women aged 55 and older will take part. The goal is to see if this approach lowers th…

This study tests a new drug called JSKN003 against standard chemotherapy in 400 people with HER2-low breast cancer that has spread and stopped responding to earlier treatments. Participants are randomly assigned to receive either JSKN003 or a standard chemo drug chosen by their d…

This phase 2 trial compares two chemotherapy combinations given before surgery for triple-negative breast cancer. About 520 women will receive either nab-paclitaxel plus carboplatin or nab-paclitaxel plus epirubicin. The goal is to see which combo better eliminates cancer cells i…

This study is testing a new oral drug called dalpiciclib in 420 people with hormone receptor-positive advanced breast cancer. Researchers are watching how well it works and what side effects occur in everyday medical practice, not a strict lab setting. The goal is to see if it ca…

This study tests a new drug called YL202 combined with other anti-cancer medicines (toripalimab or furmonertinib) in people with advanced solid tumors, including breast and lung cancer. The goal is to find safe doses and see if the combination shrinks tumors. About 414 adults age…

This study tests proton radiation therapy for women with early-stage breast cancer. The goal is to see if targeting only the tumor area can keep cancer from coming back while causing fewer side effects. About 132 women aged 50 and older will take part. Researchers will track recu…

This early-stage trial tests a new drug called OKI-219 in people with advanced solid tumors or breast cancer that have a specific PI3K gene mutation. The drug is designed to block the mutant protein and slow cancer growth. Up to 200 participants will receive OKI-219 alone or comb…

This study compares a 3-week course of proton radiation to the standard 5-week course for women with breast cancer who need radiation to the breast or chest wall and nearby lymph nodes. The goal is to see if the shorter schedule causes fewer severe skin and tissue side effects wh…

This early-phase study tests a new oral drug called SYN818 combined with olaparib in 110 adults with advanced solid tumors, including ovarian and breast cancers that have BRCA mutations or related DNA repair problems. The main goals are to find a safe dose and check for side effe…

This study looks at women who have had breast surgery and radiation before and need another breast surgery. Because radiation increases the risk of wound complications, the researchers want to see if giving a week of antibiotics or using a wound VAC (a special dressing) helps pre…

This phase 2 trial compares the experimental drug trastuzumab deruxtecan (T-DXd) to standard chemotherapy given before surgery for HER2-positive breast cancer. About 370 participants will receive either T-DXd or standard treatment for three cycles, then further treatment is chose…

This study compares magnetic resonance imaging (MRI) with standard diagnostic techniques like mammography to see which method best finds and defines breast cancer. Researchers will enroll about 500 women with suspicious breast lesions to evaluate accuracy. The goal is to improve …

This study is testing a new blood test called EXoPred that uses artificial intelligence and laser technology to find tiny particles from cancer cells. The goal is to detect breast, colon, pancreatic, ovarian, and lung cancers at an early stage. Researchers will enroll 1,400 peopl…

This study is testing an artificial intelligence tool that collects family cancer history through WhatsApp to predict genetic risk of breast cancer. Researchers will enroll 800 women already identified as high-risk by their doctors and compare the AI's predictions with standard g…

This study tests whether a genetic and epigenetic panel can predict heart damage caused by chemotherapy or immunotherapy in breast cancer patients. Researchers will analyze blood samples from 1,000 participants before and during treatment to see if certain genetic markers signal …

This study tests a new imaging method that combines MRI with near-infrared light to get a clearer picture of breast cancer tumors. Twenty women with breast cancer will receive this extra scan before surgery. The goal is to see if this tool can help doctors better detect and plan …

This study is testing a new device that uses specially designed bacteria and laser technology to find and study rare tumor cells in the blood of breast cancer patients. The goal is to improve early detection and personalized treatment. The study will include 80 women with either …

This study looks at whether artificial intelligence can help detect breast cancer using standard chest CT scans that don't require a special dye. Researchers will compare the AI's accuracy to mammograms and breast MRIs in 5,000 women. The goal is to see if this approach could off…

This early study at Mayo Clinic is testing whether a new 3D ultrasound technique can better tell if lymph nodes under the arm contain cancer in people with breast cancer. About 55 adults who already need a lymph node biopsy or have a clip placed will get both standard 2D and the …

This study is testing a new ultrasound imaging method called Contrast Enhanced Super-Resolution (CESR) to see if it can better detect and tell apart cancerous and non-cancerous lesions in the breast, liver, and kidney. It involves 40 participants: 10 healthy volunteers to fine-tu…

This study is testing a new method called BRAVE that uses sound waves to measure breast tissue stiffness, aiming to find cancer without X-rays or painful compression. Researchers will enroll 300 adults who have a breast mass and a recent mammogram. The goal is to see how well thi…

This study is testing a new, non-invasive ultrasound method to see if it can tell the difference between benign and malignant breast tumors. Researchers will also check if it can measure how well breast cancer responds to chemotherapy. Up to 250 women with breast lumps or breast …

This study is testing a new type of PET scan that uses a radioactive tracer to detect a protein called TROP2 on breast cancer cells. The goal is to see if this scan can predict how well a targeted drug (ADC therapy) will work for each patient. About 60 adults with breast cancer w…

This study aims to see if new, advanced MRI scans can more accurately diagnose breast cancer and measure how well treatment is working. Researchers will enroll 1000 women with suspicious breast lumps. The goal is to help doctors create more personalized treatment plans and improv…

This study tests whether a special PET/MRI scan using a radioactive tracer (18F-FFNP) can detect early signs that hormone therapy is working in breast cancer. About 53 postmenopausal women with a certain type of breast cancer will get the scan before and after taking anastrozole …

This study is testing a new device called MammoWave that uses low-power microwaves instead of X-rays to find breast lesions. About 600 women will lie face-down while the device scans their breasts for about 10 minutes. The goal is to see if this safe, radiation-free method can ac…

This study aims to see if a new test, using trained dogs and artificial intelligence, can detect breast cancer from a person's breath. About 1,200 women scheduled for routine breast cancer screening or biopsy will provide a breath sample by breathing into a mask. The results from…

This phase III trial is testing whether routine brain MRIs every 6 months can detect brain metastases earlier in people with stage IV breast cancer who have no symptoms. Participants are randomly assigned to either scheduled scans or standard care (scans only if symptoms appear).…

This study is testing a new imaging agent called 18F-T2, which is designed to highlight tumors that produce a protein called CAIX. About 200 adults with various cancers (like kidney, lung, or breast cancer) will receive an injection of 18F-T2 and then undergo a PET/CT scan. The g…

This study tests a new PET imaging method that uses a radioactive tracer to spot HER2 proteins on breast cancer cells. The goal is to see if the scan can predict how well patients will respond to antibody-drug conjugate therapy. Researchers will enroll 50 adults with HER2-positiv…

Women with extremely dense breasts have a higher risk of breast cancer, and tumors are harder to see on standard mammograms. This large study of 36,000 women aged 50-75 will test two extra screening methods—contrast-enhanced mammography and a shorter MRI—to see if they can find c…

This study is testing a new blood-based diagnostic that looks at tiny particles from breast cancer cells to determine the cancer's molecular subtype. Researchers will compare results from this test with standard tissue biopsies in 1,500 people with advanced breast cancer. If accu…

This study is testing a new radioactive imaging agent that targets a protein called LRRC15, found on many cancer cells. Researchers will use PET scans to see if this agent can better detect and stage cancers like pancreatic, breast, lung, and others. The trial includes 26 healthy…

This study enrolls 400 women at high risk for breast cancer to see if a shorter, abbreviated MRI scan works as well as a full-length MRI for early detection. Participants will get MRI scans every 6 months. The goal is to develop faster, personalized screening that could make regu…

This study is testing two new ways to find breast cancer in women at high risk: a blood test that looks for tumor DNA and a special mammogram that uses a low-dose radioactive tracer. About 100 women who already need a biopsy will get both tests first. The goal is to see if these …

This study tests a new imaging agent called pHLIP ICG that makes breast cancer cells glow during surgery. The goal is to help surgeons see and remove all cancerous tissue more accurately. The trial involves 55 adults with early-stage breast cancer who have not had prior treatment…

This study is testing whether a breath test can detect breast cancer in women aged 40 to 74. Researchers will collect breath samples from over 5,000 women before their standard biopsy or MRI and compare the chemical patterns between those found to have cancer and those who do not…

