New targeted chemo aims to hit tumors harder, spare healthy tissue
NCT ID NCT04969835
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-phase trial tests AVA6000, a chemotherapy drug that is designed to activate only in tumors, potentially reducing side effects. About 158 adults with advanced solid tumors (like breast, ovarian, or salivary gland cancer) will receive the drug intravenously. The main goals are to check safety and find the right dose.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- AVA6000 (a targeted form of the chemotherapy drug doxorubicin, designed to activate only in tumors)
- What this could lead to
- If successful, this could lead to a more targeted chemotherapy that reduces side effects by activating only in tumors.
- What could go wrong
- This is a very early Phase 1 trial, so safety and effectiveness are not yet known. It may not work or could have unexpected side effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Email: •••••@•••••
Locations
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Fred Hutchinson Cancer Center
RECRUITINGSeattle, Washington, 98109, United States
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Memorial Sloan Kettering Cancer Center
RECRUITINGNew York, New York, 10065, United States
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St James's University Hospital, The Leeds Teaching Hospitals NHS Trust
RECRUITINGLeeds, LS9 7TF, United Kingdom
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The Beatson West of Scotland Cancer Centre, NHS Greater Glasgow & Clyde
RECRUITINGGlasgow, G12 0YN, United Kingdom
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The Christie NHS Foundation Trust
RECRUITINGManchester, M20 4BX, United Kingdom
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The Freeman Hospital, Newcastle-upon-Tyne NHS Foundation Trust
RECRUITINGNewcastle upon Tyne, NE7 7DN, United Kingdom
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The Royal Marsden, NHS Foundation Trust
RECRUITINGLondon, SM2 5PT, United Kingdom
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University of Texas MD Anderson Cancer Center
RECRUITINGHouston, Texas, 77030, United States
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Weston Park Cancer Centre, Sheffield Teaching Hospitals NHS Foundation Trust
NOT_YET_RECRUITINGSheffield, S10 2SJ, United Kingdom
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