SOFT TISSUE SARCOMA

This study is testing whether a shorter, more intense course of radiation before surgery works as well as the standard longer course for treating soft tissue sarcomas. Researchers will compare 5 treatments over 1-2 weeks versus 25 treatments over 5 weeks in 30 patients. The goal …

This study is testing whether adding an experimental immunotherapy drug called retifanlimab to standard chemotherapy (gemcitabine and docetaxel) is safe and more effective for treating advanced soft tissue sarcoma. The goal is to see if the combination can better control the canc…

This is an early-stage study testing a new drug called MT-4561 in people with various advanced solid tumors who have run out of standard treatment options. The main goals are to find a safe dose, see how the body processes the drug, and check for any early signs that it might hel…

This study is testing whether a combination of two drugs, cadonilimab and anlotinib, can help control advanced soft tissue sarcoma that has continued to grow after standard first-line chemotherapy. It will involve about 27 adults to see if the treatment shrinks tumors and is safe…

This study is testing a non-invasive treatment called High Intensity Focused Ultrasound (HIFU) for people with soft tissue sarcoma or desmoid tumors. HIFU uses targeted sound waves to try to destroy tumor cells from outside the body, aiming to control the disease with minimal sid…

This trial is testing if a drug called capmatinib, already used for some lung cancers, can help adults with rare or uncommon cancers that have specific changes in a gene called MET. The goal is to see if the drug shrinks tumors or provides long-term benefit for these hard-to-trea…

This study is testing if an immunotherapy drug called dostarlimab works better than standard chemotherapy as a first treatment for adults with certain rare, advanced cancers that have spread or cannot be surgically removed. About 120 participants will be randomly assigned to rece…

This Canadian study tests whether special vacuum dressings can reduce serious wound complications after leg sarcoma surgery. About 291 patients who receive radiation before surgery will be randomly assigned to get either the vacuum dressing or a standard dressing for one week. Re…

This large study is testing if adding chemotherapy before and after surgery helps prevent the cancer from spreading in patients with a high-risk type of soft tissue sarcoma. It will compare standard surgery and radiation to that same treatment plus 12 weeks of chemotherapy. The g…

This is a first-in-human study testing a new type of engineered immune cell therapy for patients with advanced soft tissue or bone sarcoma. The main goals are to find a safe dose and see if the treatment can help control the disease. The trial will enroll about 40 patients who ha…

This early-stage trial is testing a new, personalized vaccine made from a patient's own tumor. The goal is to see if this vaccine can help the patient's immune system recognize and fight their cancer, especially when standard immunotherapy has stopped working. The study will enro…

This study is testing whether injecting an experimental drug called tigilanol tiglate directly into tumors can destroy them in people with advanced soft tissue sarcoma. The trial will enroll about 40 adults to see if the injections shrink or eliminate the treated tumors and help …

This early-stage study is testing a new radioactive drug treatment for people with advanced solid tumors that have stopped responding to standard therapies. Researchers will first use a special imaging scan to see if patients' tumors are likely to respond, then give the radioacti…

This study is testing an oral medication called anlotinib for people with advanced forms of soft tissue sarcoma that have spread or cannot be removed by surgery. The main goal is to see if the drug can shrink tumors or slow their growth compared to standard chemotherapy. The tria…

This study is testing a new, shorter radiation treatment for soft tissue sarcoma in the arms or legs. It aims to see if using targeted proton or carbon ion radiation for 2-3 weeks before surgery is safe and causes fewer wound healing problems than the standard 5-week treatment. T…

This is a first-in-human study testing a new cancer drug called AVA6000 in patients with advanced solid tumors that have spread or cannot be removed by surgery. The drug is a modified version of a common chemotherapy (doxorubicin) designed to be activated only inside tumors, pote…

This is a first-in-human study testing a new type of personalized cell therapy for children and young adults (up to age 21) whose solid tumors have come back or haven't responded to standard treatments. Doctors will collect a patient's own immune cells (T cells), genetically modi…

This program provides access to an experimental treatment called DNG64-CAR-V for patients with advanced pancreatic cancer, sarcoma, or breast cancer who have no other effective options left. The treatment uses a specially engineered virus designed to target and kill cancer cells …

This study compares two cancer drugs, trabectedin and gemcitabine, to see which works better for controlling advanced leiomyosarcoma after initial chemotherapy has stopped working. It will enroll 100 adults whose cancer has progressed despite previous treatment. The trial include…

This study is testing a multi-step treatment plan for people with high-risk soft tissue sarcoma that can be surgically removed. The goal is to see if combining chemotherapy, an immunotherapy drug (atezolizumab), radiation, and surgery can help keep the cancer from coming back lon…

This study is testing a new approach for a rare abdominal cancer called retroperitoneal sarcoma. Doctors want to see if giving a few very high doses of targeted radiation before surgery is safe and helps control the tumor. The study will enroll 50 patients to check for complicati…

This early-stage study is testing the safety of a two-part treatment for advanced sarcomas that have stopped responding to standard therapies. Doctors take a patient's own immune cells, genetically modify them to recognize and attack cancer cells, and then infuse them back. These…

This early-stage study is testing a new technique called In Vivo Lung Perfusion (IVLP) for people with bone or soft tissue sarcoma that has spread to both lungs. During surgery to remove visible tumors, doctors will deliver chemotherapy directly to one lung for 3 hours to try to …

This study is testing if a special fluorescent dye can help surgeons see tumor edges better during sarcoma removal surgery. The dye is injected before the operation and glows under a special camera, potentially helping the surgeon leave less cancerous tissue behind. Researchers w…

This study is testing a new type of PET/CT scan to see if it can create clearer pictures of soft tissue sarcoma tumors. Researchers want to know if this scan, which uses a radioactive tracer called 68Ga-DOTATATE, works better than standard scans. The goal is to improve diagnosis …

This study is testing whether a personalized exercise program before surgery helps people with soft tissue sarcoma in the leg recover better. Patients receive standard radiation and surgery, but half also do special exercises for 8 weeks beforehand. The goal is to see if this 'pr…

This study aims to understand how patients recover physically and mentally after limb-saving surgery for bone or soft tissue sarcoma in the leg. Researchers will observe 60 adult survivors, focusing on their walking patterns, physical function, and overall quality of life. The go…

This study aims to understand how people feel and function after surgery to remove a soft tissue sarcoma from their arm or leg. Researchers will ask about 150 people who had this surgery between 2010 and 2021 to fill out questionnaires and do physical tests, like walking assessme…

This study aims to learn more about how the immune system interacts with rare types of soft tissue sarcoma. Researchers will observe 400 adult patients in France who have one of nine specific rare sarcoma subtypes. The goal is to collect detailed biological and clinical informati…

This study aims to find better ways to predict if a type of cancer called soft-tissue sarcoma will spread to other parts of the body. Researchers will use a special type of MRI scan and blood tests to look for signs linked to cancer spread in 145 adult patients. The goal is to ga…