This study tests a new handheld device that uses light and artificial intelligence to check for leftover cancer cells right after a breast lump is removed. The goal is to help surgeons remove all cancer in one go, avoiding a second surgery. About 104 women having breast-conservin…

This study is testing a new device called ARTIDIS that measures how stiff or soft breast tissue is, which may help doctors tell if a lump is cancerous. About 2,700 people with suspicious breast lesions will have their biopsy tissue tested with this device. The goal is to see if i…

This study compares two types of breast imaging—molecular breast imaging (MBI) and magnetic resonance imaging (MRI)—to see how well each finds or rules out breast cancer in women at high risk. About 300 women will take part. The goal is to find out if MBI works as well as MRI, wh…

This early-phase study is testing whether a special PET scan using a drug called PYLARIFY can better detect cancer that has spread in people with pancreatic cancer, liver cancer, or breast cancer. About 36 adults will receive the scan, and doctors will compare the results to stan…

This study is testing a blood test called NovaGray RILA Breast® to see if it can predict severe capsular contracture (hardening and tightening of scar tissue around a breast implant) after radiotherapy. Researchers will enroll 250 breast cancer patients who have had a mastectomy …

This study tests whether non-experts using AI-supported ultrasound can effectively screen for breast cancer in communities with limited access to radiologists. About 4,800 women, both with and without symptoms, will receive a clinical breast exam and AI-guided ultrasound. The goa…

This early-stage trial is testing a new radioactive tracer called 68Ga-FXX489 (NNS309) for PET/CT scans. The goal is to see if it can safely and accurately detect tumors and their spread in 30 adults with suspected cancer. Researchers will measure how the tracer moves through the…

This study is testing a new 3D automated ultrasound system called ATUSA to see how well it can image suspicious breast lesions. Up to 800 women with suspicious findings on standard imaging will get an ATUSA scan before their biopsy. The goal is to collect images and compare them …

This study is testing a new AI tool called Ataraxis that analyzes images of breast cancer biopsy slides along with basic patient information to predict how well the cancer will respond to chemotherapy before surgery. The study will enroll 150 adults with early-stage breast cancer…

This study is testing whether regular MRI scans of the brain can find cancer that has spread from the breast to the brain, even before symptoms appear. It involves 214 people with metastatic or inflammatory breast cancer. The goal is to see if early detection through screening im…

This study is testing whether a blood test called a liquid biopsy can accurately detect breast cancer. Researchers will compare the blood test results with mammograms and standard tissue biopsies in 490 women. If the blood test works well, it could offer a less invasive way to sc…

This study is testing a new device called SPCTRone that uses light to analyze tissue during breast cancer surgery. The goal is to see if it can accurately tell surgeons whether all cancer has been removed, right in the operating room. About 100 women having breast-conserving surg…

This early study tests a new imaging device that combines two types of breast scans to see how well it detects estrogen-receptor-positive breast cancer. Up to 20 women with newly diagnosed breast cancer will receive an injection of a radioactive tracer and then be scanned. The re…

This study compares two types of PET scans to see which is better at finding and tracking metastatic lobular breast cancer. About 30 adults with this type of cancer will receive both an experimental FES PET/CT scan and a standard FDG PET/CT scan. The goal is to improve detection …

This study is testing whether a special type of mammogram called contrast-enhanced spectral mammography (CESM) can find breast cancers better than the standard 3D mammogram (digital breast tomosynthesis, or DBT) in women with dense breast tissue. About 2,000 women with dense brea…

This study tests a new imaging system that uses light to monitor how breast cancer responds to chemotherapy before surgery. Researchers want to see if it can accurately predict when the cancer is completely gone. The study involves 15 women with specific types of breast cancer. I…

This study in Indonesia will test whether a portable ultrasound device can help doctors quickly decide if a breast lump found during a physical exam is likely benign or possibly cancerous. 600 women with breast lumps will get an ultrasound at a primary care clinic. The goal is to…

This study is testing whether AI-assisted ultrasound and mammography can improve breast cancer screening compared to standard methods. About 16,000 women aged 35-69 will be split into two groups: one gets AI-assisted imaging, the other gets routine screening. The goal is to see i…

This study is testing a new way to detect cancer by looking at certain enzymes in the blood. Researchers will collect blood samples from 220 people—120 with breast, lung, or pancreatic cancer and 100 without cancer. They want to see if the enzyme levels are different between the …

Researchers at Mayo Clinic are testing a new breast ultrasound method to see if it can better detect breast cancer and measure how well a patient responds to treatment. The study will involve 550 adult volunteers with suspicious breast masses or biopsy-confirmed breast cancer. Pa…

This study tests two new radioactive imaging probes that target specific markers on breast cancer cells. Researchers will use PET/CT scans to see how well these probes find tumors and their spread in 200 women with breast cancer. The goal is to improve diagnosis and help guide tr…

This early-phase study aims to see if a special PET scan using 89Zr-trastuzumab can predict how well HER2-positive breast cancer patients will respond to targeted therapy. Ten newly diagnosed adults will receive the imaging agent and undergo PET/MRI scans. The goal is to improve …

This study tests if a safe green dye (indocyanine green) can help surgeons find lymph nodes that might contain cancer during a mastectomy, without needing a separate cut under the arm. About 90 women with early-stage breast cancer will receive the dye and a standard radioactive t…

This early study tests a special PET/CT scan that uses a modified tryptophan molecule to make tumors light up more clearly than normal tissue. About 24 adults with brain, breast, neuroendocrine, or rectal cancers will get one scan to see if this method helps doctors tell tumors a…

This pilot study is testing a new radioactive tracer called [18F]F-GLN for PET/CT scans in people with breast cancer. The goal is to see how well this tracer highlights tumors and to gather safety information. Up to 40 adults with known or suspected breast cancer will receive one…

This study is testing a blood test that looks for DNA signals from 20 different cancers, including lung, breast, and colon cancer. Researchers will see if the test can find cancer early, detect any cancer left after treatment, and catch a relapse before it shows up on scans. The …

This study tests a new radioactive probe called 68Ga-PFA2 for PET scans. It targets a protein called annexin A2, which is found at high levels in many cancers and helps them spread. Researchers want to see if this probe can find metastases in lung cancer patients better than curr…

This study compares a special contrast-enhanced mammogram (CEDM+CEDBT) with standard breast MRI to see if it can accurately predict whether breast cancer has been eliminated by chemotherapy. About 30 women with locally advanced breast cancer will get 1-2 of these mammograms durin…

This study is testing whether contrast-enhanced mammography (CEM) can find breast cancers better than standard mammography in women with dense breasts. Dense breast tissue can hide tumors on regular mammograms, so better imaging is needed. Researchers will enroll 1,000 women aged…

This study is testing a new blood test that uses laser technology and artificial intelligence to help doctors tell apart high-risk and low-risk breast cancer patients. About 330 people with breast cancer will give a blood sample before treatment. The test looks at tiny particles …

This study compares robotic ultrasound to traditional sonographer-led screening for breast cancer in 70,000 women aged 35-64. The goal is to see if the robot can detect cancer just as well and whether women follow up on recommended care. Participants will get a breast ultrasound …

This study is testing whether an artificial intelligence program called Mirai can better identify women at high risk for breast cancer compared to traditional risk models. Researchers will invite 200 women flagged as high-risk by Mirai to receive an additional breast MRI. The goa…

This study tests if a special ultrasound using a contrast agent (Sonazoid) can find sentinel lymph nodes as accurately as the standard radioactive tracer method in people with melanoma, breast cancer, or head & neck cancer. About 91 adults will take part, and the goal is to see i…

This study looks at whether a special PET/CT scan (68Ga-FAPI) can accurately tell if breast cancer has been cleared from lymph nodes after chemotherapy. About 150 women who have finished at least 3 rounds of treatment will get the scan before surgery. If the scan works well, it c…

This early-stage study is testing a new imaging agent called 68Ga-FL-031 to see if it can better detect and stage certain cancers, including small cell lung, breast, and nasopharyngeal tumors. Ten adults with suspected or confirmed cancer will receive both the new PET scan and a …

