SOFT TISSUE SARCOMA

This early-phase trial tests a custom-made RNA vaccine designed to help the immune system recognize and attack tumors in people with advanced melanoma or soft tissue sarcoma whose cancer has worsened despite standard immunotherapy. Up to 18 adults will receive three doses of the …

This study tests if a short course of proton therapy (5 sessions) before surgery for soft tissue sarcoma in the arms, legs, or trunk is safe and effective. About 40 adults will receive the therapy and then have standard surgery. Researchers will track wound healing problems and q…

This study tests capmatinib, a drug already approved for certain lung cancers, in adults with other rare cancers that have specific MET gene changes. About 30 participants will receive the drug to see if their tumors shrink or stop growing for at least 24 weeks. The goal is to fi…

This study tests the drug nivolumab in people with advanced rare cancers that have a specific marker (PD-L1). The goal is to see if the drug can shrink or control tumors for at least 12 months. About 28 adults who have not responded to standard treatments will take part.

This study looks at whether a vacuum (negative pressure) dressing applied right after surgery can reduce wound complications in people with soft-tissue sarcoma of the leg who had radiation before surgery. About 291 adults will be randomly assigned to get either the vacuum dressin…

This study is testing a non-invasive treatment called high intensity focused ultrasound (HIFU) for soft tissue sarcoma and small symptomatic desmoid tumors. Around 10 to 16 adults will receive HIFU as a day procedure, with the goal of destroying tumor cells using ultrasound waves…

This study tests whether adding the immunotherapy drug atezolizumab to standard chemotherapy, radiation, and surgery can delay the return of high-risk soft tissue sarcoma in the arms, legs, or trunk. About 50 adults with certain aggressive sarcoma types will receive atezolizumab …

This early-phase study tests whether giving specially engineered immune cells (HER2-CAR T cells) together with an immune checkpoint inhibitor (pembrolizumab or nivolumab) is safe and can help people with advanced sarcoma. About 25 participants will receive chemotherapy to prepare…

This early-phase study tests a technique called in vivo lung perfusion (IVLP), where chemotherapy is delivered directly into one lung during surgery to remove sarcoma tumors that have spread there. The goal is to kill any remaining microscopic cancer cells while reducing side eff…

This early-stage study is testing a new treatment called DIT309 for people with advanced bone or soft tissue sarcomas that have not responded to standard therapies. DIT309 uses specially engineered immune cells (CAR-T cells) to attack the cancer. The main goals are to check the t…

This study tests whether adding an experimental immunotherapy drug called retifanlimab to standard chemotherapy (gemcitabine and docetaxel) can help control advanced soft tissue sarcoma that has spread or cannot be removed by surgery. About 98 adults with this type of cancer will…

This early-stage trial tests a treatment where a child's own immune cells are collected, modified to better attack cancer, and given back as a one-time infusion. It is for children and young adults up to age 21 with solid tumors that have come back or not responded to standard th…

This study tests a new drug called envafolimab, given as a shot, combined with two chemotherapy drugs (doxorubicin and ifosfamide) as a first treatment for advanced soft tissue sarcoma. The goal is to see if this combination works better than chemo alone. About 25 adults with thi…

This study tests whether adding 4 cycles of chemotherapy around the time of surgery can help prevent the spread of a rare, high-risk soft tissue sarcoma. About 600 adults with resectable tumors will be screened; those with a high-risk genetic signature will be randomly assigned t…

This study is testing a new way of giving radiation before surgery for a rare type of cancer called retroperitoneal sarcoma. The goal is to see if this approach is safe and reduces complications during and after surgery. About 50 adults with this cancer will receive focused radia…

This early-phase trial tests a new treatment called attIL12 T-cell therapy for people with advanced soft tissue or bone sarcoma that has spread. The therapy uses the patient's own immune cells, modified to attack the cancer. The main goal is to find a safe dose and see if it can …

This study tests whether combining two drugs, cadonilimab and anlotinib, can help people with advanced or spreading soft tissue sarcoma whose first treatment stopped working. About 27 adults will take part. The goal is to see if the combo slows tumor growth and improves survival.

This study offers expanded access to an experimental treatment called DNG64-CAR-V for people with advanced pancreatic cancer, sarcoma, or breast cancer. Up to 40 patients will receive the therapy intravenously or directly into tumors, alone or with other approved cancer drugs. Th…

This study tests whether two drugs, zanzalintinib and pembrolizumab, can help control advanced soft-tissue sarcoma that has spread. About 20 adults with specific sarcoma types will receive the combination. The main goal is to check safety and side effects.

This study tests whether the immunotherapy drug dostarlimab works better than standard chemotherapy as the first treatment for people with advanced cancers that have specific genetic markers (dMMR/MSI). The cancers studied are rare types like pancreatic, stomach, and small bowel …

This study tests a 5-day course of radiation before surgery for soft tissue sarcoma in the arms or legs. The goal is to treat the cancer and prevent spread while preserving healthy tissue. About 40 adults will take part to see if this shorter radiation is safe and effective.

