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Antifungal drug could boost immunotherapy for tough breast cancer

NCT ID NCT06802757

Recruiting now Disease control Sponsor: Shandong Cancer Hospital and Institute Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether adding an antifungal drug (posaconazole) to standard immunotherapy and chemotherapy can help more women with triple-negative breast cancer achieve a complete response before surgery. About 72 women with early-stage, high-risk disease will be randomly assigned to receive either the standard treatment or the standard treatment plus posaconazole. The main goal is to see if the combination increases the rate of tumor disappearance.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Posaconazole (an antifungal drug) combined with PD-1 inhibitors (immunotherapy) and chemotherapy
What this could lead to
If this works, it could increase the number of patients whose tumors completely disappear before surgery, potentially improving long-term outcomes for triple-negative breast cancer.
What could go wrong
This is a small, early-phase (Phase 2) trial with only 72 participants. The added benefit of posaconazole is unproven in humans for this purpose, and side effects from the combination are unknown.

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Conditions

The condition(s) this trial relates to.

breast cancer breast neoplasm triple-negative breast carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BREAST CANCER

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Breast Cancer Center Shandong Cancer Hospital and Institute Shandong First Medical University and Shandong Academy of Medical Sciences

    RECRUITING

    Jinan, Shandong, 250117, China

    Contact Phone: •••-•••-•••• Email: •••••@•••••

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