This study is looking at whether a brain MRI can spot cancer that has spread to the brain in people with certain types of breast cancer (triple negative or HER2-positive, stage IIb or III) who have no symptoms. About 100 participants will get a contrast-enhanced brain MRI, give a…

This study tests whether a green dye called indocyanine green (ICG) can accurately find cancer that has spread to lymph nodes in breast cancer patients who have already had chemotherapy. About 100 adults will receive the dye along with standard methods during surgery. The goal is…

This study aims to improve how doctors find and treat breast cancer that has spread to the brain. Twenty adults with ER-positive breast cancer and brain tumors will get an extra PET scan (FES PET/CT) before their standard radiation planning. Researchers will compare this scan wit…

This study is testing a new, highly sensitive blood test to measure tiny particles called extracellular vesicles that are released by breast cancer cells. Researchers will compare levels in women with early or metastatic breast cancer to healthy controls. The goal is to see if th…

This study tests a community-based program to help underserved adults get screened for breast, lung, and prostate cancers. Researchers will work with local resource spots to offer screenings and follow-up care. The goal is to see if this approach increases screening rates and cat…

This study tests a special MRI technique called TMEM-MRI that looks at the tumor environment to see how likely breast cancer is to spread. About 95 women with operable breast cancer will get this MRI before their standard biopsy or surgery. The goal is to see if this imaging meth…

This study is testing whether using an artificial intelligence (AI) tool called Mirai to guide MRI screening can help find breast cancers earlier. Researchers will enroll 400 women aged 40-89 who are at high risk according to the AI model. Participants will receive a supplemental…

This study is testing whether a new MRI technique using a substance called hyperpolarized pyruvate gives consistent results in people with solid tumors. About 109 participants will have two special MRI scans to see if the images are reproducible. The goal is to improve how doctor…

This study trains Nigerian radiologists to use tablet-based ultrasound to guide breast biopsies, a method that is more accurate than the blind biopsies or surgical excisions currently used. Nine hundred women with suspicious breast lumps will participate. The goal is to make this…

This study tests whether contrast-enhanced mammography (CEM) can safely reduce the number of breast biopsies for women with breast findings that are suspicious but not highly suspicious (BI-RADS 4A or 4B). About 2,100 women scheduled for a biopsy will first get a CEM. The goal is…

This study tests a new blood test that looks for tiny molecules called MicroRNA in people with breast cancer. The goal is to see how accurate the test is at detecting the disease. Researchers will compare results from 100 participants, including healthy volunteers, to measure the…

This study is testing whether a blood test can find tumor DNA in people with cancer. If successful, it could lead to a less invasive way to diagnose cancer compared to current methods like tissue biopsies. The study will enroll 40 adults with newly diagnosed breast, colorectal, l…

This pilot study compares contrast-enhanced digital breast tomosynthesis (CE-DBT) to standard MRI in 20 women with known breast lesions. Researchers want to see if CE-DBT can give doctors similar confidence in identifying suspicious areas. If it works, it might offer a quicker or…

This study compares two PET scan tracers—standard 18F-FDG and newer 68Ga-FAPI-46—in 20 women with ER-positive breast cancer. The goal is to see if the new tracer finds more cancer lesions, especially where the standard one may miss them. Better detection could lead to more accura…

This study is testing whether adding a special type of mammogram (contrast-enhanced mammography, or CEM) every two years to the standard yearly 3D mammogram can find new breast cancers in women who have already had breast cancer. The goal is to see if CEM detects more cancers whi…

This study tests a low-risk surgical procedure called LYMPHA, done at the same time as breast cancer lymph node removal, to prevent lymphedema—a chronic, painful arm swelling. About 80 women undergoing breast cancer surgery will be randomly assigned to receive LYMPHA or standard …

This large Phase 3 trial tests whether giving lidocaine (a numbing medicine) through an IV during breast cancer surgery can prevent persistent pain that often follows. Over 1,600 adults having lumpectomy or mastectomy will be randomly assigned to receive lidocaine or a placebo. T…

This study tests an AI-powered virtual coach app that helps women at risk for breast cancer set and track goals for physical activity, diet, and alcohol use. Over 2,000 women in Greece, Lithuania, Spain, and Sweden will be randomly assigned to standard advice or the app plus advi…

This early-stage trial tests a cream made from inactivated Akkermansia muciniphila bacteria to prevent skin injury in 40 breast or head/neck cancer patients receiving radiation. The cream is applied three times daily to the radiation area. The main goal is to see if it is safe an…

This study tests whether taking an inactivated (killed) form of the bacterium Bacteroides fragilis can prevent diarrhea caused by chemotherapy. The trial will enroll 200 cancer patients about to start chemotherapy regimens known to cause diarrhea. Participants will receive either…

This study tests whether wearing a compression bandage after mastectomy can prevent lymphoceles—painful fluid collections that often occur after surgery. Researchers will compare 84 breast cancer patients who receive a drain plus bandage versus drain alone. The goal is to see if …

This study tests whether desloratadine, a common allergy medication, can prevent nerve damage caused by taxane chemotherapy in breast cancer patients. About 116 participants will receive either desloratadine or a placebo for 12 weeks while on chemotherapy. The goal is to see if t…

This study tracks how nerve pain from chemotherapy develops in breast cancer patients. It also tests a brain-stimulating device called a closed-loop brain-computer interface to see if it can prevent that pain. About 45 participants will be observed or receive the experimental sti…

This study tests whether a smartphone app, combined with nutrition education, can help people at high risk for cancer eat healthier and reduce their cancer risk. About 170 participants will either get the app or standard advice, and researchers will measure changes in diet qualit…

This study tests a procedure called Immediate Lymphatic Reconstruction (ILR) done during breast cancer surgery to prevent lymphedema, a painful arm swelling. About 98 high-risk women will be randomly assigned to receive ILR or standard care. Researchers will track who develops ly…

This study tests whether a home-based telerehabilitation program, starting 10 days after breast cancer surgery, can prevent common complications like pain, shoulder stiffness, and swelling. 155 women who had a mastectomy or quadrantectomy will be randomly assigned to either the t…

This study tests whether wearing tight-fitting surgical gloves and compression knee socks during chemotherapy can prevent nerve damage (neuropathy) in breast cancer patients. The idea is that compression narrows blood vessels, reducing the amount of chemo drugs reaching the hands…

This study looks at different preventive surgeries for women with gene mutations that raise their risk of ovarian cancer. Researchers want to see if removing the fallopian tubes first and delaying ovary removal works as well as standard surgery or close monitoring. About 480 wome…

This study tests whether Stimulan Rapid Cure, a local antibiotic, can reduce infections in women receiving tissue expanders during mastectomy for breast cancer. About 392 participants will be randomly assigned to receive the antibiotic or standard care. The goal is to see if this…

This study tests whether a gel containing diclofenac, a common anti-inflammatory drug, can prevent severe skin irritation caused by radiation therapy. About 156 adults with head/neck or breast cancer will apply the gel or a placebo to the treated skin three times daily during the…

This study tests whether starting sexual health counseling and using non-hormonal moisturizer right away can prevent vaginal dryness and sexual problems in premenopausal women with breast cancer who are on ovarian suppression. Fifty women will be randomly assigned to either this …

This phase 2 trial tests whether drinking tart cherry juice can prevent nerve damage (neuropathy) caused by the chemotherapy drug paclitaxel in breast and ovarian cancer patients. About 86 participants will be randomly assigned to receive either a high or low dose of the juice du…

This phase 2 trial tests whether riluzole, a drug already approved for ALS, can prevent the cognitive problems (often called 'chemo brain') that many cancer patients face during chemotherapy. The study will enroll 24 adults with various cancers who are about to start chemotherapy…

This study tests a virtual program that includes webinars and online visits to help women at high risk for breast cancer adopt healthier lifestyles. The goal is to see if women will stick with the program and whether it helps them reduce their risk. About 1,500 women from a large…

This study tests whether a nerve block given before mastectomy can prevent depression and chronic pain afterward. Researchers will compare 140 women who receive the block to those who do not. The goal is to see if this simple procedure can improve recovery and quality of life.