This study tests two chemotherapy drugs, trabectedin and gemcitabine, in people with advanced leiomyosarcoma (a rare soft tissue cancer) that has spread or cannot be removed by surgery. All participants have already received at least one prior chemotherapy treatment. The goal is …

This study tests a drug called AL3818 (anlotinib) for people with a rare cancer called alveolar soft part sarcoma that has spread or cannot be removed by surgery. The goal is to see if the drug can shrink tumors or slow cancer growth. Participants take AL3818 pills daily, and the…

This early-phase study tests a new drug (177Lu-DFC413) that delivers radiation directly to cancer cells in adults with advanced solid tumors like pancreatic, lung, breast, colorectal, and soft tissue cancers. The main goals are to check safety, find the right dose, and see if it …

This study tests whether a 5-day course of radiation before surgery for soft tissue sarcoma is as safe and effective as the standard 25-day course. About 75 adults with sarcoma in an arm, leg, trunk, or abdomen will receive the shorter radiation and then surgery. The main goal is…

This study tests an experimental drug called MT-4561 in people with advanced solid tumors (like lung, breast, or pancreatic cancer) who have run out of standard options. The goal is to find a safe dose and see if the drug can shrink tumors. About 27 adults will take part in this …

This early-phase study tests a new drug called AVA6000, a chemotherapy that is designed to activate only inside tumors, potentially reducing side effects. It is for people with advanced solid tumors (like breast, ovarian, or salivary gland cancer) that have not responded to stand…

This phase 3 trial tests whether adding ADI-PEG 20 to standard chemotherapy (gemcitabine and docetaxel) helps control advanced leiomyosarcoma, a rare soft tissue cancer. About 300 adults whose cancer has worsened after prior treatment will receive either the study drug or a place…

This study tests a shorter course of proton or carbon ion radiation (2-3 weeks instead of the usual 5 weeks) before surgery for soft tissue sarcoma in the arms or legs. The goal is to see if this approach reduces wound healing problems and treatment interruptions. About 42 adults…

This study compares a shorter, higher-dose radiation schedule (hypofractionated) to the standard longer schedule before surgery for soft tissue sarcoma. The goal is to see if the shorter approach is safe and effective at killing tumor cells. 30 adults with sarcoma in the arm, leg…

This study tests an experimental drug, tigilanol tiglate, injected directly into tumors in people with advanced or metastatic soft tissue sarcoma of the arms, legs, or body wall. The goal is to see if the drug can shrink or destroy the treated tumors. About 40 adults will take pa…

This study is testing whether a special type of PET/CT scan, using a tracer called 68Ga-DOTATATE, can better detect soft tissue sarcomas. The goal is to see if this imaging method can find tumors more clearly than standard scans, which may help doctors decide if a targeted radiat…

This study looks at whether giving sarcoma patients early access to mental healthcare before and after surgery can help reduce depression and anxiety. About 60 adults with bone or soft tissue sarcoma will be randomly assigned to get either early psychiatric support or usual care.…

This study looks at whether doing exercise before radiation and surgery for soft tissue sarcoma can improve arm or leg function and help wounds heal better. Researchers will enroll 24 adults with sarcoma in an arm or leg. Participants will exercise before their standard treatment…

This study tests if a personalized exercise program before surgery helps people with soft tissue sarcoma recover faster and with less disability. About 30 adults with lower-limb sarcoma will either receive standard care or a tailored prehabilitation plan during radiotherapy. The …

This study looks at how removing soft tissue sarcoma from the arms or legs affects a person's body image, quality of life, and physical abilities like walking and joint movement. Researchers will ask 150 patients who had surgery between 2010 and 2021 to fill out questionnaires an…

This study tests whether a dye injected during surgery can help surgeons see if they have removed all of a sarcoma tumor. About 50 adults with bone or soft tissue sarcoma will take part. The dye's accuracy will be compared to standard lab tests on the removed tissue.

This early study tests whether contrast-enhanced ultrasound (CEUS) can help doctors see how soft tissue sarcoma responds to radiation therapy before surgery. Ten adults with sarcoma will get CEUS scans at three points during treatment. The goal is to see if this imaging method ca…

This study is testing whether special MRI scans and blood tests can predict if soft-tissue sarcoma will spread to other parts of the body. Researchers will enroll 145 adults with high-risk sarcomas. The goal is to find biomarkers that help doctors personalize treatment without ex…

This study looks at how people who had limb-saving surgery for bone or soft tissue sarcoma in their leg are doing physically and emotionally. Researchers will use surveys and walking tests to measure function, pain, and quality of life. The goal is to learn more about recovery an…

This study aims to learn more about the immune system's role in rare soft tissue sarcomas. Researchers will collect and analyze blood and tumor samples from 400 patients with these uncommon cancers. The goal is to find patterns that could help predict how the disease will progres…