This study tests whether wearing compression gloves and stockings during chemo, plus acupuncture after, can prevent nerve damage (peripheral neuropathy) in breast cancer patients. About 384 people will be randomly assigned to one of four groups: compression only, acupuncture only…

This study tests whether taking alpha lipoic acid, a common antioxidant supplement, can prevent or reduce skin irritation caused by radiation therapy in breast cancer patients. Researchers will enroll 40 women with early-stage breast cancer who are scheduled for radiation. The go…

This study compares annual mammograms to a personalized screening schedule based on each woman's breast cancer risk. Participants choose or are assigned to either annual screening or risk-based screening, which uses genetic testing and personal history. The goal is to see if pers…

This study tests whether dapagliflozin, a drug used for diabetes and heart failure, can prevent heart damage caused by a common type of chemotherapy (anthracyclines) in breast cancer patients. One hundred women will receive either dapagliflozin or a placebo daily during their che…

This study looks at whether a 12-week aerobic and resistance exercise program can lower breast cancer risk in women with dense breast tissue. Researchers will measure changes in blood markers and breast tissue samples from 46 physically inactive women aged 18-59. Participants are…

This study tests a surgery called lymphovenous bypass (LVB) to prevent lymphedema—painful arm swelling—in breast cancer patients who had lymph nodes removed. About 136 participants will either get LVB plus physiotherapy or physiotherapy alone. The goal is to see if the surgery re…

This study tests two low-dose hormone drugs, exemestane and tamoxifen, in 140 postmenopausal women at high risk for breast cancer. The goal is to see which one better maintains quality of life over 12 months while helping prevent cancer. Participants take a daily pill and complet…

This study tests whether a comprehensive program can prevent lymphedema (chronic arm swelling) in women undergoing lymph node removal for breast cancer. The program includes immediate lymphatic reconstruction during surgery, self-directed lymphatic massage, and regular arm measur…

This study tests whether adding one-on-one support from a Diné peer navigator to a culturally-tailored tablet education program helps more Native American women get mammograms. About 200 women aged 40-74 on the Navajo Nation who haven't had a mammogram in the past year will take …

This study compares two types of nerve blocks for pain relief in women undergoing breast cancer surgery. One group receives a single-level block, while another receives a two-level block, with some patients also getting the medication dexmedetomidine. The goal is to see which app…

This study tests whether cancer patients can complete a supervised exercise program from home using video calls. The program includes resistance training with dumbbells and aerobic exercise. Researchers want to see if this approach is practical and helps patients maintain functio…

This study compares two exercise programs for women receiving chemotherapy for early-stage breast cancer. One program uses a fixed amount of walking each week, while the other adjusts the amount based on how each woman responds. The goal is to see which approach better improves c…

This study looks at whether a structured 12-week exercise program can improve fitness and recovery in women who have had DIEP flap breast reconstruction after mastectomy. Half of the 78 participants will follow the exercise program, while the other half will receive standard care…

This study tests an 8-week nurse-led self-management program for women with breast cancer who experience taste changes from taxane-based chemotherapy. The program includes education, symptom tracking, and personalized advice to help with eating and nutrition. Researchers will mea…

This study is testing whether a mobile app called Mighty Pro can help young women with breast cancer feel less distressed. The trial will include 120 women aged 18 to 45 who are patients at a specific cancer center. Participants will use the app for 26 weeks, and researchers will…

This study tests a new way to help breast cancer survivors become more active. Instead of focusing on effort, the program focuses on how exercise makes you feel. About 85 survivors who finished treatment within the last 5 years will join. They will wear an activity monitor and an…

This study compares two types of nerve blocks given before modified radical mastectomy to see which provides better pain relief and reduces the need for strong painkillers. Eighty women scheduled for surgery will receive one of the two blocks, and researchers will track their pai…

This Phase 3 trial tests whether Nuvastatic 300 mg capsules can reduce the crushing fatigue that often comes with chemotherapy. About 250 women with metastatic triple-negative breast cancer will take either the supplement or a placebo three times daily for 60 days while continuin…

This study tests whether a nicotine cessation program can help women with breast cancer quit nicotine before reconstructive surgery. About 20 women who use nicotine and are scheduled for mastectomy or lumpectomy with reconstruction will take part. The program includes up to four …

This study looks at whether adding hyperbaric oxygen therapy to a structured exercise program can reduce joint and muscle pain caused by aromatase inhibitors in breast cancer survivors. Forty older survivors with pain will either do exercise alone or exercise plus daily hyperbari…

This study tests whether a therapy called Meaning-Centered Psychotherapy for Latinos (MCP-L) can help reduce anxiety and depression in 300 Latino patients with advanced cancer. Participants receive either MCP-L or standard cognitive behavioral therapy over about 3 months. The goa…

This study tests whether a program of exercise and personalized nutrition before breast cancer treatment (called prehabilitation) can help women recover faster and feel better. Researchers will measure fitness, strength, and quality of life in 66 women with early-stage breast can…

This study tests whether a non-invasive device that gently stimulates a nerve in the ear can help prevent nausea caused by chemotherapy in breast cancer patients. Participants use the device twice daily around their chemo sessions, alongside standard anti-nausea medication. The g…

This study tests a navigation program for cancer patients starting immunotherapy. The program helps with essential needs like food, transportation, and housing, and tracks side effects. Researchers want to see if this support helps patients continue their treatment and improves t…

This study tests two different nerve block techniques—bilevel erector spinae plane block and pecto-serratus block—to see which provides better pain relief after modified radical mastectomy in breast cancer patients. Sixty women will be enrolled and their painkiller use and pain s…

This study tests whether taking omega-3 fish oil capsules and doing simple resistance exercises with elastic bands can help cancer patients maintain muscle mass and strength. It involves 288 adults with various cancers who are at risk of muscle wasting. The goal is to improve phy…

This early-stage trial tests a new drug called GB18 in 18-36 cancer patients who are losing weight and appetite due to their illness (cachexia). The drug is given as a shot under the skin. The main goal is to check safety, but researchers will also see if it helps patients gain w…

This study is testing a mobile app called TEAMWork that gives breast cancer patients advice on talking to their employers and doctors about work. The goal is to help patients keep their jobs during and after treatment. About 546 adults with breast cancer who are about to start or…

This study looks at whether starting resistance exercise training before breast cancer surgery can help reduce common side effects like fatigue, muscle loss, and reduced strength. The study involves 68 postmenopausal women with breast cancer who are scheduled for chemotherapy bef…

This study tests whether a community-based exercise program can improve memory, attention, and brain health in women who have had breast cancer. About 160 survivors, aged 50 and older, will either take part in aerobic exercise or health education sessions. The goal is to see if p…

This study tests an Arabic-language AI mobile app designed to support women with breast cancer during chemotherapy. The app monitors symptoms, sends medication reminders, and provides educational content. Researchers will compare 130 women who use the app plus usual care to those…

This study tests whether a single 60-minute counseling session can reduce anxiety and depression in breast cancer patients who are waiting for ongoing therapy. About 26 participants will receive the session plus a booklet, and researchers will measure how helpful and practical it…

This study tests a culturally tailored web app (CAI) designed to help Asian American breast cancer survivors better manage cancer pain and related depressive symptoms. Researchers will enroll 300 women of Chinese, Korean, or Japanese descent who have had breast cancer and experie…

This study compares two types of nerve blocks—ESPBs and TAPs—for controlling pain after DIEP flap breast reconstruction surgery. About 102 women with breast cancer will receive one of the two blocks before surgery. The goal is to see if the newer ESPB method provides equivalent p…

This study tests whether a program combining physical therapy, yoga, and patient education can reduce joint and muscle pain caused by hormone therapy in breast cancer patients. About 108 women with non-metastatic breast cancer and moderate-to-severe pain will be randomly assigned…

This study tests a one-session telehealth program that teaches pain coping skills to older women (55+) with breast cancer who have ongoing pain. Participants also receive five short follow-up calls. The goal is to see if this brief training can reduce pain severity and interferen…

This study tests whether a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) can reduce nerve pain caused by chemotherapy in breast and gynecologic cancer survivors. About 19 women who have persistent pain after chemo will receive…

This study tests two digital mindfulness programs—one live over Zoom and one self-paced app—to see if they can reduce depression in younger breast cancer survivors. It includes 402 women diagnosed at or before age 50 who finished cancer treatment at least 6 months ago and have el…

This pilot study is testing a new, less invasive breast surgery called endoscopic video-assisted nipple-sparing mastectomy (E-NSM) for women with early-stage breast cancer or those at high risk. The goal is to see if this technique can reduce surgical trauma and improve cosmetic …

This study tests if starting a personalized exercise program early can prevent or reduce joint and muscle pain caused by aromatase inhibitors, a common hormone therapy for breast cancer. About 182 postmenopausal women with hormone-sensitive breast cancer will either receive the e…

This pilot study in Singapore tests whether exercise therapy and cognitive behavioral therapy (CBT) can reduce fatigue and improve treatment adherence in female breast cancer patients. 100 women who have completed surgery and chemotherapy will be enrolled. The study focuses on wh…

This study tests whether adding acupuncture and acupressure to standard anti-nausea medicine can better reduce chemotherapy-induced nausea. About 90 cancer patients with ongoing nausea will be split into two groups: one gets the extra acupuncture, the other gets medicine alone. T…

This study tests whether a probiotic supplement can help reduce diarrhea and belly discomfort in breast cancer patients taking the drug Abemaciclib. About 80 participants will get either the supplement or a placebo for two months, while also using standard anti-diarrhea medicine.…

This study tests whether a special light therapy can reduce skin damage caused by radiation treatment in women with breast cancer. 60 women who have had breast-conserving surgery and are scheduled for radiation will either receive standard skin care alone or standard care plus po…

This study tests whether wearing a virtual reality (VR) headset during daily radiation therapy can help manage anxiety in people with prostate, breast, lung, or head and neck cancer. About 54 patients will use a Meta Quest 2 headset during their treatments, and researchers will t…

This study tests whether watching augmented reality (AR) health education videos can help reduce anxiety and depression in women after breast cancer surgery. 60 female patients will be randomly assigned to receive either standard education alone or standard education plus AR vide…

This study compares two approaches for breast cancer patients who still have cancer in their sentinel lymph node after chemotherapy: removing the underarm lymph nodes (surgery) or treating them with radiation. The goal is to see if radiation can reduce the risk of arm swelling (l…

This study tests whether an Enhanced Recovery After Surgery (ERAS) protocol can reduce opioid prescriptions and pain after breast conserving surgery. 260 breast cancer patients will be randomly assigned to receive either the ERAS protocol or standard care. The ERAS protocol inclu…

This study tests whether a specific nerve block (SPSIP block) can reduce pain and the need for strong painkillers after mastectomy and lymph node removal. About 50 women with breast cancer will receive either the nerve block or a placebo before surgery. The goal is to improve rec…

This study tests a remote group program called CRAFT-G for breast cancer survivors who struggle with thinking and memory problems after treatment. The program includes six online group sessions led by an occupational therapist, plus computer-based brain training three times a wee…

This study tests a community-based course called BBCSI, led by trained peers, to see if it helps Black breast cancer survivors feel better day-to-day. About 46 women with early-stage breast cancer will take part. The goal is to improve quality of life, not to treat the cancer its…

This study looks at whether giving only radiation after lumpectomy is safe and effective for women aged 60 and older with early-stage, low-risk breast cancer. The goal is to see if skipping hormone therapy can improve quality of life while still controlling the cancer. About 300 …

This study tests whether numbing specific shoulder nerves can reduce pain in people who have shoulder pain after breast cancer surgery and radiation. Sixty adults aged 18-65 with this type of pain will be randomly assigned to receive the nerve block or standard care. The main goa…

This study tests whether inhaling scents from Asian plants can reduce distress and anxiety in breast cancer patients about to start radiotherapy. 300 adults with breast cancer will use aromatherapy and have their stress levels, anxiety, and stress hormones measured. The goal is t…

This study tests a personalized self-management program to help cancer survivors on immune checkpoint inhibitors better handle side effects and reduce anxiety or depression. About 400 adults with breast, colon, lung, skin, or rectal cancer who recently started immunotherapy will …

This study tests a remote coaching program called PRISM for people recently diagnosed with metastatic breast cancer. The program teaches stress management, goal setting, and coping skills through video sessions. Researchers want to see if it improves resilience and quality of lif…

This pilot study tests whether brodalumab, a drug used for autoimmune conditions like psoriasis, can safely reduce immune-related side effects caused by cancer immunotherapy. About 11 adults with advanced solid tumors who developed these side effects will receive brodalumab injec…

This study tests if a 4-week program combining exercise with a gentle, non-invasive brain stimulation technique (tACS) can help breast cancer survivors who struggle with memory and focus after treatment. Researchers will check if the program is practical and safe for 40 participa…

This study compares two ways to treat breast cancer that has spread to nearby lymph nodes: targeted radiotherapy or surgical removal of the nodes. The goal is to see which approach better preserves arm function and reduces the risk of long-term arm swelling. About 1,060 adults wi…

This study follows 135 women who have had breast reconstruction after mastectomy using a special dissolvable mesh called TIGR® Matrix. The goal is to see how the mesh affects their quality of life over three years. Participants will fill out a questionnaire about their symptoms a…

This trial tests whether a wearable sensor called the Alio Smart Patch can help catch early signs of febrile neutropenia, a serious infection risk from chemotherapy. Thirty adults with certain cancers will wear the patch and a glucose monitor at home, with a remote care team watc…

This study tests whether taking tart cherry concentrate and fish oil together for 12 weeks can improve joint function and reduce pain in breast cancer patients who have joint pain from their hormone therapy (aromatase inhibitors). The trial will enroll 30 women who are overweight…

This study looks at whether a 4-month yoga program can reduce joint pain and stiffness in women with breast cancer who are on hormone therapy. About 140 women who have joint pain from their treatment will either take yoga classes twice a week plus home practice, or join a waiting…

This study tests a digital app that connects young adults (ages 18-40) who have finished treatment for lymphoma, breast cancer, testicular cancer, or sarcoma. The app pairs them with trained peer navigators to help with challenges like symptoms, school, work, and relationships. R…

This study tests whether combining the drug memantine with a structured exercise program can improve memory and thinking problems (often called 'chemo brain') in women with early-stage breast cancer undergoing chemotherapy. Ninety participants will be split into three groups: mem…

This study tests whether a tablet-based video program can help rural cancer patients better understand their care and feel more coordinated. About 40 adults with early-stage breast, lung, or colon cancer living in rural Vermont will be randomly assigned to receive the videos righ…

This study tests whether avoiding opioids during breast cancer surgery can reduce pain and side effects afterward. About 200 adults having a lumpectomy or mastectomy will be randomly assigned to receive either opioid-free or standard anesthesia. Researchers will measure pain leve…

This study compares two non-drug treatments—cognitive rehabilitation (brain training) and the Unified Barlow Protocol (emotional therapy)—against a waitlist group to see if they can reduce memory and thinking problems in breast cancer survivors. 123 survivors with mild to moderat…

This study tests whether a 30-minute moderate cycling session just before chemotherapy or immunotherapy can help cancer patients maintain their fitness. 80 adults with breast, ovarian, or colorectal cancer will either receive standard advice or also exercise with a physiotherapis…

This study looks at whether extending the nightly fasting period (not eating for a longer stretch each night) can improve sleep, thinking, and quality of life in breast cancer survivors. Researchers will compare this approach to health education alone. The study involves 60 femal…

This study tests whether time-restricted eating (eating all food within an 8-hour window each day) is feasible and helpful for women undergoing chemotherapy for early-stage breast cancer. Forty participants will either follow this eating pattern or a usual diet for 24 weeks. Rese…

This study tests an 8-week telehealth occupational therapy program designed to help breast cancer survivors increase physical activity after breast-conserving surgery or mastectomy. The program is delivered via Zoom and focuses on each survivor's preferred activities. Researchers…

This pilot study is testing whether a brief, clothed upper body massage given after each radiation treatment can reduce muscle and joint pain, improve arm and shoulder mobility, and enhance quality of life for breast cancer patients. About 55 women receiving curative radiation wi…

This trial compares two ways to educate breast cancer patients before radiotherapy: a standard phone call versus a videoconference with a radiation therapist. The goal is to see if seeing a face on screen reduces patients' fears and anxiety more than a voice on the phone. About 1…

This study tests whether a 16-week virtual exercise program can improve fitness, muscle strength, and quality of life in people with indolent (slow-growing) metastatic breast cancer. Participants work with a trainer three times a week via video calls. The goal is to see if exerci…

This study compares two types of nerve blocks to manage pain and reduce opioid use in 70 adults having breast-conserving surgery. Participants will receive one of two ultrasound-guided injections before surgery. The goal is to see which method provides better pain relief and lowe…

This early-phase study tests whether psilocybin (the active ingredient in magic mushrooms) combined with talk therapy can reduce fear of cancer returning in 20 women with early-stage breast or ovarian cancer who are currently in remission. Participants receive a moderately high d…

This study compares a newer, less invasive mastectomy technique (endoscopic skin-sparing) with the standard approach in 258 women with breast cancer. The goal is to see if the endoscopic method leads to fewer wound complications and higher patient satisfaction. Participants are r…

This study looks at whether a telehealth exercise program with protein support can help women aged 65 and older with breast cancer receive all their planned chemotherapy at the right dose. Participants will either do resistance exercises and take protein or receive health educati…

This study tests whether adding visual biofeedback to standard physiotherapy improves shoulder mobility, strength, and function in women who had breast cancer surgery. Forty women with shoulder problems after surgery will be randomly assigned to either conventional physiotherapy …

This study tests whether an AI system can help doctors better manage chemotherapy side effects in people with breast or colorectal cancer. About 174 patients will be split into two groups: one where doctors use AI suggestions to adjust care, and one with standard care alone. The …

This study tests whether computer-based brain-training games can improve memory, focus, and thinking in breast cancer survivors who report cognitive problems (often called 'chemo brain'). About 386 survivors will be randomly assigned to play either specially designed neuroplastic…

This study is testing whether a 12-week physical activity program can improve quality of life and reduce pain in women with early-stage hormone receptor positive breast cancer who are on hormone therapy. About 44 participants will join an exercise program and fill out questionnai…

This study compares two group therapy programs—Mindfulness Oriented Recovery Enhancement (MORE) and Supportive Psychotherapy—to help breast cancer survivors manage joint pain caused by aromatase inhibitors. About 200 women will attend weekly two-hour sessions for eight weeks and …

This study tests whether pressing tiny seeds on specific ear points, combined with a steroid drug (dexamethasone), can prevent or reduce nausea and vomiting caused by chemotherapy in breast cancer patients. About 25 women will receive this treatment before chemo and track their s…

This study tests whether pressing on specific ear points (with tiny seeds) plus a steroid drug can prevent nausea and vomiting caused by a breast cancer treatment. About 25 adults with breast cancer will try this approach and track their symptoms for five days. The goal is to fin…

This study tests whether a home-based exercise and nutrition program, called prehabilitation, can improve physical function in adults aged 65 and older with breast cancer before they have surgery. The program includes strength, balance, and flexibility exercises tailored to each …

This pilot study tests a new type of surgical drain called the Interi Manifold against the standard Jackson-Pratt drain in women having implant-based breast reconstruction after mastectomy. The new drain has multiple branches and a special suction system that may remove fluid mor…

This study tests whether regular phone or video calls from a trained oncology nurse can help breast cancer patients on CDK inhibitor drugs catch and manage side effects early. About 124 women will be randomly assigned to either standard care or standard care plus structured telen…

This study tests whether a special spa therapy can improve skin-related quality of life in people who have skin hardening (fibrosis) after radiation for breast or head/neck cancer. About 110 adults who finished radiation at least 6 months ago will be randomly assigned to receive …

This study looks at whether a 12-week virtual dance program can improve quality of life and reduce pain, fatigue, and body image issues in breast cancer survivors who have ongoing pain after surgery. Thirty participants who had a lumpectomy or mastectomy and still have moderate t…

This study tests a decision aid for breast cancer patients experiencing nerve damage (numbness or tingling) from chemotherapy. The tool provides information about long-term nerve symptoms and helps patients discuss treatment priorities with their doctor. Researchers will enroll 2…

This study tests whether a program of specific shoulder exercises can improve muscle function and reduce pain in women who have had a mastectomy. Sixty women aged 35-55 with shoulder problems will be enrolled. The exercises focus on strengthening and stabilizing the shoulder blad…

This study is testing a new surgical technique for breast cancer called endoscopic nipple-sparing mastectomy, done through just one small cut in the armpit. The goal is to remove breast tissue while sparing the nipple and avoiding a large scar on the breast. Ten women with early-…

This study tests whether a new care pathway called AMADeuS, which includes awake surgery, same-day discharge, and telemedicine follow-up, is as safe and effective as standard hospital care for women having mastectomy with immediate breast reconstruction. One hundred women aged 18…

This study tests a two-day cognitive behavioral therapy (CBT) program to help breast cancer survivors manage joint and muscle pain caused by their hormone-blocking medication. The goal is to reduce pain, improve quality of life, and help patients stay on their prescribed treatmen…

This study tests whether a small, non-invasive device that stimulates a nerve in the ear can help breast cancer survivors manage pain, anxiety, depression, and fatigue from home. About 40 survivors who have finished primary cancer treatment and still have moderate pain will use t…

This study tests a 4-week online cognitive-behavioral therapy (CBT) program for women with BRCA1/2 mutations who have finished cancer treatment and still worry a lot about cancer coming back. Researchers will compare those who get therapy right away to those on a waitlist, measur…

This study is testing whether a genetic test can help doctors choose the best anti-nausea drugs for Chinese women with early breast cancer undergoing chemotherapy. About 200 participants will either receive standard anti-nausea medication or a personalized regimen based on their …

This large phase 3 trial is testing whether giving lidocaine (a numbing medicine) during and after breast cancer surgery can reduce the chance of long-term pain. About 4,300 women having mastectomy or breast-conserving surgery will receive either lidocaine or a placebo. The main …

This study tests if ultrasound-guided injections of dextrose (a type of sugar water) can reduce persistent chest wall and armpit pain in breast cancer survivors. Fifteen women who have finished standard physical therapy but still have pain will receive three injections over 8 wee…

This study tests if a procedure called vaginal radiofrequency can help reduce vaginal dryness in women being treated for breast cancer. The trial will include 75 women who are on hormone therapy and still have dryness despite using moisturizers. Half will continue with standard h…

This study tests two types of nerve blocks to see which one works better for pain after breast cancer surgery. 50 women having a mastectomy will get either a newer or a standard block. The goal is to find a way to reduce the need for strong painkillers like morphine and help pati…

This study tests a three-stage mental health plan for breast cancer survivors in Pakistan who also have depression. Over 26,000 women will start with guided self-help, then move to therapy or medication if needed. The goal is to see if this step-by-step approach can reduce depres…

This study tests whether nurse-delivered hypnosis before and during breast cancer surgery can lower the amount of opioid painkillers patients need after surgery. About 225 adults having breast surgery will be randomly assigned to receive hypnosis plus standard anesthesia, standar…

This study is testing a magnetic tracer called Magtrace for sentinel lymph node biopsy in women with breast cancer who are having a lumpectomy. The main goal is to see how often skin discoloration happens and how it affects patients' quality of life. Researchers will follow 184 p…

This study looks at whether mindfulness-based breathing exercises can help control symptoms and lower stress in breast cancer patients receiving chemotherapy. About 72 patients will take part, with half doing the breathing exercises and the other half receiving standard care. Res…

This study tests if progressive resistance exercise can improve arm swelling and function in people who developed lymphedema after breast cancer treatment. Fifty adults aged 18-60 who are at least 3 months past surgery will be enrolled. Participants will do supervised exercises a…

This study tests whether a program of targeted exercise and psychological support before cancer treatment (called prehabilitation) can help patients with solid tumors recover better physically and emotionally. Researchers will compare this program to standard care in 125 adults w…

This study tests a new type of radiation therapy that adapts to changes in the body during treatment, aiming to reduce side effects like skin burns and scarring. It includes 500 women with breast cancer who are at high risk of fibrosis (hardening of breast tissue). The goal is to…

This study compares two exercise programs for women who have finished breast cancer treatment. One group does supervised resistance and relaxation exercises at a facility, while the other follows a home-based resistance routine. The goal is to see which approach better improves m…

This study compares two types of nerve blocks (pectoral nerve block vs. paravertebral block) given during mastectomy to see which better prevents chronic pain. Ninety women aged 20-65 undergoing mastectomy will be randomly assigned to one of the two blocks. The goal is to reduce …

This study compares two drugs—solifenacin (used for overactive bladder) and clonidine (a common hot flash treatment)—to see which better reduces hot flashes in breast cancer patients on hormone therapy. About 110 women will take one of the pills daily for three weeks and track th…

This study tests whether taking a daily probiotic supplement for 6 months can reduce common chemotherapy side effects like nausea, vomiting, diarrhea, and nerve pain in breast cancer patients. One hundred women with stage I-III breast cancer will receive either a three-strain pro…

This small pilot study is testing whether a gentle energy therapy called Medical Reiki, given before breast cancer surgery, can improve mood, reduce stress, and help with recovery. Researchers will enroll 32 women with early-stage breast cancer who are having a mastectomy. The go…

This study tests whether the order in which mammogram images are taken affects pain and satisfaction in women who have had breast cancer. 400 women who had breast-conserving surgery will be randomly assigned to one of four view sequences during their annual surveillance mammogram…

This study looks at whether a 6-month home exercise and nutrition program can improve thinking and physical abilities in cancer survivors aged 65 and older, along with their support person. About 1,500 participants will be assigned to either a virtually supervised or unsupervised…

This study tests whether adding amantadine or duloxetine to the standard painkiller pregabalin can prevent chronic pain after mastectomy. About 150 women undergoing breast cancer surgery will be randomly assigned to one of three drug combinations. The goal is to see if these add-…

This study tests if treating insomnia first helps breast cancer survivors lose more weight. 250 women with early-stage breast cancer who are overweight and have insomnia will either get a sleep therapy (CBT-I) or sleep education before starting a weight loss program. Researchers …

This study tests whether a visual communication tool called MyCareGorithm helps newly diagnosed cancer patients understand their treatment options. About 86 patients with breast or head and neck cancer, along with their caregivers, will use the tool during consultations. The main…

This study is testing a program called MyCarePulse and ASCENT to help cancer patients overcome food-related challenges. About 100 adults recently diagnosed with certain cancers will either receive the program or standard care. The goal is to see if the program improves food secur…

This study tests a special cooling cap worn during chemotherapy to see if it helps breast cancer patients keep more of their hair and feel better emotionally. About 100 people with early-stage breast cancer will take part. Researchers will also look at certain genes to see if the…

This study is testing a special radiation device called the GammaPod to give a single, precise dose of radiation to the area where breast cancer was removed. The goal is to see if this approach can shorten the overall treatment time by a few days and improve patients' quality of …

This study tests whether a nutritional supplement called Epidiferphane can reduce common side effects of taxane chemotherapy, such as nerve damage and anemia, in breast cancer patients. About 74 participants will receive Epidiferphane alongside their standard chemo to see if it h…

This study tests a training program that teaches breast cancer survivors with memory and concentration problems (brain fog) strategies to improve daily tasks and quality of life. About 50 women who finished cancer treatment 6 months to 3 years ago will participate. The goal is to…

This study tests whether using a special dye (ICG) to map the arm's lymph vessels can make daily arm massage more effective at preventing lymphedema (swelling) after breast cancer surgery. 30 women will be randomly assigned to either ICG-guided massage or traditional massage, and…

This study tests whether a special low-calorie diet that mimics fasting, taken for 5 days each month for 6 months, can lower cholesterol and reduce side effects from aromatase inhibitors in post-menopausal breast cancer patients. Sixty women on hormone therapy will be randomly as…

About half of women stop taking aromatase inhibitors early due to side effects, raising the risk of cancer returning. This study tests whether switching to a different hormone drug or using other symptom-relief methods works better at managing those side effects. Researchers will…

This study tests whether combining electroacupuncture (needles with mild electric pulses) with self-acupressure (pressing specific points on the body) can improve quality of life for people with early-stage breast cancer undergoing chemotherapy. About 192 participants will be spl…

This study tests two different nerve block techniques to control pain after mastectomy in 40 women with breast cancer. The goal is to see which method reduces the need for morphine and other opioids, helping patients recover faster and with fewer side effects. Participants will r…

This study is testing a virtual program called Mindful After Cancer (MAC) to help breast and gynecologic cancer survivors with sexual health and body image concerns. The program combines mindfulness training, educational materials, and group support over 8 weeks via video calls. …

This study tests a 12-week exercise program for Black women who have finished breast cancer treatment. The goal is to see if the program is easy to follow and helps improve well-being. About 75 women will take part, with some starting the program right away and others waiting. Re…

This study tests a program for older adults (65+) with cancer and mild memory issues, along with their spouse or caregiver. Over six video sessions, the pair learns strategies to manage challenges. The goal is to see if the program reduces distress and improves quality of life. A…

This study tests a 16-week video exercise program for breast cancer survivors who have recently had mastectomy surgery. The program includes twice-weekly classes focused on aerobic fitness, balance, and strength. Researchers will track attendance and measure improvements in fitne…

This study tests whether Revaree Plus, a hyaluronic acid vaginal suppository, can improve vaginal dryness in women with hormone-receptor-positive breast cancer. About 60 participants will use the suppository for 8 weeks. Researchers will measure changes in vaginal health using a …

This study tests a 12-week telehealth exercise program for rural cancer survivors who have ongoing fatigue after treatment. Participants receive personalized exercise sessions via video calls and an app, and provide small blood samples at home. The goal is to see if the program r…

This study tests a program called CARES that provides nurse navigators and counselors to rural cancer patients. The goal is to see if this support helps patients start and finish treatment more quickly and improves their quality of care. About 320 adults with solid tumors like lu…

This study tests whether walking programs can reduce fatigue in older breast cancer survivors (age 60+). 24 participants will either walk at a center or at home. The goal is to find a practical way to improve energy and well-being after cancer treatment.

This study tests whether the MIND diet, a mix of the Mediterranean and DASH diets, can improve thinking, memory, and energy in breast cancer survivors who have ongoing brain fog. Two hundred survivors who finished treatment 6 months to 3 years ago will either follow the MIND diet…

This study is testing whether resistance training combined with a post-workout protein drink can help women with breast cancer maintain muscle and reduce fat gain while they undergo chemotherapy. Thirty women will be randomly assigned to receive either 20 or 60 grams of whey prot…

This study offers a free, personalized exercise program for women with breast cancer. Participants can choose to exercise in person, online, or at home. The goal is to see if regular exercise improves quality of life, fitness, and overall well-being during and after cancer treatm…

This study looks at whether a weekly cycling exercise program can help breast cancer patients maintain their physical fitness during chemotherapy. About 156 women with early-stage breast cancer will either do the cycling program or receive standard care. The goal is to see if the…

This study compares two standard exercise programs to see which one better helps women increase muscle mass after breast cancer treatment. Thirty women aged 20-89 who have completed treatment (except chemotherapy) will follow either standard resistance training or a special 6-12-…

This study looks at whether coloring mandala patterns for 30 minutes during chemotherapy can help breast cancer patients feel less distressed and anxious, and more comfortable. About 60 participants will be randomly assigned to either color mandalas or receive usual care. Researc…

This study compares two approaches for breast cancer patients who need a mastectomy and radiation. The experimental group gets radiation before surgery with immediate breast reconstruction, while the standard group gets radiation after surgery with delayed reconstruction. The goa…

This study tests whether a digital support program can help people with breast, prostate, or colorectal cancer reduce the time they spend sitting during their treatment. The goal is to improve their well-being and lower future health risks. About 172 participants will use an acti…

This study tests a non-drug light treatment called photobiomodulation to see if it can improve memory and thinking problems (chemobrain) in women who had chemotherapy for breast cancer. About 200 women who finished chemo within the past year and have ongoing cognitive complaints …

This study compares opioid-free anesthesia using dexmedetomidine and lidocaine to standard opioid-based anesthesia in 158 women undergoing breast reconstruction after cancer. The goal is to see if the opioid-free approach reduces morphine use and side effects in the first 48 hour…

This study tests a digital health program called AYA STEPS for adolescent and young adult cancer survivors. The program uses video sessions and online materials to teach skills for managing symptoms like pain, fatigue, and emotional distress, and to encourage follow-up care. Rese…

This pilot study is testing whether breast cancer patients can apply azelaic acid cream twice daily during radiation treatment. The cream is meant to help with skin side effects from radiation. The study will enroll 33 adults with breast cancer who are about to start radiation th…

This study compares two types of nerve blocks to control pain after modified radical mastectomy. 110 women will receive either a costotransverse foramen block or an erector spinae plane block, both using the numbing drug bupivacaine. The goal is to see which block reduces the nee…

This study tests an online group program called Project SOAR Awakenings for Black American women diagnosed with breast cancer. The program uses small-group video chats to discuss culturally relevant topics and promote well-being. Researchers will compare participants' depression,…

This phase 3 trial is testing whether the corticosteroid dexamethasone can reduce hand-foot syndrome—a painful skin reaction—caused by liposomal doxorubicin chemotherapy in breast cancer patients. 182 participants will receive either high-dose, standard-dose, or no dexamethasone …

This study tests whether a medicated nasal spray (dexmedetomidine) can help women feel relaxed and less anxious during breast-conserving surgery for breast cancer. About 394 women will receive either the spray or a placebo before surgery. Researchers will measure sedation levels,…

This study tests whether a 16-week high-intensity interval training (HIIT) program on a stationary bike can improve thinking, memory, and heart health in women undergoing chemotherapy for breast cancer. Thirty participants will be randomly assigned to either HIIT or a stretching …

This study compares two types of nerve blocks—paravertebral and pectoral—given before implant-based breast reconstruction surgery. Researchers will measure pain levels and physical well-being in 212 adult patients. The goal is to find which block offers better recovery and comfor…

This study tests whether radiofrequency therapy, pelvic floor exercises, or both can improve pelvic floor symptoms like pain and dryness in breast cancer survivors. 117 women with stage 1 or 2 breast cancer who have pelvic floor dysfunction will be randomly assigned to one of thr…

This study looks at whether a 16-week exercise program called Get Real and Heel can increase physical activity and improve well-being in people with metastatic breast cancer. Researchers will enroll 50 participants to see if the program is feasible and helps with symptoms, qualit…

This study tests whether a cooling device called hilotherapy can reduce nerve damage symptoms (like numbness, tingling, or pain) caused by taxane chemotherapy in breast cancer patients. About 60 participants will either receive the cooling treatment during each chemo session or s…

This study looks at whether a 12-week structured exercise program can improve heart and muscle health in breast cancer survivors aged 60 and older who had chemotherapy. Sixty participants will be randomly assigned to either supervised exercise training or a yoga and stretching pr…

This study tests a new way to remove breast cancer through a single small cut in the armpit, leaving no visible scar on the breast. It is for women with small to medium breasts who need a mastectomy but want to keep their nipple. The procedure uses standard laparoscopic tools, ma…

This study looks at whether the drug gabapentin should be routinely used for pain control in women having a mastectomy (breast removal surgery). About 1,896 patients will be randomly assigned to either have gabapentin removed from their pre-surgery medication list or continue as …

This study tests whether a 6-month adapted physical activity program improves quality of life and reduces healthcare costs for women with breast cancer during active treatment. About 866 women will be randomly assigned to either the exercise program or standard recommendations fo…

This study looks at whether combining resistance and aerobic arm exercises can improve arm strength, function, and quality of life in breast cancer patients. About 40 women who are at least 15 months past surgery and not currently active will participate. The goal is to find bett…

This study looks at whether a 12-week upper arm aerobic exercise program can reduce arterial stiffness in women who have had breast cancer. Arterial stiffness is a side effect of some cancer treatments and can increase heart risk. The trial will measure changes in blood vessel fl…

This study tests whether taking creatine, a common dietary supplement, can help breast cancer survivors regain strength and endurance faster when combined with a 12-week exercise program. Sixty women who recently finished chemotherapy will be randomly assigned to exercise with or…

This study tests whether electroacupuncture can reduce stomach-related side effects like nausea, vomiting, poor appetite, and dry mouth caused by chemotherapy in breast cancer patients. About 388 women with stage I-III breast cancer will receive either standard anti-nausea drugs …

This study tests whether a 6-week online psychoeducation program can improve psychological well-being and quality of life in breast cancer survivors who finished active treatment at least one year ago. Seventy-two women will either join the online program plus standard care or re…

This study looks at whether eating only during certain hours of the day can reduce side effects from cancer treatment and improve mood and behavior. About 175 adults with colorectal or breast cancer will follow a time-restricted eating plan while receiving standard therapy. Resea…

This study tests whether a 5-day course of whole breast radiation works as well as a 9-day course for women with early-stage breast cancer. About 144 participants will be randomly assigned to one of the two schedules. The main goal is to see if the shorter treatment leads to simi…

This study compares two simple physical activity strategies—short walks after meals and brief activity snacks—to standard 30-minute exercise sessions in breast and prostate cancer survivors. The goal is to see which approach best controls blood sugar and is easiest to fit into da…

This study follows 104 breast cancer patients whose cancer has spread to the chest wall and who are having surgery to remove part of the chest wall. The goal is to see how the surgery affects their quality of life, pain, and survival. Researchers will track these outcomes over ti…

This study tests whether a mobile app called Resilience© can improve quality of life for early-stage breast cancer patients undergoing hormone therapy. The app provides education, symptom management tips, and personalized support. 180 participants in France will be randomly assig…

This study tests whether a short educational video about safe opioid use can help breast reconstruction patients use fewer painkillers after surgery. About 68 women will be randomly assigned to watch the video or receive standard care. Researchers will track how many opioids they…

This study tests a short self-help booklet designed for people recently diagnosed with certain cancers (breast, colorectal, gynecological, melanoma, or bladder) who still smoke. The goal is to see if the booklet is easy to use and helps increase their motivation to quit. About 10…

This study looks at whether a supervised program of moderate walking and strength training can safely reduce pain in breast cancer survivors who still have pain after treatment. Ten women who finished cancer therapy at least six months ago will participate. The goal is to see if …

This study tests whether using opioid-free anesthesia during mastectomy can reduce chronic pain one year after surgery. 230 breast cancer patients will be randomly assigned to receive either opioid-free or standard opioid-based anesthesia. Researchers will also look at how psycho…

This study tests a stress management program called Self-Help Plus for women with breast or gynecologic cancer in Vietnam. The goal is to see if it helps reduce anxiety and depression and improves quality of life. About 285 women will take part, with half receiving the program an…

This study aims to understand how a light-based treatment called photobiomodulation affects sexual quality of life in women with breast cancer who have menopausal symptoms like vaginal dryness and pain. About 25 women will be asked about their sexual health before and after the t…

This study tests whether adapted Argentine Tango dancing can reduce nerve damage symptoms caused by breast cancer chemotherapy. About 140 survivors who completed taxane-based chemo at least 3 months ago will take 16 dance sessions over 8 weeks. Researchers will measure changes in…

This study compares two standard pain-block methods for people having a mastectomy (breast removal) due to breast cancer or high risk. One method uses a nerve block before surgery, the other during surgery. The goal is to see which approach reduces the need for opioid painkillers…

This study tests whether a simple, 45-minute resistance exercise program (using bands) can help breast cancer survivors manage fatigue. Researchers will enroll 60 women from different income backgrounds to see if the program is practical and if income affects how well people stic…

This study is testing whether a group exercise program called Strength After Breast Cancer can be offered in a physical therapy clinic to help women who have finished breast cancer treatment improve their physical function. About 40 women will take part, completing questionnaires…

This study explores whether regular video or phone check-ins between hospice patients with advanced breast cancer and their oncology team can improve the hospice experience. About 200 participants, along with their caregivers and nurses, will take part. The goal is to see if this…

This pilot study tests whether a diet called MIND (rich in berries, leafy greens, and fish) can help protect memory and thinking in women with breast cancer who are starting chemotherapy. 43 postmenopausal women with stage II-IV breast cancer will receive either nutrition counsel…

This study tests whether brief, audio-recorded guided meditation (10-15 minutes) during daily radiation therapy can lower anxiety in people with breast or gynecologic cancers. About 34 adults will be randomly assigned to either listen to meditation practices or receive standard c…

This study tests an internet-based self-help program called eConquerFear-HK for Chinese cancer survivors who have mild to moderate fear of their cancer coming back. About 48 people who finished treatment for early-stage breast or colorectal cancer will try the program. The goal i…

This study is testing a web-based program called CUMACA-M that uses artificial intelligence to help long-term breast cancer survivors (at least 5 years past treatment) manage ongoing physical, emotional, and social issues. The program offers personalized modules to address each w…